Abundance analysis of two late A-type stars HD 32115 and HD 37594

We have performed abundance analysis of two slowly rotating, late A-type stars, HD 32115 (HR 1613) and HD 37594 (HR 1940), based on obtained echelle spectra covering the spectral range 4000-9850 AAngstrom. These spectra allowed us to identify an extensive line list for 31 chemical elements, the most complete to date for A-type stars. Two approaches to abundance analysis were used, namely a ``manual'' (interactive) and a semi-automatic procedure for comparison of synthetic and observed spectra and equivalent widths. For some elements non-LTE (NLTE) calculations were carried out and the corresponding corrections have been applied. The abundance pattern of HD 32115 was found to be very close to the solar abundance pattern, and thus may be used as an abundance standard for chemical composition studies in middle and late A stars. Further, its H-alpha line profile shows no core-to-wing anomaly like that found for cool Ap stars and therefore also may be used as a standard in comparative studies of the atmospheric structures of cool, slowly rotating Ap stars. HD 37594 shows a metal deficiency at the level of -0.3 dex for most elements and triangle-like cores of spectral lines. This star most probably belongs to the Delta Scuti group.Comment: 10 pages, 4 figure

Chemistry for Sustainable Development 15 (2007) 109116 Organic Polysulphides in Bottom Sediments of the Gulf of Finland

Abstract In the samples of bottom sediments of the Gulf of Finland in its eastern part, 43 organic compounds containing sulphur were identified and estimated quantitatively by means of gas chromatography mass spectrometry. It is shown that polysulphides are widespread in the bottom sediments of the investigated part of the Gulf of Finland. An increase in the concentrations of sulphur-containing compounds with an increase in the salt content of water and with an increase in the depth of the gulf from the east to the west was detected. The high concentration of sulphur-containing organic compounds in bottom sediments in the region from the west edge of the island of Kotlin to 28 degrees of eastern longitude provides evidence that there exist the conditions for the formation of hydrogen sulphide zones stable in this region

The Problem of Law-Abiding Behavior among Minors in Educational Institutions: Domestic and Foreign Experience

At present, the problem of sustaining the law-abiding behavior of minors in educational institutions, identifying and eliminating the causes and conditions that contribute to the development of deviant behavior of students is becoming more and more topical. This paper presents the results of a monitoring study of the current state of the activities carried out by educational institutions to form the law-abiding behavior of minors in the territorial entities of the Russian Federation. It also presents the results of a theoretical study of the foreign experience of educational institutions in the framework of maintaining the law-abiding behavior of minors in the educational environment. The conclusions have been drawn that a system-activity approach should be the basis of an educational impact in educational institutions which will provide: the formation of students’ readiness for self-development; the design and construction of a social environment for the development of students based on moral principles, traditional Russian values, relevant scientific knowledge and skills, respect for the traditions of the multinational, multicultural and multiconfessional Russian society; active educational and cognitive activities of students; building educational and moral education activity, taking account of the individual age-related psychological and physiological characteristics of students and with a focus on educational results. The materials of the paper are part of a large-scale study within the framework of the "Conception for the development of a system for the prevention of neglect and juvenile delinquency for the period up to 2020", conducted by a team of scientists from 2017 to 2020, whose scientific interests lie in the study of the problem of deviant behavior of minors

DIFFERENTIATION OF NK CELLS. A LOOK THROUGH THE PRISM OF TRANSCRIPTION FACTORS AND INTRACELLULAR MESSENGERS

All lymphoid cells are referred to as an innate or adaptive immunity unit in terms of the mechanisms of performing immune reactions. The functional activity of natural killer (NK) cells is not associated with pre-activation processes resulting from contact with antigen, rearrangement of antigen-recognition receptor genes, and clonal proliferation. In this regard, NK cells are traditionally referred to as cells of innate immunity. Previously, it was believed that NK cells represent the only population of innate immunity lymphoid cells, but, more recently, there has been increasing evidence in the literature concerning existence of different populations of these cells, thus serving a basis for isolating a common cluster called Innate Lymphoid Cells (ILC). According to the ILC classification, NK cells are classified as the first group of innate lymphoid cells according to their overall functional characteristics, as well as contribution of the T-bet transcription factor to their differentiation. Complexity, multistage and partially nonlinear character of NK cell differentiation are associated with influence of the cellular microenvironment, consistent expression of transcription factors and activation of various intracellular signaling pathways in NK cells. The review considers positioning of NK cells in the ILC classification, the main transcription factors involved in NK cell differentiation. The authors are seeking for generalization of the major routes of intracellular signal transmission in NK cells depending on their activation by cytokines located in the cellular microenvironment and affecting NK cells. The decidual NK cells during pregnancy represent a special object of NK cell differentiation. Stromal cells, trophoblast cells and macrophages are present in the decidua, in addition to NK cells. The review concerns a special case of microenvironmental effects upon expression of transcription factors and activation of NK intracellular messengers, while considering trophoblast cells an example of such influences. The recently discovered variety of NK cells, induced by the microenvironment in the course of their differentiation, requires further study

Physics and Chemistry of the Hydrogen Fluoride Production Process from Fluorine Containing Waste

The impact of the aluminum industry wastes on the environment is established. The resource efficient method of aluminum industry fluorine-containing wastes processing, which includes wastes oxidizing roasting to remove carbon component and the interaction of fluorine- containing particles with sulfuric acid in order to produce hydrogen fluoride, is considered. The economic and environmental effect of the proposed processing method is substantiated

Local cytokine levels as prognostic factors for early relapse of non-muscle-invasive bladder carcinoma

The aim of our study is to assess the local cytokine levels as prognostic factors for early relapse in NMIBC patients. 75 patients with NMIBC were enrolled in the study: 51 with primary NMIBC and 24 with initially recurrent NMIBC, LG and HG tumors were diagnosed in each group. Patients with primary NMIBC were monitored during 9 months after treatment: TURB and chemotherapy (No. 6). During TURB samples of tumors were taken, supernatants were obtained and tissue cytokine levels were measured (IL-1β, IL-6, IL-10, IL-18, TNFα, IFNγ, IL-8) by ELISA test. The results showed that in patients with primary NMIBC early relapses were diagnosed in 15 (46.8%) of LG tumors and in 11 (45%) of HG tumors matching that there was no difference depending upon tumor grade. In initially recurrent tumors of both LG and HG NMIBC the amounts of cytokines were maximal: in LG tumors they exceeded the primary ones from 7.1 (IFNγ) to 300 (IL-6) while in HG - from 2.0 (IL-10) to 9.7 (IL-6). The amounts of IL-1β, IL-6, IL-10, IFNγ, IL-8 were higher in those LG primary tumors which relapsed in 6-9 months compared to the ones which didn't, though their levels were much lower than in initially manifested relapse (from 2.6 times for IFNy to 150 times for IL-6). A similar trend, though not for all the same cytokines, was observed in HG tumors: tissue levels of IL-6, IL-10, IL-18 and TNFα were higher in tumors which relapsed in 6-9 months after treatment. The increase of 2 cytokines' levels were common for both LG and HG tumors (IL-6 and IL-10). This finding might be considered as a new prognostic factor of the early relapse. We conclude that relapse of LG and HG NMIBC is related to some immune mechanisms, namely to local hyperproduction of cytokines, especially IL-6 and IL-10, though IL-1β, IL-8, IFNγ could have an impact on LG and IL-18, TNFα — on HG tumors. Taking into account common signaling pathways of IL-6 and IL-10 like JAK/STAT, these transcription factors might be potential targets for new effective approaches to treatment

Маркеры рака мочевого пузыря: их роль и прогностическая значимость (обзор литературы)

This review article is devoted to the main problems of early diagnostic and prognosis of non-muscle-invasive bladder cancer, which accounts for 75 % of all newly detected cases of bladder cancer according to statistics. Chromosomal disorders that have been detected in urothelial cells can lead to the development of non-muscle-invasive bladder cancer. The review highlights the main problems of existing diagnostic systems for bladder cancer, their disadvantage and limitations of use in practice. Special attention is given to tumor stem cells, which are actively involved in the development of relapses of malignant neoplasms, and, also play an important role in the development of chemo - and radioresistance of tumor cells. Their significance in the diagnosis, detection of disease recurrence and the possibility of using the data obtained to adjustment therapeutic methods of treatment in oncology is one of the main tasks in cancer pathology.Обзорная статья посвящена основным проблемам диагностики и раннего прогнозирования немышечно-инвазивного рака мочевого пузыря, на долю которого, по данным статистики, приходится 75 % всех впервые выявленных случаев рака мочевого пузыря. В клетках уротелия, как показывают результаты многих исследований, выявлены хромосомные нарушения, обусловливающие развитие немышечно-инвазивного рака мочевого пузыря. В обзоре обозначены основные проблемы существующих диагностических систем при немышечно-инвазивном раке мочевого пузыря, их недостатки и ограничения использования в повседневной работе. Отдельное внимание уделяется опухолевым стволовым клеткам, которые принимают активное участие в развитии рецидивов злокачественных новообразований, а также играют важную роль в развитии химио- и радиорезистентности опухолевых клеток. Определение их значимости в диагностике, выявлении рецидива заболевания и возможности использования полученных данных для корректировки терапевтических методов лечения в онкологии является одной из основных задач

Immunobiological Characteristics of Cholera Toxin B-Subunit

Carried out was immunobiological evaluation of cholera toxin B subunit preparations obtained using different experimental and production methods. It was demonstrated that B subunit preparations were non-toxic for biomodels and did not cause significant pathological alterations in their organs and tissues. They also did not alter the condition of immunocompetent cells at different stages of their cycle, and promote anti-toxic antibodies production. Thus, B subunit preparations under study can be considered as promising components of cholera vaccine