“Working the System”—British American Tobacco's Influence on the European Union Treaty and Its Implications for Policy: An Analysis of Internal Tobacco Industry Documents

Katherine Smith and colleagues investigate the ways in which British American Tobacco influenced the European Union Treaty so that new EU policies advance the interests of major corporations, including those that produce products damaging to health

Tectonic Mode Switches Recorded at the Northern Edge of the Australian Plate During the Pliocene and Pleistocene

We report new data from medium‐high grade metamorphic rocks found at the northern margin of the Lengguru Fold Belt in West Papua. The study involved a systematic analysis of cross‐cutting structures to establish the relative timing of deformation, together with isotopic dating to define when these tectono‐thermal events occurred. These data show that the region underwent multiple episodes of deformation within the last six million years. Metamorphic mineral growth was associated with the development of ductile shear zones. This episode occurred during a phase of crustal stretching associated with the formation of a metamorphic core complex. Metamorphic zircon growth at 4.9 to 5.3 Ma was documented in two of the dated samples. These data are interpreted to post‐date the peak pressure and temperature conditions of the phase of regional crustal stretching. The shear fabrics associated with the metamorphic core complex were later overprinted by at least two generations of folds. The change in mode from crustal extension to shortening reflects a tectonic mode switch. A subsequent mode switch is documented by numerous brittle extensional faults that cross‐cut the earlier formed ductile fabrics. We interpret ca. 0.75-1.51 Ma (U-Th)/He age data to reflect cooling associated with the later stages of crustal shortening (marked by folds) or the later extensional unroofing of the peninsula. This work demonstrates that an orogen can record multiple tectonic mode switches within several million years. These outcomes should be considered in studies of ancient orogens where analytical uncertainties associated with isotopic dating may mask short‐lived mode switches

Rethinking European integration history in light of capitalism: the case of the long 1970s

This introduction outlines the possibilities and perspectives of an intertwining between European integration history and the history of capitalism. Although debates on capitalism have been making a comeback since the 2008 crisis, to date the concept of capitalism remains almost completely avoided by historians of European integration. This introduction thus conceptualizes ‘capitalism’ as a useful analytical tool that should be used by historians of European integration and proposes three major approaches for them to do so: first, by bringing the question of social conflict, integral to the concept of capitalism, into European integration history; second, by better conceptualizing the link between European governance, Europeanization and the globalization of capitalism; and thirdly by investigating the economic, political and ideological models or doctrines that underlie European cooperation, integration, policies and institutions. Finally, the introduction addresses the question of the analytical benefits of an encounter between capitalism and European integration history, focusing on the case of the 1970s. This allows us to qualify the idea of a clear-cut rupture, and better highlight how the shift of these years resulted from a complex bargaining that took place in part at the European level

The genetic content of chromosomal inversions across a wide latitudinal gradient

There is increasing evidence regarding the role of chromosomal inversions in relevant biological processes such as local adaptation and speciation. A classic example of the adaptive role of chromosomal polymorphisms is given by the clines of inversion frequencies in Drosophila subobscura, repeatable across continents. Nevertheless, not much is known about the molecular variation associated with these polymorphisms. We characterized the genetic content of ca. 600 individuals from nine European populations following a latitudinal gradient by analysing 19 microsatellite loci from two autosomes (J and U) and the sex chromosome (A), taking into account their chromosomal inversions. Our results clearly demonstrate the molecular genetic uniformity within a given chromosomal inversion across a large latitudinal gradient, particularly from Groningen (Netherlands) in the north to Málaga (Spain) in the south, experiencing highly diverse environmental conditions. This low genetic differentiation within the same gene arrangement across the nine European populations is consistent with the local adaptation hypothesis for th evolutionof chromosomal polymorphisms. We also show the effective role of chromosomal inversions in maintaining different genetic pools within these inverted genomic regions even in the presence of high gene flow. Inversions represent thus an important barrier to gene flux and can help maintain specific allelic combinations with positive effects on fitness. Consistent patterns of microsatellite allele-inversion linkage disequilibrium particularly in loci within inversions were also observed. Finally, we identified areas within inversions presenting clinal variation that might be under selection