115 research outputs found
Growth and Decay in Life-Like Cellular Automata
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 15/11/2009
- Field of study
We propose a four-way classification of two-dimensional semi-totalistic
cellular automata that is different than Wolfram's, based on two questions with
yes-or-no answers: do there exist patterns that eventually escape any finite
bounding box placed around them? And do there exist patterns that die out
completely? If both of these conditions are true, then a cellular automaton
rule is likely to support spaceships, small patterns that move and that form
the building blocks of many of the more complex patterns that are known for
Life. If one or both of these conditions is not true, then there may still be
phenomena of interest supported by the given cellular automaton rule, but we
will have to look harder for them. Although our classification is very crude,
we argue that it is more objective than Wolfram's (due to the greater ease of
determining a rigorous answer to these questions), more predictive (as we can
classify large groups of rules without observing them individually), and more
accurate in focusing attention on rules likely to support patterns with complex
behavior. We support these assertions by surveying a number of known cellular
automaton rules.Comment: 30 pages, 23 figure
Supermassive Binaries and Extragalactic Jets
- Author
- A. Alberdi
- A. Boksenberg
- A. Soltan
- A.M. Dumont
- A.P. Koratkar
- A.P. Koratkar
- A.R. Sandage
- A.R.S. Black
- A.V. Filippenko
- B. Reipurth
- B.J. Wills
- B.J. Wills
- B.J. Wills
- B.J. Wills
- B.M. Peterson
- C.M. Gaskell
- C.M. Gaskell
- C.M. Gaskell
- C.M. Gaskell
- C.M. Gaskell
- C.M. Gaskell
- C.M. Gaskell
- C.M. Gaskell
- D Maoz
- D. Alloin
- D. Golombek
- D. Lynden-Bell
- D.B. Shaffer
- D.E. Osterbrock
- D.E. Osterbrock
- D.E. Osterbrock
- D.E. Osterbrock
- D.M. Crenshaw
- D.P. Whitmire
- Duquennoy
- E. Perez
- E.I. Rosenblatt
- E.M. Burbidge
- E.R. Capriotti
- Eracleous
- F. Governato
- F.Z. Cheng
- G. Ghisellini
- G. Giuricin
- G. Giuricin
- G. Stirpe
- G. Stirpe
- G. Xu
- G. Zotti De
- G.J. Ferland
- G.K. Miley
- G.K. Miley
- G.R. Blumenthal
- G.W. Collins II
- H.C. Ford
- H.E. Smith
- H.K.C. Yee
- I. Wanders
- I. Wanders
- I. Wanders
- J. B. Oke
- J. Clavel
- J. Kormendy
- J. Kormendy
- J. Makino
- J.A. Baldwin
- J.B. Hutchings
- J.B. Hutchings
- J.E. Conway
- J.E. Conway
- J.E. Conway
- J.J. Lu
- J.L. Tonry
- J.M. Mazzarella
- J.M. Shuder
- J.M. Shuder
- J.P. Halpern
- J.P. Halpern
- J.S. Miller
- J.W. Sulentic
- J.W. Sulentic
- K. Chen
- K. Chen
- K. Korista
- K.S. Anderson
- Komberg
- L. Woltjer
- M. Eracleous
- M. Valtonen
- M.C. Begelman
- M.J. Disney
- M.S. Brotherton
- N. Roos
- N. Roos
- N. Roos
- P. Marziani
- P. Marziani
- R. Lynds
- R. Zamir
- R.D. Ekers
- R.H. Miller
- R.P. Norris
- R.R.J. Antonucci
- R.R.J. Antonucci
- R.W. Hunstead
- S. Collin
- S. Collin-Souffrin
- S. Veilleux
- S. Veilleux
- S.A. Grandi
- S.M. Simkin
- W. Kundt
- W. Kundt
- W. Kundt
- W. Wamsteker
- W. Zheng
- W. Zheng
- W. Zheng
- W.C. Keel
- W.C. Keel
- W.C. Saslaw
- W.G. Mathews
- W.G. Mathews
- W.G. Mathews
- W.G. Mathews
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1996
- Field of study
Some quasars show Doppler shifted broad emission line peaks. I give new
statistics of the occurrence of these peaks and show that, while the most
spectacular cases are in quasars with strong radio jets inclined to the line of
sight, they are also almost as common in radio-quiet quasars. Theories of the
origin of the peaks are reviewed and it is argued that the displaced peaks are
most likely produced by the supermassive binary model. The separations of the
peaks in the 3C 390.3-type objects are consistent with orientation-dependent
"unified models" of quasar activity. If the supermassive binary model is
correct, all members of "the jet set" (astrophysical objects showing jets)
could be binaries.Comment: 31 pages, PostScript, missing figure is in ApJ 464, L105 (see
http://www.aas.org/ApJ/v464n2/5736/5736.html
Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits
- Author
- A de Jong
- A Radaelli
- AK Ghosh
- Antonia Radaelli
- B Acres
- C Zanotto
- Carlo De Giuli Morghen
- Carlo Zanotto
- CF Hung
- CH Chen
- D Baxby
- DM Harper
- E Georges
- E Pozzi
- E Pozzi
- EJ Davidson
- Eleana Pozzi
- FUTURE II Study Group
- G Meneguzzi
- GL Eiben
- J Taylor
- J Taylor
- J Zhou
- JB Hudson
- JB Johnston
- JL Brandsma
- K Butz
- K Münger
- K Schäfer
- KU Jansen
- L Chen
- L Gissmann
- L Gissmann
- L Rambout
- LA Koutsky
- LA Koutsky
- LJ Smyth
- LK Borysiewicz
- M Adams
- M Thomas
- MA Skinner
- MS Campo
- MS Campo
- N Hafner
- ND Christensen
- ND Christensen
- O Picard
- P Di Bonito
- P Hawley-Nelson
- PJ Baldwin
- R Hildesheim
- RA DeFilippis
- RA Moore
- S Duensing
- S Kanodia
- S Massa
- S Zwaveling
- SA Leachman
- SH van der Burg
- Sole Pacchioni
- SP Wilczynski
- T Ristriani
- TJ Blanchard
- TW Tobery
- W Meschede
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
Background: Around half million new cases of cervical cancer arise each year, making the development of an effective therapeutic vaccine against HPV a high priority. As the E6 and E7 oncoproteins are expressed in all HPV-16 tumour cells, vaccines expressing these proteins might clear an already established tumour and support the treatment of HPV-related precancerous lesions.
Methods: Three different immunisation regimens were tested in a pre-clinical trial in rabbits to evaluate the humoral and cell-mediated responses of a putative HPV-16 vaccine. Fowlpoxvirus (FP) recombinants separately expressing the HPV-16 E6 (FPE6) and E7 (FPE7) transgenes were used for priming, followed by E7 protein boosting.
Results: All of the protocols were effective in eliciting a high antibody response. This was also confirmed by interleukin-4 production, which increased after simultaneous priming with both FPE6 and FPE7 and after E7 protein boost. A cell-mediated immune response was also detected in most of the animals.
Conclusion: These results establish a preliminary profile for the therapy with the combined use of avipox recombinants, which may represent safer immunogens than vaccinia-based vectors in immuno-compromised individuals, as they express the transgenes in most mammalian cells in the absence of a productive replication
Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma
- Author
- A Giangreco
- A Jemal
- A Saxena
- A Woiwode
- Adi F. Gazdar
- AH Bild
- AJ Bass
- Ariane C. Williams
- AS Ishkanian
- B Chi
- B Chi
- BA Weir
- BP Coe
- Bradley P. Coe
- C Baldwin
- C Garnis
- C Guerra
- C Luk
- Calum MacAulay
- Cathie Garnis
- Chad A. Malloff
- Chang-Qi Zhu
- CJ Murray
- CM Croce
- DA Rew
- DG Albertson
- DM Parkin
- Dorothy Hwang
- G Dieci
- G Scagliotti
- G Tonon
- GH Fisher
- H Tanaka
- HS Kim
- J Kendall
- J Sambrook
- Jennifer Campbell
- John C. English
- John D. Minna
- John Yee
- K Jong
- KA Kwei
- Kelsie L. Thu
- L Johnson
- L Marshall
- L Schramm
- L Schramm
- LA Garraway
- LA Garraway
- M Khojasteh
- M Sato
- M Sato
- Ming-Sound Tsao
- N Gomez-Roman
- NA Faustino
- P Cabart
- R Chari
- R Meuwissen
- Raj Chari
- RD Ramirez
- RJ White
- RJ White
- RS Herbst
- RW Henry
- S Cabarcas
- S Perner
- SA Johnson
- SE Butcher
- SJ Goodfellow
- SK Watson
- SM Sy
- Stephen Lam
- Timon P. H. Buys
- VG Tusher
- Wan L. Lam
- WD Travis
- William Pao
- William W. Lockwood
- Wistuba II
- WW Lockwood
- WW Lockwood
- X Zhao
- ZA Felton-Edkins
- Publication venue
- Public Library of Science
- Publication date
- 01/07/2010
- Field of study
William Lockwood and colleagues show that the focal amplification of a gene, BRF2, on Chromosome 8p12 plays a key role in squamous cell carcinoma of the lung
Epigenetics and airways disease
- Author
- A Barton
- A Bird
- A Kumar
- A Petronis
- A Suzuki
- A You
- AE Ehrenhofer-Murray
- AJ Bannister
- AJ de Ruijter
- AP Feinberg
- AR Karpf
- AS Hutchins
- ASJ Baldwin
- BD Jenkins
- BG Cosio
- BG Cosio
- BP Ashburner
- BR Migeon
- C Napoli
- C Tufarelli
- CL Peterson
- CL Peterson
- D Loppow
- D Takai
- D Ukena
- D Vercelli
- DB Seligson
- DJ Evans
- DR Pilch
- DS Stevenson
- DY Lee
- E Metzger
- E Vire
- EH Bayne
- ER Vossenaar
- F Chedin
- F Song
- FD Urnov
- G Egger
- G Zardo
- GL Cuthbert
- GM Vidanes
- GP Holmquist
- GW Chalmers
- H Tagami
- H Zhong
- I Fernandes
- I Retamales
- I Wilmut
- II Ouspenski
- IM Adcock
- J Bender
- J Wen
- JA Marwick
- JC Eissenberg
- JC Hogg
- JC Hogg
- JC Rice
- JE Brownell
- JG Herman
- K Ito
- K Ito
- K Ito
- K Ito
- K Ito
- K Ito
- K Ito
- K Katsoulis
- K Okamoto
- K Tomita
- K Yamada
- KD Robertson
- KY Lee
- L Chen
- L Gao
- L Hart
- L Yan
- L Zhou
- M Freitag
- M Ito
- M Johnson
- M Karin
- M Nie
- M Okano
- M Porcu
- M Saraiva
- MG Goll
- MG Pray-Grant
- MG Rosenfeld
- MJ Carrozza
- MW Covert
- N Kunert
- N Sengupta
- O Moradei
- P Byvoet
- P Cheung
- P Jeppesen
- P Viatour
- PA Jones
- PA Marks
- PJ Barnes
- PJ Barnes
- PJ Barnes
- PJ Rugg-Gunn
- PL Jones
- Q Feng
- R Chaudhuri
- R Holliday
- R Jaenisch
- R Marmorstein
- R Metivier
- S Ghosh
- S Henikoff
- S Lim
- S Ogawa
- S Rea
- S Santangelo
- S Zochbauer-Muller
- S Zochbauer-Muller
- S Zochbauer-Muller
- SA Belinsky
- SA Kharitonov
- SH Baek
- SI Grewal
- SL Werner
- SV Culpitt
- SY Roth
- T Chen
- T Hirota
- T Jenuwein
- T Lechner
- TA McKinsey
- TA McKinsey
- TH Leung
- V Macek
- VG Allfrey
- VM Keatings
- VV Ogryzko
- VV Ogryzko
- W An
- W Fischle
- W Fischle
- W Fischle
- XJ Yang
- XJ Yang
- Y Fan
- Y Higashimoto
- Y Huyen
- Y Ohmori
- Y Shi
- Y Zhang
- Y Zhang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2006
- Field of study
Epigenetics is the term used to describe heritable changes in gene expression that are not coded in the DNA sequence itself but by post-translational modifications in DNA and histone proteins. These modifications include histone acetylation, methylation, ubiquitination, sumoylation and phosphorylation. Epigenetic regulation is not only critical for generating diversity of cell types during mammalian development, but it is also important for maintaining the stability and integrity of the expression profiles of different cell types. Until recently, the study of human disease has focused on genetic mechanisms rather than on non-coding events. However, it is becoming increasingly clear that disruption of epigenetic processes can lead to several major pathologies, including cancer, syndromes involving chromosomal instabilities, and mental retardation. Furthermore, the expression and activity of enzymes that regulate these epigenetic modifications have been reported to be abnormal in the airways of patients with respiratory disease. The development of new diagnostic tools might reveal other diseases that are caused by epigenetic alterations. These changes, despite being heritable and stably maintained, are also potentially reversible and there is scope for the development of 'epigenetic therapies' for disease
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
- Bates S
- Batista HD
- Bauchmuller K
- Bauer M
- Baumgarten G
- Baxter L
- Beaton C
- Beattie S
- Beavis V
- Bechan S
- Bejia T
- Belciu I
- Belda MT
- Bell G
- Bell R
- Bell S
- Bellandi M
- Bello J
- Beloeil H
- Belskiy V
- Ben-Menachem E
- Benavent P
- Benevento A
- Bengeri S
- Bennett C
- Bennett M
- Bennett R
- Bennett V
- Bentley C
- Beretta L
- Berg A
- Bergin C
- Bernard A
- Berntsen E
- Bertram W
- Bester D
- Bester M
- Bettega F
- Bettinelli A
- Bhardwaj N
- Bhatia K
- Bhula C
- Bi Y
- Biais M
- Biccard BM
- Bidd H
- Bidgoli J
- Biffen A
- Bignami E
- Bilolikar A
- Bin Mustapha MT
- Birch J
- Bishop DG
- Biyase T
- Bizios C
- Blackwell C
- Blackwood D
- Blaj M
- Blakemore SP
- Bland M
- Blunt M
- Blyth K
- Bocchino S
- Bodansky D
- Bodger P
- Boer C
- Boereboom C
- Boggiano V
- Bogner G
- Bolaji B
- Bolton D
- Boone M
- Boschi L
- Boshier P
- Botes M
- Botis I
- Bottini C
- Bottrill F
- Bouchez S
- Boulton K
- Bouris V
- Bourner L
- Boutsikos G
- Bouwman A
- Bouwman RA
- Bowrey S
- Boxall L
- Boyd C
- Bradburn M
- Bradley J
- Branagan G
- Branco T
- Brand B
- Brandsborg B
- Breitenstein S
- Brennan A
- Brennan E
- Brenner L
- Brincat M
- Briscoe R
- Bristogiannis S
- Brooke J
- Brookes J
- Brookes M
- Brooks C
- Broomby R
- Brotto AF
- Brown A
- Brown CW
- Brown G
- Brown J
- Brown J
- Brown L
- Brown R
- Brown R
- Browning J
- Bruma D
- Brunete T
- Brunswicker A
- Bryant H
- Bua E
- Buccimazza I
- Buckley S
- Buerkle C
- Buhre W
- Buhre W
- Buhrer T
- Builu PM
- Buise M
- Bullock C
- Bunwarie B
- Burns K
- Burrows L
- Burrows T
- Burston B
- Burtenshaw A
- Burton M
- Busuioc M
- Butryn I
- Butt G
- Byrne K
- Cabezuelo E
- Cabral R
- Cabral TDN
- Cabrini L
- Cacala S
- Cai F
- Cai Y
- Cain H
- Cairns C
- Cakova V
- Calderwood C
- Callaghan M
- Campbell D
- Campbell D
- Campbell D
- Campbell G
- Campbell G
- Campbell K
- Campbell M
- Campbell T
- Campey L
- Camsooksai J
- Cancho D
- Candido K
- Cang J
- Cannavo M
- Cao J
- Cao Y
- Cao Z
- Cardellino S
- Cardosa J
- Cardoso G
- Cardy J
- Carmino L
- Carp CP
- Carr A
- Carrera R
- Carroll C
- Carroll J
- Caser E
- Castano Moreira B
- Castano B
- Castle G
- Cavanagh S
- Cawthorn L
- Cernea DD
- Chaddock M
- Chaloulis P
- Chan A
- Chan HMH
- Chan M
- Chan P
- Chan V
- Chan WK
- Chan WKJ
- Chan YL
- Chande S
- Chandler B
- Chandra S
- Chandrasekharan S
- Chang YH
- Chaniotaki F
- Charitos E
- Charlalampidoy A
- Charles R
- Chatterjee D
- Chatterjee J
- Chatzimichali CA
- Chau S
- Chazova E
- Cheah C
- Cheah S
- Cheeseman M
- Cheing Y
- Chen C
- Chen C
- Chen F
- Chen F
- Chen H
- Chen J
- Chen J
- Chen L
- Chen L
- Chen L-L
- Chen P
- Chen Q
- Chen R
- Chen S
- Chen S
- Chen S
- Chen Y
- Chen Y
- Chen Y
- Chen Y
- Chen Z
- Cheng B
- Cheng KH
- Cheng Z
- Cheong E
- Cherian R
- Cherrett V
- Chetty RR
- Chew M
- Chhabra A
- Chicken D-W
- Chilinciuc I
- Chin II
- Chirkut S
- Chisbert Cuenca V
- Chlorou D
- Choi H-MD
- Choi S
- Chow L
- Christian R
- Christiansen IC
- Christmas N
- Christodoulidis G
- Christodoulopoulou T
- Christofaki M
- Christoforidis D
- Chronis C
- Chu HM
- Chu S
- Chua P
- Chukkambotla S
- Chung CKE
- Cifra E
- Ciobanu C
- Ciobotaru OR
- Cirstea E
- Clark R
- Clarkson A
- Clarkson R
- Claxton A
- Clemmons K
- Cloro LM
- Clyde A
- Cobzaru I
- Codita A
- Colangelo A
- Colangelo C
- Colling K
- Collins H
- Collins M
- Collins N
- Colvin C
- Commey T
- Comptaer N
- Conde C
- Conradie A
- Constantin K
- Cook T
- Cooper L
- Cooper L
- Cooper M
- Cooper R
- Cooper S
- Copaciu E
- Cope J
- Copetti E
- Copley E
- Copotoiu SM
- Coppens M
- Corneci D
- Cornell J
- Cornish J
- Correia da Silva RFM
- Corti D
- Costanzo E
- Costelloe H
- Cotter R
- Cotterell S
- Cotterill D
- Coughlan E
- Coulter I
- Coulter S
- Coutinho F
- Cowton A
- Cox H
- Cozar OI
- Craig J
- Craven R
- Craw N
- Craw S
- Creary T
- Cripps H
- Critchley R
- Cronje L
- Cruickshank R
- Cruikshanks A
- Cruz S
- Cueva A
- Cunha P
- Curley G
- Currow H
- Czepanski C
- Czeslick E
- D'Andrea R
- da Costa Fischer BF
- Dafnios N
- Dai H
- Dai Q
- Dai Q
- Dai SY
- Daikou P
- Dalamagka M
- Dalampini E
- Dali-Kemmery L
- Dalton E
- Damant R
- Daniel C
- Daniel GD
- Daniel H
- Daniel H
- Daniel S
- Dankl D
- Darko J
- Darwish S
- Das S
- Dasrath A
- Datson A
- Daubeny T
- Daugaard M
- Davari M
- Dave T
- Davies C
- Davies H
- Davies K
- Davies K
- Davies L
- Davies Z
- Davis E
- Davis F
- Davis S
- Daya B
- De Andres Ibanez JA
- de Araujo DM
- De Baerdemaeker L
- de Beer J
- de Boer HD
- De Bruyne A
- de Campos Ferreira MF
- de Fretes J
- de Gasperi J
- De Hert S
- De Jongh K
- De Kegel D
- De Meyer JN
- De Oliveira MC
- de Rudnicki S
- de Swardt M
- de Vasconcellos K
- de Villiers M
- de Wet J
- Deacon M
- Deblaere I
- Dedemadi G
- Deen T
- Deepak S
- Deighton K
- Deja M
- Delgado Garcia DR
- Delgado Navarro C
- Della Rocca G
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- Xue R
- Yagnik A
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- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
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- Yuan D
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- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
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- Zhang H
- Zhang H
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- Zhang Q
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- Zhang Y
- Zhang Y
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- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
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- Zhao W
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- Zheng L
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- Zhong Y
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- Zhou H
- Zhou H
- Zhou J
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- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Unilateral inguinofemoral lymphadenectomy in patients with early-stage vulvar squamous cell carcinoma and a unilateral metastatic sentinel lymph node is safe.
- Author
- all GROINSS-V I and II participants
- Baldwin PJW
- Boll D
- Brännström M
- Cibula D
- Coleman R
- Covens A
- De Hullu JA
- DiSilvestro PA
- Gaarenstroom KN
- Holland CM
- Kjolhede P
- Mannel RS
- Monk BJ
- Nugent D
- Nunns D
- Oonk MHM
- Provencher D
- Runnebaum IB
- Slangen BFM
- Slomovitz BM
- Tamussino K
- Tjiong MY
- Van der Kolk WL
- Van der Velden J
- Van der Zee AGJ
- Van Doorn HC
- Van Dorst EBL
- Van Driel WJ
- Vergote I
- Widschwendter M
- Zanagnolo V
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
OBJECTIVE: Optimal management of the contralateral groin in patients with early-stage vulvar squamous cell carcinoma (VSCC) and a metastatic unilateral inguinal sentinel lymph node (SN) is unclear. We analyzed patients who participated in GROINSS-V I or II to determine whether treatment of the contralateral groin can safely be omitted in patients with a unilateral metastatic SN. METHODS: We selected the patients with a unilateral metastatic SN from the GROINSS-V I and II databases. We determined the incidence of contralateral additional non-SN metastases in patients with unilateral SN-metastasis who underwent bilateral inguinofemoral lymphadenectomy (IFL). In those who underwent only ipsilateral groin treatment or no further treatment, we determined the incidence of contralateral groin recurrences during follow-up. RESULTS: Of 1912 patients with early-stage VSCC, 366 had a unilateral metastatic SN. Subsequently, 244 had an IFL or no treatment of the contralateral groin. In seven patients (7/244; 2.9% [95% CI: 1.4%-5.8%]) disease was diagnosed in the contralateral groin: five had contralateral non-SN metastasis at IFL and two developed an isolated contralateral groin recurrence after no further treatment. Five of them had a primary tumor ≥30 mm. Bilateral radiotherapy was administered in 122 patients, of whom one (1/122; 0.8% [95% CI: 0.1%-4.5%]) had a contralateral groin recurrence. CONCLUSION: The risk of contralateral lymph node metastases in patients with early-stage VSCC and a unilateral metastatic SN is low. It appears safe to limit groin treatment to unilateral IFL or inguinofemoral radiotherapy in these cases
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L Barabási
- AA Andreadis
- AA Borisy
- AA Farooqui
- AA Qutub
- AA Qutub
- AA Vlessis
- AB Nathens
- AB Parsons
- AB Parsons
- AB Thompson
- AB Thomson
- AC Bayne
- AC Bharti
- AC Cave
- AC Mello Filho
- AD d'Hardemare
- AD de Silva
- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
- AE Aust
- AE Baue
- AE Finefrock
- AE Heazell
- AE Heazell
- AE Kartikasari
- AEC Ihekwaba
- AEC Ihekwaba
- AF Tramontano
- AH Berg
- AH Koeppen
- AH Koeppen
- AH Tong
- AI Bush
- AI Bush
- AI Bush
- AI Bush
- AI Faden
- AJ Ghio
- AJ Ghio
- AJ Ghio
- AJ Hulbert
- AJ Kowaltowski
- AJ Lusis
- AJ Matthews
- AJ Reyes
- AJ van Oostrom
- AJ Watson
- AJ White
- AJ Williams
- AK Junk
- AL Beal
- AL Hemdahl
- AL Hopkins
- AL Hopkins
- AL Lagan
- AL Mark
- AL Sirén
- AL Sirén
- AL Sirén
- AL Takeda
- AM Abeles
- AM Borzychowski
- AM Choi
- AM Dolga
- AM Elneihoum
- AM Elneihoum
- AM Feist
- AM Harvey
- AM Jenkinson
- AM Lin
- AM Samuni
- AM Snyder
- AN Crowson
- AN Tabah
- AP Bolger
- AP Breen
- AP Liappis
- AR Kallianpur
- AR Kallianpur
- AR Martin
- AR Ness
- AR Rechner
- AR Rumbold
- AS Baldwin Jr
- AS Binbrek
- AS Kaprelyants
- AS Wierzbicki
- AT McKie
- AV Lebedev
- AV Perkins
- AV Rao
- AW Maresso
- AY Andreyev
- AY Sun
- B Chakravarti
- B Chance
- B Cronin
- B de Valk
- B De Vries
- B Desoize
- B Drayer
- B Faller
- B Goodell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Huppertz
- B Jayawardhana
- B Kwak
- B Lachili
- B Lipinski
- B Mackenzie
- B Marshall
- B Mignotte
- B Oldenburg
- B Poeggeler
- B Pradines
- B Pradines
- B Regland
- B Russell
- B Schiessl
- B Shipley
- B Skibska
- B Sturm
- B Thorand
- B Wang
- B Wolff
- B Wolozin
- B Wolozin
- B Xu
- B Zhang
- B Zhou
- BA Maddux
- BA Molitoris
- BB Aggarwal
- BB Aggarwal
- BB Aggarwal
- BB Aggarwal
- BB Sizoo
- BB Song
- BB Song
- BC Daniels
- BC Jones
- BD LaMarca
- BH Havsteen
- BI Giasson
- BI Hoffman
- BJ Marshall
- BK Kennedy
- BK Rinehart
- BK Wagner
- BL Halvorsen
- BL Zhao
- BM Babior
- BN Ames
- BP Leung
- BP Oberg
- BP Yu
- BR Kwak
- BR Otto
- BS Chen
- BS van Asbeck
- BT Mossman
- BV Naidu
- BY Tung
- BØ Palsson
- C Arnaud
- C Beaumont
- C Behl
- C Biondi
- C Bolin
- C Bozzini
- C Breymann
- C Brooksbank
- C Bubici
- C Bubici
- C Burdon
- C Camaschella
- C Camaschella
- C Caris
- C Cavdar
- C Chen
- C Delaby
- C Demougeot
- C Finch
- C Fleury
- C García-Ruiz
- C Gasche
- C Gasche
- C Gerhäuser
- C Goble
- C Henry
- C Herce-Pagliai
- C Herder
- C Hershko
- C Hershko
- C Hershko
- C Hershko
- C Jacob
- C Kenyon
- C Knox
- C Kretz-Remy
- C Kunsch
- C Köhle
- C Leadbeater
- C Li
- C Lu
- C Manach
- C Manach
- C Manach
- C Mancuso
- C Moon
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- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
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- Bao Weidong
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- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
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- Bemrose Richard
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- BenKahla Alia
- Benke J
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- Beugelsdijk Tony J.
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- Buckingham Judith M.
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- McLean James
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- McLeod Michael P.
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- McMurray Amanda
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- Mungall Andy
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- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
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- Zhou Xingyu
- Zhou Yingyuan
- Zhu Wangqin
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- Zoghbi J
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
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