38 research outputs found

    Association of Intraocular Pressure With Human Immunodeficiency Virus

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    PURPOSE: Prior studies have shown an association between human immunodeficiency virus (HIV) and reduced intraocular pressures (IOP). The purpose of this study was to determine if patients with HIV on highly active antiretroviral therapy (HAART) had any difference in their IOP compared with patients without HIV or with HIV who are not on HAART. DESIGN: Retrospective cross-sectional study. METHODS: We included 400 patients from our academic eye center between 2000 and 2016. Group 1 (G1) consisted of patients with HIV on HAART (n = 176), Group 2 (G2) consisted of patients with HIV who were not on HAART (n = 48), and Group 3 (G3) consisted of controls without HIV (n = 176). An analysis of variance (ANOVA) was performed to compare mean IOP values. Multivariate linear and logistic regression models were performed to assess factors impacting IOP. Difference in IOP was the primary outcome being measured. RESULTS: The mean IOPs in mm Hg were 13.7 +/- 5.1 (G1), 13.1 +/- 3.6 (G2), and 17.3 +/- 3.8 (G3), P \u3c .01. In regression modeling, having a CD4 count CONCLUSIONS: Absolute CD4 counts may play a role in IOP fluctuations. This association was found in patients with HIV regardless of whether patients were on HAART

    Management of sobbing tot in a pediatric dental office: A review

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    The most common way by which child expresses fear and anxiety is by crying at dental office. Proper knowledge and understanding are required to deliver effective dental treatment to a child by the application of various behavioral management techniques. Treating a crying child is one of the most demanding and tiring situations encountered in dentistry. Behavior management in a crying child is a continuum interaction with the child, directed toward communication and education in an endeavor, to allay anxiety and fear and to promote understanding of good oral health and the process by which it is achieved. This article was aimed to review the various reasons for stimulation of cry of the child in the dental office and behavior techniques employed by the dentist for proper management of the child

    DESIGN AND PERFORMANCE VERIFICATION OF NEWLY DEVELOPED DISPOSABLE STATIC DIFFUSION CELL FOR DRUG DIFFUSION/PERMEABILITY STUDIES

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    Objectives: The present study describes a disposable static diffusion cell for in vitro diffusion studies to achieve better results as compared to well existing Franz diffusion cell (FDC) in terms of the absence of bubbles, variable receptor compartment, ease of handling, and faster results.Materials and Methods: The cell consists of a cup-shaped donor compartment made of semi permeable that could be either cellophane membrane or, animal skin fitted to a rigid frame, which is supported on a plastic plate that contains a hole for the sample withdrawal. The receptor compartment is a separate unit, and it could be any container up to 500ml volume capacity. The most preferred receptor compartment is glass beaker. In the present study, goatskin was used as semi-permeable membrane and verification of its performance was carried out through diffusion studies using gel formulations of one each of the four-selected biopharmaceutical classification system (BCS) class drugs. Metronidazole, diclofenac sodium, fluconazole, and sulfadiazine were used as model drugs for BCS Class I, II, III, and IV, respectively.Results: The newly developed diffusion cell (NDDC) was found to provide faster and more reproducible results as compared to FDC. At the time interval of 24 h, the cell was found to exhibit a higher diffusion of metronidazole, diclofenac sodium, fluconazole, and sulfadiazine by 0.65, 0.65, 0.32, and 0.81 folds, respectively. The faster release obtained with NDDC was attributed to a larger surface area of skin as compared to that in FDC.Conclusion: It was concluded that better reproducibility of results could be achieved with NDDC

    Calibration of the CMS hadron calorimeters using proton-proton collision data at root s=13 TeV

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    Methods are presented for calibrating the hadron calorimeter system of theCMSetector at the LHC. The hadron calorimeters of the CMS experiment are sampling calorimeters of brass and scintillator, and are in the form of one central detector and two endcaps. These calorimeters cover pseudorapidities vertical bar eta vertical bar ee data. The energy scale of the outer calorimeters has been determined with test beam data and is confirmed through data with high transverse momentum jets. In this paper, we present the details of the calibration methods and accuracy.Peer reviewe

    COVID-19 real-time tracker and analytical report

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    Theoretical - While the COVID-19 episode was accounted for to initially start from Wuhan, China, it has been pronounced as a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 by WHO, and it has spread to throughout 180 nations when of this paper was being created. As the sickness spreads all over the planet, it has developed into an overall pandemic, imperiling the condition of worldwide general wellbeing and turning into a genuine danger to the worldwide local area. To battle and forestall the spread of the sickness, all people ought to be well-educated regarding the quickly changing province of COVID-19. In the undertaking of achieving this level headed, a COVID-19 continuous scientific tracker has been worked to give the most recent status of the infection and significant scientific bits of knowledge. The ongoing tracker is intended to oblige the general crowd without cutting edge factual inclination. It expects to convey bits of knowledge through different clear and succinct information representations that are upheld by strong measurable establishments also solid information sources.&nbsp

    Effect of mineral trioxide aggregate as a direct pulp capping agent in cariously exposed permanent teeth

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    Aims and Objectives: To evaluate the effectiveness of mineral trioxide aggregate (MTA) when used as a pulp capping agent in permanent teeth with carious exposure (≀1mm) after root formation is completed. Materials and Methods: Clinical follow-up was performed on 32 mandibular molars with deep occlusal caries, in patients in the age group range of 18 to 42 years. Carious pulpal exposures were treated by direct pulp capping with MTA, followed by a base of light cure glass ionomer cement and restored with amalgam. Clinical and radiographic examinations were carried out periodically at 1, 3, 6, 9, 12, 18 and 24 months. Results: After 24 months clinical and radiographic follow-up, it was found that 25 (out of 32) patients had successful outcome. However, two patients failed to return for evaluation after permanent restoration, and five patients exhibited clinical failure. Conclusions: Mineral trioxide aggregate was found to be an effective material when used for direct pulp capping in permanent teeth. However, further investigations with a larger sample size are needed to support these findings

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