24 research outputs found
Building the cosmic distance scale: from Hipparcos to Gaia
Hipparcos, the first ever experiment of global astrometry, was launched by
ESA in 1989 and its results published in 1997 (Perryman et al., Astron.
Astrophys. 323, L49, 1997; Perryman & ESA (eds), The Hipparcos and Tycho
catalogues, ESA SP-1200, 1997). A new reduction was later performed using an
improved satellite attitude reconstruction leading to an improved accuracy for
stars brighter than 9th magnitude (van Leeuwen & Fantino, Astron. Astrophys.
439, 791, 2005; van Leeuwen, Astron. Astrophys. 474, 653, 2007).
The Hipparcos Catalogue provided an extended dataset of very accurate
astrometric data (positions, trigonometric parallaxes and proper motions),
enlarging by two orders of magnitude the quantity and quality of distance
determinations and luminosity calibrations. The availability of more than 20000
stars with a trigonometric parallax known to better than 10% opened the way to
a drastic revision of our 3-D knowledge of the solar neighbourhood and to a
renewal of the calibration of many distance indicators and age estimations. The
prospects opened by Gaia, the next ESA cornerstone, planned for launch in June
2013 (Perryman et al., Astron. Astrophys. 369, 339, 2001), are still much more
dramatic: a billion objects with systematic and quasi simultaneous astrometric,
spectrophotometric and spectroscopic observations, about 150 million stars with
expected distances to better than 10%, all over the Galaxy. All stellar
distance indicators, in very large numbers, will be directly measured,
providing a direct calibration of their luminosity and making possible detailed
studies of the impacts of various effects linked to chemical element
abundances, age or cluster membership. With the help of simulations of the data
expected from Gaia, obtained from the mission simulator developed by DPAC, we
will illustrate what Gaia can provide with some selected examples.Comment: 16 pages, 16 figures, Conference "The Fundamental Cosmic Distance
scale: State of the Art and the Gaia perspective, 3-6 May 2011, INAF,
Osservatorio Astronomico di Capodimonte, Naples. Accepted for publication in
Astrophysics & Space Scienc
A Model for the Development of the Rhizobial and Arbuscular Mycorrhizal Symbioses in Legumes and Its Use to Understand the Roles of Ethylene in the Establishment of these two Symbioses
We propose a model depicting the development of nodulation and arbuscular mycorrhizae. Both processes are dissected into many steps, using Pisum sativum L. nodulation mutants as a guideline. For nodulation, we distinguish two main developmental programs, one epidermal and one cortical. Whereas Nod factors alone affect the cortical program, bacteria are required to trigger the epidermal events. We propose that the two programs of the rhizobial symbiosis evolved separately and that, over time, they came to function together. The distinction between these two programs does not exist for arbuscular mycorrhizae development despite events occurring in both root tissues. Mutations that affect both symbioses are restricted to the epidermal program. We propose here sites of action and potential roles for ethylene during the formation of the two symbioses with a specific hypothesis for nodule organogenesis. Assuming the epidermis does not make ethylene, the microsymbionts probably first encounter a regulatory level of ethylene at the epidermisâoutermost cortical cell layer interface. Depending on the hormone concentrations there, infection will either progress or be blocked. In the former case, ethylene affects the cortex cytoskeleton, allowing reorganization that facilitates infection; in the latter case, ethylene acts on several enzymes that interfere with infection thread growth, causing it to abort. Throughout this review, the difficulty of generalizing the roles of ethylene is emphasized and numerous examples are given to demonstrate the diversity that exists in plants
Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study
Introduction: Consensus criteria for pediatric severe sepsis have standardized enrollment for research studies. However, the extent to which critically ill children identified by consensus criteria reflect physician diagnosis of severe sepsis, which underlies external validity for pediatric sepsis research, is not known. We sought to determine the agreement between physician diagnosis and consensus criteria to identify pediatric patients with severe sepsis across a network of international pediatric intensive care units (PICUs). Methods: We conducted a point prevalence study involving 128 PICUs in 26 countries across 6 continents. Over the course of 5 study days, 6925 PICU patients <18 years of age were screened, and 706 with severe sepsis defined either by physician diagnosis or on the basis of 2005 International Pediatric Sepsis Consensus Conference consensus criteria were enrolled. The primary endpoint was agreement of pediatric severe sepsis between physician diagnosis and consensus criteria as measured using Cohen's ?. Secondary endpoints included characteristics and clinical outcomes for patients identified using physician diagnosis versus consensus criteria. Results: Of the 706 patients, 301 (42.6 %) met both definitions. The inter-rater agreement (? ± SE) between physician diagnosis and consensus criteria was 0.57 ± 0.02. Of the 438 patients with a physician's diagnosis of severe sepsis, only 69 % (301 of 438) would have been eligible to participate in a clinical trial of pediatric severe sepsis that enrolled patients based on consensus criteria. Patients with physician-diagnosed severe sepsis who did not meet consensus criteria were younger and had lower severity of illness and lower PICU mortality than those meeting consensus criteria or both definitions. After controlling for age, severity of illness, number of comorbid conditions, and treatment in developed versus resource-limited regions, patients identified with severe sepsis by physician diagnosis alone or by consensus criteria alone did not have PICU mortality significantly different from that of patients identified by both physician diagnosis and consensus criteria. Conclusions: Physician diagnosis of pediatric severe sepsis achieved only moderate agreement with consensus criteria, with physicians diagnosing severe sepsis more broadly. Consequently, the results of a research study based on consensus criteria may have limited generalizability to nearly one-third of PICU patients diagnosed with severe sepsis
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFb signaling, p53 and beta-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy
The Nature of the Donor Stars in Ultra-Compact AM CVn Binaries
Contains fulltext :
36565.pdf (publisher's version ) (Closed access)We show the results of recent efforts to determine the nature of the donor stars in ultra-compact AM CVn binaries, with the goal of constraining their evolutionary history. We find that the systems in general appear to have hot, massive, semi-degenerate donor stars rather than cool, degenerate ones. We discuss the implications for the formation of AM CVn stars, and for their gravitational-wave signals in future space-borne detectors such as the Laser Interferometer Space Antenna (LISA)
Generalising unitary time evolution
In this third Quantum Interaction (QI) meeting it is time to examine our failures. One of the weakest elements of QI as a field, arises in its continuing lack of models displaying proper evolutionary dynamics. This paper presents an overview of the modern generalised approach to the derivation of time evolution equations in physics, showing how the notion of symmetry is essential to the extraction of operators in quantum theory. The form that symmetry might take in non-physical models is explored, with a number of viable avenues identified
Distribution of contourite drifts on convergent margins: Examples from the Hikurangi subduction margin of New Zealand
Contourite drift systems form a significant component of the marine clastic sedimentary record. Although contourites form in all tectonic settings, few studies have described their development along convergent margins; such characterization is needed to underpin oceanographic and palaeoenvironmental studies in active settings. This study is the first to document contourite drift development along the Hikurangi subduction margin of New Zealand. Integration of bathymetric, seismic and well data enables five classes of drift to be recognized around the subduction wedge, occurring in three principal associations: (i) an upper slope drift association of giant elongate mounded (ca 150 km long, 50 km wide and up to 1100 m thick) and plastered drifts (ca 300 km long, 8 km wide and <600 m thick), which occurs upon and inboard of a major intrabasinal thrustâcored high, whose long axis parallels the coast; shallow bottom currents disperse subâparallel to this axis; (ii) a spatiotemporally discontinuous association of confined and mounded hybrid drifts (ca 500 m long, <2 km wide and up to 500 m thick) that occurs along the midâtoâouter slope domain of the wedge, recording the interaction of alongâslope and downslope currents within trenchâslope basins; and (iii) a trench fill assemblage that implies the passage of abyssal bottom currents across a 40 km reach of the trenchâaxial Hikurangi ChannelâlevĂ©e, with associated modification of the channel form and of overbank sediment waves. The fundamental presence of contourites along this margin appears to depend on the orientation and strength of oceanographic bottom currents. However, drift type and evolution vary depending on the slope gradient and the presence of irregular seafloor topography created by tectonic structures. The documented drifts are generally smaller, less continuous, and develop more intermittently than similar styles of drifts documented on passive margins; this mode of occurrence may be characteristic of contourite development on convergent margins