PENINGKATAN KUALITAS PRODUKSI DENGAN PENERAPAN DESAIN EKSPERIMEN SHAININ DI PT. XYZ

The high percentage of re jects due to de fects during the production process in P T. XYZ, encouraged the researcher to de sign experiments using Shainin method. Shainin method begins with multi-vary testing to see the spread of rejected products proportion based on time to time, unit to unit and within unitgroups. The tests performed showed significant gains in all three groups (A, C, and D groups in the 3rd shifts and capper 1, 2). Furthermore, concentration chart testing shows the location of defects that recur in group A and the group C on capper 1 and capper 2. Paired comparison testing results indicate torque band as Red X and seal torque as Pink X. Moreover, the results of product / process search shows pressure drying closing cone as Red X and low pressure lifting as Pink X. The four tests performed on these factors indicate interaction so that response surface can be performed. Thus, it was obtained that the value to minimize Green Y on low pressure lifting of parameter setting was 3.5-4.0 bar, closing cone of drying pressure was 2.1 to 3.0 bar, the torque band was 8.8 to 10, 9 Lb.in and seal torque was 6.0-7.5 Lb.in

BUDAYA TIONGHOA PADA RAGAM GAMBAR MOTIF BATIK JAWA-MADURA

Batik Jawa-Madura memiliki perbendaharaan motif dan pola yang amat beragam, dimana setiap motif dan pola tersebut memiliki ritual dan pemaknaan khusus yang merupakan manifestasi dari nilai-nilai kebudayaan masyarakat Jawa dan Madura itu sendiri. Dari sekian banyak motif dan pola batik Jawa, penulis melihat adanya kesamaan yang cukup signifikan dengan pola dan motif yang berasal dari kebudayaan asli Tionghoa. Berdasarkan fenomena tersebut, penelitian ini bertujuan untuk membuktikan seberapa jauh budaya Tionghoa berpengaruh dalam penciptaan motif batik, dan bagaimana kedua kebudayaan tersebut saling mempengaruhi perkembangan batik di Jawa dan Madura. Penelitian ini menggunakan metode analisa kualitiatif deskriptif, dengan teknik pengumpulan data melalui studi literatur mengenai penelusuran sejarah masuknya kebudayaan Tionghoa di Indonesia, asal-muasal dan perkembangan batik di Jawa, dan ragam motif dan pola yang berasal dari daratan Cina. Penelitian ini diharapkan dapat memberikan wawasan mengenai peranan kebudayaan Tionghoa dalam perkembangan kebudayaan Jawa-Madura, serta sejauh mana kebudayaan Tionghoa melandasi penciptaan pola dan motif yang terdapat pada batik Jawa-Madura

Efficacy of Continuous Interleukin 1 Blockade in Mevalonate Kinase Deficiency: A Multicenter Retrospective Study in 13 Adult Patients and Literature Review

OBJECTIVE: To report efficacy and tolerance of interleukin 1 blockade in adult patients with mevalonate kinase deficiency (MKD). METHODS: We retrospectively collected data on 13 patients with MKD who had received anakinra (n = 10) and canakinumab (n = 7). RESULTS: Anakinra resulted in complete or partial remission in 3/10 and 5/10 patients, respectively, and no efficacy in 2/10, but a switch to canakinumab led to partial remission. Canakinumab resulted in complete or partial remission in 3/7 and 4/7 patients, respectively. CONCLUSION: These data support frequent partial responses, showing a better response with canakinumab. The genotype and therapeutic outcomes correlation should help in the personalization of treatment

The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection—evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology

Due to its poor capacity for regeneration, the heart is particularly sensitive to the loss of contractile cardiomyocytes. The onslaught of damage caused by ischaemia and reperfusion, occurring during an acute myocardial infarction and the subsequent reperfusion therapy, can wipe out upwards of a billion cardiomyocytes. A similar program of cell death can cause the irreversible loss of neurons in ischaemic stroke. Similar pathways of lethal cell injury can contribute to other pathologies such as left ventricular dysfunction and heart failure caused by cancer therapy. Consequently, strategies designed to protect the heart from lethal cell injury have the potential to be applicable across all three pathologies. The investigators meeting at the 10th Hatter Cardiovascular Institute workshop examined the parallels between ST-segment elevation myocardial infarction (STEMI), ischaemic stroke, and other pathologies that cause the loss of cardiomyocytes including cancer therapeutic cardiotoxicity. They examined the prospects for protection by remote ischaemic conditioning (RIC) in each scenario, and evaluated impasses and novel opportunities for cellular protection, with the future landscape for RIC in the clinical setting to be determined by the outcome of the large ERIC-PPCI/CONDI2 study. It was agreed that the way forward must include measures to improve experimental methodologies, such that they better reflect the clinical scenario and to judiciously select combinations of therapies targeting specific pathways of cellular death and injury

Genetic variation of macronutrient tolerance in Drosophila melanogaster

Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of similar to 200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.Peer reviewe

Building a Methodological Foundation for Impactful Urban Planetary Health Science.

Anthropogenic environmental change will heavily impact cities, yet associated health risks will depend significantly on decisions made by urban leaders across a wide range of non-health sectors, including transport, energy, housing, basic urban services, and others. A subset of planetary health researchers focus on understanding the urban health impacts of global environmental change, and how these vary globally and within cities. Such researchers increasingly adopt collaborative transdisciplinary approaches to engage policy-makers, private citizens, and other actors in identifying and evaluating potential policy solutions that will reduce environmental impacts in ways that simultaneously promote health, equity, and/or local economies-in other words, maximising 'co-benefits'. This report presents observations from a participatory workshop focused on challenges and opportunities for urban planetary health research. The workshop, held at the 16th International Conference on Urban Health (ICUH) in Xiamen, China, in November 2019, brought together 49 participants and covered topics related to collaboration, data, and research impact. It featured research projects funded by the Wellcome Trust's Our Planet Our Health (OPOH) programme. This report aims to concisely summarise and disseminate participants' collective contributions to current methodological practice in urban planetary health research

Polymorphic variants of genes involved in homocysteine metabolism in celiac disease

Celiac disease (CD) is a polygenic chronic enteropathy conferring an increased risk for various nutrient deficiency states. Hyperhomocysteinemia is a frequent finding in CD and may be related to the development of venous thrombosis, cardiovascular disease, and stroke in untreated CD patients. Recently, a possible excess in the frequency of the MTHFR c.677C>T (rs1801133) gene variant in CD patients was reported. The purpose of this study was to determine if there exist differences in the distribution of polymorphic variants of genes involved in homocysteine/methyl group metabolism between CD patients and the general population. A set of 10 gene polymorphisms (MTHFR rs1801133, MTR rs1805087, MTHFD1 rs2236225, MTRR rs1801394, CBS 844ins68, BHMT1 rs7356530 and rs3733890, BHMT2 rs526264 and rs625879, and TCN2 rs1801198) was tested in 134 patients with CD and 160 matched healthy controls. The frequency of the MTR rs1805087 GG genotype in CD patients was lower than in controls (0.01 and 0.06, respectively), although statistical significance was not achieved (P = 0.06). For the other analyzed polymorphisms, there was no evidence of difference in both allelic and genotypic distribution between cases and controls. The exhaustive Multifactor Dimensionality Reduction analysis revealed no combination of interactive polymorphisms predicting the incidence of CD. In contrast to the well-documented clinical observations of increased risks of vascular disease in patients with longstanding untreated CD, in our group of patients no significant association with CD was found for all tested polymorphic variants of genes involved in homocysteine metabolism. These findings should be replicated in studies with a larger sample size

T-regulatory cell modulation: the future of cancer immunotherapy?

T-regulatory cells suppress anti-tumour immunity in cancer patients and in murine tumour models. Furthermore, their activity is likely to have an effect on the effectiveness of immunotherapeutic treatments for cancer. Here we describe the current status of developing clinical strategies for modulating Treg activity in cancer patients