Análisis de la evolución y adaptación de la asistencia sanitaria en la pandemia provocada por el SARS-Cov-2. Respuesta sanitaria e implementación de nuevas soluciones

Tesis por compendio de publicaciones[ES] El presente estudio analiza la evolución y adaptación la respuesta sanitaria en la pandemia provocada por el SARS-CoV-2 en el año 2020. Centrándose en las necesidades sanitarias como consecuencia de la enfermedad, haciendo especial hincapié en el abordaje no farmacológico y las necesidades de rehabilitación funcional de los pacientes. Si bien es cierto que la sintomatología de los pacientes oscila de cuadros asintomáticos a largos periodos en unidades de cuidados intensivos (UCI), hasta el momento no se han identificado los determinantes para la evolución en el desarrollo de la gravedad clínica. Actualmente se dispone de gran información sobre las secuelas de los pacientes que han superado la enfermedad. Aunque estas secuelas al igual que los cuadros clínicos son muy variables; prevalecen la afectación de los sistemas respiratorio, cardiaco y neurológico, dando lugar a secuelas que limitan funcionalmente a los pacientes, manifestándose con debilidad y fatiga o disnea. Cabe destacar la fibrosis pulmonar como una de las secuelas a nivel pulmonar, causante de la ya descrita clínica residual del paciente. El abordaje temprano del paciente es fundamental. Un buen control de la sintomatología mejorará el estado del paciente y disminuirá la mortalidad. La implementación de soluciones innovadoras, como la que se presenta, mediante la creación de una plataforma colaborativa de tele-rehabilitación, permiten mejorar el seguimiento y la asistencia a los pacientes

Aplicación de metodologías basadas en la simulación clínica en el Grado en Fisioterapia

Memoria ID-021. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2021-2022

RespiraConNosotros: A Viable Home-Based Telerehabilitation System for Respiratory Patients

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Listas de verificación para la elaboración, tutorización y evaluación de Trabajos Fin de Grado

El Trabajo Fin de Grado (TFG) es una asignatura obligatoria en los títulos de Grado. La diversidad existente en el tipo de trabajo y la falta de mecanismos de coordinación originan disparidad de criterios en la elaboración-tutorización y evaluación-calificación de estos. El objetivo de este trabajo fue diseñar un instrumento que facilitase la realización, tutorización y evaluación de los TFG en la titulación de Grado en Fisioterapia en una universidad pública española. Se diseñaron 6 listas de verificación, una común que incluía las normas de estilo, extensión y estructura y otras 5 para los tipos de TFG contemplados: trabajo de investigación, revisión bibliográfica sistemática, proyectos de investigación, trabajo profesional (caso clínico y protocolo de intervención). Los apartados de las listas y sus epígrafes fueron consensuados entre un equipo de 11 profesores de la titulación. Las listas fueron distribuidas durante el segundo cuatrimestre de 2021 entre profesores y estudiantes de 4º curso. Disponer de listas de verificación organizadas por apartados y epígrafes facilita la elaboración, tutorización y evaluación de los TFG, minimiza la aparición de errores durante las mismas y resultan instrumentos fácilmente exportables a otras universidades y titulaciones en el ámbito de las Ciencias de la Salud

Elaboración de listas de verificación para la realización, tutorización y evaluación de Trabajos Fin de Grado

Memoria ID-10 Ayudas de la Universidad de Salamanca para la innovación docente, curso 2020-2021

Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study

This study evaluates the impact of breast cancer (BC) in health related quality of life (HRQL) and in psychological distress (PD) during the initial phases of the disease and looks for contributing factors. A multicentric case-control study, EpiGEICAM, was carried out. Incident BC cases and age- and residence- matched controls were included. Clinical, epidemiological, HRQL (SF-36) and PD information (GHQ-28) was collected. We used multivariable logistic regression models to estimate OR of low HRQL and of PD in cases compared to controls, and to identify factors associated with low HRQL and with PD. Among 896 BC cases and 890 control women, cases had poorer scores than both, the reference population and the control group, in all SF-36 scales. BC women with lower education, younger, active workers, never smokers, those with comorbidities, in stage IV and with surgical treatment had lower physical HRQL; factors associated with low mental HRQL were dissatisfaction with social support, being current smoker and having children. Cases had a fivefold increased odds of PD compared to controls. Managing comorbidities and trying to promote social support, especially in younger and less educated women, could improve well-being of BC patients

Corrigendum: Quality of life and quality of education among physiotherapy students in Europe

Funding: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by the National Medical Research Council (NMRC) through the SingHealth PULSES II Centre Grant (CG21APR1013). The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.Introduction: Physiotherapy education varies worldwide, with some countries offering on-the-job training while others have bachelor’s or master’s degree programs. There are also differences in postgraduate education across Europe (1). Teaching techniques to future physiotherapists also present challenges due to variations in learning styles and attitudes towards clinical-practical teaching. National universities and their faculties can differ in various ways, and health systems and policies impact rehabilitation and physiotherapy methods, too. There is a limited number of empirical studies comparing the experience of physiotherapy students at different institutions (2–4), highlighting the variations in physiotherapy education worldwide (5, 6). In this study, we focused on the comparison of bachelor’s degree programs in physiotherapy in Europe.info:eu-repo/semantics/publishedVersio

Anti-Spike antibodies 3 months after SARS-CoV-2 mRNA vaccine booster dose in patients on hemodialysis: the prospective SENCOVAC study

Background: Patients on hemodialysis are at high-risk for complications derived from coronavirus disease 2019 (COVID-19). The present analysis evaluated the impact of a booster vaccine dose and breakthrough severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on humoral immunity 3 months after the booster dose. Methods: This is a multicentric and prospective study assessing immunoglobulin G anti-Spike antibodies 6 and 9 months after initial SARS-CoV-2 vaccination in patients on hemodialysis that had also received a booster dose before the 6-month assessment (early booster) or between the 6- and 9-month assessments (late booster). The impact of breakthrough infections, type of vaccine, time from the booster and clinical variables were assessed. Results: A total of 711 patients [67% male, median age (range) 67 (20-89) years] were included. Of these, 545 (77%) received an early booster and the rest a late booster. At 6 months, 64 (9%) patients had negative anti-Spike antibody titers (3% of early booster and 29% of late booster patients, P =. 001). At 9 months, 91% of patients with 6-month negative response had seroconverted and there were no differences in residual prevalence of negative humoral response between early and late booster patients (0.9% vs 0.6%, P =. 693). During follow-up, 35 patients (5%) developed breakthrough SARS-CoV-2 infection. Antibody titers at 9 months were independently associated with mRNA-1273 booster (P =. 001), lower time from booster (P =. 043) and past breakthrough SARS-CoV-2 infection (P <. 001). Conclusions: In hemodialysis patients, higher titers of anti-Spike antibodies at 9 months were associated with mRNA-1273 booster, lower time from booster and past breakthrough SARS-CoV-2 infectionThe present project has been supported by Fresenius Medical Care, Diaverum, Vifor Pharma, Vircell, Fundación Renal Iñigo Álvarez de Toledo and ISCIII FEDER funds RICORS2040 (RD21/0005

COVID-19 Severity and Survival over Time in Patients with Hematologic Malignancies: A Population-Based Registry Study

Mortality rates for COVID-19 have declined over time in the general population, but data in patients with hematologic malignancies are contradictory. We identified independent prognostic factors for COVID-19 severity and survival in unvaccinated patients with hematologic malignancies, compared mortality rates over time and versus non-cancer inpatients, and investigated post COVID-19 condition. Data were analyzed from 1166 consecutive, eligible patients with hematologic malignancies from the population-based HEMATO-MADRID registry, Spain, with COVID-19 prior to vaccination roll-out, stratified into early (February–June 2020; n = 769 (66%)) and later (July 2020–February 2021; n = 397 (34%)) cohorts. Propensity-score matched non-cancer patients were identified from the SEMI-COVID registry. A lower proportion of patients were hospitalized in the later waves (54.2%) compared to the earlier (88.6%), OR 0.15, 95%CI 0.11–0.20. The proportion of hospitalized patients admitted to the ICU was higher in the later cohort (103/215, 47.9%) compared with the early cohort (170/681, 25.0%, 2.77; 2.01–3.82). The reduced 30-day mortality between early and later cohorts of non-cancer inpatients (29.6% vs. 12.6%, OR 0.34; 0.22–0.53) was not paralleled in inpatients with hematologic malignancies (32.3% vs. 34.8%, OR 1.12; 0.81–1.5). Among evaluable patients, 27.3% had post COVID-19 condition. These findings will help inform evidence-based preventive and therapeutic strategies for patients with hematologic malignancies and COVID-19 diagnosis.Depto. de MedicinaFac. de MedicinaTRUEFundación Madrileña de Hematología y HemoterapiaFundación Leucemia y LinfomaAsociación Madrileña de Hematología y Hemoterapiapu

Examining the immune signatures of SARS-CoV-2 infection in pregnancy and the impact on neurodevelopment: Protocol of the SIGNATURE longitudinal study

The COVID-19 pandemic represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge on pathophysiological mechanisms of neuropsychiatric diseases. One of these opportunities is the study of the relationships between inflammation, brain development and an increased risk of suffering neuropsychiatric disorders. Based on the hypothesis that neuroinflammation during early stages of life is associated with neurodevelopmental disorders and confers a greater risk of developing neuropsychiatric disorders, we propose a cohort study of SARS-CoV-2-infected pregnant women and their newborns. The main objective of SIGNATURE project is to explore how the presence of prenatal SARS-CoV-2 infection and other non-infectious stressors generates an abnormal inflammatory activity in the newborn. The cohort of women during the COVID-19 pandemic will be psychological and biological monitored during their pregnancy, delivery, childbirth and postpartum. The biological information of the umbilical cord (foetus blood) and peripheral blood from the mother will be obtained after childbirth. These samples and the clinical characterisation of the cohort of mothers and newborns, are tremendously valuable at this time. This is a protocol report and no analyses have been conducted yet, being currently at, our study is in the recruitment process step. At the time of this publication, we have identified 1,060 SARS-CoV-2 infected mothers and all have already given birth. From the total of identified mothers, we have recruited 537 SARS-COV-2 infected women and all of them have completed the mental health assessment during pregnancy. We have collected biological samples from 119 mothers and babies. Additionally, we have recruited 390 non-infected pregnant women.This work has received support from the Fundación Alicia Koplowitz to realize the epigenetic wide association study and to the clinical assessment to the children. This work has also received public support from the Consejería de Salud y Familias para la financiación de la investigación, desarrollo e innovación (i + d + i) biomédica y en ciencias de la salud en Andalucía (CSyF 2021 - FEDER). Grant Grant number PECOVID- 0195-2020. Convocatoria financiada con Fondo Europeo de Desarrollo Regional (FEDER) al 80% dentro del Programa Operativo de Andalucía FEDER 2014-2020. Andalucía se mueve con Europa. NG-T received payment under Rio Hortega contract CM20-00015 with the Carlos III Health Institute.Peer reviewe