100 research outputs found

    CROWN-TO-ROOT RATIO IN ENDODONTIC SURGERY: A SURVIVAL STUDY

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    Aim: to assess the influence of the crown height (CH), root length (RL) and crown-to-root ratio (CRR) on the survival of te- eth subjected to surgical endodontic retreatment and classi- fied as periapically healed. Methods: a single operator performed all the endodontic mi- crosurgery interventions. The present analysis selected the te- eth classified as ‘‘complete periapical healing’’ according to the Molven-Halse-Grung scale. The periapical radiographs were analyzed by two independent calibrated examiners, who measured CH and RL in a blind manner. The CRR was calcula- ted as the ratio of the two variables CH and RL. The measure- ments were performed by comparing the post-operative radio- graphs (t0) with those taken for a previous retrospective analysis (t1) and the most recent available (t2). An independent statistician conducted a survival analysis using Kaplan-Meier plots and a log-rank test (a = 0.05). Results: thirty-eight patients were evaluated, each one contri- buting to the study with a single tooth. The mean follow-up pe- riod was 5,96 ± 3,36 years. Comparing the CRR and RL values between t1 and t2, the difference was found statistically signifi- cant (p = 0.03). Survival was improved for the teeth with roots longer than 7 mm. There were no statistically significant diffe- rences among the remaining comparisons. Conclusions: root length ≄ 7mm exhibited better chances of long-term survival. Over time, a risk of further decrease of cli- nical RL due to periodontal disease and consequent increase of CRR could be critical by a mechanical point of view. Other studies are needed

    Fertility preservation in ovarian tumours

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    A considerable number of patients with a cancer diagnosis are of childbearing age and have not satisfied their desire for a family. Despite ovarian cancer (OC) usually occurring in older patients, 3%–14% are diagnosed at a fertile age with the overall 5-year survival rate being 91.2% in women ≀44 years of age when it is found at 1A–B stage. In this scenario, testing the safety and the efficacy of fertility sparing strategies in OC patients is very important overall in terms of quality of life. Unfortunately, the lack of randomised trials to validate conservative approaches does not guarantee the safety of fertility preservation strategies. However, evidence-based data from descriptive series suggest that in selected cases, the preservation of the uterus and at least one part of the ovary does not lead to a high risk of relapse. This conservative surgery helps to maintain organ function, giving patients of childbearing age the possibility to preserve their fertility. We hereby analysed the main evidence from the international literature on this topic in order to highlight the selected criteria for conservative management of OC patients, including healthy BRCA mutations carriers

    Brain Ultrasound as a Diagnostic and Follow up Method of Lateral Ventricle Dilatation in Hospitalised Children at the Neurology Department – Pediatric Clinic

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    A child’s full development is tied closely to the full development of the human’s central nervous system, which is why there are so many cases reported with central nervous system illnesses in children. Being very familiar with a child’s normal development, a Pediatric Neurologist doctor is capable of noticing any sort of neurological deviation during the first month of child’s development which can be backed up with diagnostic methods such as: Transfontanellare Ultrasonography which is the chosen method to diagnose such anomalies and also helps keep track of them.Key words: Brain ultrasonography, ventriculomegaly, our clinical experience

    Does Bentonite Cause Cytotoxic and Whole-Transcriptomic Adverse Effects in Enterocytes When Used to Reduce Aflatoxin B1 Exposure?

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    Aflatoxin B1 (AFB1) is a major food safety concern, threatening the health of humans and animals. Bentonite (BEN) is an aluminosilicate clay used as a feed additive to reduce AFB1 presence in contaminated feedstuff. So far, few studies have characterized BEN toxicity and efficacy in vitro. In this study, cytotoxicity (WST-1 test), the effects on cell permeability (trans-epithelial electrical resistance and lucifer yellow dye incorporation), and transcriptional changes (RNA-seq) caused by BEN, AFB1 and their combination (AFB1 + BEN) were investigated in Caco-2 cells. Up to 0.1 mg/mL, BEN did not affect cell viability and permeability, but it reduced AFB1 cytotoxicity; however, at higher concentrations, BEN was cytotoxic. As to RNA-seq, 0.1 mg/mL BEN did not show effects on cell transcriptome, confirming that the interaction between BEN and AFB1 occurs in the medium. Data from AFB1 and AFB1 + BEN suggested AFB1 provoked most of the transcriptional changes, whereas BEN was preventive. The most interesting AFB1-targeted pathways for which BEN was effective were cell integrity, xenobiotic metabolism and transporters, basal metabolism, inflammation and immune response, p53 biological network, apoptosis and carcinogenesis. To our knowledge, this is the first study assessing the in vitro toxicity and whole-transcriptomic effects of BEN, alone or in the presence of AFB1

    Implementing smartphone enabled collaborative travel: Routes to success in the tourism domain.

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    Smartphone technology can help identify current and anticipate future patterns of behaviour and, with its social networking capabilities, allow users to imagine and organise collaborative travel opportunities, such as lift share. This has led to the development of collaborative apps designed to enable activities like lift sharing. Such apps require new norms of behaviour to establish a user base and research has yet to address the socio-cultural barriers to both the use of this technology to organise travel and the sharing of personal space that collaborative travel entails. This paper reports the findings of a study which designed, built and tested a collaborative travel app in the tourism domain. Data derived from exploratory interviews, post-trial interviews and a questionnaire reveal that user age and extent of mobile engagement play a less significant role than expected, while other aspects of the social exchange, notably social tie strength, trust and obligations play a more marked role. A conceptual framework and discussion of strategies to address these barriers provides insight into appropriate contexts and routes for implementation of collaborative travel apps

    A Typology of Digital Sharing Business Models: A Design Science Research Approach

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    The digitally enabled sharing economy, also called the “digital sharing economy” (DSE), has changed patterns of consumption by introducing new choices and channels for provision and receipt of services. The DSE encompasses sharing systems whose business models may vary distinctly from platform to platform. Although business models in the context of the sharing economy have been studied so far, we have observed that the current literature does not provide an approach that covers all the possible business models (in the broadest sense of the term) that (potentially) exist within the scope of the DSE. The present paper, therefore, aims to propose a typology of business models in the DSE that covers a wide space of models – even those which may not involve “business” in the commercial sense. This is achieved through an iterative inductive process based on a design science research approach. The typology can assist in positioning the current and future sharing systems in the DSE by systematically classifying their business models. It is intended to serve as a guiding tool for the sustainability assessment of platforms from both resource and socio-economic perspectives. The present study can also enable researchers and practitioners to capture and systematically analyse digital sharing business models based on a structured, actionable approach
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