7 research outputs found
Oligomerization of Uukuniemi virus nucleocapsid protein
- Author
- Publication venue
- Publication date
- 01/01/2010
- Field of study
Background Uukuniemi virus (UUKV) belongs to the Phlebovirus genus in the family Bunyaviridae. As a non-pathogenic virus for humans UUKV has served as a safe model bunyavirus in a number of studies addressing fundamental questions such as organization and regulation of viral genes, genome replication, structure and assembly. The present study is focused on the oligomerization of the UUKV nucleocapsid (N) protein, which plays an important role in several steps of virus replication. The aim was to locate the domains involved in the N protein oligomerization and study the process in detail. Results A set of experiments concentrating on the N- and C-termini of the protein was performed, first by completely or partially deleting putative N-N-interaction domains and then by introducing point mutations of amino acid residues. Mutagenesis strategy was based on the computer modeling of secondary and tertiary structure of the N protein. The N protein mutants were studied in chemical cross-linking, immunofluorescence, mammalian two-hybrid, minigenome, and virus-like particle-forming assays. The data showed that the oligomerization ability of UUKV-N protein depends on the presence of intact α-helices on both termini of the N protein molecule and that a specific structure in the N-terminal region plays a crucial role in the N-N interaction(s). This structure is formed by two α-helices, rich in amino acid residues with aromatic (W7, F10, W19, F27, F31) or long aliphatic (I14, I24) side chains. Furthermore, some of the N-terminal mutations (e.g. I14A, I24A, F31A) affected the N protein functionality both in mammalian two-hybrid and minigenome assays. Conclusions UUKV-N protein has ability to form oligomers in chemical cross-linking and mammalian two-hybrid assays. In mutational analysis, some of the introduced single-point mutations abolished the N protein functionality both in mammalian two-hybrid and minigenome assays, suggesting that especially the N-terminal region of the UUKV-N protein is essential for the N-N-interaction.Peer reviewe
Nucleotide divergence vs. gene expression differentiation: comparative transcriptome sequencing in natural isolates from the carrion crow and its hybrid zone with the hooded crow
- Author
- Albertson
- Backstrom
- Barker
- Barton
- Bateson
- Bekkevold
- Brodin
- Brodin
- Carroll
- Cheviron
- Craig
- Dutheil
- Ellegren
- Enard
- Gibson
- Gilad
- Griffith
- Haas
- Haas
- Haerty
- Haring
- Hewitt
- Hillier
- Hoekstra
- Hudson
- Ihaka
- Immelmann
- Jiang
- Khaitovich
- Khaitovich
- King
- Kryukov
- Kryukov
- Kryukov
- Lynch
- Mayr
- Meise
- Milá
- Moore
- Mortazavi
- Parkin
- Pavlova
- Randler
- Ridley
- Rolando
- Rottscheidt
- Rozas
- Saetre
- Saino
- Saino
- Saino
- Saino
- Saino
- Skelton
- Spiridonova
- Staubach
- Stearns
- Steinfartz
- Stephens
- Stephens
- Storey
- Tautz
- van Tuinen
- Vera
- Warren
- Wolf
- Wray
- Zink
- Publication venue
- 'Wiley'
- Publication date
- Field of study
SER-1, a Caenorhabditis elegans 5-HT2-like receptor, and a multi-PDZ domain containing protein (MPZ-1) interact in vulval muscle to facilitate serotonin-stimulated egg-laying
- Author
- Backstrom
- Bany
- Barritt
- Bastiani
- Brenner
- Buhot
- Burette
- Bécamel
- Bécamel
- Bécamel
- Carnell
- Chao
- Coyne
- Dakoji
- Dempsey
- Desai
- Dong
- Ebnet
- Gavarini
- Georgescu
- Griffon
- Halford
- Hall
- Hamazaki
- Hamdan
- Hobert
- Hobson
- Hong Xiao
- Horvitz
- Huang
- Jeanneteau
- Jeansonne
- John Plenefisch
- Joubert
- Kamath
- Katherine A. Smith
- Kimber
- Komuniecki
- Kramer
- Krapivinsky
- Lee
- Lee
- Li Lin
- Mancini
- McCormack
- Mello
- Mello
- Moghal
- Osten
- Parker
- Poliak
- Ponting
- Richard Komuniecki
- Robert J. Hobson
- Roth
- Sawin
- Schafer
- Sheng
- Shyn
- Simmer
- Sitek
- Sulston
- Trent
- Tsalik
- Ullmer
- Vera M. Hapiak
- Waggoner
- Waggoner
- White
- Wu
- Wyszynski
- Xia
- Xiang
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Materials for absorbable and nonabsorbable surgical sutures
- Author
- Altman
- Andriano
- Barie
- Barrows
- Barrows
- Bezwada
- Bezwada
- Bezwada
- Bostman
- Bunn
- Canarelli
- Casey
- Casey
- Chu
- Chu
- Chu
- Chu
- Chu
- Chu
- Chu
- Chu
- Chu
- Chu
- Chujo
- Collins
- Costantini
- Dang
- DeFife
- Deng
- Doddi
- Doi
- Duprez
- Earland
- Edlich
- Farnsworth
- FDA
- Frazza
- Fredericks
- Goldstein
- Grizzi
- Guo
- Guo
- Guo
- Guo
- Guo
- Guo
- Hong
- Horwitz
- Im
- Im
- Jokhadze
- Joshi
- Kadono
- Kangas
- Kaplan
- Katsarava
- Katz
- Katz
- Kloos
- Kohan
- Kulkarni
- Lazaris
- Lee
- Lee
- Li
- Listner
- Liu
- Liu
- Martin
- McCaul
- Mercer
- Miller
- Molea
- Moncrieff
- Moynihan
- Nelson
- Oberhoffner
- Pang
- Pang
- Pang
- Pineros-Fernandez
- Reed
- Reid
- Robson
- Roby
- Roby
- Rodeheaver
- Rodeheaver
- Saikku-Backstrom
- Scalzo
- Schmitt
- Sendelbeck
- Shalaby
- Shalaby
- Shalaby
- Song
- Stock
- Sutow
- Tomihata
- Tomihata
- Tomihata
- Tsitlanadze
- Tsitlanadze
- Urban
- Vakili
- Van Heerden
- Vera
- Von Fraunhofer
- Williams
- Wishman
- Wu
- Wu
- Zhang
- Zuber
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Ligand-specific differential regulation of 5-hydroxytryptamine receptors: functional selectivity in serotonergic signaling
- Author
- Aghajanian
- Backstrom
- Barnes
- Berg
- Berg
- Berg
- Berg
- Berg
- Berg
- Bhatnagar
- Björk
- Brea
- Burns
- Cabrera-Vera
- Cussac
- Cussac
- De Deurwaerdere
- Englander
- Fitzgerald
- Gettys
- Glennon
- Gonzalez-Maeso
- Gonzalez-Maeso
- Gray
- Gurevich
- Gurwitz
- Halberstadt
- Hanley
- Hannon
- Heusler
- Huang
- Kenakin
- Kenakin
- Kenakin
- Kenakin
- Kenakin
- Kenakin
- Kenakin
- Knauer
- Krobert
- Kurrasch-Orbaugh
- Kurrasch-Orbaugh
- Lanfumey
- Lin
- Manning
- Mannoury
- Marty
- Millan
- Milligan
- Milligan
- Moya
- Neubig
- Newman-Tancredi
- Newman-Tancredi
- Newman-Tancredi
- Newman-Tancredi
- Nichols
- Niswender
- Patel
- Price
- Rajagopal
- Raote
- Rosenzweig-Lipson
- Roth
- Schlag
- Schmid
- Schmid
- Schulte
- Smith
- Stout
- Strachan
- Urban
- Urizar
- Valdizan
- van Hooft
- Werry
- Willins
- Yadav
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Social Data: Biases, Methodological Pitfalls, and Ethical Boundaries
- Author
- A Nicholas
- A Ricardo
- A Scott
- A Torralba
- Abbe Mowshowitz
- Abdulfatai Popoola
- Abhay Sukumaran
- Adam Fourney
- Adam Mann
- Adam N Joinson
- Aditya Pal
- Akshay Java
- Alan Mislove
- Alex Rosenblat
- Alexandra Olteanu
- Alexandra Olteanu
- Alexandra Olteanu
- Alexandra Olteanu
- Alexandra Olteanu
- Alexandra Olteanu
- Alexandra Olteanu
- Alexandra Olteanu
- Alice E Marwick
- Alice E Marwick
- Amit Sharma
- Amit Sharma
- Andre Oboler
- Andrew Schwartz
- Andrew Yates
- Andr�s Michael S Bernstein
- Aniko Hannak
- Aniko Hannak
- Anne Archambault
- Anne Aula
- Anne Bowser
- Anne Oeldorf-Hirsch
- Arnaud De Myttenaere
- Arvind Narayanan
- Asaf Beasley
- Axel Bruns
- Axel Bruns
- Axel Bruns
- Aylin Caliskan-Islam
- Barbara Poblete
- Bernd Carsten Stahl
- Bimal Viswanath
- Boyd Danah
- Brendan Daniel M Romero
- Brent Hecht
- Bryce Goodman
- Caitlin Mclaughlin
- Carlos Castillo
- Carlos Castillo
- Carlos Castillo
- Chenliang Li
- Chris Anderson
- Chris Drummond
- Chris Preist
- Christian Reuter
- Christian Sandvig
- Christo Wilson
- Claire Cain Miller
- Claudia Wagner
- Cliff Lampe
- Cliff Lampe
- Cristian Danescu-Niculescu-Mizil
- Cynthia Dwork
- Cynthia Rudin
- D I Adam
- D I Adam
- D Mitja
- D-P. Nguyen
- Daniel Gayo Avello
- Daniel Gayo-Avello
- Daniel Preot�iucpreot�iuc-Pietro
- Daniele Fanelli
- Daphne Chang
- Dario Amodei
- David John Hughes
- David Jurgens
- David Jurgens
- David Lazer
- David Lazer
- David Silverman
- Davide Proserpio
- Deen Freelon
- Delia Mocanu
- Delip Rao
- Derek Ruths
- Diego Saez-Trumper
- Dimitar Nikolov
- Dirk Hovy
- Dong Nguyen
- Dongyuan Bang Hui Lim
- Dos Virgile Landeiro
- Doug Schuler
- Eduardo Ruiz
- Edward Newell
- Edward Newell
- Elad Yom-Tov
- Emilio Ferrara
- Emilio Zagheni
- Emilio Zagheni
- Emre K?c?man
- Emre K?c?man
- Emre K?c?man
- Emre K?c?man
- Emre Kiciman
- Emre Munmun De Choudhury
- Erhard Rahm
- Eric Gilbert
- Eric Gilbert
- Eric Horvitz
- Erin Kenneally
- Eszter Hargittai
- Eszter Hargittai
- Ethan Cohen-Cole
- Eunil Sang Jib Kwon
- Eyal Carmi
- Eytan Bakshy
- Eytan Bakshy
- Eytan Bakshy
- Fabrizio Silvestri
- Felix Ming Fai Wong
- Fernando Diaz
- Fernando Diaz
- Fernando Diaz
- Fernando Diaz
- Filip Radlinski
- Florian Tramer
- Fons Wijnhoven
- Fred Morstatter
- Fred Morstatter
- Gang Wang
- Gary King
- Gary King
- Giovanni Quattrone
- Guy Shani
- H Wallach
- Hai Liang
- Hamid Ekbia
- Hannah Jean Miller
- Hassan Saif
- Hassan Saif
- Hazim Almuhimedi
- Hyunwoo Chun
- H�seyin Oktay
- I Ian
- Ilknur Celik
- Ingmar Venkata Rama Kiran Garimella
- Ingmar Weber
- Isaac Johnson
- J Christopher
- J Sean
- Jacob Metcalf
- Jacob Ratkiewicz
- Jaime Teevan
- James Grimmelmann
- James Howison
- James Matthew
- James Mccorriston
- Janne Lindqvist
- Jeremy Ginsberg
- Jes�s Bobadilla
- Jiang Yang
- Jie Tang
- Jilin Chen
- Jim Maddock
- Joan Dimicco
- Johan Ugander
- Jonathan Cinnamon
- Joseph Konstan
- Josh Terrell
- Jos� Van Dijck
- Juhi Kulshrestha
- Julia D Fraustino
- Julia Schwarz
- Jure Leskovec
- Justin Cheng
- Justin Cheng
- Justin Cheng
- Justin Cranshaw
- Justin Sampson
- Kalev Leetaru
- Kashmir Hill
- Kate Crawford
- Kate Crawford
- Kate Crawford
- Kate Crawford
- Kate Crawford
- Kate Ehrlich
- Kathy Charmaz
- Katrin Weller
- Katrin Weller
- Kaveri Subrahmanyam
- Kenneth Joseph
- Kevin Macg
- Kien Pham
- Kira Radinsky
- Kiri Wagstaff
- Kj Ryan
- Kristina Lerman
- Kristina Lerman
- Kristina Lerman
- Kurt Thomas
- L Daniel
- L Norbert
- L S Cynthia
- Lars Backstrom
- Laura Reed
- Lauren Kirchner
- Lev Muchnik
- Lichan Hong
- Lindsay Poirier
- Linna Li
- Liza Potts
- Loizos Michael
- Lucia Specia
- Lucie Flekova
- Luke Hutton
- Luke Hutton
- M Meredith
- M Momin
- M Momin
- Maeve Duggan
- Maeve Duggan
- Marina Sokolova
- Mark Dredze
- Mark Dredze
- Mark Graham
- Markus Eni Mustafaraj
- Martin Shelton
- Matthew J Salganik
- Matthew Richardson
- Matthias R James W Pennebaker
- Mattias Rost
- Mauro Coletto
- Meeyoung Cha
- Meredith Ringel Munmun De Choudhury
- Michael Zimmer
- Michael Zimmer
- Michail Vlachos
- Michal Kosinski
- Michele Starnini
- Mike Dave D&apos
- Miles Osborne
- Miles Osborne
- Miller Mcpherson
- Moira Burke
- Moira Burke
- Monica Anderson
- Mor Naaman
- Moritz Hardt
- Mossaab Bagdouri
- Mrinal Kumar
- Muhammad Bilal Zafar
- Nan Lin
- Nasir Naveed
- Nicholas Diakopoulos
- Nicole B Boyd
- Nir Grinberg
- Nitin Jindal
- Norah Abokhodair
- O Matthew
- O&apos
- Olteanu
- Olteanu
- Pablo Barbera
- Paolo Giardullo
- Parantapa Bhattacharya
- Patrick Meier
- Paul Bennett
- Paul Ohm
- Paul R Rosenbaum
- Paul Resnick
- Pedro Calais Guerra
- R Colin
- Ralph Gross
- Raphael Ottoni
- Raphael Ottoni
- Raviv Cohen
- Ricardo Baeza
- Ricardo Baeza-Yates
- Richard Mccreadie
- Rishabh Mehrotra
- Rohilla Cosma
- Russell Lyons
- Ruth Garcia-Gavilanes
- Ryen White
- Sai Teja Peddinti
- Salvatore Scellato
- Sam Burnett
- Sandra Gonz�lez-Bail�n
- Sandra Gonz�lez-Bail�n
- Sara Hajian
- Sarah Vieweg
- Sarah Vieweg
- Sarita Yardi Schoenebeck
- Sauvik Das
- Scott Counts
- Scott Munmun De Choudhury
- Shaomei Wu
- Sharad Goel
- Sherlock Campbell
- Shirin Nilizadeh
- Shuang-Hong Yang
- Sinan Aral
- Sitaram Asur
- Sofiane Abbar
- Solon Barocas
- Solon Barocas
- Solon Barocas
- Sophie Chou
- Subhasree Isaac L Johnson
- Susan Dumais
- Symeon Papadopoulos
- Taha Yasseri
- Tarleton Gillespie
- Tatjana Scheffler
- Tehila Minkus
- Tim Harford
- Tolga Bolukbasi
- Tom Gruber
- U N Ocha
- U N Ocha
- Umashanthi Pavalanathan
- Umashanthi Pavalanathan
- Us White House
- Valentina Grasso
- Virgile Landeiro
- W Ryen
- Wai-Tat Vera Liao
- Walid Magdy
- Wanita Sherchan
- Wei Gao
- Wei Gong
- Wei Gong
- William M Trochim
- Winter Mason
- Xin Yan
- Yabing Liu
- Yana Volkovich
- Yang Wang
- Yelena Mejova
- Yishi Haji Mohammad Saleem
- Yu Ru Munmun De Choudhury
- Yu-Ru Lin
- Yusuke Yamamoto
- Yuxiao Dong
- Zengbin Zhang
- Zeynep Tufekci
- Zoltan Gyongyi
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
Contributions of Quaternary botany to modern ecology and biogeography
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- Aakala T
- Aalto M
- Aario R.
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- Abel Schaad D
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- Petit RJ
- Petit RJ
- Pettorelli N
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- Pfeiffer M
- Phillips BL
- Pickett STA
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- Pigott CD
- Pigott CD
- Pigott CD
- Pigott CD
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- Pigott CD.
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- Pigott CD.
- Pigott CD.
- Pigott CD.
- Pigott CD.
- Pigott CD.
- Pigott CD.
- Pimm SL.
- Pini R
- Piotti A
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- Pires MM
- Pirzamanbein B
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- Price GJ
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- Raczka MF
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- Ralska-Jasiewiczowa M
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- Ramstack Hobbs JM
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- Rapacciuolo G
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- Ratcliffe DA.
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- Read DJ.
- Reczyńska K
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- Renberg I
- Reside AE
- Restrepo A
- Reu B
- Rey F
- Rey F
- Rey F
- Reyer CPO
- Reyer CPO
- Rhemtulla JM
- Ricciardi A
- Ricciardi A
- Ricciardi A.
- Richards K.
- Richards PW.
- Richards PW.
- Richardson DM
- Richardson DM
- Rick TC
- Ricklefs RE.
- Ricklefs RE.
- Rijsdijk KF
- Rijsdijk KF
- Rijsdijk KF
- Ritchie JC
- Ritchie JC
- Ritchie JC
- Ritchie JC
- Ritchie JC.
- Ritchie JC.
- Ritchie JC.
- Ritchie JC.
- Ritchie JC.
- Ritchie JC.
- Ritchie JC.
- Ritchie JC.
- Rivas-Torres GF
- Rivers M.
- Roberts DR
- Roberts DR
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- Roberts L.
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- Roberts P
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- Robin V
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- Robinson BL.
- Robinson GS
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- Ross LC
- Ross NJ
- Ross NJ.
- Rotherham ID
- Roughgarden J.
- Roxburgh SH
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- Ruddiman WF
- Ruddiman WF.
- Ruddiman WF.
- Ruddiman WF.
- Ruddiman WF.
- Ruddiman WF.
- Ruddiman WF.
- Rudolph K.
- Rueger BF
- Rule S
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- Rull V
- Rull V
- Rull V
- Rull V
- Rull V
- Rull V.
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- Rull V.
- Rull V.
- Rull V.
- Rull V.
- Rull V.
- Rull V.
- Rull V.
- Ruosch M
- Rutherford D.
- Saltré F
- Saltré F
- Samartin S
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- Sandel B.
- Sanderson JG
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- Sarmiento FO.
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- Saulnier-Talbot É.
- Saulnier-Talbot É.
- Saupe EE
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- Sayer CD
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- Schweiger AH
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- Seddon AWR
- Seddon AWR
- Seddon AWR
- Seddon AWR
- Seddon AWR
- Seeley M
- Segerström U
- Seidl R
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- Selling OH.
- Selling OH.
- Selwood KE
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- Seppä H
- Seppä H
- Serebryanny LR.
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- Sernander R.
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- Silander JA.
- Silvertown J.
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- Summerhayes GR
- Summerhayes GR
- Sussman R.
- Svenning J-C
- Svenning J-C
- Svenning J-C
- Svenning J-C
- Svenning J-C
- Svenning J-C
- Svenning J-C
- Svenning J-C
- Svenning J-C
- Svenning J-C.
- Svenning J-C.
- Swetnam TW
- Swetnam TW
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- Thuiller W
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- Tsukada M.
- Turner J.
- Turner MG
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- Turney CSM
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- Turvey ST
- Turvey ST.
- Tweiten MA
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- Tyrberg T.
- Tzedakis PC
- Tzedakis PC
- Tzedakis PC
- Tzedakis PC
- Tzedakis PC
- Tzedakis PC
- Tzedakis PC.
- Tüxen R.
- Umbanhowar CE
- Umbanhowar CE.
- Urban MA
- Urban MC
- Urrego DH
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- Valencia BG
- Valencia BG
- Valsecchi V
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- van der Geer AAE
- van der Hammen T
- van der Hammen T
- van der Hammen T
- van der Hammen T.
- van der Knaap WO
- van der Leeuw S
- van der Sande MT
- van der Veken S
- van Geel B
- van Geel B
- van Geel B
- van Geel B
- van Geel B
- van Geel B
- van Geel B.
- van Geel B.
- van Leeuwen JFN
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- van Nes EH
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- Vargot EV
- Vaupell C.
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- Velichkevich FY
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- Velichkevich FY
- Velichkevich FY
- Velichkevich FY
- Velichkevich FY
- Velichkevich FY
- Velichkevich FY.
- Velichkevich FY.
- Vellend M
- Vellend M
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- Vellend M.
- Veloz SD
- Vendramin GG
- Vera F.
- Verbesselt J
- Vergeer P
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- Verschuren D
- Vescovi E
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- Vild O
- Villavicencio NA
- Virah-Sawmy M
- Virah-Sawmy M
- Virah-Sawmy M
- Visser ME
- Vitousek PM
- Vitousek PM
- Vitousek PM
- Vitousek PM.
- Volkov I
- von Holle B
- von Post L.
- von Post L.
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- von Post L.
- von Post L.
- von Post L.
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- Wallace AR.
- Waller LA.
- Waller MP
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- Watts WA
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- Watts WA.
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- Webb DA.
- Webb DA.
- Webb SL
- Webb SL.
- Webb SL.
- Webb T
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- Webb T.
- Webb T.
- Webb T.
- Webb T.
- Webb T.
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- Whitehead DR.
- Whitehouse NJ
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- Whitlock C
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- Wilkinson DM.
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- Williamson MH
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- Williamson MH.
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
- Willis KJ
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- Willis KJ
- Willis KJ
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- Willis KJ
- Willis KJ.
- Willis KJ.
- Willner W
- Wilmshurst JM
- Wilmshurst JM
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- Wilson JRU
- Wimsatt WC.
- Wingard GL
- Wisz MS
- With KA.
- Witmer MC
- Wolkovitch EM
- Wood JR
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- Wood JR
- Wood JR
- Woodbridge J
- Woods KD
- Woolbright SA
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- Worsley AT
- Worth JRP
- Wright HE
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- Wulf A.
- Xhauflair H
- Yasuhara M
- Yeung ACY
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- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study