Consequences of Connection: Loneliness, Reading, and Robots

Modern communication technologies are reshaping the ways humans connect with one another as well as how we converse with machines of our own making. Our question in this essay is whether digital communication is changing the nature of conversation and, if so, what the implications may be for us as people. Our analysis identifies three sets of parameters for approaching these issues: linguistic (structure of conversations, communication medium, modulating the conversation to suit the perceived needs of our interlocutor, controlling the conversation), social (inner- or other-directed behavior, front stage or back stage behavior, strong or weak social ties, loneliness), and cognitive (level of intellectual engagement). We use these parameters to explore some of the linguistic, social, and cognitive consequences of electronically-mediated communication, of social reading onscreen, and of conversing with social robots

Control Freaks: How Online and Mobile Communication is Reshaping Social Contact

The year was 1956. At the time, the word “computer” referred to a roomful of hardware. “Telephones” were bulky black devices, tethered to walls (and, at least in the US, exclusively owned by the phone company). But a new gadget appeared on the scene that was destined to revolutionize our perceptions of technology – and our ability to manipulate it.The new contraption was a television remote control

Control Freaks: How Online and Mobile Communication is Reshaping Social Contact

The year was 1956. At the time, the word “computer” referred to a roomful of hardware. “Telephones” were bulky black devices, tethered to walls (and, at least in the US, exclusively owned by the phone company). But a new gadget appeared on the scene that was destined to revolutionize our perceptions of technology – and our ability to manipulate it. The new contraption was a television remote control

Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures:Workflow and practical tips

Healthy myelin is essential for proper brain function. When the myelin sheath is damaged, fast saltatory impulse conduction is lost and neuronal axons become vulnerable to degeneration. Thus, regeneration of the myelin sheath by encouraging oligodendrocyte lineage cells to remyelinate the denuded axons is a promising therapeutic target for demyelinating diseases such as multiple sclerosis. Ex vivo organotypic cerebellar slice cultures are a useful model to study developmental myelination, demyelination, remyelination and remyelination failure. In these cultures, the cerebellum's three-dimensional architecture and various cell populations remain largely intact, providing a realistic and relatively cost-efficient model that can be easily manipulated by the addition of viral vectors, pharmaceuticals or (transgenic) cells to augment or replace resident cell populations. Moreover, slice cultures can be treated with lysolecithin or polyinosinic:polycytidylic acid to induce demyelination and mimic efficient as well as inefficient remyelination. It can be challenging to set up slice cultures for the first time, as in our experience, seemingly minor differences in technique and materials can make a great difference to the quality of the cultures. Therefore, this report provides an in-depth description for the generation and maintenance of ex vivo organotypic cerebellar cultures for demyelination-remyelination studies with a focus on practical tips for scientists that are new to this technique

Costly encounters of the empathic kind: a typology

While considerable attention is being accorded to emotions in International Relations, this article seeks to integrate empathy into these interdisciplinary debates. It counters the dominant assumption that empathy tends to be largely benign and beneficial by conceptualizing a typology of the costs of empathy. The dimensions of costs addressed are epistemological, cognitive, emotional, material, and embodied. I argue that these costs are frequently tangible for those who make the ethical-political choice to engage in empathy in situations of conflict and political violence. Drawing on social psychology approaches, empathy is located within a framework of collective narratives, emotions, and social structures shaped by both micro- and macro-political processes. A model of empathy, which acknowledges social influences and the psychological mechanisms through which these influences may be mediated, contributes to a deeper understanding of how politics, psychology, and culture shape empathy and, crucially, helps understand the conditions which may affect the successes, limitations, and failures of empathy in the (international) political sphere. The article offers empirical illustrations of the costs of empathy drawing on examples from Israel and Palestine

Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement

BACKGROUND: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive syndromes is a significant determinant of short- and long-term outcomes. Although remarkable progress has been made in the understanding of RV function and failure since the meeting of the NIH Working Group on Cellular and Molecular Mechanisms of Right Heart Failure in 2005, significant gaps remain at many levels in the understanding of cellular and molecular mechanisms of RV responses to pressure and volume overload, in the validation of diagnostic modalities, and in the development of evidence-based therapies. METHODS: A multidisciplinary working group of 20 international experts from the American Thoracic Society Assemblies on Pulmonary Circulation and Critical Care, as well as external content experts, reviewed the literature, identified important knowledge gaps, and provided recommendations. RESULTS: This document reviews the knowledge in the field of RV failure, identifies and prioritizes the most pertinent research gaps, and provides a prioritized pathway for addressing these preclinical and clinical questions. The group identified knowledge gaps and research opportunities in three major topic areas: 1) optimizing the methodology to assess RV function in acute and chronic conditions in preclinical models, human studies, and clinical trials; 2) analyzing advanced RV hemodynamic parameters at rest and in response to exercise; and 3) deciphering the underlying molecular and pathogenic mechanisms of RV function and failure in diverse pulmonary hypertension syndromes. CONCLUSIONS: This statement provides a roadmap to further advance the state of knowledge, with the ultimate goal of developing RV-targeted therapies for patients with RV failure of any etiology

Mapping Hansard Impression Management Strategies through Time and Space

Impolite behaviour is thought to be easier to investigate than polite or politic behaviour in diachronic contexts, because of attracting more evaluative comment. But an approach based on such metapragmatic commentary can miss a lot of facework strategies in contexts such as the UK parliament (modern and historical). In this paper, I draw on Historic Hansard datasets (1812–2003) to demonstrate how a (semi)automatic method involving contiguous searches of two-to-four features can better reveal the nuances of these MPs’ facework strategies than a focus on metapragmatic terms has afforded hitherto. The (semi)automatic method uses the recently created Historic Thesaurus Semantic Tagger (HTST) to search for meaning constellations (Archer and Malory 2017). Meaning constellations relating to facework are made up of sequences of semantic fields and/or parts-of-speech which, when organised in certain ways, achieve im/politeness, politic behaviour, strategic ambiguity, a combination of face enhancement and face threat, etc. This paper discusses a number of these meaning constellations, with a particular focus on those which engage in both face enhancement and face aggravation simultaneously (whilst nonetheless avoiding the label, “unparliamentary language”)

Linking Symptom Inventories using Semantic Textual Similarity

An extensive library of symptom inventories has been developed over time to measure clinical symptoms, but this variety has led to several long standing issues. Most notably, results drawn from different settings and studies are not comparable, which limits reproducibility. Here, we present an artificial intelligence (AI) approach using semantic textual similarity (STS) to link symptoms and scores across previously incongruous symptom inventories. We tested the ability of four pre-trained STS models to screen thousands of symptom description pairs for related content - a challenging task typically requiring expert panels. Models were tasked to predict symptom severity across four different inventories for 6,607 participants drawn from 16 international data sources. The STS approach achieved 74.8% accuracy across five tasks, outperforming other models tested. This work suggests that incorporating contextual, semantic information can assist expert decision-making processes, yielding gains for both general and disease-specific clinical assessment

Clinical outcomes and response to treatment of patients receiving topical treatments for pyoderma gangrenosum: a prospective cohort study

Background: pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment. Objective: to estimate the effectiveness of topical therapies in the treatment of PG. Methods: prospective cohort study of UK secondary care patients with a clinical diagnosis of PG suitable for topical treatment (recruited July 2009 to June 2012). Participants received topical therapy following normal clinical practice (mainly Class I-III topical corticosteroids, tacrolimus 0.03% or 0.1%). Primary outcome: speed of healing at 6 weeks. Secondary outcomes: proportion healed by 6 months; time to healing; global assessment; inflammation; pain; quality-of-life; treatment failure and recurrence. Results: Sixty-six patients (22 to 85 years) were enrolled. Clobetasol propionate 0.05% was the most commonly prescribed therapy. Overall, 28/66 (43.8%) of ulcers healed by 6 months. Median time-to-healing was 145 days (95% CI: 96 days, ∞). Initial ulcer size was a significant predictor of time-to-healing (hazard ratio 0.94 (0.88;80 1.00); p = 0.043). Four patients (15%) had a recurrence. Limitations: No randomised comparator Conclusion: Topical therapy is potentially an effective first-line treatment for PG that avoids possible side effects associated with systemic therapy. It remains unclear whether more severe disease will respond adequately to topical therapy alone