Capital Privado Centrado en Empresas Familiares y Pequeñas y Medianas Empresas: Revisión y Análisis de Mapeo Científico del Campo Científico Reciente

Private equity is mostly invested in established firms, of which family firms are the dominant form. This article reports the recent evolution of the scientific research on the PE focused on family firms and small and medium-sized enterprises. The purpose is to identify the main themes related to the field between 1992 and 2018 and to identify and analyze the major thematic areas throughout the period. The methodology applied is the science mapping analysis, which shows that: (i) published research on the field is concentrated in two main thematic areas: corporate governance-entrepreneurship and innovation-management, and; (ii) there has been an atomization of the research field during the last six years. Throughout this article, the authors develop a more complete understanding of the PE scientific field focused on family owned SMEs and provide suggestions for those looking for alternatives to traditional bank financing.El capital inversión (private equity)se invierte principalmente en empresas establecidas, de las cuales las empresas familiares son la forma dominante. Este artículo analiza la reciente evolución de la investigación científica sobre private equitycentrada en las Empresas Familiares y las pequeñas y medianas empresas (PYME). El propósito es identificar los temas principales relacionados entre 1992 y 2018 y analizar las principales áreas temáticas a lo largo del período. La metodología aplicada es science mapping analysis, que muestra que: 1. la investigación publicada en el campo se concentra en dos áreas temáticas principales: gobierno corporativo-emprendimiento y gestión de la innovación, y; 2. ha habido una atomización del campo de investigación durante los últimos seis años. La investigación realiza un análisis en profundidad para entender la literatura sobre private equity, centrandose en las PYME familiares, ofreciéndose indicaciones para aquellos que buscan alternativas al financiamiento bancario tradicional

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Private equity focused on family firms & small and medium sized companies: review and science mapping analysis of the recent scientific field

Private equity is mostly invested in established firms, of which family firms are the dominant form. This article reports the recent evolution of the scientific research on the PE focused on family firms and small and medium-sized enterprises. The purpose is to identify the main themes related to the field between 1992 and 2018 and to identify and analyze the major thematic areas throughout the period. The methodology applied is the science mapping analysis, which shows that: (i) published research on the field is concentrated in two main thematic areas: corporate governance-entrepreneurship and innovation-management, and; (ii) there has been an atomization of the research field during the last six years. Throughout this article, the authors develop a more complete understanding of the PE scientific field focused on family owned SMEs and provide suggestions for those looking for alternatives to traditional bank financing.El capital inversión (private equity)se invierte principalmente en empresas establecidas, de las cuales las empresas familiares son la forma dominante. Este artículo analiza la reciente evolución de la investigación científica sobre private equitycentrada en las Empresas Familiares y las pequeñas y medianas empresas (PYME). El propósito es identificar los temas principales relacionados entre 1992 y 2018 y analizar las principales áreas temáticas a lo largo del período. La metodología aplicada es science mapping analysis, que muestra que: 1. la investigación publicada en el campo se concentra en dos áreas temáticas principales: gobierno corporativo-emprendimiento y gestión de la innovación, y; 2. ha habido una atomización del campo de investigación durante los últimos seis años. La investigación realiza un análisis en profundidad para entender la literatura sobre private equity, centrandose en las PYME familiares, ofreciéndose indicaciones para aquellos que buscan alternativas al financiamiento bancario tradicional