1,612 research outputs found
Validation of Kalman Filter alignment algorithm with cosmic-ray data using a CMS silicon strip tracker endcap
A Kalman Filter alignment algorithm has been applied to cosmic-ray data. We
discuss the alignment algorithm and an experiment-independent implementation
including outlier rejection and treatment of weakly determined parameters.
Using this implementation, the algorithm has been applied to data recorded with
one CMS silicon tracker endcap. Results are compared to both photogrammetry
measurements and data obtained from a dedicated hardware alignment system, and
good agreement is observed.Comment: 11 pages, 8 figures. CMS NOTE-2010/00
Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-Resolution Microscopy
Heterogeneity of mitogen-activated protein kinase (MAPK) activation in genetically identical cells, which occurs in response to epidermal growth factor receptor (EGFR) signaling, remains poorly understood. MAPK cascades integrate signals emanating from different EGFR spatial locations, including the plasma membrane and endocytic compartment. We previously hypothesized that in EGF-stimulated cells the MAPK phosphorylation (pMAPK) level and activity are largely determined by the spatial organization of the EGFR clusters within the cell. For experimental testing of this hypothesis, we used super-resolution microscopy to define EGFR clusters by receptor numbers (N) and average intra-cluster distances (d). From this data, we predicted the extent of pMAPK with 85% accuracy on a cell-to-cell basis with control data returning 54% accuracy (P50nm were most predictive for pMAPK level in cells. Electron microscopy revealed that these large clusters were primarily localized to the limiting membrane of multivesicular bodies (MVB). Many tighter packed dimers/multimers (d<50nm) were found on intraluminal vesicles within MVBs, where they were unlikely to activate MAPK because of the physical separation. Our results suggest that cell-to-cell differences in N and d contain crucial information to predict EGFR-activated cellular pMAPK levels and explain pMAPK heterogeneity in isogenic cells
Occlusion of the common femoral artery by cement after total hip arthroplasty: a case report
The incidence of vascular injuries after total hip arthroplasty is extremely low. In this report we describe an unusual injury to the common femoral artery. A 59-year-old Caucasian woman presented with rest pain, numbness and cramps in the operated limb after hip replacement. Cement leakage under the transverse ligament had caused occlusion of the common femoral artery necessitating vascular reconstruction. She had a good functional recovery at follow-up. To the best of our knowledge, this is the first well-documented case reporting this pathomechanism of vascular lesion to the femoral artery. This case report highlights the potential risk of such a limb-threatening complication, and awareness should lead to prevention by meticulous surgical technique (correct technique of pressurization) or to early detection of the lesio
The T2K Side Muon Range Detector
The T2K experiment is a long baseline neutrino oscillation experiment aiming
to observe the appearance of {\nu} e in a {\nu}{\mu} beam. The {\nu}{\mu} beam
is produced at the Japan Proton Accelerator Research Complex (J-PARC), observed
with the 295 km distant Super- Kamiokande Detector and monitored by a suite of
near detectors at 280m from the proton target. The near detectors include a
magnetized off-axis detector (ND280) which measures the un-oscillated neutrino
flux and neutrino cross sections. The present paper describes the outermost
component of ND280 which is a side muon range detector (SMRD) composed of
scintillation counters with embedded wavelength shifting fibers and Multi-Pixel
Photon Counter read-out. The components, performance and response of the SMRD
are presented.Comment: 13 pages, 19 figures v2: fixed several typos; fixed reference
Measurement of Through-Going Particle Momentum By Means Of Multiple Scattering With The ICARUS T600 TPC
The ICARUS collaboration has demonstrated, following the operation of a 600
ton (T600) detector at shallow depth, that the technique based on liquid Argon
TPCs is now mature. The study of rare events, not contemplated in the Standard
Model, can greatly benefit from the use of this kind of detectors. In
particular, a deeper understanding of atmospheric neutrino properties will be
obtained thanks to the unprecedented quality of the data ICARUS provides.
However if we concentrate on the T600 performance, most of the
charged current sample will be partially contained, due to the reduced
dimensions of the detector. In this article, we address the problem of how well
we can determine the kinematics of events having partially contained tracks.
The analysis of a large sample of atmospheric muons collected during the T600
test run demonstrate that, in case the recorded track is at least one meter
long, the muon momentum can be reconstructed by an algorithm that measures the
Multiple Coulomb Scattering along the particle's path. Moreover, we show that
momentum resolution can be improved by a factor two using an algorithm based on
the Kalman Filtering technique
Study of Z boson production in pPb collisions at √sNN = 5.02 TeV
© 2016 The Author.The production of Z bosons in pPb collisions at sNN=5.02 TeV is studied by the CMS experiment via the electron and muon decay channels. The inclusive cross section is compared to pp collision predictions, and found to scale with the number of elementary nucleon-nucleon collisions. The differential cross sections as a function of the Z boson rapidity and transverse momentum are measured. Though they are found to be consistent within uncertainty with theoretical predictions both with and without nuclear effects, the forward-backward asymmetry suggests the presence of nuclear effects at large rapidities. These results provide new data for constraining nuclear parton distribution functions
Search for composite and exotic fermions at LEP 2
A search for unstable heavy fermions with the DELPHI detector at LEP is
reported. Sequential and non-canonical leptons, as well as excited leptons and
quarks, are considered. The data analysed correspond to an integrated
luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV
and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172
GeV and 161 GeV. The search for pair-produced new leptons establishes 95%
confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2,
depending on the channel. The search for singly produced excited leptons and
quarks establishes upper limits on the ratio of the coupling of the excited
fermio
Search for charginos in e+e- interactions at sqrt(s) = 189 GeV
An update of the searches for charginos and gravitinos is presented, based on
a data sample corresponding to the 158 pb^{-1} recorded by the DELPHI detector
in 1998, at a centre-of-mass energy of 189 GeV. No evidence for a signal was
found. The lower mass limits are 4-5 GeV/c^2 higher than those obtained at a
centre-of-mass energy of 183 GeV. The (\mu,M_2) MSSM domain excluded by
combining the chargino searches with neutralino searches at the Z resonance
implies a limit on the mass of the lightest neutralino which, for a heavy
sneutrino, is constrained to be above 31.0 GeV/c^2 for tan(beta) \geq 1.Comment: 22 pages, 8 figure
Measurement of the t(t)over-bar production cross section in the dilepton channel in pp collisions at √s=8 TeV
The top-antitop quark (t (t) over bar) production cross section is measured in proton-proton collisions at root s = 8 TeV with the CMS experiment at the LHC, using a data sample corresponding to an integrated luminosity of 5.3 fb(-1). The measurement is performed by analysing events with a pair of electrons or muons, or one electron and one muon, and at least two jets, one of which is identified as originating from hadronisation of a bottom quark. The measured cross section is 239 +/- 2 (stat.) +/- 11 (syst.) +/- 6 (lum.) pb, for an assumed top-quark mass of 172.5 GeV, in agreement with the prediction of the standard model
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