203 research outputs found
VLT spectroscopy of NGC 3115 globular clusters
We present results derived from VLT-FORS2 spectra of 24 different globular clusters associated with the lenticular galaxy NGC 3115. A subsample of 17 globular clusters have sufficiently high signal-to-noise to allow precision measurements of absorption line-strengths. Comparing these indices to new stellar population models by Thomas et al. we determine ages, metallicities and element abundance ratios. For the first time these stellar population models explicitly take abundance ratio biases in the Lick/IDS stellar library into account. Our data are also compared with the Lick/IDS observations of Milky Way and M 31 globular clusters. Unpublished higher order Balmer lines (HgammaA ,F and HdeltaA ,F) from the Lick/IDS observations are given in the Appendix. Our best age estimates show that the observed clusters which sample the bimodal colour distribution of NGC 3115 are coeval within our observational errors (2-3 Gyr). Our best calibrated age/metallicity diagnostic diagram (Hbeta / vs. [MgFe]) indicates an absolute age of 11-12 Gyr consistent with the luminosity weighted age for the central part of NGC 3115. We confirm with our accurate line-strength measurements that the (V-I) colour is a good metallicity indicator within the probed metallicity range (-1.5 < [Fe/H] < 0.0). The abundance ratios for globular clusters in NGC 3115 give an inhomogeneous picture. We find a range from solar to super-solar ratios for both blue and red clusters. This is similar to the data for M 31 while the Milky Way seems to harbour clusters which are mainly consistent with [alpha / Fe] =~ 0.3. From our accurate recession velocities we detect, independent of metallicity, clear rotation in the sample of globular clusters. In order to explain the metallicity and abundance ratio pattern, particularly the range in abundance ratios for the metal rich globular clusters in NGC 3115, we favour a formation picture with more than two distinct formation episodes. Based on observations collected at the European Southern Observatory, Cerro Paranal, Chile (ESO No. 66.B-0131)
Dynamical symmetry breaking in a 2D electron gas with a spectral node
We study a disordered 2D electron gas with a spectral node in a vicinity of
the node. After identifying the fundamental dynamical symmetries of this
system, the spontaneous breaking of the latter by a Grassmann field is studied
within a nonlinear sigma model approach. This allows us to reduce the average
two-particle Green's function to a diffusion propagator with a random diffusion
coefficient. The latter has non-degenerate saddle points and is treated by the
conventional self-consistent Born approximation. This leads to a renormalized
chemical potential and a renormalized diffusion coefficient, where the DC
conductivity increases linearly with the density of quasiparticles. Applied to
the special case of Dirac fermions, our approach provides a comprehensive
description of the minimal conductivity at the Dirac node as well as for the
V-shape conductivity inside the bands.Comment: 13 pages, 4 figures, extended versio
Constraints on Dark Matter Annihilation in Clusters of Galaxies with the Fermi Large Area Telescope
Nearby clusters and groups of galaxies are potentially bright sources of
high-energy gamma-ray emission resulting from the pair-annihilation of dark
matter particles. However, no significant gamma-ray emission has been detected
so far from clusters in the first 11 months of observations with the Fermi
Large Area Telescope. We interpret this non-detection in terms of constraints
on dark matter particle properties. In particular for leptonic annihilation
final states and particle masses greater than ~200 GeV, gamma-ray emission from
inverse Compton scattering of CMB photons is expected to dominate the dark
matter annihilation signal from clusters, and our gamma-ray limits exclude
large regions of the parameter space that would give a good fit to the recent
anomalous Pamela and Fermi-LAT electron-positron measurements. We also present
constraints on the annihilation of more standard dark matter candidates, such
as the lightest neutralino of supersymmetric models. The constraints are
particularly strong when including the fact that clusters are known to contain
substructure at least on galaxy scales, increasing the expected gamma-ray flux
by a factor of ~5 over a smooth-halo assumption. We also explore the effect of
uncertainties in cluster dark matter density profiles, finding a systematic
uncertainty in the constraints of roughly a factor of two, but similar overall
conclusions. In this work, we focus on deriving limits on dark matter models; a
more general consideration of the Fermi-LAT data on clusters and clusters as
gamma-ray sources is forthcoming.Comment: accepted to JCAP, Corresponding authors: T.E. Jeltema and S. Profumo,
minor revisions to be consistent with accepted versio
GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma
Background: Aggressive primary brain tumors such as glioblastoma are uniquely challenging to treat. The intracranial location poses barriers to therapy, and the potential for severe toxicity. Effective treatments for primary brain tumors are limited, and 5-year survival rates remain poor. Immune checkpoint inhibitor therapy has transformed treatment of some other cancers but has yet to significantly benefit patients with glioblastoma. Early phase trials of chimeric antigen receptor (CAR) T-cell therapy in patients with glioblastoma have demonstrated that this approach is safe and feasible, but with limited evidence of its effectiveness. The choices of appropriate target antigens for CAR-T-cell therapy also remain limited. Methods We profiled an extensive biobank of patientsâ biopsy tissues and patient-derived early passage glioma neural stem cell lines for GD2 expression using immunomicroscopy and flow cytometry. We then employed an approved clinical manufacturing process to make CAR- T cells from patients with peripheral blood of glioblastoma and diffuse midline glioma and characterized their phenotype and function in vitro. Finally, we tested intravenously administered CAR-T cells in an aggressive intracranial xenograft model of glioblastoma and used multicolor flow cytometry, multicolor whole-tissue immunofluorescence and next-generation RNA sequencing to uncover markers associated with effective tumor control. Results: Here we show that the tumor-associated antigen GD2 is highly and consistently expressed in primary glioblastoma tissue removed at surgery. Moreover, despite patients with glioblastoma having perturbations in their immune system, highly functional GD2-specific CAR-T cells can be produced from their peripheral T cells using an approved clinical manufacturing process. Finally, after intravenous administration, GD2-CAR-T cells effectively infiltrated the brain and controlled tumor growth in an aggressive orthotopic xenograft model of glioblastoma. Tumor control was further improved using CAR-T cells manufactured with a clinical retroviral vector encoding an interleukin-15 transgene alongside the GD2-specific CAR. These CAR-T cells achieved a striking 50% complete response rate by bioluminescence imaging in established intracranial tumors. Conclusions: Targeting GD2 using a clinically deployed CAR-T-cell therapy has a sound scientific and clinical rationale as a treatment for glioblastoma and other aggressive primary brain tumors.Tessa Gargett, Lisa M Ebert, Nga T H Truong, Paris M Kollis, Kristyna Sedivakova, Wenbo Yu, Erica C F Yeo, Nicole L Wittwer, Briony L Gliddon, Melinda N Tea, Rebecca Ormsby, Santosh Poonnoose, Jake Nowicki, Orazio Vittorio, David S Ziegler, Stuart M Pitson, Michael P Brow
Measurement of the Tau Branching Fractions into Leptons
Using data collected with the L3 detector near the Z resonance, corresponding
to an integrated luminosity of 150pb-1, the branching fractions of the tau
lepton into electron and muon are measured to be
B(tau->e nu nu) = (17.806 +- 0.104 (stat.) +- 0.076 (syst.)) %,
B(tau->mu nu nu) = (17.342 +- 0.110 (stat.) +- 0.067 (syst.)) %.
From these results the ratio of the charged current coupling constants of the
muon and the electron is determined to be g_mu/g_e = 1.0007 +- 0.0051. Assuming
electron-muon universality, the Fermi constant is measured in tau lepton decays
as G_F = (1.1616 +- 0.0058) 10^{-5} GeV^{-2}. Furthermore, the coupling
constant of the strong interaction at the tau mass scale is obtained as
alpha_s(m_tau^2) = 0.322 +- 0.009 (exp.) +- 0.015 (theory)
Search for Neutral Higgs Bosons of the Minimal Supersymmetric Standard Model in e+e- Interactions at \sqrt{s} = 189 GeV
A search for the lightest neutral scalar and neutral pseudoscalar Higgs
bosons in the Minimal Supersymmetric Standard Model is performed using 176.4
pb^-1 of integrated luminosity collected by L3 at a center-of-mass energy of
189 GeV. No signal is observed, and the data are consistent with the expected
Standard Model background. Lower limits on the masses of the lightest neutral
scalar and pseudoscalar Higgs bosons are given as a function of tan(beta).
Lower mass limits for tan(beta)>1 are set at the 95% confidence level to be m_h
> 77.1 GeV and m_A > 77.1 GeV
Measurement of the Lifetime of the Tau Lepton
The tau lepton lifetime is measured with the L3 detector at LEP using the
complete data taken at centre-of-mass energies around the Z pole resulting in
tau_tau = 293.2 +/- 2.0 (stat) +/- 1.5 (syst) fs. The comparison of this result
with the muon lifetime supports lepton universality of the weak charged current
at the level of six per mille. Assuming lepton universality, the value of the
strong coupling constant, alpha_s is found to be alpha_s(m_tau^2) = 0.319 +/-
0.015(exp.) +/- 0.014 (theory)
Search for Extra Dimensions in Boson and Fermion Pair Production in e+e- Interactions at LEP
Extra spatial dimensions are proposed by recent theories that postulate the
scale of gravity to be of the same order as the electroweak scale. A sizeable
interaction between gravitons and Standard Model particles is then predicted.
Effects of these new interactions in boson and fermion pair production are
searched for in the data sample collected at centre-of-mass energies above the
Z pole by the L3 detector at LEP. In addition, the direct production of a
graviton associated with a Z boson is investigated. No statistically
significant hints for the existence of these effects are found and lower limits
in excess of 1 TeV are derived on the scale of this new theory of gravity
Measurement of the Probability of Gluon Splitting into Charmed Quarks in Hadronic Z Decays
We have measured the probability, n(g->cc~), of a gluon splitting into a
charm-quark pair using 1.7 million hadronic Z decays collected by the L3
detector. Two independent methods have been applied to events with a three-jet
topology. One method relies on tagging charmed hadrons by identifying a lepton
in the lowest energy jet. The other method uses a neural network based on
global event shape parameters. Combining both methods, we measure n(g->cc~)=
[2.45 +/- 0.29 +/- 0.53]%
Measurement of Triple-Gauge-Boson Couplings of the W Boson at LEP
We report on measurements of the triple-gauge-boson couplings of the W boson
in e+e- collisions with the L3 detector at LEP. W-pair, single-W and
single-photon events are analysed in a data sample corresponding to a total
luminosity of 76.7 pb^{-1} collected at centre-of-mass energies between 161 GeV
and 183 GeV. CP-conserving as well as both C- and P-conserving
triple-gauge-boson couplings are determined. The results, in good agreement
with the Standard-Model expectations, confirm the existence of the self
coupling among the electroweak gauge bosons and constrain its structure
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