High-end normal adrenocorticotropic hormone and cortisol levels are associated with specific cardiovascular risk factors in pediatric obesity: a cross-sectional study.

BACKGROUND: The hypothalamic-pituitary-adrenal (HPA) axis, and in particular cortisol, has been reported to be involved in obesity-associated metabolic disturbances in adults and in selected populations of adolescents. The aim of this study was to investigate the association between morning adrenocorticotropic hormone (ACTH) and cortisol levels and cardiovascular risk factors in overweight or obese Caucasian children and adolescents. METHODS: This cross-sectional study of 450 obese children and adolescents (aged 4 to 18 years) was performed in a tertiary referral center. ACTH, cortisol, cardiovascular risk factors (fasting and post-challenge glucose, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, triglycerides, and hypertension) and insulin resistance were evaluated. All analyses were corrected for confounding factors (sex, age, puberty, body mass index), and odds ratios were determined. RESULTS: ACTH and cortisol levels were positively associated with systolic and diastolic blood pressure, triglycerides, fasting glucose and insulin resistance. Cortisol, but not ACTH, was also positively associated with LDL-cholesterol. When adjusted for confounding factors, an association between ACTH and 2 h post-oral glucose tolerance test glucose was revealed. After stratification according to cardiovascular risk factors and adjustment for possible confounding factors, ACTH levels were significantly higher in subjects with triglycerides 6590th percentile (P 5.92 pmol/l) and cortisol (>383.5 nmol/l) although within the normal range were associated with increases in cardiovascular risk factors in this population. CONCLUSIONS: In obese children and adolescents, high morning ACTH and cortisol levels are associated with cardiovascular risk factors. High ACTH levels are associated with high triglyceride levels and hyperglycemia, while high cortisol is associated with hypertension and high LDL-cholesterol. These specific relationships suggest complex mechanisms through which the HPA axis may contribute to metabolic impairments in obesity, and merit further investigations

Theoretical Uncertainties in Electroweak Boson Production Cross Sections at 7, 10, and 14 TeV at the LHC

We present an updated study of the systematic errors in the measurements of the electroweak boson cross-sections at the LHC for various experimental cuts for a center of mass energy of 7, 10 and 14 TeV. The size of both electroweak and NNLO QCD contributions are estimated, together with the systematic error from the parton distributions. The effects of new versions of the MSTW, CTEQ, and NNPDF PDFs are considered.Comment: PDFLatex with JHEP3.cls. 22 pages, 43 figures. Version 2 adds the CT10W PDF set to analysis and updates the final systematic error table and conclusions, plus several citations and minor wording changes. Version 3 adds some references on electroweak and mixed QED/QCD corrections. Version 4 adds more references and acknowledgement

Combination of electroweak and QCD corrections to single W production at the Fermilab Tevatron and the CERN LHC

Precision studies of the production of a high-transverse momentum lepton in association with missing energy at hadron colliders require that electroweak and QCD higher-order contributions are simultaneously taken into account in theoretical predictions and data analysis. Here we present a detailed phenomenological study of the impact of electroweak and strong contributions, as well as of their combination, to all the observables relevant for the various facets of the p\smartpap \to {\rm lepton} + X physics programme at hadron colliders, including luminosity monitoring and Parton Distribution Functions constraint, $W$ precision physics and search for new physics signals. We provide a theoretical recipe to carefully combine electroweak and strong corrections, that are mandatory in view of the challenging experimental accuracy already reached at the Fermilab Tevatron and aimed at the CERN LHC, and discuss the uncertainty inherent the combination. We conclude that the theoretical accuracy of our calculation can be conservatively estimated to be about 2% for standard event selections at the Tevatron and the LHC, and about 5% in the very high $W$ transverse mass/lepton transverse momentum tails. We also provide arguments for a more aggressive error estimate (about 1% and 3%, respectively) and conclude that in order to attain a one per cent accuracy: 1) exact mixed ${\cal O}(\alpha \alpha_s)$ corrections should be computed in addition to the already available NNLO QCD contributions and two-loop electroweak Sudakov logarithms; 2) QCD and electroweak corrections should be coherently included into a single event generator.Comment: One reference added. Final version to appear in JHE

Implementation of electroweak corrections in the POWHEG BOX: single W production

We present a fully consistent implementation of electroweak and strong radiative corrections to single W hadroproduction in the POWHEG BOX framework, treating soft and collinear photon emissions on the same ground as coloured parton emissions. This framework can be easily extended to more complex electroweak processes. We describe how next-to-leading order (NLO) electroweak corrections are combined with the NLO QCD calculation, and show how they are interfaced to QCD and QED shower Monte Carlo. The resulting tool fills a gap in the literature and allows to study comprehensively the interplay of QCD and electroweak effects to W production using a single computational framework. Numerical comparisons with the predictions of the electroweak generator HORACE, as well as with existing results on the combination of electroweak and QCD corrections to W production, are shown for the LHC energies, to validate the reliability and accuracy of the approachComment: 31 pages, 7 figures. Minor corrections, references added and updated. Final version to appear in JHE

Proceedings of the Workshop on Monte Carlo's, Physics and Simulations at the LHC PART II

These proceedings collect the presentations given at the first three meetings of the INFN "Workshop on Monte Carlo's, Physics and Simulations at the LHC", held at the Frascati National Laboratories in 2006. The first part of these proceedings contains pedagogical introductions to several basic topics of both theoretical and experimental high pT LHC physics. The second part collects more specialised presentations.Comment: 157 pages, 136 figures; contribution by M. Grazzini has been adde

Time-integrated luminosity recorded by the BABAR detector at the PEP-II e+e- collider

This article is the Preprint version of the final published artcile which can be accessed at the link below.We describe a measurement of the time-integrated luminosity of the data collected by the BABAR experiment at the PEP-II asymmetric-energy e+e- collider at the ϒ(4S), ϒ(3S), and ϒ(2S) resonances and in a continuum region below each resonance. We measure the time-integrated luminosity by counting e+e-→e+e- and (for the ϒ(4S) only) e+e-→μ+μ- candidate events, allowing additional photons in the final state. We use data-corrected simulation to determine the cross-sections and reconstruction efficiencies for these processes, as well as the major backgrounds. Due to the large cross-sections of e+e-→e+e- and e+e-→μ+μ-, the statistical uncertainties of the measurement are substantially smaller than the systematic uncertainties. The dominant systematic uncertainties are due to observed differences between data and simulation, as well as uncertainties on the cross-sections. For data collected on the ϒ(3S) and ϒ(2S) resonances, an additional uncertainty arises due to ϒ→e+e-X background. For data collected off the ϒ resonances, we estimate an additional uncertainty due to time dependent efficiency variations, which can affect the short off-resonance runs. The relative uncertainties on the luminosities of the on-resonance (off-resonance) samples are 0.43% (0.43%) for the ϒ(4S), 0.58% (0.72%) for the ϒ(3S), and 0.68% (0.88%) for the ϒ(2S).This work is supported by the US Department of Energy and National Science Foundation, the Natural Sciences and Engineering Research Council (Canada), the Commissariat à l’Energie Atomique and Institut National de Physique Nucléaire et de Physiquedes Particules (France), the Bundesministerium für Bildung und Forschung and Deutsche Forschungsgemeinschaft (Germany), the Istituto Nazionale di Fisica Nucleare (Italy), the Foundation for Fundamental Research on Matter (The Netherlands), the Research Council of Norway, the Ministry of Education and Science of the Russian Federation, Ministerio de Ciencia e Innovación (Spain), and the Science and Technology Facilities Council (United Kingdom). Individuals have received support from the Marie-Curie IEF program (European Union) and the A.P. Sloan Foundation (USA)

SUSY QCD corrections to electroweak gauge boson production with an associated jet at the LHC

We study the stability of the neutral- and charged-current Drell-Yan process in association with a jet as a standard candle at the LHC under the inclusion of O(alpha_s) supersymmetric QCD (SQCD) corrections within the MSSM. We include the decay of the electroweak gauge boson into dileptons, i.e. we consider the production of charged lepton--anti-lepton or lepton-neutrino final states with one hard jet. We find that the SQCD corrections are negligible for the integrated cross section. Only at high lepton transverse momentum can they induce effects of the percent level.Comment: 21 pages, 9 figures, 2 table

Proceedings of the Workshop on Monte Carlo's, Physics and Simulations at the LHC PART I

These proceedings collect the presentations given at the first three meetings of the INFN "Workshop on Monte Carlo's, Physics and Simulations at the LHC", held at the Frascati National Laboratories in 2006. The first part of these proceedings contains pedagogical introductions to several basic topics of both theoretical and experimental high pT LHC physics. The second part collects more specialised presentations.Comment: 239 pages, 222 figure

Measurement of sigma(e+ e- -> pi+ pi-) from threshold to 0.85 GeV^2 using Initial State Radiation with the KLOE detector

We have measured the cross section of the radiative process e+e- -> pi+pi-gamma with the KLOE detector at the Frascati phi-factory DAPHNE, from events taken at a CM energy W=1 GeV. Initial state radiation allows us to obtain the cross section for e+e- -> pi+pi-, the pion form factor |F_pi|^2 and the dipion contribution to the muon magnetic moment anomaly, Delta a_mu^{pipi} = (478.5+-2.0_{stat}+-5.0_{syst}+-4.5_{th}) x 10^{-10} in the range 0.1 < M_{pipi}^2 < 0.85 GeV^2, where the theoretical error includes a SU(3) ChPT estimate of the uncertainty on photon radiation from the final pions. The discrepancy between the Standard Model evaluation of a_mu and the value measured by the Muon g-2 collaboration at BNL is confirmed.Comment: 17 pages, 11 figures, revised treatment of FSR uncertainty, version to appear on Physics Letters

Measurement of σ(e+e−→π+π−γ(γ))\sigma(e^+e^-\to\pi^+\pi^-\gamma(\gamma)) and the dipion contribution to the muon anomaly with the KLOE detector

We have measured the cross section $\sigma(e^+e^-\to\pi^+\pi^-\gamma(\gamma))$ at DA$\Phi$NE, the Frascati \phi-factory, using events with initial state radiation photons emitted at small angle and inclusive of final state radiation. We present the analysis of a new data set corresponding to an integrated luminosity of 240 pb$^{-1}$. We have achieved a reduced systematic uncertainty with respect to previously published KLOE results. From the cross section we obtain the pion form factor and the contribution to the muon magnetic anomaly from two pion states in the mass range $0.592 < M_{\pi\pi} < 0.975$ GeV. For the latter we find $\Delta a^{\pi\pi}_\mu = (387.2\pm0.5_{\rm stat}\pm2.4_{\rm exp}\pm2.3_{\rm th})\times 10^{-10}$Comment: Minor text revisions, version to appear on Physics Letters