481 research outputs found

    Data Security Using Stegnography and Quantum Cryptography

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    Stegnography is the technique of hiding confidential information within any media. In recent years variousstegnography methods have been proposed to make data more secure. At the same time differentsteganalysis methods have also evolved. The number of attacks used by the steganalyst has only multipliedover the years. Various tools for detecting hidden informations are easily available over the internet, sosecuring data from steganalyst is still considered a major challenge. While various work have been done toimprove the existing algorithms and also new algorithms have been proposed to make data behind theimage more secure. We have still been using the same public key cryptography like Deffie-Hellman andRSA for key negotiation which is vulnerable to both technological progress of computing power andevolution in mathematics, so in this paper we have proposed use of quantum cryptography along withstegnography. The use of this combination will create key distribution schemes that are uninterceptable thusproviding our data a perfect security.Keywords: Stegnography, Steganalysis, Steganalyst, Quantum Cryptography

    COMPUTER-ASSISTED DRUG DESIGNING OF TRIAZOLE DERIVATIVE OF NOSCAPINE AS TUBULIN-BINDING ANTICANCER DRUG

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    Objective: Microtubule-interfering drugs are commonly used to treat malignant disorders owing to indispensable role of this cytoskeletal element. These drugs include paclitaxel, docetaxel, and the Vinca alkaloids; however, owing to their non-selective action and overpolymerizing effects, these chemotherapy drugs are confounded by complications with serious toxicity (particularly, peripheral neuropathies, gastrointestinal toxicity, myelosuppression, and immunosuppression) (by taxanes) or depolymerizing effects (by Vincas) on microtubules. Thus, there is urgent need to explore novel tubulin-binding agents that are significantly effective and comparatively less toxic compared to currently available drugs for the treatment of human cancer. The current study focuses fusion of two novel anticancer compounds with low toxicity, i.e., noscapine and triazole to generate a new ligand derivative.Methods: Using computer-aided drug designing approach and molecular docking, molecular interaction of these derivatives with αβ-tubulin heterodimer was confirmed and investigated by molecular docking along with dynamics simulation.Results: A greater affinity of the newly designed ligands for binding to tubulin was predicted. The predictive binding free energy (Gbind,pred) of these derivatives (ranging from −10.5178 to −16.8473 kcal/mol) based on linear interaction energy method with a surface generalized born continuum salvation model showed improved binding affinity with tubulin as compared to the lead compound. natural α-Noscapine (−5.505 kcal/mol). The binding energy of ligand determined using LigX, i.e., MM/GBVI was found to be −23.208 kcal/mol.Conclusion: We found that designed derivative compounds have better efficacy as compared noscapine and triazole

    Biofuels for Defence Use: Past, Present And Future

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    Defence sector desires to attain energy self-sufficiency and security. In recent years, emergence of biofuel as an alternative source has raised the hopes of Defence. Ethanol and bio-diesel are currently being used as blends in different parts of the world. While, bio-diesel is mostly being blended in 2-20% in different parts of the world, ethanol blending has reached upto 85%. Owing to the sustainability reasons, the choice of feedstock for ethanol production is gradually changing from corn to lignocelluloses biomass. Jatropha curcas, is still the choice feedstockfor bio-diesel in most third world countries. This institute has put in rigrous efforts to identify high yielding varieties of Jatropha, improving its yield, standardizing trans-esterification to obtain high quality bio-diesel and its trials and testing in various vehicles and equipment. Second generation biofuels using biomass such as farm and forest wastes as feedstocks are promising in terms of their overall sustainability and volume produced. They can be used as drop in fuels. However, time is required to utilize their potential fully. Algae, the third generation biofuel feedstock still needs extensive R&D to make it economically sustainable. Whatever, the technology used, defence forces will accept any biofuel, which should be available constantly and priced below the existing petroleum fuels. The scope of producing by-products and finding a lucarative market for these products can ensure that prices ofbiofuels remain lower than the petroleum fuel

    Minimized Group Delay FIR Low Pass Filter Design Using Modified Differential Search Algorithm, Journal of Telecommunications and Information Technology, 2023, nr 3

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    Designing a finite impulse response (FIR) filter with minimal group delay has proven to be a difficult task. Many research studies have focused on reducing pass band and stop band ripples in FIR filter design, often overlooking the optimization of group delay. While some works have considered group delay reduction, their approaches were not optimal. Consequently, the achievement of an optimal design for a filter with a low group delay value still remains a challenge. In this work, a modified differential search optimization algorithm has been used for the purpose of designing a minimal group delay FIR filter. The results obtained have been compared with the classical techniques and they turned out to be promising

    Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

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    A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

    Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

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    A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

    Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

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    The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

    Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

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    Reconstruction of signal amplitudes in the CMS electromagnetic calorimeter in the presence of overlapping proton-proton interactions

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    A template fitting technique for reconstructing the amplitude of signals produced by the lead tungstate crystals of the CMS electromagnetic calorimeter is described. This novel approach is designed to suppress the contribution to the signal of the increased number of out-of-time interactions per beam crossing following the reduction of the accelerator bunch spacing from 50 to 25 ns at the start of Run 2 of the LHC. Execution of the algorithm is sufficiently fast for it to be employed in the CMS high-level trigger. It is also used in the offline event reconstruction. Results obtained from simulations and from Run 2 collision data (2015-2018) demonstrate a substantial improvement in the energy resolution of the calorimeter over a range of energies extending from a few GeV to several tens of GeV.Peer reviewe

    Observation of the Production of Three Massive Gauge Bosons at root s=13 TeV

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    The first observation is reported of the combined production of three massive gauge bosons (VVV with V = W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis is based on a data sample recorded by the CMS experiment at the CERN LHC corresponding to an integrated luminosity of 137 fb(-1). The searches for individualWWW, WWZ, WZZ, and ZZZ production are performed in final states with three, four, five, and six leptons (electrons or muons), or with two same-sign leptons plus one or two jets. The observed (expected) significance of the combinedVVV production signal is 5.7 (5.9) standard deviations and the corresponding measured cross section relative to the standard model prediction is 1.02(-0.23)(+0.26). The significances of the individual WWW and WWZ production are 3.3 and 3.4 standard deviations, respectively. Measured production cross sections for the individual triboson processes are also reported
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