20 research outputs found
Worldwide Organization of Neurocritical Care: Results from the PRINCE Study Part 1
- Author
- Abdo W. F.
- Abdullah J. M.
- Abrego G. C.
- Afshinnik A.
- Aggarwal D. G.
- Aguilar G.
- Aguilera S.
- Ahmad A.
- Aiyagari V.
- Al-Jehani H.
- Al-Suwaidan F.
- ALHAJJ HASSAN Ali
- Ali A.
- Allan P.
- Allasia M.
- Allen David Michael
- Almemari A.
- Altaweel L.
- Alvarez H.
- Amatangelo M.
- Amorim P.
- Anderson G.
- Andersson KIM JIMMY
- Aneman A.
- Ansari S.
- Badenes R.
- Badjatia N.
- Ball R.
- Barge D.
- Barrachina L. G.
- Basignani C.
- Bass F.
- Bautista D.
- Bauza C.
- Beer R.
- Berkeley J.
- Berman M.
- Bernard F.
- Bershad E. M.
- Bhonagiri D.
- Bilotta F.
- Bird S.
- Biston P.
- Bleck T. P.
- Bonomo J.
- Bosel J.
- Bowling S.
- Bradford C.
- Brehaut S. S.
- Breitenfeld T.
- Bshabshe A. A.
- Calvillo E.
- Camputaro L. A.
- Carandang R.
- Carter T.
- Chalela J.
- Chan A.
- Chang C.
- Chapman M.
- Chaudhry B.
- Chou S.
- Chung D.
- Ciro J. D.
- Claassen J.
- Clark S.
- Connolyy L. S.
- Coplin W. M.
- Cordina S.
- Coronel E. B.
- Costilla M.
- Cross L.
- Cummings K.
- da Silva I. R. F.
- Damani R.
- David Freeman W.
- Davis R.
- de Azambuja Rodrigues P. M.
- De Georgia M.
- de Oliveira J.
- Deeb A. M.
- DeFilippis M.
- Dhar R.
- Dias C.
- Dickinson M.
- Dissin J.
- Dixit S.
- Domeniconi G.
- Domingues J. R. S.
- Donaldson K.
- Dowling S.
- Dugan G.
- Dujardin M. -F.
- Emanuel B.
- Eriksson E.
- Eskiogly E.
- Ethan Kahn D.
- Falla J.
- Fathy A.
- Feske S.
- Finfer S.
- Fletcher J. J.
- Francis B.
- Francken S.
- Frank J. I.
- Garg S.
- Garvin R.
- Georgiadis A.
- Gil B.
- Gilvaz P. C.
- Giraldo E. A.
- Glassner S.
- Glickman S.
- Goldenberg F. D.
- Gomez M.
- Gomez O.
- Gonzalez J. R. Y.
- Gordon E.
- Gorman Michael Murray
- Goyal K.
- Graffagnino C.
- Granillo J. F.
- Greer D.
- Gritsan A.
- Guisado R.
- Gupta P.
- Habre W.
- Hall W.
- Hammond N.
- Hantson P.
- Harvey D.
- Hashmi M.
- Hebert C.
- Helbok R.
- Hemphill III J. C.
- Hemphill J. C.
- Henderson G.
- Hernandez Aguilar Orisel
- Herrera E. A.
- Hightower B.
- Hirsch K. G.
- Hobohm C.
- Hoesch R.
- Hopkins P.
- Horn J.
- Hubner K. E.
- Jabbary A. A.
- Jarquin-Valdivia A. A.
- Javier Provencio J.
- Jenkinson E.
- Jibaja M.
- John S.
- Johnson L.
- Johnston G.
- Jordan D.
- Josephson S. A.
- Julian F. B.
- Junker C.
- Kamran Athar M.
- Kapinos G.
- Karanjia N.
- Katila A.
- Kern CHRISTOPH ALEXANDER
- Kim A.
- Kirkwood J.
- Ko N.
- Kobata H.
- Koenig M.
- Kottapally M.
- Kramer A.
- Krauchi O. R.
- Kuiper M.
- Kuisle L.
- Kumar M.
- Kunze K.
- Kutsogiannis D. J.
- Lacerda Gallardo A. J.
- Laiwattana D.
- Landry R.
- Langdon J. R.
- Laskowitz D. T.
- Lasocki S.
- Layon A. J.
- Lazaridis C.
- Lele A.
- LeRoux P. D.
- Levine J. M.
- Llano M.
- Lokin J.
- Lopez Delgado H. J.
- Luengo R. -I. G.
- Madhusudan M.
- Madrinan-Navia H.
- Maldonado I. L.
- Maldonado N.
- Malek A.
- Manno E.
- Marinoff N.
- Martin R. H.
- Martinez J.
- Martinez J. E.
- McArthur C.
- McBride M.
- McCredie V.
- McCrum B.
- McNett M.
- Medary I. B.
- Medow J.
- Meeker M.
- Mejia-Mantilla J. H.
- Merlani P.
- Meyfroidt G.
- Mijangos-Mendez J. C.
- Miller A.
- Miller D. W.
- Milzman D.
- Mirski M.
- Mishra S.
- Misiewska-Kaczur A.
- Mokhtari M.
- Mora J. E.
- Moreda M.
- Moretti J. I.
- Muehlschlegel S.
- Mukaddam S.
- Muller M. C. A.
- Murillo R.
- Murthy H. H. K.
- Nagayama M.
- Naidech A.
- Nair D.
- Napolitano Silvano
- Nathan B.
- Nazliel B.
- Neto A. R.
- O'Connor A.
- O'Leary M.
- O'Phelan K.
- Ochoa M. E.
- Oddo M.
- Olmecah H. M.
- Palo J. E.
- Parra A.
- Pattnaik S.
- Paucar J. L. C.
- Paul G.
- Paulson A.
- Paxton J.
- Pegoli M.
- Peled H.
- Pelunkova L.
- Perez D.
- Pfaulser B.
- Pinto D. B.
- Poch E. J.
- Poli S.
- Pou J. A. L.
- Promsin P.
- Puvanendiran S.
- Raffa P.
- Rajajee V.
- Ramirez-Arce J.
- Ramos-Gomez L. A.
- Rao V. A.
- Rasulo F.
- Rawal R.
- Ray B.
- Renard S.
- Reshi R. A.
- Rincon F.
- Rison R. A.
- Rivera O. S.
- Roberts B.
- Roberts D.
- Rodgers H.
- Rodricks M.
- Rodriguez-Vega G.
- Romero C.
- Rosciani F.
- Rosengart A.
- Rosenthal E.
- Sajjad R.
- Salgado E.
- Samavedam S.
- Sanchez B.
- Sanchez O.
- Santos G.
- Sarma A. K.
- Sarwal A.
- Schiefecker A.
- Schirotzek I.
- Schneck M.
- Schoenenberger S.
- Schumacher H. C.
- Seder D.
- Seppelt I.
- Sharaby M.
- Sheehan K.
- Sheth K.
- Shieber S.
- Shilkin J.
- Shiraz S. A.
- Shukla U.
- Shushma P.
- Shutter L.
- Singares E. S.
- Singhal N. S.
- Sinha V.
- Smith M.
- Smith R.
- Smith W. S.
- Sohal J.
- Sokhal N.
- Song J.
- Sorond F.
- Sternberg S.
- Stevenson Porter N.
- Suarez J. I.
- Sukumaran A. V.
- Sung G.
- Svigelj V.
- Taccone F. S.
- Taccone Fabio Silvio
- Tack L.
- Tamayo G.
- Tan B.
- Tegedor B. V.
- Teitelbaum J.
- Tena S. A.
- Teran M. D.
- Tesoro E.
- Titova Y.
- Torbey M.
- Tran H.
- Treggiari M.
- Trim T.
- Tuppeny M.
- Vadi S.
- Vaitkevicius H.
- Vallance S.
- Van Bui T.
- Vanamoorthy P.
- VANDEN BERGHE GREET CLARA
- Varelas P.
- Varga M.
- Venkatasubba Rao C. P.
- Verma V.
- Vespa P.
- Videtta W.
- Villalobos M.
- Vosylius S.
- Wartenberg K.
- Welbourne J.
- Wilensky E. M.
- Williamson C.
- Wittebole X.
- Wong G. K. C.
- Wright J. C.
- Xu G.
- Yarad E.
- Yazbeck M. F.
- Zahrani A. R. A.
- Zavala E.
- Zraiki H.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Effect of lung recruitment and titrated Positive End-Expiratory Pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome - A randomized clinical trial
- Author
- Abdalla G.
- Abrahao Hajjar L.
- Abrantes Saraiva S.
- Abrunhosa A.
- Adler Maccagnan Pinheiro Besen B.
- Adrieno Westphal G.
- Afiq Syahmi Ramli M.
- Aires de Araujo Neto J.
- Akemi Higo M.
- Alberti da Silva G.
- Almeida Delfino Duarte P.
- Almeida Victorino J.
- Alves Ferreira Goncalves F.
- Amado Rabelo L.
- Amador Correia T.
- Amarante Costa A.
- Amato M. B. P.
- Andrade A. H. V.
- Andrioli de Araujo P.
- Anibal Leite Barros Agostinho T.
- Antoniazzi R.
- Aparecida Leite M.
- Aparecida Pereira J.
- Aparecida Pessoa Conde K.
- Azevedo L.
- Azzi Barbosa N.
- Baccaro Rossetti Santana H.
- Balzi A. P.
- Baptista Filho M. L. A.
- Barberena Moraes R.
- Barbosa Cerantola R.
- Barbosa Gomes Galas F. R.
- Barbosa P. G.
- Barboza Carnevalli Bueno T.
- Barros de Oliveira M. E.
- Barros Duarte I. J.
- Barroso A.
- Bassi E.
- Bastos de Moura E.
- Bastos Vieira P. C.
- Bautista-Rincon D. F.
- Belacho Azeredo Coutinho J.
- Belda F. J.
- Bermudez W. F.
- Bernadete Caser E.
- Berto P.
- Berwanger O.
- Bezerra Lima Z.
- Bin da Silva S. R.
- Blattner C.
- Bolognese D.
- Bonaccorsi Fernandino B.
- Bonin Campos L.
- Borba Pereira T.
- Botelho Foernges R.
- Braga Hagreaves Ribeiro de Freitas R.
- Breckenfeld Heirel D. C.
- Brocco Magnan G.
- Bruinje Cosentino M. F.
- Buarque Souza de Lima M. H.
- Burigo Grumann A. C.
- Buss E. K.
- Buttignol M.
- Cadavid Gutierrez C.
- Caldeira Filho M.
- Calderon L. E.
- Camargo Narciso R.
- Camassola A. P.
- Campos N. M. P.
- Campos Tonussi R. L.
- Carbonell J. A.
- Carolina Salomao M.
- Caser E. B.
- Castaneda J. A.
- Castro Escobar Furlan F.
- Cattelan Bonorino K.
- Cavalcante Lola Biazzoto E. P.
- Cavalcanti A. B.
- Chagas C. E. R. C.
- Charro F. A.
- Christmann Wawrzeniak I.
- Cisari G.
- Coelho M.
- Colozza Mecatti G.
- Conceicao Andrade L.
- Conti Ramos R.
- Cordeiro de Abreu Filho C. A.
- Cordioli R.
- Correia Santos Bonomo D.
- Cortegiani A.
- Costa Carvalho L. F.
- Costa G.
- Costa Lisboa T.
- Costa M.
- Cruz Carbonell R. C.
- da Cunha S.
- da Graca Pasquotto de Lima Assef M.
- da Silva Bettega F.
- da Silva Franco R. S.
- da Silva Guimaraes B. L.
- da Silva K. S.
- da Silva M. S.
- da Silva Marques L.
- da Silva Motta J.
- da Silva P. N.
- Dadam M.
- Dal-Pizzol F.
- Damiani L. P.
- De Alencar Filho M. S.
- de Almeida M. M. M. F.
- de Andrade K. M.
- De Aquino Martins P.
- de Araujo Macedo Pinto W.
- de Araujo Nazare M.
- de Assuncao Melo L.
- de Azevedo Naves S.
- de Brito Cordeiro R.
- de Brito Sobrinho E.
- de Campos Balzano P.
- de Carvalho A.
- De Carvalho Borges M.
- De Carvalho C. R. R.
- de Carvalho Fonseca Assuncao N. S.
- de Carvalho M. A.
- de Carvalho-Filho M. A.
- de Faria Cordeiro H.
- De Lima Assef M. D. G. P.
- de Linhares J. M.
- de Lucca F. C.
- de Marchi Benfica A. F.
- de Menezes Ferreira C.
- De Moraes Paisani D.
- De Moraes Regenga M.
- de Oliveira Dias R.
- De Oliveira Filho W.
- de Oliveira M. C.
- de Oliveira Maia M.
- De Oliveira R. P.
- de Oliveira Teixeira L.
- de Paiva A. P.
- de Pinho J. C.
- de Souza Andrade Neto J.
- de Souza G. F.
- de Souza Machado Y. L.
- de Souza Nobrega M.
- de Souza Oliveira Garcia T.
- de Souza R. R.
- de Souza Trindade R.
- de Vasconcellos Baldisserotto S.
- Deczka Morsch R.
- Delascio Lopes R.
- Deucher R. A. O.
- Dias Alves J.
- Dias Brugugnolli I.
- Dias Chiavegato L.
- Dias da Silva F.
- Dias de Almeida S.
- Dias E Santos J. A.
- Diaz-Quijano F. A.
- Diogo Sala A.
- Do Espirito Santo J. A.
- Do Val Tavares P. E.
- Domingos Correa T.
- Dos Anjos Sad F. C.
- Dos Santos Francisco R.
- Dos Santos Ramos N. C.
- Dragosavac D.
- Eberhart Neto E.
- Elias Aquim E.
- Elias de Oliveira N.
- Esneda Rocha Gaona M.
- Espitia Hernandez A. M.
- Fadhil Hadi Bin Jamaluddin M.
- Falcao J. G.
- Farran J.
- Favretto J.
- Fernandes Machado L.
- Ferrando C.
- Ferreira da Silva S. D.
- Ferreira de Souza M. M.
- Ferreira Sousa M.
- Festti J.
- Fialkow L.
- Flavio Costa Filho F.
- Florizel Almeida de Araujo M.
- Fonseca de Sousa J.
- Fonseca Silva T.
- Fontoura Prado K.
- Fornazari J. C.
- Franca de Oliveira M. C.
- Franci D.
- Franco M. R.
- Franke C.
- Franz da Costa A.
- Freitas I.
- Frizera Vassallo P.
- Furtado Lamego L.
- Gacel A.
- Gallego D. A.
- Garay M.
- Gasparetto Maccari J.
- Gatelli Noronha C.
- Gatti Cirillo C.
- Gaudin A.
- Genelhu G.
- Germano A.
- Gessolo Lins P.
- Giancursi T. S.
- Giarratano A.
- Giraldo Ramirez N.
- Giraldo-Ramirez N. D.
- Girardelli Baptista W. C.
- Girotto F.
- Giuberti J.
- Gomez Ravetti C.
- Goncalves Libanio P.
- Gontijo-Coutinho C. M.
- Gonzalez H. H.
- Gorka J.
- Goulart R.
- Griebler M.
- Guerra de Almeida A.
- Guimaraes Dantas B.
- Guimaraes de Carvalho F. L.
- Guimaraes H. P.
- Guimaraes Leal Guadalupe E.
- Gut A. L.
- Hadrich M.
- Hasan M. S.
- Helenditi Fernandes Camurca Martins R.
- Henn Moura R.
- Herek A.
- Hirata F.
- Hirota A. S.
- Hoher J.
- Hurtado J.
- Ishiwaki S.
- Isola A.
- Iwamoto T.
- Jorge A. C.
- Junqueira Ribeiro L.
- Kohl Pinheiro E.
- Kretzer L. P.
- Lacerda V.
- Ladeira J. P.
- Lage de Assis Rocha D.
- Lameira Verissimo A.
- Laranjeira L. N.
- Lessa Soares F.
- Lesti Esteves A. R.
- Lima de Andrade A.
- Lima Silva M. M.
- Lisboa de Souza R.
- Lobo S.
- Locks Stahlhofer L.
- Longhi Simoes de Almeida S.
- Loureiro Sebold M.
- Lovato W. J.
- Luzzi S.
- Macedo Araujo L.
- Machado F. R.
- Machado J. A.
- Magalhaes Carvalho Grion C.
- Maia I. S.
- Maia R.
- Manozzo Boniatti M.
- Mara Gomes T.
- Marcal de Vasconcelos M. O.
- Marco R.
- Marques Andrade G.
- Marques Barroso C.
- Marques Ferreira Mendez V.
- Martines Moralez G.
- Martins Arruda J.
- Martins de Lima G.
- Martins De Stefano L.
- Martins Dzivielevski B.
- Martins G. A.
- Martins Lima Silva M.
- Martins Santos T.
- Massariol T. C.
- Matheus Cadamuro F.
- Matos Brito Coelho C.
- Matsui M.
- Mayumi Higa R.
- Mazza B. F.
- Medina Matos A.
- Melo Silva R.
- Mendes Filho S. P.
- Menezes de Rezende C.
- Metran Nascente A. P.
- Mezzaroba A. L.
- Milioli Ferreira D.
- Miranda Barreto Mourao L.
- Miranda Mafra Oliveira M.
- Miura M. C.
- Morais M. O.
- Morales D.
- Morales M.
- Moreira de Sousa M.
- Moreira R.
- Mousinho Gomes R. L.
- Muniz R.
- Murilo Domingues S.
- Naia A.
- Nakad Orsatti V.
- Naranjo Sierra S.
- Nardela R.
- Nascimento Loureiro N.
- Nazareno Conceicao C.
- Nedel W.
- Nery P.
- Nin N.
- Nobre V.
- Nogueira de Paula L.
- Nogueira Filho W.
- Nomoto S.
- Nowak I.
- Nunes M.
- Oliveira C.
- Oliveira de Paula A. E.
- Oliveira Lage J.
- Orozco Levi M.
- Ortiz G.
- Ortiz M.
- Osaku E. F.
- Osni Machado F.
- Osorio Guerreiro M.
- Ospina-Tascon G. A.
- Paiva de Souza A.
- Paiva T. K. B.
- Pantaleao S. L.
- Papacidero C. H.
- Parolo E.
- Passos Amato M. B.
- Pastore L.
- Paulino C.
- Peixoto E.
- Peliser P.
- Penna Guimaraes H.
- Pereira da Silva E.
- Pereira Santos J. R.
- Peres Bainy M.
- Peres I.
- Peretti Torelly A.
- Pfuetzenreiter F.
- Pimentel Alvim S. H.
- Pincelli M.
- Pinheiro de Almeida J.
- Pinheiro de Oliveira R.
- Pinto Goncalves C. H.
- Piras C.
- Pires Barrientto L. C.
- Pizarro C.
- Plata Valdivieso R.
- Povoa P.
- Puig J.
- Quinones E.
- Rai Hakumat Rai V.
- Raineri S. M.
- Ramos F.
- Ramos Mello M.
- Ramos Nicolau da Costa L.
- Ray A.
- Rea-Neto A.
- Rebello de Jesus K.
- Rech T. H.
- Reese F. B.
- Reis D. L.
- Reis H.
- Rejane de Lima C.
- Resende E.
- Rezegue de Moraes Rego L.
- Ribas Rosa de Oliveira A. M.
- Ribeiro Campos D.
- Ribeiro de Carvalho C. R.
- Ribeiro de Santis Santiago R.
- Ribeiro Machado F.
- Ribeiro Moreira A.
- Ribeiro Salgado D.
- Riccio P.
- Rios F.
- Rios Vieira S. R.
- Ritter C.
- Rocha Rodrigues da Silva F.
- Rodrigues da Cruz M.
- Rodrigues M.
- Rodrigues Torres de Carvalho F.
- Romano E. R.
- Romano M.
- Rossi Peras Americo V.
- Rosso Verdeal J. C.
- Rubini P.
- Russotto V.
- Rutzen W.
- Ryoji Takatani R.
- Sa Malbouisson L. M.
- Saldanha Dos Santos R.
- Samartino Zavanelli G.
- Sanches Laranjeira A.
- Sande L.
- Santa Maria Lucin G.
- Santa Rosa Santana H.
- Santos Pellegrini J. A.
- Santucci Cesar de Assuncao M.
- Satoshi Inagaki A.
- Scalzo A. C.
- Schmitz de Figueiredo F.
- Schwan Filho F.
- Schwarz P.
- Seczynska B.
- Sega A.
- Seiji Ueno Gil F.
- Semboloni Bitencourt W.
- Serpa Neto A.
- Shahnaz Hasan M.
- Silva Cavallaro Torres K.
- Silva de Almeida P.
- Silva de Araujo A.
- Silva de Souza A.
- Silva J. M.
- Silva M.
- Silva Maia I.
- Silva Sales B.
- Simoes da Silva F.
- Simoes Giancursi T.
- Siqueira da Silva A.
- Sisconetto L.
- Soares Nasrala M. L.
- Soro M.
- Souza Amorim D.
- Souza da Silva R.
- Souza Dos Santos L.
- Souza Marques A.
- Souza Ribeiro M.
- Spegiorin Moreno M.
- Sperotto G.
- Staffa Gonzaga da Silva L.
- Steponovicius Piedade Cruz F.
- Stucchi E. M.
- Suzumura E. A.
- Szczeklik W.
- Tadahiro Ikeoka D.
- Tagliari L.
- Taniguchi L. N. T.
- Tavares Gurgel S. J.
- Teixeira C.
- Teixeira de Gois A. F.
- Teixeira Pinheiro T.
- Thompson M. M.
- Tibery Queiroz Cardoso L.
- Tierno P.
- Torres D.
- Torres P.
- Toshiyuki Tanita M.
- Toufen C.
- Tozo T. C.
- Tucci M. R.
- Valente Barbas C. S.
- Valiatti J. L.
- Vantini Capasso Palamim C.
- Vargas M.
- Vasconcelos de Sousa G.
- Vasconcelos R.
- Veiga de Oliveira A. L.
- Vendrame L. S.
- Verissimo A.
- Vieda E.
- Vieira de Lacerda N. M.
- Vieira Do Nascimento Martins E.
- Vieira S. R. R.
- Vilela Costa Pinto B.
- Vilela Siqueira H.
- Villasante Troncoso E. M.
- Vinicius Pereira M.
- Vitor Fera J.
- Werneck V.
- Yen Ju C.
- Yudi Horikawa F.
- Zampieri F.
- Zandonai C. L.
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2017
- Field of study
IMPORTANCE: The effects of recruitment maneuvers and positive end-expiratory pressure (PEEP) titration on clinical outcomes in patients with acute respiratory distress syndrome (ARDS) remain uncertain. OBJECTIVE: To determine if lung recruitment associated with PEEP titration according to the best respiratory-system compliance decreases 28-day mortality of patients with moderate to severe ARDS compared with a conventional low-PEEP strategy. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, randomized trial conducted at 120 intensive care units (ICUs) from 9 countries from November 17, 2011, through April 25, 2017, enrolling adults with moderate to severe ARDS. INTERVENTIONS: An experimental strategy with a lung recruitment maneuver and PEEP titration according to the best respiratory-system compliance (n = 501; experimental group) or a control strategy of low PEEP (n = 509). All patients received volume-assist control mode until weaning. MAIN OUTCOMES AND MEASURES: The primary outcome was all-cause mortality until 28 days. Secondary outcomes were length of ICU and hospital stay; ventilator-free days through day 28; pneumothorax requiring drainage within 7 days; barotrauma within 7 days; and ICU, in-hospital, and 6-month mortality. RESULTS: A total of 1010 patients (37.5% female; mean [SD] age, 50.9 [17.4] years) were enrolled and followed up. At 28 days, 277 of 501 patients (55.3%) in the experimental group and 251 of 509 patients (49.3%) in the control group had died (hazard ratio [HR], 1.20; 95% CI, 1.01 to 1.42; P = .041). Compared with the control group, the experimental group strategy increased 6-month mortality (65.3% vs 59.9%; HR, 1.18; 95% CI, 1.01 to 1.38; P = .04), decreased the number of mean ventilator-free days (5.3 vs 6.4; difference, −1.1; 95% CI, −2.1 to −0.1; P = .03), increased the risk of pneumothorax requiring drainage (3.2% vs 1.2%; difference, 2.0%; 95% CI, 0.0% to 4.0%; P = .03), and the risk of barotrauma (5.6% vs 1.6%; difference, 4.0%; 95% CI, 1.5% to 6.5%; P = .001). There were no significant differences in the length of ICU stay, length of hospital stay, ICU mortality, and in-hospital mortality. CONCLUSIONS AND RELEVANCE: In patients with moderate to severe ARDS, a strategy with lung recruitment and titrated PEEP compared with low PEEP increased 28-day all-cause mortality. These findings do not support the routine use of lung recruitment maneuver and PEEP titration in these patients. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01374022
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
- Author
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world’s largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ~30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death
The value of open-source clinical science in pandemic response: lessons from ISARIC
- Author
- Abbas A.
- Abdukahil S. A.
- Abdulkadir N. N.
- Abe R.
- Abel L.
- Absil L.
- Acharya S.
- Acker A.
- Adachi S.
- Adam E.
- Adriao D.
- Ageel S. A.
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- Ain Q.
- Ainscough K.
- Aisa T.
- Ait Hssain A.
- Ait Tamlihat Y.
- Akimoto T.
- Akmal E.
- Al Qasim E.
- Al-dabbous T.
- Al-Fares A.
- Alalqam R.
- Alam T.
- Alegesan S.
- Alegre C.
- Alessi M.
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- Alexandre K.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
The value of open-source clinical science in pandemic response: lessons from ISARIC
- Author
- Abbas A.
- Abdukahil S. A.
- Abdulkadir N. N.
- Abe R.
- Abel L.
- Absil L.
- Acharya S.
- Acker A.
- Adachi S.
- Adam E.
- Adriao D.
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- Ain Q.
- Ainscough K.
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- Alalqam R.
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- Trieu H. T.
- Tripathy S.
- Tromeur C.
- Trontzas I.
- Trouillon T.
- Truong J.
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- Tubiana S.
- Tuite H.
- Turmel J. -M.
- Turtle L. C. W.
- Tveita A.
- Twardowski P.
- Uchiyama M.
- Udayanga P. I.
- Udy A.
- Ullrich R.
- Umer Z.
- Uribe A.
- Usman A.
- Vajdovics C.
- Val-Flores L.
- Valle A. L.
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- van Dyk M.
- van Gulik L.
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- Vieira C.
- Vijayan D.
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- Villar J.
- Villeneuve P. -M.
- Villoldo A.
- Vinh Chau N. V.
- Visseaux B.
- Visser H.
- Vitiello C.
- Vonkeman H.
- Vuotto F.
- Wahab N. H.
- Wahab S. A.
- Wahid N. A.
- Wainstein M.
- Wan Muhd Shukeri W. F.
- Wang C. -H.
- Webb S. A.
- Wei J.
- Weil K.
- Wen T. P.
- Wesselius S.
- West T. E.
- Wham M.
- Whelan B.
- White N.
- Wicky P. H.
- Wiedemann A.
- Wijaya S. O.
- Wille K.
- Willems S.
- Williams V.
- Wils E. -J.
- Wing Yiu N.
- Wong C.
- Wong T. F.
- Wong X. C.
- Wong Y. S.
- Xian G. E.
- Xian L. S.
- Xuan K. P.
- Xynogalas I.
- Yacoub S.
- Yakop S. R. B. M.
- Yamazaki M.
- Yazdanpanah Y.
- Yee Liang Hing N.
- Yelnik C.
- Yeoh C. H.
- Yerkovich S.
- Yokoyama T.
- Yonis H.
- Yousif O.
- Yuliarto S.
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- Zabbe M.
- Zacharowski K.
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- Zucman D.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Global Survey of Outcomes of Neurocritical Care Patients: Analysis of the PRINCE Study Part 2
- Author
- Abdo Wilson F
- Afshinnik Arash
- Aggarwal Deepesh G
- Aguilar Gerardo
- Aguilera Sergio
- Ahmad Ahmad
- Aiyagari Venkatesh
- Al Bshabshe Ali
- Al Jabbary Ahmed
- Al Zahrani Amer Rashed
- Al-Jehani Hosam
- Al-Suwaidan Faisal
- Alberto Camputaro Luis
- Ali Abbas
- Allan Patrick
- Allasia Mariela
- Allen Michelle
- Almemari Ayesha
- Altaba Tena Susana
- Altaweel Laith
- Alvarez Hector
- Amatangelo Mary
- Amorim Pedro
- Anderson Gabriella
- Andre Sonia
- Aneman Anders
- Ansari Safdar
- Athar M Kamran
- Avalos Herrera Edgar
- Badenes Rafael
- Badjatia Neeraj
- Ball Ron
- Barge Deborah
- Basignani Cherlynn
- Bass Francess
- Bautista Coronel Ermitao
- Bautista Diego
- Bauza Colleen
- Beer Ronny
- Berghe Caroline
- Berkeley Jennifer
- Berman Michael
- Bernal Julian Francisco
- Bernard Francis
- Bershad Eric M
- Bhonagiri Deepak
- Bilotta Federico
- Bird Simon
- Biston Patrick
- Bleck Thomas P
- Bonomo Jordan
- Bosel Julian
- Bowling Susana
- Bradford Celia
- Brehaut Scott S
- Breitenfeld Tomislav
- Calvillo Eusebia
- Cam Paucar Juan Luis
- Carandang Raphael
- Carter Teresa
- Castillo Abrego Guadalupe
- Chalela Julio
- Chan Alexander
- Chang Cherylee
- Chapman Martin
- Chaudhry Burhan
- Chou Sherry
- Chung David
- Claassen Jan
- Clark Sarah
- Connolyy Lauren S
- Coplin William M
- Cordina Steve
- Costilla Marcelo
- Cross Laura
- Cummings Kathie
- Damani Rahul
- Davis Rhonda
- de Azambuja Rodrigues Pedro Mendes
- De Georgia Michael
- de Oliveira Janaina
- Deeb Ahmad M
- DeFilippis Michele
- Dhar Raj
- Dias Celeste
- Dickinson Matthew
- Diego Ciro Juan
- Dissin Jonathan
- Dixit Subhal
- Domeniconi Gustavo
- Donaldson Karin
- Dowling Susan
- Dugan Guy
- Dujardin Marie-France
- Elena Ochoa Maria
- Emanuel Benjamin
- Eriksson Evert
- Eskiogly Eric
- Falla Joel
- Fathy Ahmed
- Ferreira da Silva Ivan Rocha
- Feske Steven
- Finfer Simon
- Fletcher Jeffrey J
- Francis Brandon
- Francken Susanne
- Franco Granillo Juvenal
- Frank Jeffrey
- Freeman W David
- Galarza Barrachina Laura
- Garg Sanchita
- Garvin Rachel
- Georgiadis Alexandros
- Gil Bladimir
- Gilvaz PC
- Giraldo Elias A
- Glassner Stuart
- Glickman Scott
- Goldenberg Fernando D
- Gomez Monica
- Gomez Oscar
- Gonzalezluengo Raul-Ismael
- Gordon Errol
- Gorman Mark
- Goyal Keshav
- Graffagnino Carmelo
- Greer David
- Gritsan Alexey
- Guisado Raul
- Gupta Pramod
- Habre Wassim
- Hache-Marliere Manuel
- Hall Willey
- Hammond Naomi
- Hantson Philippe
- Harvey Daniel
- Hashmi Madiha
- Hassan Ameer
- Hebert Cullen
- Helbok Raimund
- Hemphill J Claude
- Hemphill JC
- Henderson Galen
- Hernandez Olga
- Hightower Bradley
- Hirsch Karen G
- Hobohm Carsten
- Hoesch Robert
- Hopkins Philip
- Horn Janneke
- Hubner Kathleen E
- Jarquin-Valdivia Adrian A
- Jenkinson Elizabeth
- Jibaja Manuel
- John Sayona
- Johnson Lindsey
- Johnston Greg
- Jordan Dedrick
- Josephson Scott A
- Junker Christopher
- Kahn D Ethan
- Kapinos Gregory
- Karanjia Navaz
- Katila Ari
- Kern Alexander
- Kim Anthony
- Kim Jennifer
- Kirkwood Jennifer
- Ko Nerissa
- Kobata Hitoshi
- Koenig Matthew
- Kottapally Mohan
- Kramer Andreas
- Kuiper Michael
- Kuisle Lauren
- Kumar Monisha
- Kunze Kimberley
- Kutsogiannis Demetrios Jim
- Lacerda Gallardo Angel J
- Laiwattana Denchai
- Landry Ryan
- Langdon James R
- Laskowitz Daniel T
- Lasocki Sigismond
- Layon Aj
- Lazaridis Christos
- Lele Abhijit
- LeRoux Peter D
- Levine Joshua M
- Llano Miguel
- Llopart Pou Juan Antonio
- Lokin Johnny
- Lopez Delgado Hubiel J
- Madhusudan Madhu
- Madrinan-Navia Humberto
- Maldonado Ivan L
- Maldonado Nelson
- Malek Ali
- Malin Abdullah Jafri
- Manno Edward
- Marinoff Nicole
- Martin Renee H
- Martinez Jorge E
- Martinez Julie
- McArthur Colin
- McBride Moneen
- McCredie Vicki
- McCrum Barbara
- McNett Molly
- Medary Irene B
- Medow Joshua
- Meeker Michele
- Mejia-Mantilla Jorge H
- Merlani Paolo
- Meyfroidt Geert
- Mijangos-Mendez Julio Cesar
- Miller Angela
- Miller David W
- Milzman Dave
- Mirski Marek
- Mishra Sanghamitra
- Misiewska-Kaczur Agnieszka
- Mokhtari Majid
- Mora Jacobo Elias
- Moreda Melissa
- Moretti Jose
- Muehlschlegel Susanne
- Mukaddam Sajid
- Muller Marcella CA
- Murillo Rodrigo
- Murthy Harrish HK
- Nagayama Masao
- Naidech Andrew
- Nair Deepak
- Napolitano Sarah
- Nathan Barnett
- Nazliel Bijen
- Newby Lynette
- O'Connor Anne
- O'Leary Michael
- Oddo Mauro
- Olmecah Huitzilin Mauricio
- OPhelan Kristine
- Palo Jose Emmanuel
- Parra Augusto
- Pattnaik Saroj
- Paul Gunchan
- Paulson Audrey
- Paxton Jody
- Pegoli Marianna
- Peled Harry
- Pelunkova Lucie
- Perez Adic
- Perez Diego
- Pfaulser Bettina
- Pinto Diego Barahona
- Poch Eugenio J
- Poli Sven
- Porter N Stevenson
- Promsin Panuwat
- Provencio J Javier
- Puvanendiran S
- Raffa Pablo
- Rajajee Venkatakrishna
- Ramirez-Arce Jorge
- Ramos-Gomez Luis A
- Rao Chethan P Venkatasubba
- Rao Vivek A
- Rasulo Frank
- Rawal Raj
- Ray Banambar
- Reao Neto Alvaro
- Renard Suzanne
- Reshi Rwoof A
- Rincon Fred
- Rison Richard A
- Roberts Brigit
- Roberts Debra
- Rodgers Helen
- Rodricks Michael
- Rodriguez-Vega Gloria
- Romero Krauchi Oliva
- Romero Carlos
- Rosciani Foda
- Rosengart Axel
- Rosenthal Eric
- Sajjad Rehan
- Sala Domingues Joao Roberto
- Saldarriaga Rivera Oscar
- Salgado Estuardo
- Samavedam Srinivas
- Sanchez Baltasar
- Sanchez Olive
- Santos Gabriela
- Sarma Anand K
- Sarwal Aarti
- Schiefecker Alois
- Schirotzek Ingo
- Schneck Michael
- Schoenenberger Silvia
- Schumacher Hermann C
- Seder David
- Seppelt Ian
- Sharaby Mohamed
- Sheehan Kyle
- Sheth Kevin
- Shieber Simon
- Shilkin Jane
- Shiraz Seemin Afshan
- Shukla Urvi
- Shushma Patil
- Shutter Lori
- Singares Eduardo Smith
- Singhal Neel S
- Sinha Vandana
- Smith Murline
- Smith Roger
- Smith Wade S
- Sohal Jyoti
- Sokhal Navdeep
- Song Jian
- Sorond Farzaneh
- Sternberg Shannon
- Suarez Jose
- Sukumaran Anakara
- Sung Gene
- Svigelj Viktor
- Taccone Fabio S
- Taccone Fabio Silvio
- Tack Lauren
- Tamayo Gonzalo
- Tan Benedict
- Teitelbaum Jeanne
- Teran Mario D
- Tesoro Eljim
- Titova Yulia
- Torbey Michel
- Tran Huy
- Treggiari Miriam
- Trim Tiffany
- Tuan Van Bui
- Tuppeny Misti
- Vadi Sonali
- Vaitkevicius Henrikas
- Vallance Shirley
- Vanamoorthy Ponniah
- Varelas Panayiotis
- Varga Monica
- Verma Vishwajit
- Vespa Paul
- Vidal Tegedor Barbara
- Videtta Walter
- Villalobos Milton
- Vosylius Saulius
- Wartenberg Katja
- Welbourne Jessie
- Wilensky Eileen Maloney
- Williamson Craig
- Wittebole Xavier
- Wong George KC
- Woods Wpd
- Wright Judith C
- Xu Guozheng
- Yarad Elizabeth
- Yazbeck Moussa F
- Yunen Gonzalez Jose Rafael
- Zavala Elizabeth
- Zraiki Hebaa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2020
- Field of study
BACKGROUND: Neurocritical care is devoted to the care of critically ill patients with acute neurological or neurosurgical emergencies. There is limited information regarding epidemiological data, disease characteristics, variability of clinical care, and in-hospital mortality of neurocritically ill patients worldwide. We addressed these issues in the Point PRevalence In Neurocritical CarE (PRINCE) study, a prospective, cross-sectional, observational study. METHODS: We recruited patients from various intensive care units (ICUs) admitted on a pre-specified date, and the investigators recorded specific clinical care activities they performed on the subjects during their first 7 days of admission or discharge (whichever came first) from their ICUs and at hospital discharge. In this manuscript, we analyzed the final data set of the study that included patient admission characteristics, disease type and severity, ICU resources, ICU and hospital length of stay, and in-hospital mortality. We present descriptive statistics to summarize data from the case report form. We tested differences between geographically grouped data using parametric and nonparametric testing as appropriate. We used a multivariable logistic regression model to evaluate factors associated with in-hospital mortality. RESULTS: We analyzed data from 1545 patients admitted to 147 participating sites from 31 countries of which most were from North America (69%, N = 1063). Globally, there was variability in patient characteristics, admission diagnosis, ICU treatment team and resource allocation, and in-hospital mortality. Seventy-three percent of the participating centers were academic, and the most common admitting diagnosis was subarachnoid hemorrhage (13%). The majority of patients were male (59%), a half of whom had at least two comorbidities, and median Glasgow Coma Scale (GCS) of 13. Factors associated with in-hospital mortality included age (OR 1.03; 95% CI, 1.02 to 1.04); lower GCS (OR 1.20; 95% CI, 1.14 to 1.16 for every point reduction in GCS); pupillary reactivity (OR 1.8; 95% CI, 1.09 to 3.23 for bilateral unreactive pupils); admission source (emergency room versus direct admission [OR 2.2; 95% CI, 1.3 to 3.75]; admission from a general ward versus direct admission [OR 5.85; 95% CI, 2.75 to 12.45; and admission from another ICU versus direct admission [OR 3.34; 95% CI, 1.27 to 8.8]); and the absence of a dedicated neurocritical care unit (NCCU) (OR 1.7; 95% CI, 1.04 to 2.47). CONCLUSION: PRINCE is the first study to evaluate care patterns of neurocritical patients worldwide. The data suggest that there is a wide variability in clinical care resources and patient characteristics. Neurological severity of illness and the absence of a dedicated NCCU are independent predictors of in-patient mortality.status: publishe
Notes for genera – Ascomycota
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- T Spribille
- T Spribille
- T Spribille
- T Spribille
- T Spribille
- T Trakunyingcharoen
- T Trakunyingcharoen
- T Tsuge
- T Tønsberg
- T Valadbeigi
- T Valadbeigi
- T Valadbeigi
- T Valadbeigi
- T Valadbeigi
- T Vaupotič
- T Wen
- T Yang
- T Yazawa
- TA Doherty
- TA Duong
- TA Gulder
- TA Hofmann
- TA Naumann
- TAM Jagadeesh Ram
- TC Harrington
- TC Harrington
- TC Harrington
- TC Harrington
- TC Harrington
- TC Wen
- TC Wen
- TC Wen
- TC Wen
- TD Santa Izabel
- TE Ahti
- TE Twaroch
- Teixeira M Melo de
- TF Elliott
- TH Hofton
- TH Holger
- TI Sanjuan
- TJ Dreaden
- TJ Dreaden
- TJ Ram
- TK Goh
- TK Goh
- TK Goh
- TL Esslinger
- TL Esslinger
- TL Gao
- TLB Tarnowski
- TM Kharpukhaeva
- TP Devi
- TR McDonald
- TS Santa-Izabel
- TT Liu
- TW Osmundson
- TW Wang
- TZ Buçukoglu
- U Arup
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Braun
- U Damm
- U Damm
- U Damm
- U Damm
- U Damm
- U Damm
- U Damm
- U Damm
- U Dubey
- U Jayalal
- U Jayalal
- U Jayalal
- U Jayalal
- U Jayalal
- U Kumar
- U Kumar
- U Lindemann
- U Lindemann
- U Lindemann
- U Makhija
- U Pinruan
- U Steiner
- U Søchting
- U Søchting
- UB Singh
- UB Singh
- UK Simon
- Uwe Braun
- V Agnihothrudu
- V Alstrup
- V Andjic
- V Andjic
- V Atienza
- V Flors
- V García de
- V Gonzalez-Menendez
- V Gulis
- V Gupta
- V Hosagoudar
- V Hubka
- V Hubka
- V Hubka
- V Hubka
- V Hubka
- V Hubka
- V Hubka
- V Hubka
- V Kaounas
- V Kumar
- V Kučera
- V Kučera
- V Meshram
- V Ostry
- V Poengsungnoen
- V Queloz
- V Schmidt
- V Schmidt
- V Shukla
- V Shukla
- V Shukla
- V Shukla
- V Sri-Indrasutdhi
- V Sri-indrasutdhi
- V Tarasova
- V Tiwari
- V Uppadhyay
- V Vujanovic
- V Wirth
- VA Mel’nik
- VA Mel’nik
- VA Mel’nik
- VA Mel’nik
- VA Mel’nik
- VA Mel’nik
- VA Mel’nik
- VA Mel’nik
- VA Vicente
- VA Vicente
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VB Hosagoudar
- VE Masiulionis
- VF Consolo
- VK Mahajan
- VK Mittermeier
- VL Castroagudín
- VN Tarasova
- VO Ntui
- VP Heluta
- VP Hustad
- VP Hustad
- VP Hustad
- VP Hustad
- VP Zambare
- VV Sarma
- VV Sarma
- VV Shivarov
- W Brackel von
- W Gams
- W Gu
- W Jaklitsch
- W Jaklitsch
- W Khemmuk
- W Quaedvlieg
- W Quaedvlieg
- W Quaedvlieg
- W Quaedvlieg
- W Quilhot
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Rossi
- W Shen
- W Song
- W Wang
- W Wang
- W Zhang
- WA Untereiner
- WA Untereiner
- WA Vieira
- Walter P. Pfliegler
- WB Sanders
- WB Sanders
- WB Sanders
- WD Wight
- WH Chen
- WH Chen
- WH Li
- WJ Beese
- WJ Li
- WJ Li
- WJ Li
- WJ Li
- WL Bruckart
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Jaklitsch
- WM Pitt
- WP Pfliegler
- WP Pfliegler
- WT Beaulieu
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WV Brackel
- WY Zhuang
- WY Zhuang
- WY Zhuang
- WY Zhuang
- WY Zhuang
- X Guang-yu
- X Sun
- X Vazquéz-Campos
- X Wang
- X Wang
- X Xu
- X Zhang
- X Zhao
- X Zhao
- XD Zhou
- XF Li
- XF Zhu
- XH Wang
- Xiang-Yu Zeng
- Xiaoya Ma
- XL Cheng
- XL Cheng
- XL Fan
- XL Fan
- XL Fan
- XL Fan
- XL Fan
- XM Hou
- XM Niu
- XQ Zhu
- XW Wang
- XX Liu
- XY Wang
- XY Wang
- XY Wang
- XY Wang
- XY Zeng
- Y Ando
- Y Chen
- Y Cho
- Y Cho
- Y Chu
- Y Cui
- Y Hanying
- Y Harimoto
- Y Hirooka
- Y Hirooka
- Y Hirooka
- Y Hirooka
- Y Hirooka
- Y Huang
- Y Joshi
- Y Joshi
- Y Joshi
- Y Joshi
- Y Joshi
- Y Kajitani
- Y Kambar
- Y Karagöz
- Y Li
- Y Marin-Felix
- Y Marin-Felix
- Y Marin–Felix
- Y Matsuda
- Y Matsuwaki
- Y Miyamoto
- Y Miyamoto
- Y Nagano
- Y Ohmura
- Y Ohmura
- Y Suto
- Y Suzuki
- Y Takashima
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- Y Wu
- Y Yang
- Y Yavuz
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhang
- Y Zhou
- Yamini Agrawal
- YB Lee
- YB Lee
- YC Chang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YF Han
- YH Geng
- YJ Choi
- YJ Zhao
- YL Chen
- YL Jiang
- YL Jiang
- YL Jiang
- YL Wang
- YL Zhang
- YM Li
- YM Shabana
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Zhang
- YM Zhang
- Yong-Zhong Lu
- YP Ge
- YP Tan
- YQ Du
- YR Ma
- YR Ma
- YR Ma
- YT Huang
- YW Lim
- YX Liu
- YY Chen
- YY Su
- YZ Lu
- YZ Lu
- YZ Lu
- YZ Wang
- YZ Wang
- Z Du
- Z Fangyan
- Z Ferencova
- Z Jurjevic
- Z Jurjevic
- Z Zakeri
- Z Zhang
- ZA Dyer
- ZA Randriamanantany
- ZF Yu
- ZJ Li
- ZL Luo
- ZL Luo
- ZL Luo
- ZL Luo
- ZL Luo
- ZL Yuan
- Zong-Long Luo
- ZQ Liang
- ZQ Zeng
- ZQ Zeng
- ZW Beer de
- ZW Beer de
- ZW Beer de
- ZW Ge
- Å Kruys
- Å Kruys
- Å Kruys
- Ö Tufan-Çetin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Knowledge of the relationships and thus the classification of fungi, has developed rapidly with increasingly widespread use of molecular techniques, over the past 10--15 years, and continues to accelerate. Several genera have been found to be polyphyletic, and their generic concepts have subsequently been emended. New names have thus been introduced for species which are phylogenetically distinct from the type species of particular genera. The ending of the separate naming of morphs of the same species in 2011, has also caused changes in fungal generic names. In order to facilitate access to all important changes, it was desirable to compile these in a single document. The present article provides a list of generic names of Ascomycota (approximately 6500 accepted names published to the end of 2016), including those which are lichen-forming. Notes and summaries of the changes since the last edition of `Ainsworth Bisby's Dictionary of the Fungi' in 2008 are provided. The notes include the number of accepted species, classification, type species (with location of the type material), culture availability, life-styles, distribution, and selected publications that have appeared since 2008. This work is intended to provide the foundation for updating the ascomycete component of the ``Without prejudice list of generic names of Fungi'' published in 2013, which will be developed into a list of protected generic names. This will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists, and scrutiny by procedures determined by the Nomenclature Committee for Fungi (NCF). The previously invalidly published generic names Barriopsis, Collophora (as Collophorina), Cryomyces, Dematiopleospora, Heterospora (as Heterosporicola), Lithophila, Palmomyces (as Palmaria) and Saxomyces are validated, as are two previously invalid family names, Bartaliniaceae and Wiesneriomycetaceae. Four species of Lalaria, which were invalidly published are transferred to Taphrina and validated as new combinations. Catenomycopsis Tibell Constant. is reduced under Chaenothecopsis Vain., while Dichomera Cooke is reduced under Botryosphaeria Ces. De Not. (Art. 59)
An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
- Author
- A M Udara Lakshan Attanyake
- Aasiyah Rashan
- Aasiyah Rashan
- Abby Hurd
- Abdulrahman Al-Fares
- Abhishek Dasgupta
- Abigail Beane
- Adrian Streinu-Cercel
- Adrienne Chan
- Aidan Burrell
- Alan Hartman
- Alberto Uribe
- Alejandro Martin-Quiros
- Alejandro Martín-Quiros
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Alexander J Mentzer
- Alfredo Antonio Chetta
- Ali Abbas
- Alicia Gonzalez
- Alison M Meynert
- Alistair Nichol
- Allison McGeer
- Ama Kwakyewaa Bedu-Addo
- Amanda Corley
- Amanda Rojek
- Amanda Rojek
- Amar Bhatt
- Amna Faheem
- Amy Lester-Grant
- Ana Aroca
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Anais Rampello
- Anant Kataria
- Anca Streinu-Cercel
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Kildal
- Anders Tveita
- Andra-Maris Post
- Andrea Angheben
- Andrea Ticinesi
- Andrea Villoldo
- Andreas Lind
- Andrew Dagens
- Andrew Letizia
- Andy Law
- Angela Alberti
- Anja Grosse Lordemann
- Anna Berenguera
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne-Marie Guerguerian
- Annemarie B Docherty
- Antonia Ho
- Antonio Arcadipane
- Arabella Fahy
- Ardiyan Apriyana
- Arjen M Dondorp
- Asgar Rishu
- Asgar Rishu
- Astarini Hidayah
- Audrey Dubot-Pérès
- B P Sanka Ruwan Sri Darshana
- Barbara Wanjiru Citarella
- Barbara Wanjiru Citarella
- Beathe Kiland Granerud
- Beatrice Alex
- Benjamin Bach
- Bianca Boxma
- Birgitte Stiksrud
- Bounthavy Chaleunphon
- Bountoy Sibounheuang
- Brenda Molloy
- Brenda Reeve
- Brigid Flynn
- Bronner P Gonçalves
- Bronner P Gonçalves
- Budha Charan Singh
- Cameron J Fairfield
- Carlo Ferrari
- Carlos Cañada Illana
- Carlotta Mutti
- Caroline Martins Rego
- Caroline Mudara
- Carrol Gamble
- Cassidy Codan
- Caterina Caminiti
- Catherine A Shaw
- Catherine Blier
- Catherine Marquis
- Cecilia Canepa
- Ceila Maria Sant Ana Malaque
- Chamira Kodippily
- Charlotte Summers
- Chiara Vitiello
- Chloe Donohue
- Chris Kandel
- Christel Arnold-Day
- Christiana Kartsonaki
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christopher A Green
- Clare Jackson
- Clark D Russell
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudia Figueiredo-Mello
- Claudia Montes
- Colin McArthur
- Cornelius Rau
- Dafsah Juzar
- Dag Henrik Reikvam
- Dan Meyer
- Daniel Haber
- Daniel Marino
- Danoy Chommanam
- David Bellemare
- David L Robertson
- David Maslove
- David S Y Ong
- David S Y Ong
- David Stuart
- David Thomson
- Debby Bogaert
- Deepali Kumar
- Demetrios Kutsogiannis
- Derbrenn OConnor
- Diego Fernando Bautista Rincon
- Diego Franch-Llasat
- Diptesh Aryal
- Diptesh Aryal
- Dori-Ann Martin
- Dounia Bouhmani
- Edel Meaney
- Eder Caceres
- Efstathia Mihelis
- Egle Saviciute
- Elaine McPartlan
- Elena Molinos
- Elena Ranza
- Elizabeth A Ashley
- Ellen Shadowitz
- Else Quist-Paulsen
- Eman Al Qasim
- Emily Neumann
- Emma C Thomson
- Emmanuelle A Dankwa
- Emmanuelle Denis
- Enrico Adriano
- Esteban Garcia-Gallo
- Eva Miranda Marwali
- Evert-Jan Wils
- Evert-Jan Wils
- Ewen M Harrison
- Ewen M Harrison
- Federica Fogliazza
- Federica Garofalo
- Felwa Bin Humaid
- Ferran Roche-Campo
- Fiona Griffiths
- Francesca Carlacci
- Francesco Rausa
- Francisca Adewhajah
- Frank Manetta
- Frank Olav Pettersen
- Franklina Korkor Abebrese
- François Lamontagne
- François Martin Carrier
- François Martin Carrier
- Fredrik Müller
- Frédérick D'Aragon
- G Argin
- Gail Carson
- Gail Carson
- Gamage Dona Dilanthi Priyadarshani
- Gary Leeming
- Gary Schwartz
- Gayle Carney
- Gennaro Martucci
- Georgios Pollakis
- Geraldine Goco
- Gianluigi Li Bassi
- Giorgio Economopoulos
- Giovanna Occhipinti
- Giovanna Panarello
- Giuseppe Maglietta
- Gloria Crowl
- Graham S Cooke
- Gry Kloumann Bekken
- Gyan Sandhu
- Haixia Shi
- Hannah Habraken
- Hannah Keane
- Hannah Marrinan
- Hayley Hardwick
- Hazel Bergin
- Heidi Dalton
- Hem Paneru
- Henrique Mateus Fernandes
- Himasha Muvindi
- Himed Musaab
- Hubert Tessier-Grenier
- Husna Begum
- Iam Claire E Sarmiento
- Ignacio Martin-Loeches
- Ilaria Valzano
- Imrana Khalid
- Indrek Rätsep
- Ingrid G Bustos
- Inês Carqueja
- Irene Bandoh
- ISARIC Clinical Characterisation Group
- J Kenneth Baillie
- J Kenneth Baillie
- Jacky Y Suen
- Jake Dunning
- Jake Dunning
- James Joshua Douglas
- James Joshua Douglas
- James Lee
- James Scott-Brown
- James Vickers
- Jan Cato Holter
- Janet Diaz
- Janet Harrison
- Janet Liang
- Janet T Scott
- Janice Caoili
- Janice Caoili
- Jaques Sztajnbok
- Jeff Powis
- Jennifer Lee
- Jess Gibson
- Jia Wei
- Jillian Deacon
- Jo Dalton
- Joan Gómez-Junyent
- Joan Gómez-Junyent
- Joanne Downey
- Joaquín Baruch
- Joaquín Baruch
- John Beca
- John F Fraser
- John Marshall
- Johnny McKeown
- Jonathan Bitton
- Jordi Rello
- José Antonio Lepe
- José Ernesto Vidal
- João Camões
- Juan Fiorda
- Juan Pablo Horcajada
- Judit Villar
- Julia Garcia-Diaz
- Julian Chica
- Kalynn Kennon
- Kamal Abu Jabal
- Karl Erik Müller
- Karolina Krawczyk
- Kate Ainscough
- Kathy Brickell
- Katie O'Hearn
- Kenneth A McLean
- Kevin Katz
- Kizy Sanchez de Oliveira
- Kristian Tonby
- Kusum Menon
- Lance C W Turtle
- Lars Hegelund
- Lars Heggelund
- Latsaniphone Bountthasavong
- Laura Feeney
- Laura Marsh
- Laura Merson
- Laura Merson
- Laura Patrizi
- Laveena Munshi
- Leanne Hays
- Leonardo Salazar
- Leonardo Salazar
- Liadain Reid
- Lina Morales Cely
- Linda Gail Skeie
- Linda O'Shea
- Lisa Norman
- Lisa Patterson
- Liv Hesstvedt
- Lorinda Essuman
- Lorna Murphy
- Louise Sigfrid
- Luca Sacchelli
- Lucian Durham
- Lucille Blumberg
- Luis Felipe Reyes
- Luis Felipe Reyes
- Luis Periel
- Lukas Arenz
- Madiha Hashmi
- Madiha Hashmi
- Mahdad Noursadeghi
- Malcolm G Semple
- Malcolm G Semple
- Mangala Narasimhan
- Manivanh Vongsouvath
- Maram Zahran
- Marco Echeverria-Villalobos
- Mare Pejkovska
- Margarite Grable
- Maria Angelica Rivera Nuñez
- Maria Donnelly
- Maria Lawrensia Tampubolon
- Maria Majori
- Maria Zambon
- Marianne Fraher
- Mariano Esperatti
- Marie Connor
- Marina Aiello
- Marina Lanza
- Mark G Pritchard
- Mark Pritchard
- Marlene Santos
- Martina Escher
- Mary Copland
- Massimo Palmarini
- Matteo Puntoni
- Matteo Rossetti
- Matthew Hall
- Matthew Hall
- Matthew Nelder
- Mayfong Mayxay
- Meera Chand
- Melissa Parker
- Mical Paul
- Michael Edelstein
- Michael Varrone
- Michaela Barnikel
- Michele Petrovic
- Michelle E Kho
- Michelle Girvan
- Michelle Smyth
- Mohd Basri Mat Nor
- Mohiuddin Shiekh
- Moirangthem Bikram Singh
- Moritz U G Kraemer
- Moses Siaw-Frimpong
- Muge Cevik
- Murray Dryden
- Murray Wham
- Musharaf Sadat
- Nashat Abu Salah
- Nathaniel Christy
- Netta Beer
- Nick Daneman
- Nicola Latronico
- Nicole White
- Nidyanara Castanheira
- Nina Jamieson
- Nora Fuentes
- Oana Sandulescu
- Obada Yousif
- Oleksa Rewa
- Ooyanong Phonemixay
- P G Ishara Udayanga
- Paa Kobina Forson
- Paddy Mallon
- Paolo Parducci
- Pathik Dhanger
- Patricia Fontela
- Patricia Gordon
- Patrick Archambault
- Patrizia Bonelli
- Patrizia Mammi
- Paul Klenerman
- Paul Tierney
- Paula Custodio
- Perren J Cobb
- Peter Daley
- Peter Doran
- Peter Horby
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Phil Gallagher
- Philippe Jouvet
- Phoebe Ampaw
- Phouvieng Douangdala
- Piero L Olliaro
- Piero L Olliaro
- Piret Sillaots
- Pompini Agustina Sitompul
- Pooja Varghese
- Prasan Kumar Panda
- Rachael McConnochie
- Rachael Parke
- Rajavardhan Rangappa
- Rajavardhan Rangappa
- Rajesh Mohan Shetty
- Rakesh Arora
- Rashan Haniffa
- Renata Barbalho
- Richard S Tedder
- Riinu Pius
- Rima Song
- Rob Fowler
- Robert A Fowler
- Roberta Cavalin
- Roberta Pisi
- Roberto Roncon-Albuquerque
- Robin Kobbe
- Romans Matulevics
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rumaisah Satyawati
- Rupert Higgins
- Ruth Lyons
- Ryan S Thwaites
- Sabina Mason
- Sadie Kelly
- Sally Shrapnel
- Samreen Ijaz
- Samuel Hinton
- Sandra Rossi
- Sanne Wesselius
- Santi Dewayanti
- Saptadi Yuliarto
- Sara Clohisey
- Sarah E McDonald
- Sarah Moore
- Saye Khoo
- Scott Pharand
- Sebastian Vencken
- Seán Keating
- Shaikh Sharjeel
- Sharma Keshav
- Shaun Thompson
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirley Sarfo-Mensah
- Shona C Moore
- Silvia Bertagnolio
- Silvia Castañeda
- Simon Forsyth
- Simone Piva
- Soe Soe Thwin
- Sophia Ankrah
- Sophie Halpin
- Soulichanya Phoutthavong
- Sree Satyapriya
- Srinivas Murthy
- Srinivas Murthy
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Sue Smith
- Summer Hamza
- Surya Otto Wijaya
- Susanne Dudman
- Synne Jenum
- Sérgio Gaião
- Sílvia Ferreira
- Teresa Lawrence
- Thalha Rashan
- Thipsavanh Bounphiengsy
- Thushan de Silva
- Timothy M Uyeki
- Tirupakuzhi Vijayaraghavan
- Tiziana Meschi
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Touxiong Yiaye
- Trude Steinsvik
- Uluhan Sili
- Valeria Balan
- Valeria Balan
- Valla Sahraei
- Vanessa Sancho-Shimizu
- Vegard Skogen
- Victoria Shaw
- Viladeth Praphasiri
- Vilmaris Quinones-Cardona
- Volkan Korten
- Waasila Jassat
- Waasila Jassat
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Xin Ci Wong
- Xin Ci Wong
- Yael Dishon
- Yaseen Arabi
- Yaseen Arabi
- Yock Ping Chow
- Yock Ping Chow
- Yvelynne Kelly
- Zulfiqar Sandhu
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 01/01/2022
- Field of study
Background: Whilst timely clinical characterisation of infections caused by novel SARS-CoV-2 variants is necessary for evidence-based policy response, individual-level data on infecting variants are typically only available for a minority of patients and settings.
Methods: Here, we propose an innovative approach to study changes in COVID-19 hospital presentation and outcomes after the Omicron variant emergence using publicly available population-level data on variant relative frequency to infer SARS-CoV-2 variants likely responsible for clinical cases. We apply this method to data collected by a large international clinical consortium before and after the emergence of the Omicron variant in different countries.
Results: Our analysis, that includes more than 100,000 patients from 28 countries, suggests that in many settings patients hospitalised with Omicron variant infection less often presented with commonly reported symptoms compared to patients infected with pre-Omicron variants. Patients with COVID-19 admitted to hospital after Omicron variant emergence had lower mortality compared to patients admitted during the period when Omicron variant was responsible for only a minority of infections (odds ratio in a mixed-effects logistic regression adjusted for likely confounders, 0.67 [95% confidence interval 0.61-0.75]). Qualitatively similar findings were observed in sensitivity analyses with different assumptions on population-level Omicron variant relative frequencies, and in analyses using available individual-level data on infecting variant for a subset of the study population.
Conclusions: Although clinical studies with matching viral genomic information should remain a priority, our approach combining publicly available data on variant frequency and a multi-country clinical characterisation dataset with more than 100,000 records allowed analysis of data from a wide range of settings and novel insights on real-world heterogeneity of COVID-19 presentation and clinical outcome
Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
- Author
- Abdukahil heryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Airlangga Eka
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Akwani Chika
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ampaw Phoebe
- Andini Roberto
- Andrey
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
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- Fowler Robert A.
- Fraher Marianne
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- Fraser Christophe
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- Freire Marcela Vieira
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- Greenhalf William
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- Grieco Domenico Luca
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- Hamers Raph L.
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- Harrison Ewen M.
- Harrison Janet
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- Hashmi Junaid
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- Houas Ikram
- Hough Catherine L.
- Houltham Stuart
- Hssain Ali Ait
- Hulot Jean-Sébastien
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- Johnson David W.
- Jorge García Ruth N.
- Joseph Cédric
- Joseph Mark
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- Lafhej Nadhem
- Lagrange Marie
- Laine Fabrice
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- Liu Keibun
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- Loschner Anthony L.
- Loubet Paul
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- Oliveira João
- Olliaro Piero L.
- Ong David S. Y.
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- Payen Jean-François
- Peake Sandra L.
- Peariasamy Kalaiarasu
- Peek Giles J.
- Peelman Florent
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- Quraishi Mohammed
- Qutishat Fadi
- Rabaud Christian
- Rafael Aldo
- Rafiq Marie
- Rahardjani Mutia
- Rahimi Amir Kamel
- Rahman Rozanah Abd
- Rainieri Fernando
- Rajahram Giri Shan
- Ramakrishnan Nagarajan
- Ramalho José
- Ramli Ahmad Afiq
- Rammaert Blandine
- Ramos Grazielle Viana
- Ranjan Ritika
- Rapp Christophe
- Rasmin Menaldi
- Ravi Tharmini
- Real Andre
- Rebaudet Stanislas
- Redl Sarah
- Reeve Brenda
- Rego Caroline Martins
- Reid Liadain
- Reikvam Dag Henrik
- Reis Renato
- Remy Martine
- Ren Hongru
- Resseguier Anne-Sophie
- Revest Matthieu
- Rewa Oleksa
- Reyes Luis Felipe
- Reyes Tiago
- Ribeiro Ana Freitas
- Ribeiro Maria Ines
- Richardson David
- Richardson Denise
- Richier Laurent
- Rios Ana L.
- Rishu Asgar
- Rispal Patrick
- Risso Karine
- Rizer Nicholas
- Rizo Topete Lilia María
- Robba Chiara
- Roberto André
- Roberts Stephanie
- Robertson David L.
- Robineau Olivier
- Roche-Campo Ferran
- Rodari Paola
- Rodeia Simão
- Roessler Bernhard
- Roger Pierre-Marie
- Rojek Amanda
- Rojo Jaime Cruz
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- Roncon-Albuquerque Roberto
- Roriz Mélanie
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- Rose Michael
- Rosenberger Dorothea
- Rossanese Andrea
- Rossetti Matteo
- Rossignol Bénédicte
- Rossignol Patrick
- Rousset Stella
- Roy Carine
- Roze Benoît
- Russell Clark D.
- Ryan Maeve
- Ryan Maria
- Ryckaert Steffi
- Rätsep Indrek
- Saba Isabela
- Sadat Musharaf
- Sahraei Valla
- Saint-Gilles Maximilien
- Sakiyalak Pranya
- Salazar Leonardo
- Sales Gabriele
- Sallaberry Stéphane
- Salvator Hélène
- Sanchez Emely
- Sanchez Olivier
- Sanchez-Miralles Angel
- Sancho-Shimizu Vanessa
- Sandhu Gyan
- Sandhu Zulfiqar
- Sandrine Pierre-François
- Sandulescu Oana
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- Santos Marlene
- Sarfo-Mensah Shirley
- Sarmiento Iam Claire E.
- Sarton Benjamine
- Satyapriya Sree
- Satyawati Rumaisah
- Saviciute Egle
- Saw Yen Tsen
- Schaffer Justin
- Schermer Tjard
- Scherpereel Arnaud
- Schneider Marion
- Schroll Stephan
- Schwameis Michael
- Scott Janet T.
- Scott-Brown James
- Sedillot Nicholas
- Seitz Tamara
- Selvarajoo Mageswari
- Semaille Caroline
- Semedi Bambang Pujo
- Semple Malcolm G.
- Senian Rasidah Bt
- Senneville Eric
- Sepulveda Claudia
- Sequeira Filipa
- Sequeira Tânia
- Shadowitz Ellen
- Shahidan Syamin Asyraf
- Shamsah Mohammad
- Shankar Anuraj
- Sharjeel Shaikh
- Sharma Pratima
- Shaw Catherine A.
- Shaw Victoria
- Sheenan John Robert
- Shi Haixia
- Shime Nobuaki
- Shimizu Hiroaki
- Shimizu Keiki
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- Shrapnel Sally
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- Spinuzza Elisabetta
- Spyrison Nicholas
- Sriskandan Shiranee
- Stabler Sarah
- Staudinger Thomas
- Stecher Stephanie-Susanne
- Steinsvik Trude
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- Streinu-Cercel Adrian
- Streinu-Cercel Anca
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- Stuart David
- Su Richa
- Subekti Decy
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- Suen Jacky Y.
- Sukumar Prasanth
- Sultana Asfia
- Summers Charlotte
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- Suppiah Deepashankari
- Surovcová Magdalena
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- Sweeney Lisa Mc
- Syahrin Sarah
- Syrigos Konstantinos
- Sztajnbok Jaques
- Szuldrzynski Konstanty
- Tabrizi Shirin
- Taccone Fabio S.
- Tagherset Lysa
- Taib Shahdattul Mawarni
- Taleb Sara
- Talsma Jelmer
- Tamlihat Younes Ait
- Tampubolon Maria Lawrensia
- Tan Kim Keat
- Tan Yan Chyi
- Tanaka Hiroyuki
- Tanaka Taku
- Taniguchi Hayato
- Tardivon Coralie
- Tattevin Pierre
- Taufik M Azhari
- Tawfik Hassan
- Tedder Richard S.
- Tee Tze Yuan
- Teixeira João
- Tellier Marie-Capucine
- Teoh Sze Kye
- Teotonio Vanessa
- Terpstra Pleun
- Terrier Olivier
- Terzi Nicolas
- Tessier-Grenier Hubert
- Tey Adrian
- Tham Zhang Duan
- Thanga Thurai Surain Raaj
- Thangavelu Suvintheran
- Theron Elmi
- Thibault Vincent
- Thiberville Simon-Djamel
- Thill Benoît
- Thirumanickam Jananee
- Tho Leong Chin
- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thorpe Mathew
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
- Tirupakuzhi Vijayaraghavan Bharath Kumar
- Tissot Noémie
- Toal Fiona
- Toki Maria
- Tonby Kristian
- Tonnii Sia Loong
- Torre Marta
- Torres Antoni
- Torres-Zevallos Hernando
- Towers Michael
- Trapani Tony
- Tromeur Cécile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turgeon Alexis F.
- Turmel Jean-Marie
- Turtle Lance C. W.
- Tveita Anders
- Twardowski Pawel
- Téoulé François
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasudayan Shoban Raj
- Vauchy Charline
- Vecham Pavan Kumar
- Veeran Shaminee
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vieira César
- Villanueva Joy Ann
- Villoldo Andrea
- Visseaux Benoit
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Wainstein Marina
- Walsh Laura
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Wen Tan Pei
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Bailey
- Williams Patricia J.
- Williams Virginie
- Wils Evert-Jan
- Wittman Jessica
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Yew Sing
- Xian Gan Ee
- Xian Lim Saio
- Xynogalas Ioannis
- Yamazaki Masaki
- Yang Toh Jordan Zhien
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Zaaqoq Akram
- Zabbe Marion
- Zahid Masliza
- Zahran Maram
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Elsevier BV
- Publication date
- 26/05/2023
- Field of study
Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
- Abdukahil Sheryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adam Elisabeth
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Akwani Chika
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alessi Marta
- Alex Beatrice
- Alexander Peta MA
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asensio Angel
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atif Minahel
- Atikah Ahmad Ridzuan Siti Nurul
- Atique Anika
- Auchabie Johann
- Aumaitre Hugues
- Auvet Adrien
- Ayadi Kamaluddin Muhammad Aisar
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Balazote Pablo Serrano
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Benny Binny
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bidin Farah Nadiah
- Binti Mohd Yakop Siti Rohani
- Binti Zaidan Nor Zaila
- Bisoffi Zeno
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Blumberg Lucille
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolaños Isabela
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Bozza Patricia T
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O
- Browne Alex
- Browne Shaunagh
- Brozzi Nicolas
- Brusse-Keizer Marjolein
- Bryda Petra
- Buchtele Nina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Campisi Josie
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavayas Alexandros
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chantalat Auger Christelle
- Chapplain Jean-Marc
- Charpentier Charlotte
- Chas Julie
- Che Kamaruddin Zul Amali
- Chen Anjellica
- Chen Yih-Sharng
- Chenard Léo
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chidambaram Suresh Kumar
- Chin Tho Leong
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Chow Ting Soo
- Chua Hiu Jian
- Chua Jonathan
- Chávez Iñiguez Jonathan Samuel
- Cidade Jose Pedro
- Cisneros Herreros José Miguel
- Citarella Barbara Wanjiru
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Claure-Del Granado Rolando
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Jennifer
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connolly Jennifer
- Connor Marie
- Conrad Anne
- Conway Elaine
- Cooke Graham S
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Cristella Cosimo
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Bermúdez Juan Luis
- Cruz Rojo Jaime
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew
- Curley Gerard
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- Cárcel Sheila
- D'Aragon Frédérick
- D'Ortenzio Eric
- da Silva Filipe Ana
- Da Silva Fernanda Dias
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A
- Dantas Jorge
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de Jong Menno
- de la Calle Guillermo Maestro
- de Loughry Gillian
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Piero Maria
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Dean David
- Debard Alexa
- DeBenedictis Bianca
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Delfos Nathalie M
- Deligiannis Ionna
- Dell'Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie B
- Doherty Helen
- Donnelly Christl A
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival Céline
- Douglas James Joshua
- Dournon Nathalie
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dryden Murray
- Dubee Vincent
- Dubos François
- Ducancelle Alexandre
- Duculan Toni
- Dudman Susanne
- Duggal Abhijit
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Ean Sim Choon
- Echeverria-Villalobos Marco
- Eddington Devin P
- Egan Siobhan
- Eira Carla
- Ekow Harrison Samuel Bernard
- El Sanharawi Mohammed
- Elapavaluru Subbarao
- Elharrar Brigitte
- Eliza Mohamed Nik Nur
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Endo Tomoyuki
- Eng Chan Chee
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J
- Fanning Jonathon P
- Faria Pedro
- Fateena Hanan
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferraz Mário
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira Sílvia
- Ferriere Nicolas
- Ferrão Joana
- Ficko Céline
- Figueiredo-Mello Claudia
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florence Aline-Marie
- Florio Letizia Lucia
- Flynn Deirdre
- Foley Claire
- Foley Jean
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John
- Fraser John F
- Freire Marcela Vieira
- Fritz Ricardo
- Fry Stéphanie
- Fuentes Nora
- Fukuda Masahiro
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
- Gandonniere Charlotte Salmon
- Gani Yasmin
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- Garcês Rui Caetano
- Garot Denis
- Garrait Valérie
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- Gavin Aisling
- Gavrylov Anatoliy
- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
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- Giani Marco
- Gibson Jess
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- Gilroy Elaine
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Gnall Eric
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- Goepel Siri
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- Goh Jin Yi
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- Gormley Conor
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- Grable Margarite
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- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffee Matthew J
- Griffiths Fiona
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- Groenendijk Albert
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- Guilleminault Laurent
- Guimard Thomas
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- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
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- Haji Ab Rahman Ahmad Kashfi
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- Hall Matthew
- Halpin Sophie
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Naomi
- Hammond Terese
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- Haniffa Rashan
- Hao Kok Wei
- Hardwick Hayley
- Harrison Ewen M
- Harrison Janet
- Hartman Alan
- Hashmi Junaid
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- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Henriquez-Trujillo Aquiles
- Hentzien Maxime
- Hernandez Diana
- Hernandez-Montfort Jaime
- Hershey Andrew
- Hesstvedt Liv
- Higgins Dawn
- Higgins Eibhlin
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- Povoa Pedro
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- Proença Lucia
- Pudota Sravya
- Purcell Gregory
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- Quraishi Mohammed
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- Revest Matthieu
- Rewa Oleksa
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- Tonby Kristian
- Tonnii Sia Loong
- Torre Marta
- Torres Antoni
- Torres Margarida
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- Towers Michael
- Trapani Tony
- Trioux Théo
- Tromeur Cécile
- Trontzas Ioannis
- Trouillon Tiffany
- Truong Jeanne
- Tual Christelle
- Tubiana Sarah
- Tuite Helen
- Turgeon Alexis F
- Turmel Jean-Marie
- Turtle Lance CW
- Tveita Anders
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- Van der Feltz Machteld
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Someren Gréve Frank
- van Veen Ilonka
- Van Willigen Hugo
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasconcelos Malte Kohns
- Vasudayan Shoban Raj
- Vauchy Charline
- Vecham Pavan Kumar
- Veeran Shaminee
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vidal José Ernesto
- Vieira César
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Walsh Laura
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wen Tan Pei
- Wesselius Sanne
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Bailey
- Williams Patricia J
- Williams Virginie
- Wils Evert-Jan
- Wittman Jessica
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Yew Sing
- Xian Gan Ee
- Xian Lim Saio
- Xynogalas Ioannis
- Yamazaki Masaki
- Yang Toh Jordan Zhien
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Zaaqoq Akram
- Zabbe Marion
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Elsevier BV
- Publication date
- 30/06/2023
- Field of study
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings