548 research outputs found
Diffantom: Whole-Brain Diffusion MRI Phantoms Derived from Real Datasets of the Human Connectome Project.
Food allergies are believed to be on the rise and currently management relies on the avoidance of the food. Hen's egg allergy is after cow's milk allergy the most common food allergy; eggs are used in many food products and thus difficult to avoid. A technological process using a combination of enzymatic hydrolysis and heat treatment was designed to produce modified hen's egg with reduced allergenic potential. Biochemical (SDS-PAGE, Size exclusion chromatography and LC-MS/MS) and immunological (ELISA, immunoblot, RBL-assays, animal model) analysis showed a clear decrease in intact proteins as well as a strong decrease of allergenicity. In a clinical study, 22 of the 24 patients with a confirmed egg allergy who underwent a double blind food challenge with the hydrolysed egg remained completely free of symptoms. Hydrolysed egg products may be beneficial as low allergenic foods for egg allergic patients to extent their diet. This article is protected by copyright. All rights reserved
Data on the verification and validation of segmentation and registration methods for diffusion MRI.
The verification and validation of segmentation and registration methods is a necessary assessment in the development of new processing methods. However, verification and validation of diffusion MRI (dMRI) processing methods is challenging for the lack of gold-standard data. The data described here are related to the research article entitled "Surface-driven registration method for the structure-informed segmentation of diffusion MR images" [1], in which publicly available data are used to derive golden-standard reference-data to validate and evaluate segmentation and registration methods in dMRI
Recurrence for discrete time unitary evolutions
We consider quantum dynamical systems specified by a unitary operator U and
an initial state vector \phi. In each step the unitary is followed by a
projective measurement checking whether the system has returned to the initial
state. We call the system recurrent if this eventually happens with probability
one. We show that recurrence is equivalent to the absence of an absolutely
continuous part from the spectral measure of U with respect to \phi. We also
show that in the recurrent case the expected first return time is an integer or
infinite, for which we give a topological interpretation. A key role in our
theory is played by the first arrival amplitudes, which turn out to be the
(complex conjugated) Taylor coefficients of the Schur function of the spectral
measure. On the one hand, this provides a direct dynamical interpretation of
these coefficients; on the other hand it links our definition of first return
times to a large body of mathematical literature.Comment: 27 pages, 5 figures, typos correcte
Multiple sclerosis cortical and WM lesion segmentation at 3T MRI: a deep learning method based on FLAIR and MP2RAGE.
The presence of cortical lesions in multiple sclerosis patients has emerged as an important biomarker of the disease. They appear in the earliest stages of the illness and have been shown to correlate with the severity of clinical symptoms. However, cortical lesions are hardly visible in conventional magnetic resonance imaging (MRI) at 3T, and thus their automated detection has been so far little explored. In this study, we propose a fully-convolutional deep learning approach, based on the 3D U-Net, for the automated segmentation of cortical and white matter lesions at 3T. For this purpose, we consider a clinically plausible MRI setting consisting of two MRI contrasts only: one conventional T2-weighted sequence (FLAIR), and one specialized T1-weighted sequence (MP2RAGE). We include 90 patients from two different centers with a total of 728 and 3856 gray and white matter lesions, respectively. We show that two reference methods developed for white matter lesion segmentation are inadequate to detect small cortical lesions, whereas our proposed framework is able to achieve a detection rate of 76% for both cortical and white matter lesions with a false positive rate of 29% in comparison to manual segmentation. Further results suggest that our framework generalizes well for both types of lesion in subjects acquired in two hospitals with different scanners
Construction of the Pauli-Villars-regulated Dirac vacuum in electromagnetic fields
Using the Pauli-Villars regularization and arguments from convex analysis, we
construct solutions to the classical time-independent Maxwell equations in
Dirac's vacuum, in the presence of small external electromagnetic sources. The
vacuum is not an empty space, but rather a quantum fluctuating medium which
behaves as a nonlinear polarizable material. Its behavior is described by a
Dirac equation involving infinitely many particles. The quantum corrections to
the usual Maxwell equations are nonlinear and nonlocal. Even if photons are
described by a purely classical electromagnetic field, the resulting vacuum
polarization coincides to first order with that of full Quantum
Electrodynamics.Comment: Final version to appear in Arch. Rat. Mech. Analysi
Thermodynamics of an interacting trapped Bose-Einstein gas in the classical field approximation
We present a convenient technique describing the condensate in dynamical
equilibrium with the thermal cloud, at temperatures close to the critical one.
We show that the whole isolated system may be viewed as a single classical
field undergoing nonlinear dynamics leading to a steady state. In our procedure
it is the observation process and the finite detection time that allow for
splitting the system into the condensate and the thermal cloud.Comment: 4 pages, 4 eps figures, final versio
Evolution of Cortical and White Matter Lesion Load in Early-Stage Multiple Sclerosis: Correlation With Neuroaxonal Damage and Clinical Changes.
Introduction: Changes in cortical and white matter lesion (CL, WML) load are pivotal metrics to diagnose and monitor multiple sclerosis patients. Yet, the relationship between (i) changes in CL/WML load and disease progression and between (ii) changes in CL/WML load and neurodegeneration at early MS stages is not yet established. In this work, we have assessed the hypothesis that the combined CL and WML load as well as their 2-years evolution are surrogate markers of neurodegeneration and clinical progression at early MS stages. To achieve this goal, we have studied a group of RRMS patients and have investigated the impact of both CL and WML load on neuroaxonal damage as measured by serum neurofilament light chain (sNfL). Next, we have explored whether changes in CL/WML load over 2 years in the same cohort of early-MS are related to motor and cognitive changes. Methods: Thirty-two RRMS patients (<5 years disease duration) underwent: (i) 3T MRI for CL/WML detection and clinical assessment at baseline and 2-years follow-up; and (ii) baseline blood test for sNfL. The correlation between the number and volume of CL/WML and sNfL was assessed by using the Spearman's rank correlation coefficient and a generalized linear model (GLM). A GLM was also used to assess the relationship between (i) the number/volume of new, enlarged, resolved, shrunken, stable lesions and (ii) the difference in clinical scores between two time-points. Results: At baseline, sNfL levels correlated with both total CL count/volume (ρ = 0.6/0.7, Corr-P <0.017/Corr-P < 0.001) and with total WML count/volume (ρ = 0.6/0.6, Corr-P < 0.01 for both). Baseline sNfL levels also correlated with new WML count/volume (ρ = 0.6/0.5, Corr-P < 0.01/Corr-P < 0.05) but not with new CL. Longitudinal changes in CL and WML count and volume were significantly associated with (i) sustained attention, auditory information, processing speed and flexibility (p < 0.01), (ii) verbal memory (p < 0.01); (iii) verbal fluency (p < 0.05); and (iv) hand-motor function (p < 0.05). Discussion: Changes in cortical and white matter focal damage in early MS patients correlate with global neuroaxonal damage and is associated to cognitive performances
On Higher Order Gravities, Their Analogy to GR, and Dimensional Dependent Version of Duff's Trace Anomaly Relation
An almost brief, though lengthy, review introduction about the long history
of higher order gravities and their applications, as employed in the
literature, is provided. We review the analogous procedure between higher order
gravities and GR, as described in our previous works, in order to highlight its
important achievements. Amongst which are presentation of an easy
classification of higher order Lagrangians and its employment as a
\emph{criteria} in order to distinguish correct metric theories of gravity. For
example, it does not permit the inclusion of only one of the second order
Lagrangians in \emph{isolation}. But, it does allow the inclusion of the
cosmological term. We also discuss on the compatibility of our procedure and
the Mach idea. We derive a dimensional dependent version of Duff's trace
anomaly relation, which in \emph{four}-dimension is the same as the usual Duff
relation. The Lanczos Lagrangian satisfies this new constraint in \emph{any}
dimension. The square of the Weyl tensor identically satisfies it independent
of dimension, however, this Lagrangian satisfies the previous relation only in
three and four dimensions.Comment: 30 pages, added reference
In support of the ICCAT ecosystem report card: advances in monitoring the impacts on and the state of the “foodweb and trophic relationships” ecosystem component.
In support of the development of the ICCAT Ecosystem Report Card, this paper addresses the “foodweb/trophic relationships” ecosystem component. Specifically, it contributes towards developing the following elements: (1) we describe what this component means in the context of ICCAT species and fisheries and the importance of monitoring it; (2) we describe the role of ecological indicators and ecosystem models in monitoring this ecosystem component; (3) we present a list of candidate ecological indicators that could be estimated to monitor this component; (4) we discuss the main challenges in monitoring this ecosystem component and indicator development; and finally (5), we draft a work plan to guide our future work. We invite the ICCAT community and others to contribute towards the development of ecological indicators and ecosystem models to monitor this ecosystem component. If interested, contact the corresponding authors to find out how you can contribute to this initiative.Versión del editor
In support of the IOTC ecosystem report card: Advances in monitoring the impacts on and the state of the “foodweb and trophic relationships” ecosystem component
In support of the development of the ICCAT Ecosystem Report Card, this paper addresses the
“foodweb/trophic relationships” ecosystem component. Specifically, it contributes towards
developing the following elements: (1) we describe what this component means in the context of
ICCAT species and fisheries and the importance of monitoring it; (2) we describe the role of
ecological indicators and ecosystem models in monitoring this ecosystem component; (3) we
present a list of candidate ecological indicators that could be estimated to monitor this
component; (4) we discuss the main challenges in monitoring this ecosystem component and
indicator development; and finally (5), we draft a work plan to guide our future work. We invite
the ICCAT community and others to contribute towards the development of ecological indicators
and ecosystem models to monitor this ecosystem component. If interested, contact the
corresponding authors to find out how you can contribute to this initiative
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