IJEMS: Iowa Joint Experiment in Microgravity Solidification

The Iowa Joint Experiment in Microgravity Solidification (IJEMS) is a cooperative effort between Iowa State University and the University of Iowa to study the formation of metal-matrix composites in a microgravity environment. Of particular interest is the interaction between the solid/liquid interface and the particles in suspension. The experiment is scheduled to fly on STS-69, Space Shuttle Endeavor on August 3, 1995. This project is unique in its heavy student participation and cooperation between the universities involved

Orion Guidance and Control Ascent Abort Algorithm Design and Performance Results

During the ascent flight phase of NASA s Constellation Program, the Ares launch vehicle propels the Orion crew vehicle to an agreed to insertion target. If a failure occurs at any point in time during ascent then a system must be in place to abort the mission and return the crew to a safe landing with a high probability of success. To achieve continuous abort coverage one of two sets of effectors is used. Either the Launch Abort System (LAS), consisting of the Attitude Control Motor (ACM) and the Abort Motor (AM), or the Service Module (SM), consisting of SM Orion Main Engine (OME), Auxiliary (Aux) Jets, and Reaction Control System (RCS) jets, is used. The LAS effectors are used for aborts from liftoff through the first 30 seconds of second stage flight. The SM effectors are used from that point through Main Engine Cutoff (MECO). There are two distinct sets of Guidance and Control (G&C) algorithms that are designed to maximize the performance of these abort effectors. This paper will outline the necessary inputs to the G&C subsystem, the preliminary design of the G&C algorithms, the ability of the algorithms to predict what abort modes are achievable, and the resulting success of the abort system. Abort success will be measured against the Preliminary Design Review (PDR) abort performance metrics and overall performance will be reported. Finally, potential improvements to the G&C design will be discussed

Kinematic Analysis of the 2020 Elliot Creek Landslide, British Columbia, Using Remote Sensing Data

The 2020 Elliot Creek landslide-tsunami-flood cascade originated from an 18.3 Mm3 rock slope failure in quartz diorite bedrock in a valley undergoing rapid glacial retreat. We used airborne LiDAR and optical imagery to characterize the slope and its surroundings. Using the LiDAR, we determined that two rockslides (2020 and an older undated one) occurred on this slope and shared a common basal rupture surface. We mapped two main sets of lineaments that represent structures that controlled the orientation of the lateral and rear release surfaces. Analysis of the topographic profile indicates a wedge-shaped failure block and a stepped rupture surface. Further topographic profile analysis indicates the possibility of a structurally controlled geomorphic step in the valley that corresponds with a change in the orientation of the valley. The rapid retreat of the West Grenville Glacier and the positions of the rupture surfaces suggest glacial retreat played a role in the landslides

The glacial geomorphology of the Lago Buenos Aires and Lago Pueyrredón ice lobes of central Patagonia

<p>This paper presents a glacial geomorphological map of landforms produced by the Lago General Carrera–Buenos Aires and Lago Cochrane–Pueyrredón ice lobes of the former Patagonian Ice Sheet. Over 35,000 landforms were digitized into a Geographical Information System from high-resolution (<15 m) satellite imagery, supported by field mapping. The map illustrates a rich suite of ice-marginal glacigenic, subglacial, glaciofluvial and glaciolacustrine landforms, many of which have not been mapped previously (e.g. hummocky terrain, till eskers, eskers). The map reveals two principal landform assemblages in the central Patagonian landscape: (i) an assemblage of nested latero-frontal moraine arcs, outwash plains or corridors, and inset hummocky terrain, till eskers and eskers, which formed when major ice lobes occupied positions on the Argentine steppe; and (ii) a lake-terminating system, dominated by the formation of glaciolacustrine landforms (deltas, shorelines) and localized ice-contact glaciofluvial features (e.g. outwash fans), which prevailed during deglaciation.</p

The micromorphology of glaciolacustrine varve sediments and their use for reconstructing palaeoglaciological and palaeoenvironmental change

Former glaciolacustrine systems are an important archive of palaeoglaciological, palaeoenvironmental and palaeoclimatic change. The annually laminated (varved) sediments that, under certain conditions, accumulate in former glacial lakes, offer a rare opportunity to reconstruct such changes (e.g. glacier advance and retreat cycles, glacier ablation trends, permafrost melt, nival events) at annual or even sub-annual temporal resolution. Data of this kind are desirable for their ability to guide and test numerical model simulations of glacier dynamics and palaeoclimatic change that occur over rapid time intervals, with implications for predicting future glacier response to climatic change, or the effects of weather and climate events on lake sedimentation. The most valuable records preserved in glaciolacustrine systems are continuous varved sequences formed in the distal parts of glacial lakes, where microscale lamination structures can accumulate relatively undisturbed. Technological advances, in the last few decades, have enabled improved characterisation of glaciolacustrine varve microfacies and the precise measurement of varve thickness at the micrometre scale. However, unlike in cognate fields (e.g. soil science), protocols for the robust and consistent description and interpretation of glaciolacustrine varve sediments are lacking. To fill this gap, and to provide a resource for future studies of glaciolacustrine varved sediments, this paper reviews the processes of sedimentation in glacial lake basins, and presents the defining microfacies characteristics of glacial varves using a descriptive protocol that uses consistent examination of grain size, sorting, structure, nature of contacts, development of plasmic fabrics and features such as dropgrains and intraclasts within individual laminations. These lamination types are then combined into lamination sets, whose structures can be interpreted as glaciolacustrine varves. Within this framework, we define five principal assemblages of glaciolacustrine varve microfacies which, if clearly identified in palaeoglaciolacustrine settings, enable more detailed palaeoenvironmental interpretations to be made. Finally, we discuss the utility and complexities of reconstructing the evolution of former glacial lake systems using varve microfacies and thickness datasets

Enhanced terrestrial carbon export from East Antarctica during the early Eocene

Terrestrial organic carbon (TerrOC) acts as an important CO2 sink when transported via rivers to the ocean and sequestered in coastal marine sediments. This mechanism might help to modulate atmospheric CO2 levels over short- and long timescales (103 to 106 years), but its importance during past warm climates remains unknown. Here we use terrestrial biomarkers preserved in coastal marine sediment samples from Wilkes Land, East Antarctica (~67°S) to quantify TerrOC burial during the early Eocene (~54.4 to 51.5 Ma). Terrestrial biomarker distributions indicate the delivery of plant-, soil- and peat-derived organic carbon (OC) into the marine realm. Mass accumulation rates of plant- (long-chain n-alkane) and soil-derived (hopane) biomarkers dramatically increase between the earliest Eocene (~54 Ma) and the early Eocene Climatic Optimum (EECO; ~53 Ma). This coincides with increased OC mass accumulation rates and indicates enhanced TerrOC burial during the EECO. Leaf wax δ 2H values indicate that the EECO was characterised by wetter conditions relative to the earliest Eocene, suggesting that hydroclimate exerts a first-order control on TerrOC export. Our results indicate that TerrOC burial in coastal marine sediments UOB Open could have acted as an important negative feedback mechanism during the early Eocene, but also during other warm climate intervals

A Study of T Cell Tolerance to the Tumor-Associated Antigen MDM2: Cytokines Can Restore Antigen Responsiveness, but Not High Avidity T Cell Function

BACKGROUND: Most tumor-associated antigens (TAA) currently used for immunotherapy of cancer are also expressed in normal tissues, which may induce tolerance and impair T cell-mediated immunity. However, there is limited information about how physiological expression in normal tissues alters the function of TAA-specific T cells. METHODOLOGY/PRINCIPAL FINDINGS: We used a T cell receptor transgenic model to study how MDM2 expression in normal tissues affects the function of T cells specific for this TAA that is found at high levels in many different types of tumors. We found that some MDM2-specific T cells escaped thymic deletion and persisted in the peripheral T cell pool. When stimulated with antigen, these T cells readily initiated cell division but failed to proliferate and expand, which was associated with a high rate of apoptosis. Both IL-2 and IL-15 efficiently rescued T cell survival and antigen-specific T cell proliferation, while IL-7 and IL-21 were ineffective. Antigen-stimulated T cells showed impaired expression of the effector molecules CD43, granzyme-B and IFN-γ, a defect that was completely restored when T cells were stimulated in the presence of IL-2. In contrast, IL-15 and IL-21 only restored the expression of CD43 and granzyme-B, but not IFN-γ production. Finally, peptide titration experiments with IL-2 rescued T cells indicated that they were of lower avidity than non-tolerant control T cells expressing the same TCR. CONCLUSIONS/SIGNIFICANCE: These data indicate that cytokines can rescue the antigen-specific proliferation and effector function of MDM2-specific T cells, although this does not lead to the recovery of high avidity T cell function. This study sheds light on possible limitations of immunotherapy approaches that target widely expressed TAA, such as MDM2