The Use of Biomimetic Hydrogels to Direct Stem Cell Differentiation for Tissue Engineering Applications

India Pursell is an undergraduate student in the School of Biological Sciences at Louisiana Tech University. Haley Barnett is a doctoral student in Molecular Science & Nanotechnology at Louisiana Tech University. Anna Whitehead is a research associate in Molecular Science & Nanotechnology at Louisiana Tech University. Mary Caldorera-Moore is an Assistant Professor in Biomedical Engineering, Molecular Science and Nanotechnology, and Nanosystems Engineering at Louisiana Tech University. Jamie Newman is an Assistant Professor in the School of Biological Sciences at Louisiana Tech University

Myogenic Differentiation of Adipose-Derived Stem Cells for Tissue Engineering

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Intervention and the ordering of the modern world

I am lead editor of a special issue of the Review of International Studies, which is the house journal of the British International Studies Association. The special issue arose from a competitive process. I am scheduled to have two pieces in this issue.This introductory discussion establishes the notion of intervention as a ‘social practice’ and carves out the contextual and conceptual space for the special issue as a whole. The first move is to recontextualise intervention in terms of ‘modernity’ as distinct from the sovereign states system. This shift enables a better appreciation of the dynamic and evolutionary context that generates variation in the practice of intervention over time and space and which is more analytically sensitive to the economic and cultural (as well as Great Power) hierarchies that generate rationales for intervention. The second move is to reconceptualise intervention as a specific modality of coercion relatively well-suited to the regulation or mediation of conflict between territorially bounded political communities and transnational social forces. Third is to ‘historicise’ the practice of intervention through showing how it has changed in relation to a range of international orders’ that have defined the modern world and which are each characterised by a different notion of the relationship between social and territorial space. Fourth and finally is a brief consideration of the possibility of intervention’s demise as a social practice.ESRC funded seminar series, ‘Rethinking Intervention: Intervention in the Modern World’, grant reference RES-451-26-066

Systolic blood pressure reactions to acute stress are associated with future hypertension status in the Dutch Famine Birth Cohort Study

These analyses examined the association between blood pressure reactions to acute psychological stress and subsequent hypertension status in a substantial Dutch cohort. Blood pressure was recorded during a resting baseline and during three acute stress tasks, Stroop colour word, mirror tracing and speech. Five years later, diagnosed hypertension status was determined by questionnaire. Participants were 453 (237 women) members of the Dutch Famine Birth Cohort. In analysis adjusting for a number of potential confounders, systolic blood pressure reactivity was positively related to future hypertension. This was the case irrespective of whether reactivity was calculated as the peak or the average response to the stress tasks. The association was strongest for reactions to the speech and Stroop tasks. Diastolic blood pressure reactivity was not significantly associated with hypertension. The results provide support for the reactivity hypothesis. \ud \u

Self-reported health and cardiovascular reactions to psychological stress in a large community sample: Cross-sectional and prospective associations

Exaggerated cardiovascular reactions to acute psychological stress have been implicated in a number of adverse health outcomes. This study examined, in a large community sample, the cross-sectional and prospective associations between reactivity and self-reported health. Blood pressure and heart rate were measured at rest and in response to an arithmetic stress task. Self-reported health was assessed concurrently and five years later. In cross-sectional analyses, those with excellent/good self-reported health exhibited larger cardiovascular reactions than those with fair/poor subjective health. In prospective analyses, participants who had larger cardiovascular reactions to stress were more likely to report excellent/good health five years later, taking into account their reported health status at the earlier assessment. The findings suggest that greater cardiovascular reactivity may not always be associated with negative health outcomes

Cardiovascular and cortisol reactions to acute psychological stress and cognitive ability in the Dutch Famine Birth Cohort Study

Objective: Recently, in analyses of data from a large community sample, negative cross-sectional and prospective associations between cardiac stress reactivity and obesity were observed. The present study re-examined the association between cardiovascular reactivity and adiposity in the Dutch Famine Birth Cohort, with the additional aim of examining the association between cortisol reactivity and adiposity. Methods: Blood pressure, heart rate, and salivary cortisol were measured at rest and in response to standard laboratory stress tasks in 725 adults. Height, weight, waist and hip circumference, and skin fold thickness were measured. Four to seven years later 460 participants reported current height and weight. Obesity was defined as a BMI > 30kg/m2. Results: Cross-sectional analyses revealed negative associations between all measures of adiposity and heart rate reactivity; those with a greater BMI (ß = -0.39 bpm), waist-hip ratio (ß = -0.15 bpm), and triceps and subscapular skin fold thicknesses (ß = -1.0 bpm and -1.8 bpm), or categorized as obese (-3.9 bpm) displayed smaller cardiac reactions to acute stress (all p <.001). With the exception of waist-hip ratio, the same negative associations emerged for cortisol reactivity (all p ≤ .01). In prospective analyses, low cardiac reactivity was associated with an increased likelihood of becoming or remaining obese in the subsequent 4-7 years (OR 1.03, p = .01). All associations withstood adjustment for a range of possible confounders. Conclusions: The present analyses provide additional support for the hypothesis that it is low not high cardiac and cortisol stress reactivity that is related to adiposity

Network approach to internet bandwidth distributions

This study examines the communications networks formed by direct international Internet links, weighted by bandwidth capacity, each year over the 2002–2011 period. Specifically, we analyze changes in bandwidth distributions at country, regional, and continental levels during the period and identify network communities at these different levels. We apply an urn-based model developed with country-level data to bandwidth distributions at regional and continental levels. While the 2011 global Internet network closely resembles that of 2002, the network has become more tightly interconnected over time, and the high international bandwidth regions of Northern Europe, Northern America, and Western Europe have seen a modest decline in their share of total global bandwidth. As a consequence, international bandwidth concentration is showing a slow decline. Relative connectedness as measured by percentage of bandwidth staying within UN geographic regions is decreasing, whereas the percentage remaining within the continent has been fairly constant during the analysis period. All of this must be understood in the context of enormous total international bandwidth growth between 2002 and 2011 at all levels of analysis