Apocope of Late Old Chinese short *ă: Early Central Asian loanword and Old Japanese evidence for Old Chinese disyllabic morphemes*

The morphophonology of Old Chinese has usually been reconstructed as an earlier version of the traditional reconstruction of Middle Chinese, with exclusively monosyllabic morphemes. For Old Chinese some scholars have posited syllabic morphemes with long or short vowels, or even polysyllabic morphemes, and other theories have been proposed, but it is still assumed that by Late Old Chinese any longer morphemes that once existed were already monosyllabic. However, Central Asian loans in Chinese suggest some disyllabic morphemes still existed in Late Old Chinese. They seem to be confirmed by a new study of little-noted Old Japanese transcriptions known as nigōgana. Thus the hitherto problematic Old Chinese and Old Japanese transcriptions of foreign words such as Saka and Buddha, and the monosyllabic theory of Old Chinese morphology, must be reconsidered. This paper’s new reconstructions conform to the data and have great implications for the reconstruction of Old Chinese as well as for the reconstruction of the early Chinese loans into Japanese

CANDELS: The Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey - The Hubble Space Telescope Observations, Imaging Data Products and Mosaics

This paper describes the Hubble Space Telescope imaging data products and data reduction procedures for the Cosmic Assembly Near-IR Deep Extragalactic Legacy Survey (CANDELS). This survey is designed to document the evolution of galaxies and black holes at $z\sim1.5-8$, and to study Type Ia SNe beyond $z>1.5$. Five premier multi-wavelength sky regions are selected, each with extensive multiwavelength observations. The primary CANDELS data consist of imaging obtained in the Wide Field Camera 3 / infrared channel (WFC3/IR) and UVIS channel, along with the Advanced Camera for Surveys (ACS). The CANDELS/Deep survey covers \sim125 square arcminutes within GOODS-N and GOODS-S, while the remainder consists of the CANDELS/Wide survey, achieving a total of \sim800 square arcminutes across GOODS and three additional fields (EGS, COSMOS, and UDS). We summarize the observational aspects of the survey as motivated by the scientific goals and present a detailed description of the data reduction procedures and products from the survey. Our data reduction methods utilize the most up to date calibration files and image combination procedures. We have paid special attention to correcting a range of instrumental effects, including CTE degradation for ACS, removal of electronic bias-striping present in ACS data after SM4, and persistence effects and other artifacts in WFC3/IR. For each field, we release mosaics for individual epochs and eventual mosaics containing data from all epochs combined, to facilitate photometric variability studies and the deepest possible photometry. A more detailed overview of the science goals and observational design of the survey are presented in a companion paper.Comment: 39 pages, 25 figure

CANDELS: The Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey

The Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS) is designed to document the first third of galactic evolution, over the approximate redshift (z) range 8--1.5. It will image >250,000 distant galaxies using three separate cameras on the Hubble Space Telescope, from the mid-ultraviolet to the near-infrared, and will find and measure Type Ia supernovae at z>1.5 to test their accuracy as standardizable candles for cosmology. Five premier multi-wavelength sky regions are selected, each with extensive ancillary data. The use of five widely separated fields mitigates cosmic variance and yields statistically robust and complete samples of galaxies down to a stellar mass of 10^9 M_\odot to z \approx 2, reaching the knee of the ultraviolet luminosity function (UVLF) of galaxies to z \approx 8. The survey covers approximately 800 arcmin^2 and is divided into two parts. The CANDELS/Deep survey (5\sigma\ point-source limit H=27.7 mag) covers \sim 125 arcmin^2 within GOODS-N and GOODS-S. The CANDELS/Wide survey includes GOODS and three additional fields (EGS, COSMOS, and UDS) and covers the full area to a 5\sigma\ point-source limit of H \gtrsim 27.0 mag. Together with the Hubble Ultra Deep Fields, the strategy creates a three-tiered "wedding cake" approach that has proven efficient for extragalactic surveys. Data from the survey are nonproprietary and are useful for a wide variety of science investigations. In this paper, we describe the basic motivations for the survey, the CANDELS team science goals and the resulting observational requirements, the field selection and geometry, and the observing design. The Hubble data processing and products are described in a companion paper.Comment: Submitted to Astrophysical Journal Supplement Series; Revised version, subsequent to referee repor

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant

Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes

Background The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes. Aim To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave. Methods A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records. Findings In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home. Conclusion The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine

Empires of the Silk Road A History of Central Eurasia from the Bronze Age to the Present

The first complete history of Central Eurasia from ancient times to the present day, Empires of the Silk Road represents a fundamental rethinking of the origins, history, and significance of this major world region. Christopher Beckwith describes the rise and fall of the great Central Eurasian empires, including those of the Scythians, Attila the Hun, the Turks and Tibetans, and Genghis Khan and the Mongols. In addition, he explains why the heartland of Central Eurasia led the world economically, scientifically, and artistically for many centuries despite invasions by Persians, Greeks, Arabs, Chinese, and others. In retelling the story of the Old World from the perspective of Central Eurasia, Beckwith provides a new understanding of the internal and external dynamics of the Central Eurasian states and shows how their people repeatedly revolutionized Eurasian civilization. Beckwith recounts the Indo-Europeans' migration out of Central Eurasia, their mixture with local peoples, and the resulting development of the Graeco-Roman, Persian, Indian, and Chinese civilizations; he details the basis for the thriving economy of premodern Central Eurasia, the economy's disintegration following the region's partition by the Chinese and Russians in the eighteenth and nineteenth centuries, and the damaging of Central Eurasian culture by Modernism; and he discusses the significance for world history of the partial reemergence of Central Eurasian nations after the collapse of the Soviet Union. Empires of the Silk Road places Central Eurasia within a world historical framework and demonstrates why the region is central to understanding the history of civilization.Intro -- Half Title Page -- Title Page -- Copyright -- Contents -- Preface -- Acknowledgments -- Abbreviations and Sigla -- Introduction -- Prologue: The Hero and his Friends -- 1 - The Chariot Warriors -- 2 - The Royal Scythians -- 3 - Between Roman and Chinese Legions -- 4 - The Age of Attila the Hun -- 5 - The Türk Empire -- 6 - The Silk Road, Revolution, and Collapse -- 7 - The Vikings and Cathay -- 8 - Chinggis Khan and the Mongol Conquests -- 9 - Central Eurasians Ride to a European Sea -- 10 - The Road is Closed -- 11 - Eurasia without a Center -- 12 - Central Eurasia Reborn -- Epilogue: The Barbarians -- Appendix A: The Proto-Indo-Europe and Their Diaspora -- Appendix B: Ancient Central Eurasian Ethnonyms -- Endnotes -- Bibliography -- Index -- MapsThe first complete history of Central Eurasia from ancient times to the present day, Empires of the Silk Road represents a fundamental rethinking of the origins, history, and significance of this major world region. Christopher Beckwith describes the rise and fall of the great Central Eurasian empires, including those of the Scythians, Attila the Hun, the Turks and Tibetans, and Genghis Khan and the Mongols. In addition, he explains why the heartland of Central Eurasia led the world economically, scientifically, and artistically for many centuries despite invasions by Persians, Greeks, Arabs, Chinese, and others. In retelling the story of the Old World from the perspective of Central Eurasia, Beckwith provides a new understanding of the internal and external dynamics of the Central Eurasian states and shows how their people repeatedly revolutionized Eurasian civilization. Beckwith recounts the Indo-Europeans' migration out of Central Eurasia, their mixture with local peoples, and the resulting development of the Graeco-Roman, Persian, Indian, and Chinese civilizations; he details the basis for the thriving economy of premodern Central Eurasia, the economy's disintegration following the region's partition by the Chinese and Russians in the eighteenth and nineteenth centuries, and the damaging of Central Eurasian culture by Modernism; and he discusses the significance for world history of the partial reemergence of Central Eurasian nations after the collapse of the Soviet Union. Empires of the Silk Road places Central Eurasia within a world historical framework and demonstrates why the region is central to understanding the history of civilization.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries

The Actual Achievements of Early Indo-Europeans, in Accurate Historical Context

Ricardo Duchesne’s reply to Martin Hewson’s review of his book, The Uniqueness of Western Civilization (2011), focuses on a number of important points concerning the impact of peoples speaking Indo-European languages in Antiquity and the Middle Ages. However, several of Duchesne’s key assertions need to be modified to accord with the data