Polymorphism rs3087243 is associated with the occurrence of ankylosing spondylitis in the West Algerian population

Background: Numerous studies have shown that polymorphism rs231775 of the CTLA4 gene is strongly implicated in the development of ankylosing spondylitis (AS). Other polymorphisms of this gene are candidates that may have an additional effect in susceptibility to AS. For the first time, we searched for the association of rs3087243 polymorphism located in the 3'UTR region of the CTLA4 gene with the development of SA in the Algerian population. Methods: The study involved 200 subjects (80 AS patients recruited at the rheumatology service and 120 healthy individuals unrelated). Genotyping was performed by real-time PCR (Taqman®). Analysis of the results was carried out by IBM.SPSS.Statictis® software. Results: The distribution of allele frequencies showed a significant association between the GG genotype of the polymorphism rs3087243 and AS risk (OR= 1.77 [0.98-3.21], p=0.004). Conclusion: Our data would suggest that the 3'UTR region of the CTLA4 gene could have an impact on the development of SA in the West Algerian population. These results need to be confirmed on a larger sample

The Next-to-Minimal Supersymmetric Standard Model

We review the theoretical and phenomenological aspects of the Next-to-Minimal Supersymmetric Standard Model: the Higgs sector including radiative corrections and the 2-loop beta-functions for all parameters of the general NMSSM; the tadpole and domain wall problems, baryogenesis; NMSSM phenomenology at colliders, B physics and dark matter; specific scenarios as the constrained NMSSM, Gauge Mediated Supersymmetry Breaking, U(1)'-extensions, CP and R-parity violation.Comment: 144 pages, 11 figures, corrections in Eqs.(2.2), (2.21), (B.9

Caractérisation mécanique et thermomécanique d'un stratifié Jute/époxy = Mechanical and thermomechanical characterization of jute/epoxy laminate

National audienceNous proposons dans ce papier l'élaboration et la caractérisation d'un nouveau matériau composite (stratifié) à base de renfort en fibres naturelles de type jute. Une première caractérisation d'ordre thermique concernant le renfort naturel (tissu sec) montre l'influence de la température sur le comportement mécanique du tissu, à 180°C le jute perd 50% de ses caractéristiques mécaniques. Le stratifié obtenu par infusion est polymérisé à une température inférieure à celle qui affecte les propriétés mécaniques du tissu sec. Les essais de mesure de champ par stéréo corrélation d'image numérique effectués sur des éprouvettes stratifiées jute/époxy (sens chaîne et trame) sollicitées en traction, montrent la présence d'un gradient de déformation non négligeable. Ce gradient s'explique par la variabilité liée au taux volumique local des fibres de jute d'un endroit à l'autre. Les essais mécaniques de type flexion trois points effectués sur des échantillons jute/époxy dans les sens chaîne et trame mettent en évidence une augmentation de 10% de la contrainte de rupture dans le sens trame. Les essais thermomécaniques réalisés montrent que les coefficients de dilatation thermique sens long et sens travers sont influencés par cette variabilité. Les essais de type thermogravimétriques, montent que ce stratifié absorbe jusqu'à 4% d'eau après 8h dans une enceinte climatique avec un taux d'humidité de 70%

Study of Mechanical and Thermomechanical Properties of Jute/Epoxy Composite Laminate

International audienceThis article presents the development and the characterization of composite material (laminate) containing natural jute fiber reinforcement. Thermal characterization of jute fiber reinforcement shows the influence of the temperature on the mechanical behavior of fiber. At 180°C the jute fabric loses 50% of its mechanical characteristics. The laminate obtained by a process known as infusion is polymerized at a temperature lower than that which affects the mechanical properties of dry fabric. The digital image correlation carried out on laminated jute/epoxy (warp and weft direction) under tensile test shows the presence of a considerable gradient of deformation. This gradient is explained by the variability related to the local voluminal change of jute fibers of one place to the other and the nature of the weaving of the jute fiber. The three-point bending tests show a significant dispersion of rupture stress. The thermomechanical tests carried out on samples in the two principal directions, show that the thermal coefficient of expansion in warp direction is 48% larger compared to the weft direction. The thermogravimetric test shows that this laminate absorbs up to 4% water mass after 8 h in a climatic chamber with 70% moisture content

Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population

International audienc

Association study of copy number variants in CCL3L1, FCGR3A

International audienc

No Correlation between MTHFR c.677 C \backslashtextgreater T, MTHFR c.1298 A \backslashtextgreater C, and ABCB1 c.3435 C \backslashtextgreater T Polymorphisms and Methotrexate Therapeutic Outcome of Rheumatoid Arthritis in West Algerian Population

International audienceCONTEXT: The c.677 C \backslashtextgreater T and c.1298 A \backslashtextgreater C polymorphisms of methylenetatrahydrofolate reductase (MTHFR) gene and c.3435 C \backslashtextgreater T polymorphism of ATP-Binding cassette B1 (ABCB1) gene are reported as pharmacogenetic markers, influencing the methotrexate (MTX) therapeutic outcome in rheumatoid arthritis (RA) patients. OBJECTIVES: The aims of this study were to determine the relationship between these polymorphisms and clinical response and/or adverse drug reaction (ADRs) to MTX treatment. MATERIALS AND METHODS: The cohort of our study was composed of 110 RA patients of the West Algerian population. The clinical response was evaluated using the disease activity score 28 (DAS28) and the ADRs were collected after physical examination of patients. All samples were genotyped for theses polymorphisms by TaqMan® allelic discrimination assay. RESULTS: Based on EULAR criteria, 59.09% RA patients were responders and ADRs were observed in 40.9% patients. The frequency distribution of these three polymorphisms was similar between the responders and the non-responders. The same result was found on ADRs study and no significant difference of distribution between the presence of ADRs group and absence of ADRs group was observed. DISCUSSION: Our study joins the results that found in others population in the world. CONCLUSION: We have demonstrated, for the first time in the West Algerian population, that these polymorphisms were not predictive for clinical response and/or ADRs to MTX therapeutic outcome