6 research outputs found
Purification and characterization of phenoloxidase from immunized haemolymph of Schistocerca gregaria
- Publication venue
- 'African Journals Online (AJOL)'
- Publication date
- 17/11/2015
- Field of study
Phenoloxidase (PO) is a key factor in insect immunity. On invasion of microorganisms and pathogens, prophenoloxidase (PPO) changes to its active form, PO. The present study has been conducted to purify and characterize the PO from the haemolymph of desert locust, Schistocerca gregaria (Forskal) following activation of immune system by invasion of bacteria, Bacillus thuringiensis kurstaki (Bt). PO is purified by a combination of ammonium sulfate precipitation, blue sepharose CL-6B and phenyl sepharose CL-4B chromatography yielded a 209.97-fold purity and 54.75% recovery of activity. Sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis (PAGE) reveals that the molecular weight of the purified PO is 70.154 kDa. The purified PO is characterized in terms of its biochemical and enzymatic properties by using L-DOPA as a specific substrate. Ca2+ and Cu2+ significantly stimulated PO activity when compared with other metals. The PO reaction was strongly inhibited by phenylthiourea and thiourea, moderately inhibited by ethylene diamine tetractic acid (EDTA) and poorly inhibited by ethylene glycol tetraacetic acid (EGTA) and diethyl dithiocarbamate (DTC). Inhibition of PO showed excellent recovery ability by addition of Ca2+ on EGTA-inhibited enzyme. Therefore, PO is most probably a kind of tyrosinase-type Ca2+-containing metalloenzyme. The content of Ca2+ is higher than other trace metal elements. The reactive intermediates yielded by PO with its specific substrate L-DOPA had a broad-spectrum bactericidal activity against Gram +ve bacteria (Bacillus cereus and Staphylococcus aureus) with a greater degree more than Gram-ve bacteria (Escherichia coli and Pseudomonas aeruginosa). From the present study, PO from S. gregaria is most probably a tyrosinasetype calcium-containing mono-phenoloxidase, which functions not only as a catalytic enzyme in melanin production in locusts, but perhaps also as a humoral factor in host defense via melaninization as in other insects.Key words: Schistocerca gregaria, phenoloxidase, purification
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
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- Abebe NS
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
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- Abaliksta T
- Abantanga F
- Abantanga F
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- Abd El Hameed OS
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- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
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- Abdel-Kader SM
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- Lytras D
- Lytras D
- Ma J
- Mabitsela ME
- Mabrouk M
- Macchiavello R
- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald KL
- Maceviciute K
- Macfarlane A
- Machaca M
- Machain Vega GM
- Machain Vega GM
- Maciejec L
- Madiba T
- Madkor MH
- Madrid Barrientos LA
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi AA
- Magri D
- Mahanty S
- Maharaj G
- Mahdi A
- Mahdi S
- Mahdi S
- Maher ME
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud MA
- Mahmoud MI
- Mahmoud S
- Mahmoud SME
- Mahmud K
- Maillot B
- Maimbo M
- Maimbo M
- Mairs NG
- Maison K
- Maistry N
- Majauskyte D
- Majbar A
- Majid AHHA
- Majid K
- Major CP
- Major P
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- Mak T
- Mak TWC
- Makama J
- Makinde M
- Makupe A
- Malaga B
- Malavenda M
- Malik K
- Malik P
- Malik TAM
- Mamdouh E
- Mamdouh R
- Manatakis DK
- Manchego Bautista AC
- Manchego Bautista AC
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal CE
- Maniscalco A
- Mann T
- Mannu GS
- Mano MJB
- Manrique Sila G
- Manrique Sila GC
- Manriquez-Reyes M
- Manrrique Sila G
- Mansor EY
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marcelo Delgado J
- Marey A
- Marey AS
- Margaritis M
- Maria Garcia-Perez J
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret J-B
- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
- Martin A
- Mas R
- Mason C
- Mat TNT
- Mata LPS
- Matheu A
- Mathew SW
- Matos-Puig R
- Mattar O
- Matter SM
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
- Mcaleer E
- Mcaleer S
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- McGarvie S
- Mcguigan A
- McIntosh K
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- Mcintyre R
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- Mclean AL
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- McMorran D
- Mcnish D
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- Mehdi A
- Mehrez S
- Melo Cardozo RA
- Melo R
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- Mendoza Arango MC
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mercado Rodriguez L-A
- Mericliler M
- Merlini D
- Merlini D
- Merlo MS
- Mesbah N
- Meshref A
- Messa Aguilar WL
- Messa Aguilar WL
- Metwally MM
- Migliore M
- Mihaljevic AL
- Mihaljevic AL
- Mihanovic J
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- Mikuckyte D
- Mikwar Z
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- Minguez Garcia J
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu AS
- Mironescu AS
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
- Mitul AR
- Mitul AR
- Miyarde Leon A
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo MM
- Modolo MM
- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok YT
- Mokhtar A
- Molina G
- Monaghan E
- Monaghan E
- Monrad-Hansen PW
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora JJV
- Morales C
- Morandi E
- Moreira G
- Moreno SC
- Morgan C
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- Morshedy EM
- Morsi A
- Morsi M
- Morton D
- Morton D
- Morton R
- Mosad A
- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe AM
- Mshelbwala P
- Msiska N
- Msosa V
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- Muddebihal U
- Mukin ADF
- Muktar U
- Mukuzunga C
- Muller C
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- Muller J
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- Munhoz MM
- Munipalle PC
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- Murray A
- Murutoglu B
- Musa AEK
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- Musowoya J
- Mussad A
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- Mustafa M
- Mustafa M-A
- Musyoka CK
- Mutabazi A
- Mutabazi AZ
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- Mutlu D
- Mutlu V
- Muzio E
- Myers J
- Mykoniatis I
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- Nada F
- Nadeem N
- Nadkarni S
- Naess PA
- Nagy GS
- Nahar SN
- Nair H
- Najjar M
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi SA
- Naqvi T
- Naranjo Aristizaibal FA
- Narayanan R
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- Narvestad JK
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
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- Nasir WNWM
- Nasr A
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- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
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- Nayel AR
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu SR
- Ndwambi P
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo YN
- Neo YT
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng JCK
- Ng S
- Ng YK
- Ng ZH
- Ngayu N
- Ngwa TE
- Niazi AK
- Nicholson L
- Nighat B
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- Nikoloudis N
- Nikoloudis N
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- Niranjan N
- Nirumal MK
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
- Normile C
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- North AS
- Notarnicola M
- Notarnicola M
- Nouh T
- Nouh T
- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana VJP
- Nsengiyumva C
- Ntirenganya F
- Ntirenganya F
- Nurqistan HD
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
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- O'Connor T
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- O'neill M
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- O'Neill S
- O'Shea M
- Obute RD
- Occhionorelli S
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- Ogunsua O
- Ogunyemi A
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- Olaolorun A
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- Ortega-Vazquez I
- Ortiz N
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- Oshati O
- Oshodi O
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- Palma AF
- Palomino Castillo VD
- Paludi MA
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- Panieri E
- Panteli C
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- Papailia A
- Papandrea M
- Papaskarlatos I-A
- Pape J
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- Parseliunas A
- Parthiban S
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- Pascale MM
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- Pasquali S
- Pastora J
- Pata D
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- Pata F
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- Patel V
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- Patoulias I
- Paul M
- Paul S
- Paulouski D
- Pazuskis M
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- Pektas AM
- Pellino G
- Peltrini R
- Pena L
- Pereira B
- Perenyei M
- Perera J
- Perera J
- Perez Rojas AD
- Perez Velasquez CI
- Periasammy D
- Perino M
- Peros G
- Perrotta G
- Pertersen Servin GR
- Pesenti G
- Petrikenas S
- Peycelon M
- Peycelon M
- Pezas T
- Pezas T
- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
- Pimenta ML
- Pineno-Flores C
- Pinkney T
- Pinkney T
- Pinnagoda K
- Pino W
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- Pluke K
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- Popoola A
- Porter J
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- Poskus T
- Poskus T
- Poskus T
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- Post N
- Powell A
- Prabhudesai A
- Pranevicius R
- Prasad SS
- Preckailaite E
- Primavesi F
- Prins M
- Proctor VK
- Pronin S
- Prudhomme T
- Psaila J
- Psarianos K
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- Pugliesi TB
- Pujol-Cano N
- Punja V
- Purwaningsih NA
- Puttick M
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- Qaissieh A
- Qawasmi I
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- Quintero Riaza VM
- Qureshi AU
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- Rahmah DF
- Rahmawati FN
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- Rajmohan S
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- Rakha I
- Rakita I
- Ramadan MT
- Ramarez Cabrera CC
- Ramazzini P
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- Rashad E
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- Rasoaherinomenjanahary F
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- Rausa E
- Ravishankar R
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- Raza A
- Raza I
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- Razek T
- Razi SAU
- Razmdjou S
- Razuri C
- Razzaque J
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- Redgrave N
- Redota MAP
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- Rees CM
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- Restrepo IM
- Restrepo J
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- Riente F
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- Rocke A
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- Romani Pozo DA
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- Rosello O
- Rosenberg GS
- Roslani AC
- Roslani AC
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- Roszkowski R
- Roth J
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- Rotunno G
- Rouse T
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- Rubinkiewicz M
- Rudzenskaite A
- Ruiz Panez W
- Ruiz-Tovar J
- Rulie AS
- Runigamugabo E
- Russo AA
- Rutkowski W
- Ruzzenente A
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- Saad H
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- Saad M
- Saad MM
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- Saad S
- Saadeh R
- Saami M
- Saar S
- Sabe A
- Sabe AK
- Sabeeh L
- Sabour FA
- Sabry A
- Sacco M
- Sacco R
- Sadek A
- Sadig N
- Saeed AM
- Saeed H
- Saeed M
- Saeed M
- Saeed M
- Safa H
- Sahbaz NA
- Sahel S
- Saidbadr A
- Sakr A
- Sakr A
- Sakr R
- Salah A
- Salah M
- Salah M
- Salah O
- Salah OM
- Salama M
- Salama M
- Salama Y
- Salama Y
- Salamone G
- Salcedo J
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- Saleh O
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- Salem HK
- Salem HK
- Salem M
- Salem MM
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- Salleh A
- Salleh A
- Sallinen V
- Sallinen V
- Salma M
- Salma M
- Salma U
- Salman A
- Salusso P
- Sam ZH
- Samalavicius NE
- Samaraweera DI
- Samih H
- Samir A
- Samison LH
- Sammarco G
- Sammut K
- Sampson C
- Samson G
- Samuel D
- Samuel SA
- Samy M
- Samy M
- Samy S
- Sanad A
- Sanchez Samaniego C
- Sanchez B
- Sanchez D
- Sander A
- Sandler S
- Sandoval Barrantes AM
- Sanni HA
- Sanz S
- Sapci I
- Saqlain M
- Sarafilovic H
- Saraste D
- Saravia F
- Sarmah P
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- Sasia D
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- Satoskar S
- Sauvat F
- Sava J
- Saw JE
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- Sayed F
- Sayed M
- Sayma EA
- Scalabre A
- Scalabre A
- Schadde E
- Schadde E
- Schiavone R
- Schivo D
- Schmid R
- Schmid R
- Schmitt F
- Schmitt F
- Schoewe C
- Schuetz T
- Schultz JK
- Scicluna R
- Scott M
- Segovia Lohse HA
- Segovia Lohse HA
- Seif M
- Seifelnasr O
- Seisa M
- Seisay S
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- Selvaggi L
- Semeda N
- Semiz A
- Sena-Ruiz F
- Senanayake KJ
- Senanayake WSMKJ
- Setiawan J
- Seto DM
- Seyoum N
- Sfougaris D
- Sgroi G
- Shaalan M
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- Shachykava T
- Shah A
- Shah J
- Shah R
- Shaharuddin S
- Shahbaz AR
- Shaheen A
- Shahine A
- Shahzad N
- Shaikh N
- Shaikh S
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- Shakshouk HAG
- Shalabi A
- Shalaby A
- Shalaby M
- Shalaby M
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- Shamasneh A
- Shamsedine AW
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- Shamsi GS
- Shariffuddin AM
- Sharma A
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- Shawki M
- Shawky MY
- Shawqi M
- Sheehan J
- Shehata S
- Sherif MA
- Sherman T
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- Sheshe A
- Sheta A
- Sheth S
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- Shillito S
- Shimy G
- Shiwani H
- Shiwani HA
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- Shrimanker N
- Shu Yip SB
- Shu S
- Shu S
- Shu S
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- Shu S
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- Shukla J
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- Siaw JY
- Sieda B
- Sierra S
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- Sigurdadottir J
- Sii SSY
- Sileri P
- Silvani P
- Silvestre BP
- Silvestri V
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- Simoes RL
- Simutis G
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- Sinha Y
- Sion M
- Sishuba N
- Sivaganesh S
- Skardziukaite A
- Skehan J
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- Slapelyte E
- Sleem AS
- Sleem M
- Smart N
- Smart N
- Smart N
- Smart NJ
- Smedley A
- Smith C
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- Smith D
- Snaith AC
- Snyder E
- Soares Miguel GP
- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
- Solaini L
- Solar Garcia L
- Solar Garcia L
- Soldevila-Verdeguer C
- Soley R
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- Soliman A
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- Soliman AR
- Soliman N
- Soliman NA
- Soliman S
- Soliman Y
- Sollazzo V
- Soltani N
- Som R
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- Soreide JA
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- Soreide K
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- Souaibou YI
- Souaibou YI
- Soulou V
- Spence R
- Spence R
- Spence R
- Spence R
- Spence R
- Spence R
- Spina A
- Sproule L
- Spurr M
- Sreedharan A
- Srinivasan R
- Sriram A
- Sroor F
- Sruogiene EZ
- Staerkle RF
- Starr N
- Stasinou T
- Steccanella F
- Stefanopoulos A
- Stephen A
- Stewart D
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- Subocius A
- Suleiman SI
- Summerour V
- Sund M
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- Sundstrom SM
- Suresh S
- Sutandi N
- Sutanto EPR
- Sutton P
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- Suyadi A
- Swann J
- Swaroop M
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- Syibrah KZ
- Sykes M
- Szczap A
- Szeto CCL
- Szeto KJ-Y
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
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- Tabiri S
- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha EMS
- Tahboub H
- Taher AA
- Taher M
- Taher MM
- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
- Tale F
- Tale L
- Talukder S
- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
- Tan CL
- Tan CY
- Tan JJ
- Tan JK
- Tan KSK
- Tan RCK
- Tan YK
- Tan YW
- Tanase A
- Tanase A
- Tang A
- Tang L
- Tani SI
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata MD
- Tatagiba LS
- Tawfik BA
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah MM
- Tembo T
- Temoche E
- Tennakoon A
- Teo SY
- Ter EZ
- Tessera G
- Teufelberger G
- Tew YY
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- Tewari S
- Th'ng F
- Thabet W
- Thalgaspitiya SPB
- Tham JC
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
- Thomas E
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- Thompson B
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- Thorarinsdottir H
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- Thurairaja R
- Tierney G
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- Timothy OK
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Dan I
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- De Franciscis S
- De Freitas AVC
- De La Medina AR
- de Leó
- De Leon MZP
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- de Lima CVB
- De Luca E
- De Marco P
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- Deckelbaum Dl
- Decker E
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- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- Del Pilar Paucar A
- Delforge X
- Delgado Jm
- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
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- Despotidis V
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- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
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- Di Martino N
- Di Saverio S
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- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
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- Din F
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- Dissanayake T
- Djivoh F
- Domini E
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- Donoghue D
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- Du Toit F
- Duane T
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- Duinhouwer L
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- El Gendy NH
- El Gendy A
- El Halawany M
- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
- El-Dien Ks
- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
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- El-Shahat Ns
- El-Sheemy H
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- Elbatahgy A
- Elbe P
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- Eldamaty L
- Eldeeb Az
- Eldeen Ea
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- Elena G
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- Elfiky M
- Elfil M
- Elfouly N
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- Elfouly Y
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- Elgendy Ah
- Elgendy Fi
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- Elhalawany E
- Elhamouly S
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- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
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- Elkorashy Am
- Ellison Q
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- Elnajjar Ma
- Elnemr Ae
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- Elsameea Aa
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- Elshobary M
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- Elzowawi F
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- Espinoza F
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- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
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- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
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- Faccincani R
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- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
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- Fermani C
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- Fernandez-Bueno F
- Fernandez-Vega L
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- Firdouse M
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- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
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- Fontana T
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- Forno W
- Fouad A
- Fouad D
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- Fourcade L
- Fowler Aj
- Fozard T
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- Frade F
- Fraga Gp
- Franco H
- Francois P
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- Francone E
- Freitas Av
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- Fujii F
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- Gado A
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- Gaignard E
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- Gala T
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- Galiqi G
- Galleano R
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- Galvez Cp
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- Garaycochea O
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- George R
- Germanos S
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- Gerosa A
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- Geuoshy A
- Ghaben A
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- Ghanem E
- Ghanem S
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- Gharib A
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- Ghazy Aa
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- Ghetia M
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- Grassi V
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- Gray D
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- Grella Mg
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- Griffiths E
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- Griffiths M
- Grima T
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- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
- Guasti Bpsj
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
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- Gunawan R
- Guner A
- Gunnarsson U
- Guo W
- Gupta A
- Gustafsson U
- Gyamfi Fe
- Gyanchandani N
- Gyedu A
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- Habeeb O
- Habeebullah A
- Hache-Marliere M
- Haddad N
- Hafez At
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- Hafez M
- Hafez S
- Haffreingue A
- Hafiz S
- Hagan R
- Hagar A
- Haines M
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- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
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- Hall Tf
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- Haloho A
- Hamad Mgm
- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
- Hamdan A
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- Hamill D
- Hammad A
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- Hanley I
- Hanoun S
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- Hanrahan M
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- Hantour U
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- Hany E
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- Har Pa
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- Harbord P
- Haroun A
- Harper E
- Harrison Em
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- Harrison N
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- Harrison R
- Hartford L
- Harvey N
- Hasan A
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- Hasan D
- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
- Hashish M
- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
- Hassan M
- Hassan Omm
- Hassan S
- Hassan Z
- Hassanain M
- Hassanain M
- Hassanein Ab
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- Hawkins W
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- Heffernan D
- Hegazy Em
- Hegazy Y
- Helene Fc
- Helguero-Santin Lm
- Hemeda D
- Hemingway D
- Hemmila M
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- Henderson L
- Heng He
- Henric N
- Henry F
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- Herebat A
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- Hervieux E
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- Hesham O
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- Hewage K
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- Hinojosa C
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- Ho A
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- Hodonou F
- Hogea M
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- Homeida A
- Hoogakker E
- Horobjowsky A
- Hosein Sp
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- Hossameldin A
- Houlden C
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- Huwait A
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- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
- Ibrahim A
- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
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- Ihediwa G
- Imoro O
- Ingabire Jca
- Ingabire Jca
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- Ioannidis O
- Iordache Fm
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- Irwin G
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- Kalles V
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- Kamarajah Sk
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- Kanani A
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- Kasputyte S
- Kaul A
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- Khg Li
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- Khulu Lb
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- Loaloa Mr
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- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marey A
- Marey As
- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
- Mason C
- Mata Lps
- Matheu A
- Mathew Sw
- Matos-Puig R
- Matta Jjh
- Mattar O
- Matter Sm
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
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- McGarvie S
- Mcguigan A
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- Mcintyre N
- Mcintyre R
- Mckechnie D
- Mclachlan G
- Mclean Al
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- McMorran D
- Mcnish D
- Mcphee A
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- Mehdi A
- Mehrez S
- Mejia Agv
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- Mendel H
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- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mericliler M
- Merlini D
- Merlini D
- Merlo Ms
- Mesbah N
- Meshref A
- Metwally Mm
- Migliore M
- Miguel Gps
- Mihaljevic Al
- Mihanovic J
- Mihanovic J
- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
- Mikwar Z
- Milligan W
- Milligan W
- Mingrone P
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu As
- Mironescu As
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
- Mitul Ar
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- Miyasato Hs
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
- Mohamed A
- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
- Monaghan E
- Monaghan E
- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
- Morgan C
- Morgan C
- Morshedy Em
- Morsi A
- Morsi M
- Morton D
- Morton D
- Morton R
- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
- Msosa V
- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
- Muller C
- Munera A
- Munhoz Mm
- Munipalle Pc
- Muntean L
- Muntean Li
- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
- Mussad A
- Mustafa M
- Mustafa M
- Mustafa Ma
- Musyoka Ck
- Mutabazi Az
- Mutabazi Az
- Mutlu D
- Mutlu V
- Muzio E
- Myers J
- Mykoniatis I
- Næ
- Nabawi A
- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
- Nahar Sn
- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
- Naqvi T
- Naranjo Aristizã
- Narayanan R
- Narayanan R
- Narvestad Jk
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
- Nasir Aa
- Nasr A
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- Nasr M
- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
- Nawawi A
- Nawawi A
- Nayel Ar
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo Yn
- Neo Yt
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng S
- Ng Yk
- Ng Zh
- Ngayu N
- Ngwa Te
- Niazi Ak
- Nicholson L
- Nighat B
- Nigo S
- Nikberg M
- Nikoloudis N
- Nikoloudis N
- Niragire A
- Niranjan N
- Nirumal Mk
- Niska K
- Nita Ge
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
- Normile C
- Normile C
- North As
- Notarnicola M
- Notarnicola M
- Nouh T
- Nouh T
- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
- Nsengiyumva C
- Ntirenganya F
- Nur&apos
- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
- Obute Rd
- Occhionorelli S
- Odeyemi B
- Odeyemi B
- Odutola O
- Ogunsua O
- Ogunyemi A
- Oh J
- Oh J
- Ohene-Yeboah M
- Ojeda Rrb
- Okenabirhie O
- Olajide To
- Olaolorun A
- Olivier J
- Olori S
- Olori S
- Oludara M
- Oludara M
- Olugbemi M
- Omar Aa
- Omar Me
- Omar Mfw
- Omara S
- Omer Oa
- Onimowo J
- Onuoha C
- Oosterkamp A
- Opoku-Agyeman R
- Oram S
- Orbegozo Pat
- Orchard M
- Ortega I
- Ortega I
- Ortega-Vazquez I
- Ortiz N
- Orton P
- Osagie O
- Osei-Nketiah S
- Oshati O
- Oshodi O
- Osinowo A
- Osinowo A
- Osman M
- Osman N
- Osman O
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- Oswald D
- Otero-Dí
- Othman M
- Ots R
- Otten K
- Oumer R
- Owen C
- Owusu F
- Owusu F
- Ozben V
- Ozkan Bb
- Ozkan Bb
- Ozkan Bb
- Ozmen Bb
- Pé
- Paž
- Pabla G
- Pacheco Rda
- Padmore G
- Pagano G
- Pagnozzi J
- Pagnozzi J
- Pahlsson Hi
- Pai S
- Palayan K
- Palkhi Eya
- Palliyil M
- Palliyil Mm
- Palma A
- Palma Af
- Paludi Ma
- Paludi Ma
- Panait N
- Panez Wr
- Panieri E
- Panteli C
- Papageorgiou D
- Papailia A
- Papandrea M
- Papaskarlatos Ia
- Pape J
- Parakh J
- Parakh J
- Paramasivan A
- Parasyris S
- Pardo G
- Parent V
- Park Eh
- Park J
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- Parker R
- Parkinson L
- Parmentier B
- Parpoudi S
- Parreno-Sacdalan Md
- Parseliunas A
- Parthiban S
- Pascale G
- Pascale Mm
- Pasini M
- Pasquali S
- Pastora J
- Pata D
- Pata D
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata G
- Pata G
- Patel K
- Patel K
- Patel P
- Patel P
- Patel S
- Patel V
- Paterson-Brown S
- Patoulias I
- Paul M
- Paul S
- Paulouski D
- Peñ
- Peck Fs
- Pektaş
- Pellino G
- Peltrini R
- Pereira B
- Perenyei M
- Perera J
- Perera J
- Periasammy D
- Perino M
- Peros G
- Perrotta G
- Pesenti G
- Petrikenas S
- Peycelon M
- Peycelon M
- Pezas T
- Pezas T
- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
- Pimenta Ml
- Pineñ
- Pinkney T
- Pinkney Td
- Pinnagoda K
- Pino W
- Pitt Sk
- Ploski J
- Pluke K
- Poš
- Podevin G
- Podevin G
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- Popa M
- Popoola A
- Popoola A
- Porter J
- Poskus T
- Poskus T
- Poskus T
- Poskus T
- Post N
- Powell A
- Pozo Dar
- Prabhudesai A
- Pranevicius R
- Prasad Ss
- Preckailaite E
- Primavesi F
- Prins M
- Proctor Vk
- Pronin S
- Prudhomme T
- Psaila J
- Psarianos K
- Psarianos K
- Pugliesi Tb
- Pujol-Cano N
- Puma Cmh
- Punja V
- Purwaningsih Na
- Puttick M
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- Puyana Jc
- Qadir Mrm
- Qaissieh A
- Qawasmi I
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- Quayle J
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- Quezada Jhj
- Qumbos Aa
- Qureshi Au
- Qureshi Au
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- Radkowiak D
- Radojkovic M
- Rahantasoa Fcfp
- Rahmah Df
- Rahmawati Fn
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- Rajmohan S
- Rakauskas R
- Rakha I
- Rakita I
- Ramadan Mt
- Ramazzini P
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- Rangarajan M
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- Raptis Da
- Raptis Da
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- Rashad E
- Rashad M
- Rashed Am
- Rashid A
- Rashid M
- Rashwan H
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- Raslan C
- Rasoaherinomenjanahary F
- Rath M
- Rausa E
- Ravishankar R
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- Rayne S
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- Rayne S
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- Raza A
- Raza I
- Raza I
- Razek T
- Razmdjou S
- Razuri C
- Razzaque J
- Reali C
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- Recinos G
- Recinos G
- Recinos G
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- Reda A
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- Redgrave N
- Redota Map
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- Rekhis S
- Renaux-Petel M
- Restrepo Im
- Restrepo J
- Reunis E
- Reza L
- Reza L
- Rezq A
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- Riaz A
- Riaz Mm
- Riaza Vmq
- Ribaldi S
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- Rickard J
- Rida Ahef
- Riente F
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- Ripa M
- Riswan Nz
- Rivas R
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- Robert E
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- Robertson N
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- Roche Mo
- Rocke A
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- Rodriguez X
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- Rojas Adp
- Rojas Nmu
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- Roszkowski R
- Roth J
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- Rotunno G
- Rouse T
- Roxas Mf
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- Rubinkiewicz M
- Rudzenskaite A
- Ruiz-Tovar J
- Rulie As
- Runigamugabo E
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- Rutkowski W
- Ruzzenente A
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- Saad H
- Saad Ha
- Saad M
- Saad Mm
- Saad R
- Saad S
- Saadeh R
- Saami M
- Saar S
- Sabe A
- Sabe Ak
- Sabeeh L
- Sabour Fa
- Sabry A
- Sacco M
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- Sadek A
- Sadig N
- Saeed Am
- Saeed H
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- Saeed M
- Saeed M
- Safa H
- Sahbaz Na
- Sahel S
- Saidbadr A
- Sakr A
- Sakr A
- Sakr R
- Salah A
- Salah M
- Salah M
- Salah O
- Salah Om
- Salama M
- Salama M
- Salama Y
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- Salamone G
- Salas Mdce
- Salcedo J
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- Saleh O
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- Salleh A
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- Sallinen V
- Sallinen V
- Salma M
- Salma M
- Salma U
- Salman A
- Salusso P
- Sam Zh
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- Samaniego Cs
- Samaraweera Di
- Samih H
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- Samison Lh
- Sammarco G
- Sammut K
- Sampson C
- Samson G
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- Sanz S
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- Sarafilovic H
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- Sasia D
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- Saw Je
- Sayed A
- Sayed F
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- Sayma Ea
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- Scalabre A
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- Schiavone R
- Schivo D
- Schmid R
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- Schultz Jk
- Scicluna R
- Scott M
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- Semeda N
- Semiz A
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- Senanayake Kj
- Senanayake Mkj
- Senanayake W
- Septiem Jg
- Servin Grp
- Setiawan J
- Seto Dm
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- Sfougaris D
- Sgroi G
- Shaalan M
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- Shachykava T
- Shah A
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- Shah R
- Shaharuddin S
- Shahbaz Ar
- Shaheen A
- Shahine A
- Shahzad N
- Shaikh N
- Shaikh S
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- Shalabi A
- Shalaby A
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- Shamasneh A
- Shamsedine Aw
- Shamsi G
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- Shehata S
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- Shillito S
- Shimy G
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- Shrimanker N
- Shu S
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- Shukla J
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- Sigurdadottir J
- Sii Ssy
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- Sila Gm
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- Silvani P
- Silvestri V
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- Simoes Rl
- Simutis G
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- Sivaganesh S
- Skardž
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- Smedley A
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- Snyder E
- Sobnach S
- Sodde P
- Soeselo Da
- Sokratous A
- Solaini L
- Soldevila-Verdeguer C
- Soley R
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- Soliman Na
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- Solis Laz
- Sollazzo V
- Soltani N
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- Souaibou Yi
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- Soulou V
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- Spence R
- Spence R
- Spence R
- Spence R
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- Spurr M
- Sreedharan A
- Srinivasan R
- Sriram A
- Sroor F
- Sruogiene Ez
- Staerkle Rf
- Starr N
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- Steccanella F
- Stefanopoulos A
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- Stewart D
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- Stourton F
- Strazdas A
- Strupas K
- Strupas K
- Strupas K
- Stuva J
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- Styles K
- Suá
- Suarez A
- Suarez Aab
- Subocius A
- Suleiman Si
- Summerour V
- Sund M
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- Sunderland G
- Sundstrom Sm
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- Sutanto Epr
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- Syibrah Kz
- Sykes M
- Szczap A
- Szeto Ccl
- Szeto Kj
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- Tabiri S
- Tabiri S
- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha Ems
- Tahboub H
- Taher Aa
- Taher M
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- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
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- Talukder S
- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
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- Tan Cy
- Tan Jj
- Tan Jk
- Tan Ksk
- Tan Rck
- Tan Yk
- Tan Yw
- Tanase A
- Tanase A
- Tang A
- Tang L
- Tani Si
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata Md
- Tatagiba Ls
- Tawfik Ba
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah Mm
- Tembo T
- Temoche E
- Tennakoon A
- Teo Sy
- Ter Ez
- Tessera G
- Teufelberger G
- Tew Yy
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- Tewari S
- Th&apos
- Thabet W
- Thalgaspitiya Spb
- Tham Jc
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
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- Thorarinsdottir H
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- Thurairaja R
- Ticona Wa
- Tierney G
- Tilston Tw
- Timothy Ok
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- Todd O
- Toeema Ag
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- Tori Sa
- Torrance Hd
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- Torres Cpg
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- Toto Ö
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola Sk
- Tugnoli G
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- Turkustani S
- Turner M
- Tutino R
- Tverskis Z
- Tyler R
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- Tze Rge
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- Tzikos G
- Uš
- Ubhi Hk
- Ubiali P
- Ugalde P
- Ukwenya Y
- Uluş
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbonas T
- Urbonas T
- Urniež
- Urniezius Z
- Urquizu Mc
- Usaityte A
- Utter M
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- Vaicius A
- Valcarcel-Saldañ
- Valioulis I
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- Varcada M
- Vargas M
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- Vartanoglu T
- Vartic M
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- Vasquez G
- Vasquez I
- Veen T
- Vega Gmm
- Vega Gmm
- Velá
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- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Alc
- Verjee A
- Vermaas M
- Veronese E
- Viš
- Vianna P
- Vicario E
- Vico Td
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- Villegas Mi
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- Walsh U
- Waqar M
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- Ward S
- Warda M
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- Winstanley J
- Witherspoon P
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- Wogensen F
- Wogensen F
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- Wold Tb
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- Yeung En
- Yeung Mha
- Yifieyeh A
- Yildirim R
- Yip C
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- Ymeri S
- Yoganathan P
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- Younis A
- Youssef D
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- Zachariades Dc
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- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Assessment of antibacterial genes of emerging queen Apis mellifera L. induced by the bacterium Paenibacillus larvae larvae
- Publication venue
- 'Academy of Science of South Africa'
- Publication date
- 19/09/2022
- Field of study
This study evaluated the expression of antimicrobial abaecin and defensin genes in virgin honey-bee queens (Apis mellifera) following induction of 4th larval instar with the bacterium Paenibacillus larvae larvae (1.07 × 102 CFU/queen); to investigate whether the presence of bacteria affects the immune response as well as gene transcript levels for the immune proteins. The total body proteins of bacteria-treated queens showed a highly significant increase, and the appearance of new proteins patterns and/or disappearance of others. The gene expression profile of treated queens showed up-regulation equalled four-fold of the defensin gene, whereas no progression occurred in the abacien gene. This finding likewise greatly affects the diseases challenging this pollinator
Determinants of morbidity and mortality following emergency abdominal surgery in children in low-income and middle-income countries
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Abo-ryia M
- Aboarab A
- Abouelnasr A
- Abouzahra A
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- Abozyed MAF
- Abuseif M
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- Adams R
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- Adekoya A
- Adel A
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- Ademuyiwa AO
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- Adeniyi A
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- Al-Aarag AA-R
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- Alghamdi M
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- Elebute O
- Elena G
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- Elfouly Y
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- Elkholy A
- Elkolaly SS
- Elkorashy AM
- Elmelegy R
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- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
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- Elshafay AE
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- Elsheikh S
- Elsherbiny AS
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
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- Elwan A
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- Fahiem A
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- Farah A
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- Farinella E
- Farooq T
- Fattah AA
- Fattah IA
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- Glasbey JC
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- Habeeb MA
- Habeebullah A
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- Hafiz S
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- Hemingway D
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- Herrera Puma CM
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- Saad M
- Saad S
- Sabeeh L
- Sabry A
- Sadek A
- Sadig N
- Saeed AM
- Saeed H
- Saeed M
- Saeed M
- Safa H
- Sakr A
- Sakr R
- Salah O
- Salama M
- Salama Y
- Salama Y
- Saleh O
- Salleh A
- Salma M
- Samaraweera DI
- Samih H
- Samir A
- Sampson C
- Samuel D
- Samy S
- Sarsik S
- Sarwary S
- Satoskar R
- Satoskar S
- Sauvat F
- Sayed A
- Sayma EA
- Scalabre A
- Schadde E
- Schivo D
- Schmid R
- Schmitt F
- Schoewe C
- Seif M
- Seifelnasr O
- Seisa M
- Sgroi G
- Shaalan M
- Shabkah A
- Shafik DE
- Shah A
- Shah J
- Shah R
- Shah R
- Shaker H
- Shaker R
- Shalaby A
- Shalhoub J
- Shatkar V
- Shawki M
- Shawki M
- Sheehan J
- Shehata S
- Sherif MA
- Sheshe A
- Shimy G
- Shiwani H
- Shu Yip SB
- Shu S
- Shukla J
- Sieda B
- Sierra S
- Siguantay M
- Sila GM
- Singh S
- Sinha S
- Sinha Y
- Sion M
- Sivaganesh S
- Skehan J
- Skelly B
- Slade R
- Smart NJ
- Smith C
- Snaith AC
- Snyder E
- Sodde P
- Soeselo DA
- Soliman AR
- Soltani N
- Song J
- Song J
- Soreide K
- Soreide K
- Souaibou YI
- Spence R
- Spence R
- Spina A
- Sreedharan A
- Sreedharan A
- Sriram A
- Staerkle RF
- Starr N
- Stasinou T
- Stewart D
- Stoddart M
- Suleiman SI
- Summerour V
- Sund M
- Sundstrom SM
- Sutanto EPR
- Sutton P
- Swann J
- Sykes M
- Szczap A
- Tabiri S
- Tabiri S
- Tade A
- Taha EMS
- Taiwo O
- Talukder S
- Talukder S
- Tammam A
- Tan JJ
- Tanase A
- Tang A
- Tarek A
- Tarek A
- Tatagiba LS
- Tawfik G
- Taylor F
- Teasdale E
- Tedjaatmadja C
- Temoche E
- Tessera G
- Teufelberger G
- Tewari S
- Th'ng F
- Tham JC
- Thanusan V
- Tharmalingam S
- Thomas E
- Thompson B
- Thomson P
- Thorarinsdottir H
- Thorsen K
- Tierney G
- Tilston TW
- Toeema AG
- Tolba H
- Tolg C
- Torrance HD
- Tou S
- Tracy J
- Tun M
- Turati L
- Turner M
- Tze RGE
- Ubhi HK
- Ugalde P
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
- Urquizu MC
- Utter M
- Van Duren B
- Varcada M
- Vella-Baldacchino M
- Velsquez CIP
- Venskutonis D
- Venugopal C
- Vergara Celis JM
- Veronese E
- Vida LC
- Vimalachandran D
- Vivekanantham S
- Vlachogiorgos A
- Wagener M
- Walsh U
- Ward S
- Warda M
- Warwick AM
- Weber P
- Weinstein MS
- Wheeler J
- Whewell H
- Wiiliams O
- Wild JRL
- Williams E
- Williams G
- Williamson A
- Wilson A
- Wilson MSJ
- Winstanley J
- Woin E
- Wold TB
- Wolf B
- Wondimu S
- Wong CS
- Woodward H
- Worku M
- Wredberg C
- Wright NJ
- Xerri T
- Yallop L
- Yavuz MA
- Yee J
- Yeo LS
- Yeung ENW
- Yong CO
- Youssef D
- Youssif JH
- Zachariades D-C
- Zakir M
- Zalabia MF
- Zamarin K
- Zani A
- Zardab A
- Zegarra S
- Zeidan S
- Zerihun AB
- Zidan H
- Zidan H
- Zidan M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zimmermann EF
- Zuber M
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2016
- Field of study
Background: Child health is a key priority on the global health agenda, yet the provision of essential and emergency surgery in children is patchy in resource-poor regions. This study was aimed to determine the mortality risk for emergency abdominal paediatric surgery in low-income countries globally. Methods: Multicentre, international, prospective, cohort study. Self-selected surgical units performing emergency abdominal surgery submitted prespecified data for consecutive children aged <16 years during a 2-week period between July and December 2014. The United Nation's Human Development Index (HDI) was used to stratify countries. The main outcome measure was 30-day postoperative mortality, analysed by multilevel logistic regression. Results: This study included 1409 patients from 253 centres in 43 countries; 282 children were under 2 years of age. Among them, 265 (18.8%) were from low-HDI, 450 (31.9%) from middle-HDI and 694 (49.3%) from high-HDI countries. The most common operations performed were appendectomy, small bowel resection, pyloromyotomy and correction of intussusception. After adjustment for patient and hospital risk factors, child mortality at 30 days was significantly higher in low-HDI (adjusted OR 7.14 (95% CI 2.52 to 20.23), p<0.001) and middle-HDI (4.42 (1.44 to 13.56), p=0.009) countries compared with high-HDI countries, translating to 40 excess deaths per 1000 procedures performed. Conclusions: Adjusted mortality in children following emergency abdominal surgery may be as high as 7 times greater in low-HDI and middle-HDI countries compared with high-HDI countries. Effective provision of emergency essential surgery should be a key priority for global child health agendas