Aligning the Good Practice MASK With the Objectives of the European Innovation Partnership on Active and Healthy Ageing

The reference sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) were renewed in 2019. The DG Sante good practice Mobile Airways Sentinel networK was reviewed to meet the objectives of the EIP on AHA. It included 1) Management of care process, 2) Blueprint of digital transformation, 3) EIP on AHA, innovation to market, 4) Community for monitoring and assessment framework, 5) Political, organizational, technological and financial readiness, 6) Contributing to European co-operation and transferability, 7) Delivering evidence of impact against the triple win approach, 8) Contribution to the European Digital Transformation of Health and Care and 9) scale of demonstration and deployment of innovation.Peer reviewe

T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques

Objectives: To analyze correlates of protection in macaques exposed to SIV. Methods: Peripheral blood mononuclear cells (PBMC) from macaques inoculated intrarectally with various dilutions of SIV were examined for their in vitro proliferative response to SIV envelope peptides and generation of SIV-specific antibodies. Some macaques previously exposed intravenously to subinfectious doses of SIV were subsequently challenged 16 months later with an infectious intrarectal dose of SIV. Results: The viral-specific immune responses of macaques exposed to infectious doses of SIV were characterized by generation of antibodies and weak or undetectable T-cell-mediated responses. In contrast, macaques inoculated with doses of SIV below the threshold required for seroconversion and recovery of virus exhibited T-cell proliferation in response to SIV envelope synthetic peptides. The macaques that had previously been exposed to SIV resisted the subsequent virus challenge, whereas the naive macaques (never exposed to SIV) all became infected. Conclusions: The inability to productively infect macaques previously exposed to subinfectious doses of SIV suggests that a T-cell-mediated response may confer long-term protection against infection, and that AIDS vaccines should be designed to optimize the cellular arm of the immune response

A synchronous language with partial delay specification for real-time systems programming

International audienceHigh-level formal programming languages require system designers to provide a very precise description of the system during early development phases, which may in some cases lead to arbitrary choices (i.e. the designer "overspecifies" the system). In this paper, we propose an extension of synchronous dataflow languages where the designer can specify that he does not care whether some communication is immediate or delayed. It is then up to the compiler to choose where to introduce delays, in a way that breaks causality cycles and satisfies latency requirements imposed on the system

Controlling a biological invasion: a non-classical dynamic economic model

Intertemporal allocation, Nonconvexities, Biological invasion, Invasive species, Renewable resource economics, D9, Q2,