858 research outputs found
Scaling property of the critical hopping parameters for the Bose-Hubbard model
Recently precise results for the boundary between the Mott insulator phase
and the superfluid phase of the homogeneous Bose-Hubbard model have become
available for arbitrary integer filling factor g and any lattice dimension d >
1. We use these data for demonstrating that the critical hopping parameters
obey a scaling relationship which allows one to map results for different g
onto each other. Unexpectedly, the mean-field result captures the dependence of
the exact critical parameters on the filling factor almost fully. We also
present an approximation formula which describes the critical parameters for d
> 1 and any g with high accuracy.Comment: 5 pages, 5 figures. to appear in EPJ
Methods of recovery technical equipment of the city by using new trends
The article deals with the current state of technical equipment of the city, which today is generally in very poor condition. The article also discusses the current unsatisfactory conceptual and coordination solution of engineering network, there are described various reasons why accede to restore technical equipment of the city, and on this basis are described of the possibility of restoration of these buildings with the use of new trends in the field of engineering networ
Recommended from our members
Pattern formation on Ge by low energy ion beam erosion
Modification of nanoscale surface topography is inherent to low-energy ion beam erosion processes and is one of the most important fields of nanotechnology. In this report a comprehensive study of surface smoothing and self-organized pattern formation on Ge(100) by using different noble gases ion beam erosion is presented. The investigations focus on low ion energies ( 2000 eV) and include the entire range of ion incidence angles. It is found that for ions (Ne, Ar) with masses lower than the mass of the Ge target atoms, no pattern formation occurs and surface smoothing is observed for all angles of ion incidence. In contrast, for erosion with higher mass ions (Kr, Xe), ripple formation starts at incidence angles of about 65° depending on ion energy. At smaller incident angles surface smoothing occurs again. Investigations of the surface dynamics for specific ion incidence angles by changing the ion fluence over two orders of magnitude gives a clear evidence for coarsening and faceting of the surface pattern. Both observations indicate that gradient-dependent sputtering and reflection of primary ions play crucial role in the pattern evolution, just at the lowest accessible fluences. The results are discussed in relation to recently proposed redistributive or stress-induced models for pattern formation. In addition, it is argued that a large angular variation of the sputter yield and reflected primary ions can significantly contribute to pattern formation and evolution as nonlinear and non-local processes as supported by simulation of sputtering and ion reflection
Recommended from our members
Ripple coarsening on ion beam-eroded surfaces
Abstract: The temporal evolution of ripple pattern on Ge, Si, Al2O3, and SiO2 by low-energy ion beam erosion with Xe + ions is studied. The experiments focus on the ripple dynamics in a fluence range from 1.1 × 1017 cm-2 to 1.3 × 1019 cm-2 at ion incidence angles of 65° and 75° and ion energies of 600 and 1,200 eV. At low fluences a short-wavelength ripple structure emerges on the surface that is superimposed and later on dominated by long wavelength structures for increasing fluences. The coarsening of short wavelength ripples depends on the material system and angle of incidence. These observations are associated with the influence of reflected primary ions and gradient-dependent sputtering. The investigations reveal that coarsening of the pattern is a universal behavior for all investigated materials, just at the earliest accessible stage of surface evolution
Fractional photon-assisted tunneling in an optical superlattice: large contribution to particle transfer
Fractional photon-assisted tunneling is investigated both analytically and
numerically for few interacting ultra-cold atoms in the double-wells of an
optical superlattice. This can be realized experimentally by adding periodic
shaking to an existing experimental setup [Phys. Rev. Lett. 101, 090404
(2008)]. Photon-assisted tunneling is visible in the particle transfer between
the wells of the individual double wells. In order to understand the physics of
the photon-assisted tunneling, an effective model based on the rotating wave
approximation is introduced. The validity of this effective approach is tested
for wide parameter ranges which are accessible to experiments in double-well
lattices. The effective model goes well beyond previous perturbation theory
approaches and is useful to investigate in particular the fractional
photon-assisted tunneling resonances. Analytic results on the level of the
experimentally realizable two-particle quantum dynamics show very good
agreement with the numerical solution of the time-dependent Schr\"odinger
equation. Far from being a small effect, both the one-half-photon and the
one-third-photon resonance are shown to have large effects on the particle
transfer.Comment: 9 pages, 11 png-figure
High flux table-top soft X-ray source driven by sub-2-cycle, CEP stable, 1.85 μm 1 kHz pulses for carbon K-edge spectroscopy
We report on the first table-top high flux source of coherent soft X-ray radiation up to 400 eV, operating at 1 kHz. This source
covers the carbon K-edge with a beam brilliance of (4.3 ± 1.2) × 1015 photons/s/mm2/strad/10% bandwidth and a photon
flux of (1.9 ± 0.1) × 107 photons/s/1% bandwidth. We use this source to demonstrate table-top X-ray near edge fine structure
spectroscopy at the carbon K-edge of a polyimide foil and retrieve the specific absorption features corresponding to the
binding orbitals of the carbon atoms in the foil.Peer ReviewedPostprint (author's final draft
Case study for the assessment of the biogeophysical effects of a potential afforestation in Europe
BACKGROUND: A regional-scale sensitivity study has been carried out to investigate the climatic effects of forest cover change in Europe. Applying REMO (regional climate model of the Max Planck Institute for Meteorology), the projected temperature and precipitation tendencies have been analysed for summer, based on the results of the A2 IPCC-SRES emission scenario simulation. For the end of the 21st century it has been studied, whether the assumed forest cover increase could reduce the effects of the greenhouse gas concentration change.
RESULTS: Based on the simulation results, biogeophysical effects of the hypothetic potential afforestation may lead to cooler and moister conditions during summer in most parts of the temperate zone. The largest relative effects of forest cover increase can be expected in northern Germany, Poland and Ukraine, which is 15-20% of the climate change signal for temperature and more than 50% for precipitation. In northern Germany and France, potential afforestation may enhance the effects of emission change, resulting in more severe heavy precipitation events. The probability of dry days and warm temperature extremes would decrease.
CONCLUSIONS: Large contiguous forest blocks can have distinctive biogeophysical effect on the climate on regional and local scale. In certain regions of the temperate zone, climate change signal due to greenhouse gas emission can be reduced by afforestation due to the dominant evaporative cooling effect during summer. Results of this case study with a hypothetical land cover change can contribute to the assessment of the role of forests in adapting to climate change. Thus they can build an important basis of the future forest policy
Hierarchy and Feedback in the Evolution of the E. coli Transcription Network
The E.coli transcription network has an essentially feedforward structure,
with, however, abundant feedback at the level of self-regulations. Here, we
investigate how these properties emerged during evolution. An assessment of the
role of gene duplication based on protein domain architecture shows that (i)
transcriptional autoregulators have mostly arisen through duplication, while
(ii) the expected feedback loops stemming from their initial cross-regulation
are strongly selected against. This requires a divergent coevolution of the
transcription factor DNA-binding sites and their respective DNA cis-regulatory
regions. Moreover, we find that the network tends to grow by expansion of the
existing hierarchical layers of computation, rather than by addition of new
layers. We also argue that rewiring of regulatory links due to
mutation/selection of novel transcription factor/DNA binding interactions
appears not to significantly affect the network global hierarchy, and that
horizontally transferred genes are mainly added at the bottom, as new target
nodes. These findings highlight the important evolutionary roles of both
duplication and selective deletion of crosstalks between autoregulators in the
emergence of the hierarchical transcription network of E.coli.Comment: to appear in PNA
Sex-dependent influence of endogenous estrogen in pulmonary hypertension
Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models that display female susceptibility estrogens may play a causative role.
Objectives: To clarify the influence of endogenous estrogen and gender in PH and assess the therapeutic potential of a clinically available aromatase inhibitor.
Methods: We interrogated the effect of reduced endogenous estrogen in males and females using the aromatase inhibitor, anastrozole, in two models of PH; the hypoxic mouse and Sugen 5416/hypoxic rat. We also determined the effects of gender on pulmonary expression of aromatase in these models and in lungs from PAH patients.
Results: Anastrozole attenuated PH in both models studied, but only in females. To verify this effect was due to reduced estrogenic activity we confirmed that in hypoxic mice inhibition of estrogen receptor alpha also has a therapeutic effect specifically in females. Female rodent lung displays increased aromatase and decreased BMPR2 and Id1 expression compared to male. Anastrozole treatment reversed the impaired BMPR2 pathway in females. Increased aromatase expression was also detected in female human pulmonary artery smooth muscle cells compared to male.
Conclusions: The unique phenotype of female pulmonary arteries facilitates the therapeutic effects of anastrozole in experimental PH confirming a role for endogenous estrogen in the disease pathogenesis in females and suggests aromatase inhibitors may have therapeutic potential
A simple histone code opens many paths to epigenetics
Nucleosomes can be covalently modified by addition of various chemical groups on several of their exposed histone amino acids. These modifications are added and removed by enzymes (writers) and can be recognized by nucleosome-binding proteins (readers). Linking a reader domain and a writer domain that recognize and create the same modification state should allow nucleosomes in a particular modification state to recruit enzymes that create that modification state on nearby nucleosomes. This positive feedback has the potential to provide the alternative stable and heritable states required for epigenetic memory. However, analysis of simple histone codes involving interconversions between only two or three types of modified nucleosomes has revealed only a few circuit designs that allow heritable bistability. Here we show by computer simulations that a histone code involving alternative modifications at two histone positions, producing four modification states, combined with reader-writer proteins able to distinguish these states, allows for hundreds of different circuits capable of heritable bistability. These expanded possibilities result from multiple ways of generating two-step cooperativity in the positive feedback - through alternative pathways and an additional, novel cooperativity motif. Our analysis reveals other properties of such epigenetic circuits. They are most robust when the dominant nucleosome types are different at both modification positions and are not the type inserted after DNA replication. The dominant nucleosome types often recruit enzymes that create their own type or destroy the opposing type, but never catalyze their own destruction. The circuits appear to be evolutionary accessible; most circuits can be changed stepwise into almost any other circuit without losing heritable bistability. Thus, our analysis indicates that systems that utilize an expanded histone code have huge potential for generating stable and heritable nucleosome modification states and identifies the critical features of such systems.Kim Sneppen and Ian B. Dod
- …