Habitat preservation and restoration: Do homebuyers have preferences for quality habitat?

This research examines homebuyers' preferences for nearby riparian habitat, an important issue because quality riparian habitat competes for water resources with other activities in semi-arid regions and because federal and local governments allocate significant resources to riparian habitat preservation and restoration plans. Riparian vegetation surveys comprising comprehensive measures of the ecological characteristics of riparian habitat were completed in the metropolitan Tucson study area and the data incorporated into a hedonic analysis of single family residential house prices. The results indicate that high quality riparian habitat adds value to nearby homes and that instead of indiscriminately valuing "green" open space, nearby homebuyers distinguish between biologically significant riparian vegetation characteristics. This research also suggests that it is worthwhile to account for the heterogeneity of natural amenities in hedonic analysis. Furthermore the results suggest that riparian preservation and restoration programs are more likely to receive public support if they incorporate features that are preferred by nearby homeowners. Our study's results show that household preferences for existing riparian habitat match features of the ecologically-functional riparian habitat envisaged in a recently funded joint federal-city urban riparian restoration project in Tucson, Arizona.Environmental amenities characteristics Valuation Restoration Preservation

Levelling the playing field: A case study of how non-market values can compete in policy debates over wastewater allocation in a semi-arid region

In this paper we describe how benefits are transferred from previous non-market valuation research to inform the public policy debate on the allocation of treated wastewater to Riparian Projects in the semi-arid city of Tucson, Arizona, United States. Specifically, we transfer property premiums associated with proximity to riparian habitat to two proposed, and one accidental, urban Riparian Project. The study demonstrates that nearby property owners would likely benefit from wastewater reuse in riparian corridor restoration projects. Furthermore, the variable costs of supplying supplementary treated wastewater to one of the Riparian Projects are covered by incremental property tax revenues. We conclude that there is a window of opportunity to utilize a portion of Tucson's treated wastewater, over half of which is currently discharged at the northern end of the city, for additional in-town riparian restoration projects. Such riparian restoration projects also provide a mechanism for Endangered Species Act compliance

Assessing the socio-economic impacts of green/blue space, urban residential and road infrastructure projects in the Confluence (Lyon): a hedonic pricing simulation approach

Urban green/blue spaces are put under pressure as urban areas grow, develop and evolve. It is increasingly recognized, however, that green/blue spaces provide important ecosystem services, stimulate higher real estate prices and prevent flooding problems. This paper aims to assess and compare the socio-economic impacts of potential green/blue space, urban residential and road infrastructure development scenarios in the Lyon Confluence project area (France), using the Sustainable Urbanizing Landscape Development (SULD) hedonic pricing simulation model. Results show four major tendencies regarding the value-added of green/blue spaces in urban landscapes: (1) cities become more compact; (2) population densities increase; (3) real estate values rise; and (4) demographic distribution patterns change. The magnitude of these impacts depends, however, on the quality and size of the intervention, the social classes attracted to the intervention area and on the location of the intervention relative to existing residential areas, urban centres, road infrastructure and environmental amenities

Understanding the sources of uncertainty to reduce the risks of undesirable outcomes in large-scale freshwater ecosystem restoration projects: an example from the Murray–Darling Basin, Australia

There are a growing number of large-scale freshwater ecological restoration projects worldwide. Assessments of the benefits and costs of restoration often exclude an analysis of uncertainty in the modelled outcomes. To address this shortcoming we explicitly model the uncertainties associated with measures of ecosystem health in the estuary of the Murray– Darling Basin, Australia and how those measures may change with the implementation of a Basin-wide Plan to recover water to improve ecosystem health. Specifically, we compare two metrics – one simple and one more complex – to manage end-of-system flow requirements for one ecosystem asset in the Basin, the internationally important Coorong saline wetlands. Our risk assessment confirms that the ecological conditions in the Coorong are likely to improve with implementation of the Basin Plan; however, there are risks of a Type III error (where the correct answer is found for the wrong question) associated with using the simple metric for adaptive management.&nbsp

Incorporating Indigenous Knowledge Systems into Collaborative Governance for Water: Challenges and Opportunities

The importance of Indigenous knowledge systems for environmental decision-making is now widely recognized. In the context of collaborative approaches to environmental governance, scholars and practitioners have recognized that Western knowledge is not sufficient, and that ideas, practices, and knowledge from Indigenous peoples is essential. Collaborative environmental governance practice tends to make assumptions about how Indigenous knowledge systems can be incorporated into decision-making without reflecting satisfactorily on contrasting perspectives of Indigenous peoples themselves; these perspectives are partially captured in the Indigenous governance literature. This essay draws on empirical research in British Columbia, a place where First Nations have been approached by organizations involved in water governance to be involved in collaborative decision-making. The research reveals an important disconnect between the perspectives of Indigenous knowledge-holders and the people promoting “integration” of this knowledge into collaborative decision-making processes. We offer suggestions for reconciling collaborative approaches to water governance with Indigenous knowledge systems and the values and perspectives of Indigenous peoples

GS32, a Novel Golgi SNARE of 32 kDa, Interacts Preferentially with Syntaxin 6

Syntaxin 1, synaptobrevins or vesicle-associated membrane proteins, and the synaptosome-associated protein of 25 kDa (SNAP-25) are key molecules involved in the docking and fusion of synaptic vesicles with the presynaptic membrane. We report here the molecular, cell biological, and biochemical characterization of a 32-kDa protein homologous to both SNAP-25 (20% amino acid sequence identity) and the recently identified SNAP-23 (19% amino acid sequence identity). Northern blot analysis shows that the mRNA for this protein is widely expressed. Polyclonal antibodies against this protein detect a 32-kDa protein present in both cytosol and membrane fractions. The membrane-bound form of this protein is revealed to be primarily localized to the Golgi apparatus by indirect immunofluorescence microscopy, a finding that is further established by electron microscopy immunogold labeling showing that this protein is present in tubular-vesicular structures of the Golgi apparatus. Biochemical characterizations establish that this protein behaves like a SNAP receptor and is thus named Golgi SNARE of 32 kDa (GS32). GS32 in the Golgi extract is preferentially retained by the immobilized GST–syntaxin 6 fusion protein. The coimmunoprecipitation of syntaxin 6 but not syntaxin 5 or GS28 from the Golgi extract by antibodies against GS32 further sustains the preferential interaction of GS32 with Golgi syntaxin 6

Vorapaxar in the secondary prevention of atherothrombotic events

Item does not contain fulltextBACKGROUND: Thrombin potently activates platelets through the protease-activated receptor PAR-1. Vorapaxar is a novel antiplatelet agent that selectively inhibits the cellular actions of thrombin through antagonism of PAR-1. METHODS: We randomly assigned 26,449 patients who had a history of myocardial infarction, ischemic stroke, or peripheral arterial disease to receive vorapaxar (2.5 mg daily) or matching placebo and followed them for a median of 30 months. The primary efficacy end point was the composite of death from cardiovascular causes, myocardial infarction, or stroke. After 2 years, the data and safety monitoring board recommended discontinuation of the study treatment in patients with a history of stroke owing to the risk of intracranial hemorrhage. RESULTS: At 3 years, the primary end point had occurred in 1028 patients (9.3%) in the vorapaxar group and in 1176 patients (10.5%) in the placebo group (hazard ratio for the vorapaxar group, 0.87; 95% confidence interval [CI], 0.80 to 0.94; P<0.001). Cardiovascular death, myocardial infarction, stroke, or recurrent ischemia leading to revascularization occurred in 1259 patients (11.2%) in the vorapaxar group and 1417 patients (12.4%) in the placebo group (hazard ratio, 0.88; 95% CI, 0.82 to 0.95; P=0.001). Moderate or severe bleeding occurred in 4.2% of patients who received vorapaxar and 2.5% of those who received placebo (hazard ratio, 1.66; 95% CI, 1.43 to 1.93; P<0.001). There was an increase in the rate of intracranial hemorrhage in the vorapaxar group (1.0%, vs. 0.5% in the placebo group; P<0.001). CONCLUSIONS: Inhibition of PAR-1 with vorapaxar reduced the risk of cardiovascular death or ischemic events in patients with stable atherosclerosis who were receiving standard therapy. However, it increased the risk of moderate or severe bleeding, including intracranial hemorrhage. (Funded by Merck; TRA 2P-TIMI 50 ClinicalTrials.gov number, NCT00526474.)