Scalable data management in distributed information systems

[EN] In the era of cloud computing and huge information systems, distributed applications should manage dynamic workloads; i.e., the amount of client requests per time unit may vary frequently and servers should rapidly adapt their computing efforts to those workloads. Cloud systems provide a solid basis for this kind of applications but most of the traditional relational database systems are unprepared to scale up with this kind of distributed systems. This paper surveys different techniques being used in modern SQL, NoSQL and NewSQL systems in order to increase the scalability and adaptability in the management of persistent data. © 2011 Springer-Verlag.This work has been supported by EU FEDER and Spanish MICINN under research grants TIN2009-14460-C03-01 and TIN2010-17193Pallardó Lozoya, MR.; Esparza Peidro, J.; García Escriva, JR.; Decker, H.; Muñoz Escoí, FD. (2011). Scalable data management in distributed information systems. Lecture Notes in Computer Science. 7046:208-217. https://doi.org/10.1007/978-3-642-25126-9_31S2082177046Helland, P.: Life beyond distributed transactions: an apostate’s opinion. In: 3rd Biennial Conf. on Innov. Data Syst. Research (CIDR), Asilomar, CA, USA, pp. 132–141 (2007)Finkelstein, S., Jacobs, D., Brendle, R.: Principles for inconsistency. In: 4th Biennial Conf. on Innov. Data Syst. Research (CIDR), Asilomar, CA, USA (2009)Chang, F., Dean, J., Ghemawat, S., Hsieh, W.C., Wallach, D.A., Burrows, M., Chandra, T., Fikes, A., Gruber, R.: Bigtable: A distributed storage system for structured data. In: 7th Symp. on Operat. Syst. Design and Implem. (OSDI), pp. 205–218. USENIX Assoc., Seattle (2006)Cooper, B.F., Baldeschwieler, E., Fonseca, R., Kistler, J.J., Narayan, P.P.S., Neerdaels, C., Negrin, T., Ramakrishnan, R., Silberstein, A., Srivastava, U., Stata, R.: Building a cloud for Yahoo! IEEE Data Eng. 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Research (CIDR), Asilomar, CA, USA, pp. 1–8 (2011)Microsoft Corp.: Windows Azure: Microsoft’s cloud services platform (2011), http://www.microsoft.com/windowsazure/VoltDB, Inc.: VoltDB technical overview: Next generation open-source SQL database with ACID for fast-scaling OLTP applications (2010), Downloadable from: http://voltdb.com/_pdf/VoltDBTechnicalOverviewWhitePaper.pd

Consistency in scalable systems

[EN] While eventual consistency is the general consistency guarantee ensured in cloud environments, stronger guarantees are in fact achievable. We show how scalable and highly available systems can provide processor, causal, sequential and session consistency during normal functioning. Failures and network partitions negatively affect consistency and generate divergence. After the failure or the partition, reconciliation techniques allow the system to restore consistency.This work has been supported by EU FEDER and Spanish MICINN under research grants TIN2009-14460-C03-01 and TIN2010-17193.Ruiz Fuertes, MI.; Pallardó Lozoya, MR.; Muñoz-Escoí, FD. (2012). Consistency in scalable systems. En On the Move to Meaningful Internet Systems: OTM 2012. Springer Verlag (Germany). 7566:549-565. https://doi.org/10.1007/978-3-642-33615-7_7S5495657566Ahamad, M., Bazzi, R.A., John, R., Kohli, P., Neiger, G.: The power of processor consistency. 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ACM, New York (2010), http://doi.acm.org/10.1145/1807167.1807280Cholvi, V., Jiménez, E., Anta, A.F.: Interconnection of distributed memory models. J. Parallel Distrib. Comput. 69(3), 295–306 (2009)Cooper, B.F., Ramakrishnan, R., Srivastava, U., Silberstein, A., Bohannon, P., Jacobsen, H., Puz, N., Weaver, D., Yerneni, R.: PNUTS: Yahoo!’s hosted data serving platform. PVLDB 1(2), 1277–1288 (2008)Daudjee, K., Salem, K.: Lazy Database Replication with Ordering Guarantees. In: Proc. Int. Conf. Data Eng., pp. 424–435. IEEE-CS (2004)Daudjee, K., Salem, K.: Lazy Database Replication with Snapshot Isolation. In: Proc. Int. Conf. Very Large Data Bases, pp. 715–726. ACM (2006)DeCandia, G., Hastorun, D., Jampani, M., Kakulapati, G., Lakshman, A., Pilchin, A., Sivasubramanian, S., Vosshall, P., Vogels, W.: Dynamo: Amazon’s Highly Available Key-value Store. In: ACM Symp. Oper. Syst. Princ., pp. 205–220 (2007)Fernández, A., Jiménez, E., Cholvi, V.: On the interconnection of causal memory systems. 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Review of progress in Fast Ignition

Copyright 2005 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Physics of Plasmas, 12(5), 057305, 2005 and may be found at http://dx.doi.org/10.1063/1.187124

1923 - A.C.C Bible Lecture Week, Abilene Christian College

This is program for the 1923 Sixth Annual Bible Lecture Week at Abilene Christian College. Uploaded by Jackson Hager

Early carboniferous brachiopod faunas from the Baoshan block, west Yunnan, southwest China

38 brachiopod species in 27 genera and subgenera are described from the Yudong Formation in the Shidian-Baoshan area, west Yunnan, southwest China. New taxa include two new subgenera: Unispirifer (Septimispirifer) and Brachythyrina (Longathyrina), and seven new species: Eomarginifera yunnanensis, Marginatia cylindrica, Unispirifer (Unispirifer) xiangshanensis, Unispirifer (Septimispirifer) wafangjieensis, Brachythyrina (Brachythyrina) transversa, Brachythyrina (Longathyrina) baoshanensis, and Girtyella wafangjieensis. Based on the described material and constraints from associated coral and conodont faunas, the age of the brachiopod fauna from the Yudon Formation is considered late Tournaisian (Early Carboniferous), with a possibility extending into earlyViseacutean.<br /

Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1

High-risk mutations in several genes predispose to both colorectal cancer (CRC) and endometrial cancer (EC). We therefore hypothesised that some lower-risk genetic variants might also predispose to both CRC and EC. Using CRC and EC genome-wide association series, totalling 13,265 cancer cases and 40,245 controls, we found that the protective allele [G] at one previously-identified CRC polymorphism, rs2736100 near TERT, was associated with EC risk (odds ratio (OR) = 1.08, P = 0.000167); this polymorphism influences the risk of several other cancers. A further CRC polymorphism near TERC also showed evidence of association with EC (OR = 0.92; P = 0.03). Overall, however, there was no good evidence that the set of CRC polymorphisms was associated with EC risk, and neither of two previously-reported EC polymorphisms was associated with CRC risk. A combined analysis revealed one genome-wide significant polymorphism, rs3184504, on chromosome 12q24 (OR = 1.10, P = 7.23 × 10−9) with shared effects on CRC and EC risk. This polymorphism, a missense variant in the gene SH2B3, is also associated with haematological and autoimmune disorders, suggesting that it influences cancer risk through the immune response. Another polymorphism, rs12970291 near gene TSHZ1, was associated with both CRC and EC (OR = 1.26, P = 4.82 × 10−8), with the alleles showing opposite effects on the risks of the two cancers

Parental origin of sequence variants associated with complex diseases

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldEffects of susceptibility variants may depend on from which parent they are inherited. Although many associations between sequence variants and human traits have been discovered through genome-wide associations, the impact of parental origin has largely been ignored. Here we show that for 38,167 Icelanders genotyped using single nucleotide polymorphism (SNP) chips, the parental origin of most alleles can be determined. For this we used a combination of genealogy and long-range phasing. We then focused on SNPs that associate with diseases and are within 500 kilobases of known imprinted genes. Seven independent SNP associations were examined. Five-one with breast cancer, one with basal-cell carcinoma and three with type 2 diabetes-have parental-origin-specific associations. These variants are located in two genomic regions, 11p15 and 7q32, each harbouring a cluster of imprinted genes. Furthermore, we observed a novel association between the SNP rs2334499 at 11p15 and type 2 diabetes. Here the allele that confers risk when paternally inherited is protective when maternally transmitted. We identified a differentially methylated CTCF-binding site at 11p15 and demonstrated correlation of rs2334499 with decreased methylation of that site.info:eu-repo/grantAgreement/EC/FP7/21807

Alterações nas reservas de sementes de Dalbergia nigra ((Vell.) Fr. All. ex Benth.) durante a hidratação

Seed imbibitions is the first stage of the germination process and is characterized by the hydration of tissues and cells and the activation and/or induction of the enzymes responsible for mobilizing reserves for respiration and the construction of new cell structures. The objective of this study was to investigate the alterations in reserve substances during slow hydration of Bahia Rosewood (Dalbergia nigra) seeds in water. Seeds from two different lots (Lot I and II) were placed in saturated desiccators (95-99% RH) to hydrate at 15 and 25 °C until water contents of 10, 15, 20 and 25% were reached. At each level of hydration, changes in lipid reserves, soluble carbohydrates, starch and soluble proteins were evaluated. The mobilization of reserves was similarly assessed in both lots, with no differences being observed between the two hydration temperatures. Lipid contents showed little variation during hydration, while the contents of soluble carbohydrates and starch decreased after the 15% water content level. Soluble proteins showed a gradual tendency to decrease between the control (dry seeds) up to 25% water content