Projected pH reductions by 2100 might put deep North Atlantic biodiversity at risk

This study aims to evaluate the potential for impacts of ocean acidification on North Atlantic deep-sea ecosystems in response to IPCC AR5 Representative Concentration Pathways (RCPs). Deep-sea biota is likely highly vulnerable to changes in seawater chemistry and sensitive to moderate excursions in pH. Here we show, from seven fully coupled Earth system models, that for three out of four RCPs over 17% of the seafloor area below 500 m depth in the North Atlantic sector will experience pH reductions exceeding ?0.2 units by 2100. Increased stratification in response to climate change partially alleviates the impact of ocean acidification on deep benthic environments. We report on major pH reductions over the deep North Atlantic seafloor (depth >500 m) and at important deep-sea features, such as seamounts and canyons. By 2100, and under the high CO2 scenario RCP8.5, pH reductions exceeding ?0.2 (?0.3) units are projected in close to 23% (~15%) of North Atlantic deep-sea canyons and ~8% (3%) of seamounts – including seamounts proposed as sites of marine protected areas. The spatial pattern of impacts reflects the depth of the pH perturbation and does not scale linearly with atmospheric CO2 concentration. Impacts may cause negative changes of the same magnitude or exceeding the current target of 10% of preservation of marine biomes set by the convention on biological diversity, implying that ocean acidification may offset benefits from conservation/management strategies relying on the regulation of resource exploitation

Global citizenship as the completion of cosmopolitanism

A conception of global citizenship should not be viewed as separate from, or synonymous with, the cosmopolitan moral orientation, but as a primary component of it. Global citizenship is fundamentally concerned with individual moral requirements in the global frame. Such requirements, framed here as belonging to the category of individual cosmopolitanism, offer guidelines on right action in the context of global human community. They are complementary to the principles of moral cosmopolitanism – those to be used in assessing the justice of global institutions and practices – that have been emphasised by cosmopolitan political theorists. Considering principles of individual and moral cosmopolitanism together can help to provide greater clarity concerning individual duties in the absence of fully global institutions, as well as clarity on individual obligations of justice in relation to emerging and still-developing trans-state institutions

Approaches to improve the determination of eligibility for plant variety protection: I evaluation of morphological characteristics

The demonstration of distinctness through comparisons of morphological characteristics is an essential require¬ment in order to obtain Plant Variety Protection (PVP) and registration. Desires for increased international harmoni¬zation and the increasing size of reference collections place increased emphasis on improving the efficiency of the process. Morphological characteristics are notoriously affected by environment and many may be correlated in their expression. We developed an approach using inbred lines of maize (Zea mays L.) to evaluate characteristics according to their performance for 9 parameters encompassing 3 categories of Variability, Power and Genotype by Environment interaction. These data provide a basis for selecting a reduced core set of characteristics with the goal of retaining discriminational ability while decreasing the time and resources required to obtain and to compare morphologies

A lambda-calculus with constructors

(avec annexes)International audienceWe present an extension of the lambda(eta)-calculus with a case construct that propagates through functions like a head linear substitution, and show that this construction permits to recover the expressiveness of ML-style pattern matching. We then prove that this system enjoys the Church-Rosser property using a semi-automatic `divide and conquer' technique by which we determine all the pairs of commuting subsystems of the formalism (considering all the possible combinations of the nine primitive reduction rules). Finally, we prove a separation theorem similar to Böhm's theorem for the whole formalism

Traffic-Related Air Pollution and All-Cause Mortality during Tuberculosis Treatment in California.

BackgroundAmbient air pollution and tuberculosis (TB) have an impact on public health worldwide, yet associations between the two remain uncertain.ObjectiveWe determined the impact of residential traffic on mortality during treatment of active TB.MethodsFrom 2000-2012, we enrolled 32,875 patients in California with active TB and followed them throughout treatment. We obtained patient data from the California Tuberculosis Registry and calculated traffic volumes and traffic densities in 100- to 400-m radius buffers around residential addresses. We used Cox models to determine mortality hazard ratios, controlling for demographic, socioeconomic, and clinical potential confounders. We categorized traffic exposures as quintiles and determined trends using Wald tests.ResultsParticipants contributed 22,576 person-years at risk. There were 2,305 deaths during treatment for a crude mortality rate of 1,021 deaths per 10,000 person-years. Traffic volumes and traffic densities in all buffers around patient residences were associated with increased mortality during TB treatment, although the findings were not statistically significant in all buffers. As the buffer size decreased, fifth-quintile mortality hazards increased, and trends across quintiles of traffic exposure became more statistically significant. Increasing quintiles of nearest-road traffic volumes in the 100-m buffer were associated with 3%, 14%, 19%, and 28% increased risk of death during TB treatment [first quintile, referent; second quintile hazard ratio (HR)=1.03 [95% confidence interval (CI): 0.86, 1.25]; third quintile HR=1.14 (95% CI: 0.95, 1.37); fourth quintile HR=1.19 (95% CI: 0.99, 1.43); fifth quintile HR=1.28 (95% CI: 1.07, 1.53), respectively; p-trend=0.002].ConclusionsResidential proximity to road traffic volumes and traffic density were associated with increased all-cause mortality in patients undergoing treatment for active tuberculosis even after adjusting for multiple demographic, socioeconomic, and clinical factors, suggesting that TB patients are susceptible to the adverse health effects of traffic-related air pollution. https://doi.org/10.1289/EHP1699

Beam position measurement in the CEBAF recirculating linacs by use of pseudorandom pulse sequences

The recirculating linear accelerator at CEBAF presents unique problems in beam position measurement. As many as five beams with different energies may be simultaneously in the linac. Modulation of the beam intensity by pseudorandom pulse sequences offers a simple, effective method for distinguishing between the individual beamlets

The unusual hydrocarbon emission from the early carbon star HD 100764: The connection between aromatics and aliphatics

We have used the Infrared Spectrograph (IRS) on the Spitzer Space Telescope to obtain spectra of HD 100764, an apparently single carbon star with a circumstellar disk. The spectrum shows emission features from polycyclic aromatic hydrocarbons (PAHs) that are shifted to longer wavelengths than normally seen, as characteristic of ``class C'' systems in the classification scheme of Peeters et al. All seven of the known class C PAH sources are illuminated by radiation fields that are cooler than those which typically excite PAH emission features. The observed wavelength shifts are consistent with hydrocarbon mixtures containing both aromatic and aliphatic bonds. We propose that the class C PAH spectra are distinctive because the carbonaceous material has not been subjected to a strong ultraviolet radiation field, allowing relatively fragile aliphatic materials to survive.Comment: 11 pages (in emulateapj), 5 tables, 7 figures. Accepted for publication in Ap

Therapeutic targeting of integrin αvβ6 in breast cancer

BACKGROUND: Integrin ?v?6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of ?v?6 has yet to be elucidated in breast cancer.METHODS: Protein expression of integrin subunit beta6 (?6) was measured in breast cancers by immunohistochemistry (n &gt; 2000) and ITGB6 mRNA expression measured in the Molecular Taxonomy of Breast Cancer International Consortium dataset. Overall survival was assessed using Kaplan Meier curves, and bioinformatics statistical analyses were performed (Cox proportional hazards model, Wald test, and Chi-square test of association). Using antibody (264RAD) blockade and siRNA knockdown of ?6 in breast cell lines, the role of ?v?6 in Human Epidermal Growth Factor Receptor 2 (HER2) biology (expression, proliferation, invasion, growth in vivo) was assessed by flow cytometry, MTT, Transwell invasion, proximity ligation assay, and xenografts (n ? 3), respectively. A student's t-test was used for two variables; three-plus variables used one-way analysis of variance with Bonferroni's Multiple Comparison Test. Xenograft growth was analyzed using linear mixed model analysis, followed by Wald testing and survival, analyzed using the Log-Rank test. All statistical tests were two sided.RESULTS: High expression of either the mRNA or protein for the integrin subunit ?6 was associated with very poor survival (HR = 1.60, 95% CI = 1.19 to 2.15, P = .002) and increased metastases to distant sites. Co-expression of ?6 and HER2 was associated with worse prognosis (HR = 1.97, 95% CI = 1.16 to 3.35, P = .01). Monotherapy with 264RAD or trastuzumab slowed growth of MCF-7/HER2-18 and BT-474 xenografts similarly (P &lt; .001), but combining 264RAD with trastuzumab effectively stopped tumor growth, even in trastuzumab-resistant MCF-7/HER2-18 xenografts.CONCLUSIONS: Targeting ?v?6 with 264RAD alone or in combination with trastuzumab may provide a novel therapy for treating high-risk and trastuzumab-resistant breast cancer patients.<br/

Characterization of maize germplasm: comparison of morphological datasets compiled using different approaches to data recording

Different methods are used to report morphological data to evaluate the eligibility criterion of distinctness for Plant Variety Protection (PVP). We compared morphological data for 152 maize (Zea mays L.) inbred lines generated according to both US (metric data) and EU data (summarized by reference to “note” scores from check inbreds). While modal notes were very similar for US and EU data, on average only 42.8% of the characteristics had identi¬cal scores. Associations among inbreds on the basis of comparisons of single or multiple characteristics were very similar regardless of data type. We conclude that maize morphological data collected according to either of these protocols cannot meaningfully be combined into a single dataset. However, each data type, provided an equivalent mechanism to test for distinctness. These results cause us to more fundamentally question the degree of reliance that should be placed upon morphological data for PVP and other applications, including for the man¬agement of accessions conserved in gene-banks

Nucleation of vortex arrays in rotating anisotropic Bose-Einstein condensates

The nucleation of vortices and the resulting structures of vortex arrays in dilute, trapped, zero-temperature Bose-Einstein condensates are investigated numerically. Vortices are generated by rotating a three-dimensional, anisotropic harmonic atom trap. The condensate ground state is obtained by propagating the Gross-Pitaevskii equation in imaginary time. Vortices first appear at a rotation frequency significantly larger than the critical frequency for vortex stabilization. This is consistent with a critical velocity mechanism for vortex nucleation. At higher frequencies, the structures of the vortex arrays are strongly influenced by trap geometry.Comment: 5 pages, two embedded figures. To appear in Phys. Rev. A (RC