Validation of the Thai version of the family reported outcome measure (FROM-16)© to assess the impact of disease on the partner or family members of patients with cancer

© The Author(s). 2019Background: Cancer not only impairs a patient's physical and psychosocial functional behaviour, but also contributes to negative impact on family members' health related quality of life. Currently, there is an absence of a relevant tool in Thai with which to measure such impact. The aim of this study was to translate and validate the Family Reported Outcome Measure (FROM-16) in Thai cancer patients' family members. Methods: Thai version of FROM-16 was generated by interactive forward-backward translation process following standard guidelines. This was tested for psychometric properties including reliability and validity, namely content validity, concurrent validity, known group validity, internal consistency, exploratory and confirmatory factor analysis. Construct validity was examined by comparing the Thai FROM-16 version with the WHOQOL-BREF-THAI. Results: The internal consistency reliability was strong (Cronbach's alpha = 0.86). A Negative moderate correlation between the Thai FROM-16 and WHOQOL-BREF-THAI was observed (r = - 0.4545, p < 0.00), and known group validity was proved by a statistically significant higher score in family members with high burden of care and insufficient income. The factor analysis supported both 3-factor and 2-factor loading model with slight difference when compared with the original version. Conclusions: The Thai FROM-16 showed good reliability and validity in Thai family members of patients with cancer. A slight difference in factor analysis results compared to the original version could be due to cross-culture application.Peer reviewedFinal Published versio

Identifying factors associated with sedentary time after stroke. Secondary analysis of pooled data from nine primary studies.

<p><b>Background</b>: High levels of sedentary time increases the risk of cardiovascular disease, including recurrent stroke.</p> <p><b>Objective</b>: This study aimed to identify factors associated with high sedentary time in community-dwelling people with stroke.</p> <p><b>Methods</b>: For this data pooling study, authors of published and ongoing trials that collected sedentary time data, using the activPAL monitor, in community-dwelling people with stroke were invited to contribute their raw data. The data was reprocessed, algorithms were created to identify sleep-wake time and determine the percentage of waking hours spent sedentary. We explored demographic and stroke-related factors associated with total sedentary time and time in uninterrupted sedentary bouts using unique, both univariable and multivariable, regression analyses.</p> <p><b>Results</b>: The 274 included participants were from Australia, Canada, and the United Kingdom, and spent, on average, 69% (SD 12.4) of their waking hours sedentary. Of the demographic and stroke-related factors, slower walking speeds were significantly and independently associated with a higher percentage of waking hours spent sedentary (p = 0.001) and uninterrupted sedentary bouts of <i>>30</i> and <i>>60 min</i> (p = 0.001 and p = 0.004, respectively). Regression models explained 11–19% of the variance in total sedentary time and time in prolonged sedentary bouts.</p> <p><b>Conclusion</b>: We found that variability in sedentary time of people with stroke was largely unaccounted for by demographic and stroke-related variables. Behavioral and environmental factors are likely to play an important role in sedentary behavior after stroke. Further work is required to develop and test effective interventions to address sedentary behavior after stroke.</p

An overview on the Impact of Food Fraud Incidences in Various Countries and its Detection Methods, Assessment Techniques and Preventive Measures

Food fraud is not just a local issue but perhaps a global phenomenon. If the food available in the market are undetected or poorly controlled, this can harm consumer health. Food fraud causes a lack of traceability of supply chains and may eventually be a risk to food safety. The purpose of this paper is to acquaint the various types of food fraud and to evaluate the detection methods in identifying the adulterants. It also addresses the importance of vulnerability assessment of food fraud and key actions required for its prevention. Fighting food fraud will remain a race between the fraudsters and scientists developing new methods to prevent them. The review is unique that it summarized food fraud types, basic and instrument-based detection techniques for adulterants identification and it also focuses on the international governing bodies concerned with food laws and regulations. This study also provides perceptions of the interplay between vulnerability assessment and food fraud prevention

The microaerophilic microbiota of de-novo paediatric inflammatory bowel disease: the BISCUIT study

&lt;p&gt;Introduction: Children presenting for the first time with inflammatory bowel disease (IBD) offer a unique opportunity to study aetiological agents before the confounders of treatment. Microaerophilic bacteria can exploit the ecological niche of the intestinal epithelium; Helicobacter and Campylobacter are previously implicated in IBD pathogenesis. We set out to study these and other microaerophilic bacteria in de-novo paediatric IBD.&lt;/p&gt; &lt;p&gt;Patients and Methods: 100 children undergoing colonoscopy were recruited including 44 treatment naïve de-novo IBD patients and 42 with normal colons. Colonic biopsies were subjected to microaerophilic culture with Gram-negative isolates then identified by sequencing. Biopsies were also PCR screened for the specific microaerophilic bacterial groups: Helicobacteraceae, Campylobacteraceae and Sutterella wadsworthensis.&lt;/p&gt; &lt;p&gt;Results: 129 Gram-negative microaerophilic bacterial isolates were identified from 10 genera. The most frequently cultured was S. wadsworthensis (32 distinct isolates). Unusual Campylobacter were isolated from 8 subjects (including 3 C. concisus, 1 C. curvus, 1 C. lari, 1 C. rectus, 3 C. showae). No Helicobacter were cultured. When comparing IBD vs. normal colon control by PCR the prevalence figures were not significantly different (Helicobacter 11% vs. 12%, p = 1.00; Campylobacter 75% vs. 76%, p = 1.00; S. wadsworthensis 82% vs. 71%, p = 0.312).&lt;/p&gt; &lt;p&gt;Conclusions: This study offers a comprehensive overview of the microaerophilic microbiota of the paediatric colon including at IBD onset. Campylobacter appear to be surprisingly common, are not more strongly associated with IBD and can be isolated from around 8% of paediatric colonic biopsies. S. wadsworthensis appears to be a common commensal. Helicobacter species are relatively rare in the paediatric colon.&lt;/p&gt

An Investigation into the Impact of COVID-19 on the Performance of a Non-profit Microfinance Institution

This article deals with the effect of the COVID-19 pandemic on the performance of a non-profit microfinance institution operating in the Nilgiris and Perambalur districts of Tamil Nadu in India. The primary focus of the paper is on the microfinance institute’s financial performance in terms of outreach and portfolio quality before and after the coronavirus outbreak. The most worrisome factors that were encountered in due course of the study include a decline in loan portfolio and clientele, and an increasing trend in portfolio at risk (PAR) percentage due to a surge in client overdues, outstanding loan amount and rise in number of delinquent clients. These negative impacts on performance were further investigated by establishing a connection to the clients’ repayment ability. A survey was conducted among the women clients of the microfinance institution by enlisting 120 respondents, 60 from each district to identify the various constraints faced by them in loan repayment as a result of the government-imposed lockdown that affected their livelihood and curbed their source of income. Therefore, an attempt has been made to bring out the ground level realities that played an important role in disrupting the normal functioning of the microfinance institution during the pandemic outbreak. This will prove useful in setting guidelines for future crises of like nature to enable microfinance institutions to keep functioning efficiently without any drastic changes to their performance

Trade Competitiveness of Palm Oil Export from ASEAN Countries

Aims: To study the competitiveness, import intensity and structural break of palm oil exports from ASEAN member countries to the Indian market for the period 2000 to 2020. Data and Methodology: The relevant data was collected from UNCOMTRADE for the period of 21 years (2000 to 2020). The tools used for the analysis were Revealed Symmetric Comparative Advantage (RSCA), Import Intensity Index (III) and Chow test. Results: The study revealed that Indonesia had lost its comparative advantage due to differential tariff rates imposed by India between Indonesia and its close competitor Malaysia. After 2011, the import intensity index clarifies that there was a gradual decrease in imports from Indonesia. However, Malaysia and Thailand showed an upward trend in import intensity index till the year 2018. After 2018, Singapore had an upward trend in import intensity. From chow test, there was a significant difference in importing palm oil from ASEAN countries to India before and after signing AIFTA (ASEAN- India Free Trade Agreement). Conclusion: Considering India’s demand for palm oil which is expected to double by 2030, so sustainable palm oil cultivation is recommended and a balanced approach should be taken to fix the tariff rate to protect domestic producers and refineries without compromising consumer demand

Highly efficient, perfect, large angular and ultrawideband solar energy absorber for UV to MIR range

Although different materials and designs have been tried in search of the ideal as well as ultrawideband light absorber, achieving ultra-broadband and robust unpolarized light absorption over a wide angular range has proven to be a major issue. Light-field regulation capabilities provided by optical metamaterials are a potential new technique for perfect absorbers. It is our goal to design and demonstrate an ultra-wideband solar absorber for the ultraviolet to a mid-infrared region that has an absorptivity of TE/TM light of 96.2% on average. In the visible, NIR, and MIR bands of the solar spectrum, the absorbed energy is determined to be over 97.9%, above 96.1%, and over 95%, respectively under solar radiation according to the Air Mass Index 1.5 (AM1.5) spectrum investigation. In order to achieve this wideband absorption, the TiN material ground layer is followed by the SiO2 layer, and on top of that, a Cr layer with patterned Ti-based resonators of circular and rectangular multiple patterns. More applications in integrated optoelectronic devices could benefit from the ideal solar absorber’s strong absorption, large angular responses, and scalable construction

Low Fatigue Response of Crest-Fixed Cold-Formed Steel Drape Curved Roof Claddings

Cold-formed steel roof claddings are subjected to significant suction/uplift pressures during high wind events. In New Zealand, the strong prevailing winds makes this a common occurrence. Suction pressures are generated by the turbulence of the wind flow around the building which can vary both spatially and temporally. The weakest link in the roofing system is the connection between roof sheeting and screw fasteners, which if fails, can lead to progressive collapse of the whole roofing assembly. Fluctuating high wind suction pressures can result in either static or fatigue pull-through failure of the roof sheeting at its screw fastener connections. Current literature has covered the static and fatigue wind uplift performance of crest-fixed corrugated and trapezoidal roof claddings. However, no research has been undertaken to understand the wind uplift performance of the typical crest-fixed cold-formed steel drape curved roof claddings used in New Zealand. This issue is addressed herein. In total, 35 large scale experimental tests are presented for crest-fixed drape curved steel roof claddings subjected to static and cyclic wind suction/uplift loads applied using a Pressure Loading Actuator. The material properties of claddings were determined using tensile coupon tests while the initial geometric imperfections of claddings were measured using a laser scanner. The critical fastener reactions were determined using a three axis load cell. Crack initiation, propagation of cracks, crack patterns and the number of load cycles to failure are discussed for such claddings under different load levels. Tests showed that the drape curved roof claddings are also subjected to localised dimpling and pull-through failures at their screw connections under static and cyclic wind uplift loads with the occurrence of low cycle fatigue failures under cyclic loading

The AI-viticulture nexus: Robotics and precision technologies for sustainable vineyards

Automation technologies, such as Artificial Intelligence (AI), robotics, IoT and remote sensing, are transforming viticulture by addressing labour shortages, climate resilience challenges and resource optimization. AI-driven machine learning models process data from multispectral drones and IoT sensors to monitor soil health, water stress and canopy dynamics, enabling precision agriculture practices like targeted irrigation and nutrient delivery. Autonomous robotic systems perform tasks such as selective harvesting, pruning and pest management, enhancing operational efficiency while reducing manual labour. IoT networks provide real-time insights into microclimatic conditions, empowering growers to adopt climate-smart strategies that minimize chemical inputs and improve yield stability. Despite progress, key barriers persist: AI models require terroir-specific adaptation, fragmented datasets hinder interoperability and field validation of autonomous systems under diverse conditions remains limited. Future research must prioritize accessible solutions: low-cost sensor networks for smallholders, adaptive AI frameworks for climate volatility (e.g., drought or flood prediction) and edge computing for real-time analytics. Ethical concerns data privacy, algorithmic bias and technology access disparities demand inclusive governance. Additionally, user-friendly interfaces are essential for broad adoption. Addressing these gaps will unlock automation’s full potential in advancing sustainable viticulture: optimizing water/energy use, reducing agrochemical reliance, enhancing biodiversity and ensuring economic resilience for growers. Ultimately, integrated automation promises a balance between ecological stewardship, resource efficiency and sector-wide viability in a climate-constrained future

A monodisperse transmembrane α-helical peptide barrel

The fabrication of monodisperse transmembrane barrels formed from short synthetic peptides has not been demonstrated previously. This is in part because of the complexity of the interactions between peptides and lipids within the hydrophobic environment of a membrane. Here we report the formation of a transmembrane pore through the self-assembly of 35 amino acid α-helical peptides. The design of the peptides is based on the C-terminal D4 domain of the Escherichia coli polysaccharide transporter Wza. By using single-channel current recording, we define discrete assembly intermediates and show that the pore is most probably a helix barrel that contains eight D4 peptides arranged in parallel. We also show that the peptide pore is functional and capable of conducting ions and binding blockers. Such α-helix barrels engineered from peptides could find applications in nanopore technologies such as single-molecule sensing and nucleic-acid sequencing