Central Coast High School Student Scholarship Fundraiser

Central Coast Continuation High School (CCCHS or CCHS) is designed around the philosophy of giving students in danger of not graduating a second chance at a diploma with alternative education strategies. The problem this Capstone aims to remedy is that many of these students cannot access college for a variety of reasons after graduating high school. These students are stigmatized for attending a continuation school, are in low socio-economic (SES) brackets, and lack scholarship access - these issues prevent college access. Consequences of this problem include future lack of access to higher paying jobs, loss of societal potential, and continuing the cycle of poverty these students often currently inhabit. The project itself is a blueprint for a yearly scholarship fundraiser for CCHS to give out to their students to improve college access. For the 2020-21 school year, CCHS can and should implement this scholarship fundraiser as soon as possible in order to best serve their student population

Altered plasma membrane dynamics of bone morphogenetic protein receptor type Ia in a low bone mass mouse model.

Bone morphogenetic proteins (BMPs) are growth factors that initiate differentiation of bone marrow stromal cells to osteoblasts and adipocytes, yet the mechanism that decides which lineage the cell will follow is unknown. BMP2 is linked to the development of osteoporosis and variants of BMP2 gene have been reported to increase the development of osteoporosis. Intracellular signaling is transduced by BMP receptors (BMPRs) of type I and type II that are serine/threonine kinase receptors. The BMP type I a receptor (BMPRIa) is linked to osteogenesis and bone mineral density (BMD). BMPRs are localized to caveolae enriched with Caveolin1 alpha/beta and Caveolin beta isoforms to facilitate signaling. BMP2 binding to caveolae was recently found to be crucial for the initiation of the Smad signaling pathway. Here we determined the role of BMP receptor localization within caveolae isoforms and aggregation of caveolae as well as BMPRIa in bone marrow stromal cells (BMSCs) on bone mineral density using the B6.C3H-6T as a model system. The B6.C3H-6T is a congenic mouse with decreased bone mineral density (BMD) with increased marrow adipocytes and decreased osteoprogenitor proliferation. C57BL/6J mice served as controls since only a segment of Chr6 from the C3H/HeJ mouse was backcrossed to a C57BL/6J background. Family of image correlation spectroscopy was used to analyze receptor cluster density and co-localization of BMPRIa and caveolae. It was previously shown that BMP2 stimulation results in an aggregation of caveolae and BMPRIa. Additionally, BMSCs isolated from the B6.C3H-6T mice showed a dispersion of caveolae domains compared to C57BL/6J. The aggregation of BMPRIa that is necessary for signaling to occur was inhibited in BMSCs isolated from B6.C3H-6T. Additionally, we analyzed the co-localization of BMPRIa with caveolin-1 isoforms. There was increased percentage of BMPRIa co-localization with caveolae compared to C57BL/6J. BMP2 stimulation had no effect on the colocalization of BMPRIa with caveolin-1. Disrupting caveolae initiated Smad signaling in the isolated BMSCs from B6.C3H-6T. These data suggest that in congenic 6T mice BMP receptors aggregation is inhibited causing an inhibition of signaling and reduced bone mass

Booth-Kelly Mixed-Use District

51 pagesGraduate and undergraduate architecture students in Professor Brook Muller’s terminal studio during winter and spring terms of 2012 examined potential redevelopment scenarios for the Booth-Kelly site, located in downtown Springfield. The city anticipated redevelopment concepts and guidelines developed as part of the studio could potentially be adopted into the Downtown Refinement Plan and implemented in the future. Students identified several programmatic schemes that describe how the site could become a destination location with a pedestrian-friendly appeal. Seen as a collision of industry and nature, sharing multiple habitats and crossing paths, the site’s industrial beauty and rich history are ideal for unique design solutions that exemplify these characteristics. An in-depth focus on its ecology led many students to incorporate much of the surrounding context in a systems thinking approach. Many of the designs seek to interconnect various processes, from both onsite and offsite byproducts and resources, and to bridge natural and urban resource flows. Common themes emerged with different programmatic emphases, including: adaptive reuse, agricultural production and distribution, community education, linking downtown to industry, and adaptable piecemeal development. While each project holds a different focus, the studio collectively promoted many of the same design values

COS Ambassadors

A collection of materials and resources for COS ambassadors