The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

SQEAK: Using your Mobile Phone as a Gesture Sensor

This research looks at one approach to providing all mobile phone users with a simple low cost real time user interface allowing them to control highly interactive public space applications involving one user or a large number of simultaneous users. In order to sense accurately the real time hand movement gestures of mobile phone users the method uses miniature accelerometers that send the orientation signals over the network’s audio channel to a central computer for signal processing and application delivery. This affords that there is minimal delay, minimal connection protocol incompatibility and minimal mobile phone type or version discrimination. Without the need for mass user compliance, large numbers of users could begin to control public space cultural and entertainment applications using simple gesture movements.. Keywords Computer interaction, gesture recognition, ubiquitous computing, public entertainment, public information, mobile phone. 1