298 research outputs found
Depinning of three-dimensional drops from wettability defects
Substrate defects crucially influence the onset of sliding drop motion under
lateral driving. A finite force is necessary to overcome the pinning influence
even of microscale heterogeneities. The depinning dynamics of three-dimensional
drops is studied for hydrophilic and hydrophobic wettability defects using a
long-wave evolution equation for the film thickness profile. It is found that
the nature of the depinning transition explains the experimentally observed
stick-slip motion.Comment: 6 pages, 9 figures, submitted to ep
Increased susceptibility of Cantagalo virus to the antiviral effect of ST-246®
AbstractCantagalo virus (CTGV) is the etiologic agent of a pustular disease in dairy cows and dairy workers in Brazil with important economical and occupational impacts. Nevertheless, no antiviral therapy is currently available. ST-246 is a potent inhibitor of orthopoxvirus egress from cells and has proved its efficacy in cell culture and in animal models. In this work, we evaluated the effect of ST-246 on CTGV replication. Plaque reduction assays indicated that CTGV is 6–38 times more susceptible to the drug than VACV-WR and cowpox virus, respectively, with an EC50 of 0.0086μM and a selective index of >11,600. The analysis of β-gal activity expressed by recombinant viruses in the presence of ST-246 confirmed these results. In addition, ST-246 had a greater effect on the reduction of CTGV spread in comet tail assays and on the production of extracellular virus relative to VACV-WR. Infection of mice with CTGV by tail scarification generated primary lesions at the site of scarification that appeared less severe than those induced by VACV-WR. Animals infected with CTGV and treated with ST-246 at 100mg/kg for 5days did not develop primary lesions and virus yields were inhibited by nearly 98%. In contrast, primary lesions induced by VACV-WR were not affected by ST-246. The analysis of F13 (p37) protein from CTGV revealed a unique substitution in residue 217 (D217N) not found in other orthopoxviruses. Construction of recombinant VACV-WR containing the D217N polymorphism did not lead to an increase in the susceptibility to ST-246. Therefore, it is still unknown why CTGV is more susceptible to the antiviral effects of ST-246 compared to VACV-WR. Nonetheless, our data demonstrates that ST-246 is a potent inhibitor of CTGV replication that should be further evaluated as a promising anti-CTGV therapy
Multifrequency monitoring of the blazar 0716+714 during the GASP-WEBT-AGILE campaign of 2007
Since the CGRO operation in 1991-2000, one of the primary unresolved
questions about the blazar gamma-ray emission has been its possible correlation
with the low-energy (in particular optical) emission. To help answer this
problem, the Whole Earth Blazar Telescope (WEBT) consortium has organized the
GLAST-AGILE Support Program (GASP) to provide the optical-to-radio monitoring
data to be compared with the gamma-ray detections by the AGILE and GLAST
satellites. This new WEBT project started in early September 2007, just before
a strong gamma-ray detection of 0716+714 by AGILE. We present the GASP-WEBT
optical and radio light curves of this blazar obtained in July-November 2007,
about various AGILE pointings at the source. We construct NIR-to-UV spectral
energy distributions (SEDs), by assembling GASP-WEBT data together with UV data
from the Swift ToO observations of late October. We observe a contemporaneous
optical-radio outburst, which is a rare and interesting phenomenon in blazars.
The shape of the SEDs during the outburst appears peculiarly wavy because of an
optical excess and a UV drop-and-rise. The optical light curve is well sampled
during the AGILE pointings, showing prominent and sharp flares. A future
cross-correlation analysis of the optical and AGILE data will shed light on the
expected relationship between these flares and the gamma-ray events.Comment: 5 pages, 5 figures, to be published in A&A (Letters); revised to
match the final version (changes in Fig. 5 and related text
Therapy of uncomplicated falciparum malaria in Europe: MALTHER - a prospective observational multicentre study
Comment on "On the subtleties of searching for dark matter with liquid xenon detectors"
In a recent manuscript (arXiv:1208.5046) Peter Sorensen claims that
XENON100's upper limits on spin-independent WIMP-nucleon cross sections for
WIMP masses below 10 GeV "may be understated by one order of magnitude or
more". Having performed a similar, though more detailed analysis prior to the
submission of our new result (arXiv:1207.5988), we do not confirm these
findings. We point out the rationale for not considering the described effect
in our final analysis and list several potential problems with his study.Comment: 3 pages, no figure
Lowering the radioactivity of the photomultiplier tubes for the XENON1T dark matter experiment
The low-background, VUV-sensitive 3-inch diameter photomultiplier tube R11410
has been developed by Hamamatsu for dark matter direct detection experiments
using liquid xenon as the target material. We present the results from the
joint effort between the XENON collaboration and the Hamamatsu company to
produce a highly radio-pure photosensor (version R11410-21) for the XENON1T
dark matter experiment. After introducing the photosensor and its components,
we show the methods and results of the radioactive contamination measurements
of the individual materials employed in the photomultiplier production. We then
discuss the adopted strategies to reduce the radioactivity of the various PMT
versions. Finally, we detail the results from screening 216 tubes with
ultra-low background germanium detectors, as well as their implications for the
expected electronic and nuclear recoil background of the XENON1T experiment.Comment: 10 pages, 5 figure
Multiwavelength observations of 3C 454.3. III. Eighteen months of AGILE monitoring of the "Crazy Diamond"
We report on 18 months of multiwavelength observations of the blazar 3C 454.3
(Crazy Diamond) carried out in July 2007-January 2009. We show the results of
the AGILE campaigns which took place on May-June 2008, July-August 2008, and
October 2008-January 2009. During the May 2008-January 2009 period, the source
average flux was highly variable, from an average gamma-ray flux F(E>100MeV) >
200E-8 ph/cm2/s in May-June 2008, to F(E>100MeV)~80E-8 ph/cm2/s in October
2008-January 2009. The average gamma-ray spectrum between 100 MeV and 1 GeV can
be fit by a simple power law (Gamma_GRID ~ 2.0 to 2.2). Only 3-sigma upper
limits can be derived in the 20-60 keV energy band with Super-AGILE. During
July-August 2007 and May-June 2008, RXTE measured a flux of F(3-20 keV)=
8.4E-11 erg/cm2/s, and F(3-20 keV)=4.5E-11 erg/cm2/s, respectively and a
constant photon index Gamma_PCA=1.65. Swift/XRT observations were carried out
during all AGILE campaigns, obtaining a F(2-10 keV)=(0.9-7.5)E-11 erg/cm2/s and
a photon index Gamma_XRT=1.33-2.04. BAT measured an average flux of ~5 mCrab.
GASP-WEBT monitored 3C 454.3 during the whole 2007-2008 period from the radio
to the optical. A correlation analysis between the optical and the gamma-ray
fluxes shows a time lag of tau=-0.4 days. An analysis of 15 GHz and 43 GHz VLBI
core radio flux observations shows an increasing trend of the core radio flux,
anti- correlated with the higher frequency data. The modeling SEDs, and the
behavior of the long-term light curves in different energy bands, allow us to
compare the jet properties during different emission states, and to study the
geometrical properties of the jet on a time-span longer than one year.Comment: Accepted for publication in ApJ. Adapted Abstract. 17 pages, 19
Figures, 5 Table
A Long Baseline Neutrino Oscillation Experiment Using J-PARC Neutrino Beam and Hyper-Kamiokande
Document submitted to 18th J-PARC PAC meeting in May 2014. 50 pages, 41 figuresDocument submitted to 18th J-PARC PAC meeting in May 2014. 50 pages, 41 figuresDocument submitted to 18th J-PARC PAC meeting in May 2014. 50 pages, 41 figuresHyper-Kamiokande will be a next generation underground water Cherenkov detector with a total (fiducial) mass of 0.99 (0.56) million metric tons, approximately 20 (25) times larger than that of Super-Kamiokande. One of the main goals of Hyper-Kamiokande is the study of asymmetry in the lepton sector using accelerator neutrino and anti-neutrino beams. In this document, the physics potential of a long baseline neutrino experiment using the Hyper-Kamiokande detector and a neutrino beam from the J-PARC proton synchrotron is presented. The analysis has been updated from the previous Letter of Intent [K. Abe et al., arXiv:1109.3262 [hep-ex]], based on the experience gained from the ongoing T2K experiment. With a total exposure of 7.5 MW 10 sec integrated proton beam power (corresponding to protons on target with a 30 GeV proton beam) to a -degree off-axis neutrino beam produced by the J-PARC proton synchrotron, it is expected that the phase can be determined to better than 19 degrees for all possible values of , and violation can be established with a statistical significance of more than () for () of the parameter space
International Consortium for Health Outcomes Measurement (ICHOM): Standardized Patient-Centered Outcomes Measurement Set for Heart Failure Patients
Whereas multiple national, international, and trial registries for heart failure have been created, international standards for clinical assessment and outcome measurement do not currently exist. The working group's objective was to facilitate international comparison in heart failure care, using standardized parameters and meaningful patient-centered outcomes for research and quality of care assessments. The International Consortium for Health Outcomes Measurement recruited an international working group of clinical heart failure experts, researchers, and patient representatives to define a standard set of outcomes and risk-adjustment variables. This was designed to document, compare, and ultimately improve patient care outcomes in the heart failure population, with a focus on global feasibility and relevance. The working group employed a Delphi process, patient focus groups, online patient surveys, and multiple systematic publications searches. The process occurred over 10 months, employing 7 international teleconferences. A 17-item set has been established, addressing selected functional, psychosocial, burden of care, and survival outcome domains. These measures were designed to include all patients with heart failure, whether entered at first presentation or subsequent decompensation, excluding cardiogenic shock. Sources include clinician report, administrative data, and validated patient-reported outcome measurement tools: the Kansas City Cardiomyopathy Questionnaire; the Patient Health Questionnaire-2; and the Patient-Reported Outcomes Measurement Information System. Recommended data included those to support risk adjustment and benchmarking across providers and regions. The International Consortium for Health Outcomes Measurement developed a dataset designed to capture, compare, and improve care for heart failure, with feasibility and relevance for patients and clinicians worldwide
Identification of Radiopure Titanium for the LZ Dark Matter Experiment and Future Rare Event Searches
The LUX-ZEPLIN (LZ) experiment will search for dark matter particle
interactions with a detector containing a total of 10 tonnes of liquid xenon
within a double-vessel cryostat. The large mass and proximity of the cryostat
to the active detector volume demand the use of material with extremely low
intrinsic radioactivity. We report on the radioassay campaign conducted to
identify suitable metals, the determination of factors limiting radiopure
production, and the selection of titanium for construction of the LZ cryostat
and other detector components. This titanium has been measured with activities
of U~1.6~mBq/kg, U~0.09~mBq/kg,
Th~~mBq/kg, Th~~mBq/kg, K~0.54~mBq/kg, and Co~0.02~mBq/kg (68\% CL).
Such low intrinsic activities, which are some of the lowest ever reported for
titanium, enable its use for future dark matter and other rare event searches.
Monte Carlo simulations have been performed to assess the expected background
contribution from the LZ cryostat with this radioactivity. In 1,000 days of
WIMP search exposure of a 5.6-tonne fiducial mass, the cryostat will contribute
only a mean background of (stat)(sys) counts.Comment: 13 pages, 3 figures, accepted for publication in Astroparticle
Physic
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