1,113 research outputs found
A differential method for bounding the ground state energy
For a wide class of Hamiltonians, a novel method to obtain lower and upper
bounds for the lowest energy is presented. Unlike perturbative or variational
techniques, this method does not involve the computation of any integral (a
normalisation factor or a matrix element). It just requires the determination
of the absolute minimum and maximum in the whole configuration space of the
local energy associated with a normalisable trial function (the calculation of
the norm is not needed). After a general introduction, the method is applied to
three non-integrable systems: the asymmetric annular billiard, the many-body
spinless Coulombian problem, the hydrogen atom in a constant and uniform
magnetic field. Being more sensitive than the variational methods to any local
perturbation of the trial function, this method can used to systematically
improve the energy bounds with a local skilled analysis; an algorithm relying
on this method can therefore be constructed and an explicit example for a
one-dimensional problem is given.Comment: Accepted for publication in Journal of Physics
Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations
Background: Haptoglobin (Hp) α-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties. Hp1-1 genotype results in the production of small dimeric, Hp2-1 linear, and Hp2-2 cyclic polymeric haptoglobin molecules. We investigated the haptoglobin polymorphism in patients with celiac disease and its possible association to the presenting symptoms.
Methods: We studied 712 unrelated, biopsy-proven Hungarian celiac patients (357 children, 355 adults; severe malabsorption 32.9%, minor gastrointestinal symptoms 22.8%, iron deficiency anemia 9.4%, dermatitis herpetiformis 15.6%, silent disease 7.2%, other 12.1%) and 384 healthy subjects. We determined haptoglobin phenotypes by gel electrophoresis and assigned corresponding genotypes.
Results: Hp2-1 was associated with a significant risk for celiac disease (P = 0.0006, odds ratio [OR] 1.54, 95% CI 1.20–1.98; prevalence 56.9% in patients vs 46.1% in controls). It was also overrepresented among patients with mild symptoms (69.2%) or silent disease (72.5%). Hp2-2 was less frequent in patients than in controls (P = 0.0023), but patients having this phenotype were at an increased risk for severe malabsorption (OR 2.21, 95% CI 1.60–3.07) and accounted for 45.3% of all malabsorption cases. Celiac and dermatitis herpetiformis patients showed similar haptoglobin phenotype distributions.
Conclusions: The haptoglobin polymorphism is associated with susceptibility to celiac disease and its clinical presentations. The predominant genotype in the celiac population was Hp2-1, but Hp2-2 predisposed to a more severe clinical course. The phenotype-dependent effect of haptoglobin may result from the molecule’s structural and functional properties
Solar science with the Atacama Large Millimeter/submillimeter Array - A new view of our Sun
The Atacama Large Millimeter/submillimeter Array (ALMA) is a new powerful
tool for observing the Sun at high spatial, temporal, and spectral resolution.
These capabilities can address a broad range of fundamental scientific
questions in solar physics. The radiation observed by ALMA originates mostly
from the chromosphere - a complex and dynamic region between the photosphere
and corona, which plays a crucial role in the transport of energy and matter
and, ultimately, the heating of the outer layers of the solar atmosphere. Based
on first solar test observations, strategies for regular solar campaigns are
currently being developed. State-of-the-art numerical simulations of the solar
atmosphere and modeling of instrumental effects can help constrain and optimize
future observing modes for ALMA. Here we present a short technical description
of ALMA and an overview of past efforts and future possibilities for solar
observations at submillimeter and millimeter wavelengths. In addition, selected
numerical simulations and observations at other wavelengths demonstrate ALMA's
scientific potential for studying the Sun for a large range of science cases.Comment: 73 pages, 21 figures ; Space Science Reviews (accepted December 10th,
2015); accepted versio
Observing the Sun with the Atacama Large Millimeter-submillimeter Array (ALMA): Fast-Scan Single-Dish Mapping
The Atacama Large Millimeter-submillimeter Array (ALMA) radio telescope has
commenced science observations of the Sun starting in late 2016. Since the Sun
is much larger than the field of view of individual ALMA dishes, the ALMA
interferometer is unable to measure the background level of solar emission when
observing the solar disk. The absolute temperature scale is a critical
measurement for much of ALMA solar science, including the understanding of
energy transfer through the solar atmosphere, the properties of prominences,
and the study of shock heating in the chromosphere. In order to provide an
absolute temperature scale, ALMA solar observing will take advantage of the
remarkable fast-scanning capabilities of the ALMA 12m dishes to make
single-dish maps of the full Sun. This article reports on the results of an
extensive commissioning effort to optimize the mapping procedure, and it
describes the nature of the resulting data. Amplitude calibration is discussed
in detail: a path that utilizes the two loads in the ALMA calibration system as
well as sky measurements is described and applied to commissioning data.
Inspection of a large number of single-dish datasets shows significant
variation in the resulting temperatures, and based on the temperature
distributions we derive quiet-Sun values at disk center of 7300 K at lambda=3
mm and 5900 K at lambda=1.3 mm. These values have statistical uncertainties of
order 100 K, but systematic uncertainties in the temperature scale that may be
significantly larger. Example images are presented from two periods with very
different levels of solar activity. At a resolution of order 25 arcsec, the 1.3
mm wavelength images show temperatures on the disk that vary over about a 2000
K range.Comment: Solar Physics, accepted: 24 pages, 13 figure
Observing the Sun with Atacama Large Millimeter/submillimeter Array (ALMA): High Resolution Interferometric Imaging
Observations of the Sun at millimeter and submillimeter wavelengths offer a
unique probe into the structure, dynamics, and heating of the chromosphere; the
structure of sunspots; the formation and eruption of prominences and filaments;
and energetic phenomena such as jets and flares. High-resolution observations
of the Sun at millimeter and submillimeter wavelengths are challenging due to
the intense, extended, low- contrast, and dynamic nature of emission from the
quiet Sun, and the extremely intense and variable nature of emissions
associated with energetic phenomena. The Atacama Large Millimeter/submillimeter
Array (ALMA) was designed with solar observations in mind. The requirements for
solar observations are significantly different from observations of sidereal
sources and special measures are necessary to successfully carry out this type
of observations. We describe the commissioning efforts that enable the use of
two frequency bands, the 3 mm band (Band 3) and the 1.25 mm band (Band 6), for
continuum interferometric-imaging observations of the Sun with ALMA. Examples
of high-resolution synthesized images obtained using the newly commissioned
modes during the solar commissioning campaign held in December 2015 are
presented. Although only 30 of the eventual 66 ALMA antennas were used for the
campaign, the solar images synthesized from the ALMA commissioning data reveal
new features of the solar atmosphere that demonstrate the potential power of
ALMA solar observations. The ongoing expansion of ALMA and solar-commissioning
efforts will continue to enable new and unique solar observing capabilities.Comment: 22 pages, 12 figures, accepted for publication in Solar Physic
Next Generation Life Support Project Status
Next Generation Life Support (NGLS) is one of over twenty technology development projects sponsored by NASA's Game Changing Development Program. The NGLS Project develops selected life support technologies needed for humans to live and work productively in space, with focus on technologies for future use in spacecraft cabin and space suit applications. Over the last three years, NGLS had five main project elements: Variable Oxygen Regulator (VOR), Rapid Cycle Amine (RCA) swing bed, High Performance (HP) Extravehicular Activity (EVA) Glove, Alternative Water Processor (AWP) and Series-Bosch Carbon Dioxide Reduction. The RCA swing bed, VOR and HP EVA Glove tasks are directed at key technology needs for the Portable Life Support System (PLSS) and pressure garment for an Advanced Extravehicular Mobility Unit (EMU). Focus is on prototyping and integrated testing in cooperation with the Advanced Exploration Systems (AES) Advanced EVA Project. The HP EVA Glove Element, new this fiscal year, includes the generation of requirements and standards to guide development and evaluation of new glove designs. The AWP and Bosch efforts focus on regenerative technologies to further close spacecraft cabin atmosphere revitalization and water recovery loops and to meet technology maturation milestones defined in NASA's Space Technology Roadmaps. These activities are aimed at increasing affordability, reliability, and vehicle self-sufficiency while decreasing mass and mission cost, supporting a capability-driven architecture for extending human presence beyond low-Earth orbit, along a human path toward Mars. This paper provides a status of current technology development activities with a brief overview of future plans
An Overview of the 2014 ALMA Long Baseline Campaign
A major goal of the Atacama Large Millimeter/submillimeter Array (ALMA) is to
make accurate images with resolutions of tens of milliarcseconds, which at
submillimeter (submm) wavelengths requires baselines up to ~15 km. To develop
and test this capability, a Long Baseline Campaign (LBC) was carried out from
September to late November 2014, culminating in end-to-end observations,
calibrations, and imaging of selected Science Verification (SV) targets. This
paper presents an overview of the campaign and its main results, including an
investigation of the short-term coherence properties and systematic phase
errors over the long baselines at the ALMA site, a summary of the SV targets
and observations, and recommendations for science observing strategies at long
baselines. Deep ALMA images of the quasar 3C138 at 97 and 241 GHz are also
compared to VLA 43 GHz results, demonstrating an agreement at a level of a few
percent. As a result of the extensive program of LBC testing, the highly
successful SV imaging at long baselines achieved angular resolutions as fine as
19 mas at ~350 GHz. Observing with ALMA on baselines of up to 15 km is now
possible, and opens up new parameter space for submm astronomy.Comment: 11 pages, 7 figures, 2 tables; accepted for publication in the
Astrophysical Journal Letters; this version with small changes to
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The intensification of metallic layered phenomena above thunderstorms through the modulation of atmospheric tides
We present a multi-instrument experiment to study the effects of tropospheric thunderstorms on the mesopause region and the lower ionosphere. Sodium (Na) lidar and ionospheric observations by two digital ionospheric sounders are used to study the variation in the neutral metal atoms and metallic ions above thunderstorms. An enhanced ionospheric sporadic E layer with a downward tidal phase is observed followed by a subsequent intensification of neutral Na number density with an increase of 600 cm−3 in the mesosphere. In addition, the Na neutral chemistry and ion-molecule chemistry are considered in a Na chemistry model to simulate the dynamical and chemical coupling processes in the mesosphere and ionosphere above thunderstorms. The enhanced Na layer in the simulation obtained by using the ionospheric observation as input is in agreement with the Na lidar observation. We find that the intensification of metallic layered phenomena above thunderstorms is associated with the atmospheric tides, as a result of the troposphere-mesosphere-ionosphere coupling
The N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD
The type III secretion system (T3SS) is an essential virulence factor for Shigella flexneri, providing a conduit through which host-altering effectors are injected directly into a host cell to promote uptake. The type III secretion apparatus (T3SA) is comprised of a basal body, external needle, and regulatory tip complex. The nascent needle is a polymer of MxiH capped by a pentamer of invasion plasmid antigen D (IpaD). Exposure to bile salts (e.g. deoxycholate) causes a conformational change in IpaD and promotes recruitment of IpaB to the needle tip. It has been proposed that IpaB senses contact with host cell membranes, recruiting IpaC and inducing full secretion of T3SS effectors. While the steps of T3SA maturation and their external triggers have been identified, details of specific protein interactions and mechanisms have remained difficult to study due to the hydrophobic nature of the IpaB and IpaC translocator proteins. Here we explored the ability for a series of soluble N-terminal IpaB peptides to interact with IpaD. We found that DOC is required for the interaction and that a region of IpaB between residues 11–27 is required for maximum binding, which was confirmed in vivo. Furthermore, intramolecular FRET measurements indicated that movement of the IpaD distal domain away from the protein core accompanied the binding of IpaB11-226. Together these new findings provide important new insight into the interactions and potential mechanisms that define the maturation of the Shigella T3SA needle tip complex and provide a foundation for further studies probing T3SS activation
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