Penggulungan Daun Pada Padi Lokal Sulut Saat Kekurangan Air

Ketersediaan air merupakan salah satu faktor pembatas produksi padi di Indonesia. Kajian sifat tahan kering pada padi lokal Sulawesi Utara (Sulut) perlu dilakukan, dalam upaya mendukung tercapainya tujuan strategis meningkatkan kemampuan wilayah Sulawesi untuk menjadi pilar ketahanan pangan nasional. Penelitian ini dilakukan untuk mengevaluasi sifat tahan kering pada empat varietas padi local Sulut (Burungan, Superwin, Temo dan Ombong) pada saat kekurangan air berdasarkan karakter penggulungan daun. Setelah 14 hari perlakuan, skor penggulungan daun pada tanaman yang diairi berkisar 3-4, sedangkan pada tanaman yang tidak diairi rata-rata 9. Pada perlakuan tidak diairi skor penggulungan daun terendah pada Superwin (7,26) dibandingkan pada Burungan (8,86), Temo (8,57) dan Ombong (8,85). Berdasarkan karakter skor penggulungan daun, sifat tahan kering Superwin lebih besar dibandingkan dengan ketiga padi lokal Sulut lainnya, sehingga varietas ini potensial untuk ditanam di daerah kekurangan air.Water availability is one factor limiting rice production in Indonesia. The evaluation of drought resistance in North Sulawesi local rice is important to elevate Sulawesi capability as food security supporter. This study was conducted to evaluate drought resistance in four local rice cultivars (Burungan, Superwin, Temo and Ombong) under water deficit condition based on the leaf rolling score. After 14 days of treatment, mean of leaf rolling score in well-watered plants was 3-4, whereas in water deficit plants was 9. Under water deficit, Superwin had the lowest score (7.26) compared with Burungan (8.86), Temo (8.57), and Ombong (8.85). Based on the leaf rolling score character, drought resistance in Superwin was larger than the other 3 local rice cultivars, so that Superwin was potential to be cultivated in the water limited area

The National Pediatric Surgery Simulation Program in France: A tool to develop resident training in pediatric surgery

BACKGROUND/PURPOSE: To implement resident curriculum in France based on theoretical teaching and bed side training, the national council known as the "Collège Hospitalier et Universitaire de Chirurgie Pédiatrique" examined the relevance and feasibility of systematically introducing simulation program in the pediatric surgery resident training. MATERIAL AND METHODS: A national simulation training program was developed and took place in a 2-day session organized in 7 simulation centers in France. The program included technical (laparoscopic/suturing technique on low-fidelity models) and nontechnical (6 scenarios for standardized consultation, and a team work scenario based on errors prevention in the operative room) skills. Evaluation of the program (Likert scale from 1 (bad) to 5 (excellent) and notation on 20 points) concerned trainees and trainers. RESULTS: 40 residents (95% of all pediatric surgery French residents) attended with a ratio of trainees/trainer of ½. The training objectives earned a score of 4.46/5. The pedagogical value of the seminar scored 4.7/5, teaching quality 17.95/20, and the overall seminar score was 17.35/20. CONCLUSION: This program, unique nationally, was assessed very favorably by the participating residents and by the involved trainers. To our knowledge, it represents the first mandatory national simulation training program included within a surgical training model. LEVEL OF EVIDENCE: Level IV

Penggulungan Daun Pada Padi Lokal Sulut Saat Kekurangan Air

Ketersediaan air merupakan salah satu faktor pembatas produksi padi di Indonesia. Kajian sifat tahan kering pada padi lokal Sulawesi Utara (Sulut) perlu dilakukan, dalam upaya mendukung tercapainya tujuan strategis meningkatkan kemampuan wilayah Sulawesi untuk menjadi pilar ketahanan pangan nasional. Penelitian ini dilakukan untuk mengevaluasi sifat tahan kering pada empat varietas padi local Sulut (Burungan, Superwin, Temo dan Ombong) pada saat kekurangan air berdasarkan karakter penggulungan daun. Setelah 14 hari perlakuan, skor penggulungan daun pada tanaman yang diairi berkisar 3-4, sedangkan pada tanaman yang tidak diairi rata-rata 9. Pada perlakuan tidak diairi skor penggulungan daun terendah pada Superwin (7,26) dibandingkan pada Burungan (8,86), Temo (8,57) dan Ombong (8,85). Berdasarkan karakter skor penggulungan daun, sifat tahan kering Superwin lebih besar dibandingkan dengan ketiga padi lokal Sulut lainnya, sehingga varietas ini potensial untuk ditanam di daerah kekurangan air.Water availability is one factor limiting rice production in Indonesia. The evaluation of drought resistance in North Sulawesi local rice is important to elevate Sulawesi capability as food security supporter. This study was conducted to evaluate drought resistance in four local rice cultivars (Burungan, Superwin, Temo and Ombong) under water deficit condition based on the leaf rolling score. After 14 days of treatment, mean of leaf rolling score in well-watered plants was 3-4, whereas in water deficit plants was 9. Under water deficit, Superwin had the lowest score (7.26) compared with Burungan (8.86), Temo (8.57), and Ombong (8.85). Based on the leaf rolling score character, drought resistance in Superwin was larger than the other 3 local rice cultivars, so that Superwin was potential to be cultivated in the water limited area

The inhibition of checkpoint activation by telomeres does not involve exclusion of dimethylation of histone H4 lysine 20 (H4K20me2) [version 2; referees: 2 approved, 1 not approved]

DNA double-strand breaks (DSBs) activate the DNA damage checkpoint machinery to pause or halt the cell cycle.  Telomeres, the specific DNA-protein complexes at linear eukaryotic chromosome ends, are capped DSBs that do not activate DNA damage checkpoints.  This “checkpoint privileged” status of telomeres was previously investigated in the yeast Schizosaccharomyces pombelacking the major double-stranded telomere DNA binding protein Taz1. Telomeric DNA repeats in cells lacking Taz1 are 10 times longer than normal and contain single-stranded DNA regions. DNA damage checkpoint proteins associate with these damaged telomeres, but the DNA damage checkpoint is not activated. This severing of the DNA damage checkpoint signaling pathway was reported to stem from exclusion of histone H4 lysine 20 dimethylation (H4K20me2) from telomeric nucleosomes in both wild type cells and cells lacking Taz1.  However, experiments to identify the mechanism of this exclusion failed, prompting our re-evaluation of H4K20me2 levels at telomeric chromatin.  In this short report, we used an extensive series of controls to identify an antibody specific for the H4K20me2 modification and show that the level of this modification is the same at telomeres and internal loci in both wild type cells and those lacking Taz1.  Consequently, telomeres must block activation of the DNA Damage Response by another mechanism that remains to be determined

OPTIMALISASI PERAN PEREMPUAN DALAM MENINGKATKAN POTENSI WISATA BAHARI MELALUI SEKOLAH PEREMPUAN DAN PENGEMBANGAN UMKM

Abstrak: Tambakbulusan merupakan desa di kawasan pesisir utara Jawa Tengah. Desa ini cukup potensial untuk dikembangkan, antara lain mangrove, keberagaman produk UMKM, dan Pantai Glagah Wangi yang menjadi tujuan wisata. Untuk itu, Badan Eksekutif Mahasiswa Fakultas Perikanan dan Ilmu Kelautan Universitas Diponegoro melalui kegiatan Program Peningkatan Kapasitas Organisasi Mahasiswa (PPK Ormawa)-nya bertujuan membentuk Sekolah Perempuan lengkap dengan kurikulumnya untuk meningkatkan softskill kelompok kader perempuan dan melakukan pemberdayaan UMKM di Desa Tambakbulusan. Kegiatan yang dilakukan selama 5 bulan ini telah berhasil membentuk kelompok baru Kader Perempuan dengan 20 orang anggota. Kelompok tersebut telah meningkat 60-70% pengetahuannya dan terampil dalam pembuatan batik. Pemberdayaan UMKM dilakukan dengan perbaikan kemasan dan pemasaran pada kader mitra dan telah berhasil menyelenggarakan Festival UMKM Desa Tambakbulusan Kabupaten Demak. Melalui kegiatan tersebut, selain pengetahuan dan penjualan UMKM meningkat 90%, Kader Perempuan yang telah terbentuk telah membuat beberapa desain batik mangrove khas Desa Tambakbulusan yang akan menjadi daya tarik wisatawan bahari yang berkunjung.Abstract: Tambakbulusan is located on the north coast of Central Java. This village has the potential to be developed, including mangroves, a variety of MSME products, and Glagah Wangi Beach which is a tourist destination. For this reason, the Student Executive Board of the Faculty of Fisheries and Marine Sciences, Diponegoro University through its Student Organization Capacity Building Program activities aims to form a Women’s School with its curriculum to improve the soft skills of women groups and empower MSMEs in Tambakbulusan Village. The activities carried out for 5 months have succeeded in forming a new group of female group with 20 members. The group has increased 60-70% in knowledge and skills in producing batik and understanding the batik wastewater treatment installation system. MSME empowerment is carried out by improving packaging and marketing and has successfully held the Tambakbulusan Village MSMEs Festival, Demak Regency. Through these activities, in addition to knowledge and saled of MSMEs increasing by 90%, the Women Group have succeeded in making several mangrove batik designs typical of Tambakbulusan Village which will become an attraction for visiting marine tourists.

The Sloan Digital Sky Survey Quasar Catalog V. Seventh Data Release

We present the fifth edition of the Sloan Digital Sky Survey (SDSS) Quasar Catalog, which is based upon the SDSS Seventh Data Release. The catalog, which contains 105,783 spectroscopically confirmed quasars, represents the conclusion of the SDSS-I and SDSS-II quasar survey. The catalog consists of the SDSS objects that have luminosities larger than M_i = -22.0 (in a cosmology with H_0 = 70 km/s/Mpc Omega_M = 0.3, and Omega_Lambda = 0.7) have at least one emission line with FWHM larger than 1000 km/s or have interesting/complex absorption features, are fainter than i > 15.0 and have highly reliable redshifts. The catalog covers an area of 9380 deg^2. The quasar redshifts range from 0.065 to 5.46, with a median value of 1.49; the catalog includes 1248 quasars at redshifts greater than four, of which 56 are at redshifts greater than five. The catalog contains 9210 quasars with i < 18; slightly over half of the entries have i< 19. For each object the catalog presents positions accurate to better than 0.1" rms per coordinate, five-band (ugriz) CCD-based photometry with typical accuracy of 0.03 mag, and information on the morphology and selection method. The catalog also contains radio, near-infrared, and X-ray emission properties of the quasars, when available, from other large-area surveys. The calibrated digital spectra cover the wavelength region 3800-9200 Ang. at a spectral resolution R = 2000 the spectra can be retrieved from the SDSS public database using the information provided in the catalog. Over 96% of the objects in the catalog were discovered by the SDSS. We also include a supplemental list of an additional 207 quasars with SDSS spectra whose archive photometric information is incomplete.Comment: Accepted, to appear in AJ, 7 figures, electronic version of Table 2 is available, see http://www.sdss.org/dr7/products/value_added/qsocat_dr7.htm

Transcription-replication conflicts: How they occur and how they are resolved

The frequent occurrence of transcription and DNA replication in cells results in many encounters, and thus conflicts, between the transcription and replication machineries. These conflicts constitute a major intrinsic source of genome instability, which is a hallmark of cancer cells. How the replication machinery progresses along a DNA molecule occupied by an RNA polymerase is an old question. Here we review recent data on the biological relevance of transcription-replication conflicts, and the factors and mechanisms that are involved in either preventing or resolving them, mainly in eukaryotes. On the basis of these data, we provide our current view of how transcription can generate obstacles to replication, including torsional stress and non-B DNA structures, and of the different cellular processes that have evolved to solve them

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR&nbsp;=&nbsp;2.05, 95%CI&nbsp;=&nbsp;1.39–3.02, p&nbsp;&lt;&nbsp;0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR&nbsp;=&nbsp;0.42, 95%CI&nbsp;=&nbsp;0.18–0.99, p&nbsp;=&nbsp;0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

Quantifying system disturbance and recovery from historical mining-derived metal contamination at Brotherswater, northwest England

The final publication is available at Springer via https://doi.org/10.1007/s10933-016-9907-1Metal ore extraction in historical times has left a legacy of severe contamination in aquatic ecosystems around the world. In the UK, there are ongoing nationwide surveys of present-day pollution discharged from abandoned mines but few assessments of the magnitude of contamination and impacts that arose during historical metal mining have been made. We report one of the first multi-centennial records of lead (Pb), zinc (Zn) and copper (Cu) fluxes into a lake (Brotherswater, northwest England) from point-sources in its catchment (Hartsop Hall Mine and Hogget Gill processing plant) and calculate basin-scale inventories of those metals. The pre-mining baseline for metal contamination has been established using sediment cores spanning the past 1,500 years and contemporary material obtained through sediment trapping. These data enabled the impact of 250 years of local, small-scale mining (1696 – 1942) to be quantified and an assessment of the trajectory towards system recovery to be made. The geochemical stratigraphy displayed in twelve sediment cores show strong correspondence to the documented history of metal mining and processing in the catchment. The initial onset in 1696 was detected, peak Pb concentrations (>10,000 µg g-1) and flux (39.4 g m-2 y-1) corresponded to the most intensive mining episode (1863-1871) and 20th century technological enhancements were reflected as a more muted sedimentary imprint. After careful evaluation, we used these markers to augment a Bayesian age-depth model of the independent geochronology obtained using radioisotope dating (14C, 210Pb, 137Cs and 241Am). Total inventories of Pb, Zn and Cu for the lake basin during the period of active mining were 15,415 kg, 5,897 kg and 363 kg, respectively. The post-mining trajectories for Pb and Zn project a return to pre-mining levels within 54-128 years for Pb and 75-187 years for Zn, although future remobilisation of metal-enriched catchment soils and floodplain sediments could perturb this recovery. We present a transferable paleolimnological approach that highlights flux-based assessments are vital to accurately establish the baseline, impact and trajectory of mining-derived contamination for a lake catchment