Influence of MWCNT/surfactant dispersions on the mechanical properties of Portland cement pastes

This work studies the reinforcing effect of Multi Walled Carbon Nanotubes (MWCNT) on cement pastes. A 0.35% solid concentration of MWCNT in powder was dispersed in deionized water with sodium dodecyl sulfate (cationic surfactant), cetylpyridinium chloride (anionic surfactant) and triton X-100 (amphoteric surfactant) using an ultrasonic tip processor. Three concentrations of each surfactant (1mM, 10mM and 100mM) were tested, and all samples were sonicated until an adequate dispersion degree was obtained. Cement pastes with additions of carbon nanotubes of 0.15% by mass of cement were produced in two steps; first the dispersions of MWCNT were combined with the mixing water using an ultrasonic tip processor to guarantee homogeneity, and then cement was added and mixed until a homogeneous paste was obtained. Direct tensile strength, apparent density and open porosity of the pastes were measured after 7 days of curing. It was found that the MWCNT/surfactants dispersions decrease the mechanical properties of the cement based matrix due to an increased porosity caused by the presence of surfactants. © Published under licence by IOP Publishing Ltd

Capacidad antioxidante de péptidos obtenidos de hidrolizados de tilapia con bromelina y papaína.

Se realizaron hidrolizados con restos del fileteado de tilapia utilizando extractos de piña y papaya como fuente de enzimas proteolíticas (bromelina y papaína). Se obtuvieron muestras de los hidrolizados a diferentes tiempos (30 minutos, 1, 24, 48 y 72 horas) eliminando los sólidos por centrifugación. Los péptidos solubles fueron separados mediante precipitación de proteínas con TCA, y la absorbancia a 280 nm del sobrenadante fue utilizada como medida de su concentración. La capacidad antioxidante de los péptidos obtenidos con bromelina y papaína a diferentes tiempos de hidrólisis fue determinada mediante la prueba de ORAC. Los péptidos obtenidos del hidrolizado elaborado a base de cascara de piña mostraron la mayor actividad antioxidante

La formación del profesorado universitario: mejora de los procesos de enseñanza-aprendizaje del alumnado con discapacidad

Las universidades españolas apuestan por la mejora de la enseñanza y aprendizaje del alumnado con diversidad funcional. La muestra de investigación fue de 44 estudiantes universitarios y 16 docentes de diversas categorías profesionales. El objetivo que se nos planteaba era investigar las demandas educativas de los estudiantes con discapacidad y conocer la formación del profesorado en el proceso de enseñanza y aprendizaje. A partir de los resultados obtenidos, los estudiantes consideran que la universidad dispone de un servicio de apoyo al estudiante adecuado. Sin embargo, el 90% piensan que existen graves problemas de accesibilidad al campus y a las aulas. Hay una similitud entre las percepciones estudiantes-profesores revelando una falta de capacitación del docente para la puesta en práctica de nuevas estrategias metodológicas didácticas.Spanish universities are committed to improving the teaching and learning of students with disabilities. The research sample was 44 college students and 16 teachers from different professional categories. The goal that we posed was to investigate the educational demands of students with disabilities and meet the training of teachers in the teaching and learning process. From the results obtained, students consider that the university has a student support service adequate. However, 90% think that there are serious problems of accessibility to campus and classrooms. There is a similarity between the student-teacher perceptions revealing a lack of training of teachers for the implementation of new teaching methodological strategies

Closure of a large lumbosacral myelomeningocele post operative defect with a human cadaveric split-thickness skin graft: a case report

Spina bifida is the most common birth defect of the central nervous system that is compatible with life, and myelomeningocele represents its most frequent form. Congenital myelomeningocele (CMM) has a worldwide incidence of 0.5 to 0.8 per 1,000 live newborns. CMM is a complex condition resulting from incomplete closure of the neural tube, mainly in the lumbosacral region. The objective of the surgical repair of the CMM is the reconstruction of all the tissue layers of the defect, avoiding possible postoperative complications. The aim of this case review is to present a re-epithelialization closure in a patient with a large CMM defect in who primary hermetic closure was not possible because there was too much tension at the edges of the defect. Therefore, human cadaveric split-thickness skin grafts were placed over the dura mater and the aponeurotic layer, covering the entire defect and an adequate healing and completely closure of the defect were observed in eight weeks. The surgical management of large meningomyelocele defects represents a major challenge and no single protocol exists for its reconstruction. The repair of an MMC defect should be performed during the first 72 hours after birth. After neurosurgical closure of the neural tube and dura, the myelomeningocele defect requires good quality skin and subcutaneous tissue with minimal wound tension for stable coverage. Human cadaveric skin grafts are considered a useful technique for temporary wound coverage because they lead to a more natural healing environment, possess ideal properties, and provide a physiological barrier that reduces microbiological contamination, in addition, it acts as a bridge to adhere to and to seal wound beds

Halogen ligth thermogravimetric technique for determining the retained water in fine aggregates used for concrete mixing design

[EN] Measuring the rate of water retention of the aggregates used in mortars and concrete is required to achieve a good mix design. The water retention, specifically absorption, is used to keep constant the water/cement ratio. This paper focuses on the study of a new technique for measuring retained water in fine aggregates. In order to obtain results, the procedure described in the existing standards takes more than 24 h. Additionally, it involves high consumption of heat energy due to the use of drying ovens. Furthermore, the results obtained remain highly variable and therefore discussed by the scientific community.In this research, a novel technique based on a halogen moisture analyzer was implemented. The technique was assessed using an experiment design with a surface response model. The most important factors and levels were identified together with the interactions between them. Finally, the model was validated and the results obtained with this technique were compared with those obtained by conventional techniques in order to verify that they were equivalent.Arias Jaramillo, Y.; Paya Bernabeu, JJ.; Ochoa Botero, JC. (2015). Halogen ligth thermogravimetric technique for determining the retained water in fine aggregates used for concrete mixing design. Journal of Thermal Analysis and Calorimetry: an international forum for thermal studies. 123:127-134. doi:10.1007/s10973-015-4902-8S127134123Djerbi Tegguer A. Determining the water absorption of recycled aggregates utilizing hydrostatic weighing approach. Constr Build Mater. 2012;27:112–6.Kasemchaisiri R, Tangtermsirikul S. A method to determine water retainability of porous fine aggregate for design and quality control of fresh concrete. Constr Build Mater. 2007;21:1322–34.Gonilho Pereira C, Castro-Gomes J, Pereira de Oliveira L. Influence of natural coarse aggregate size, mineralogy and water content on the permeability of structural concrete. Constr Build Mater. 2009;23:602–8.Cortas R, Roiziére E, Staquet S, Hamami A, Delplancke-Ogletree M. Effect of the water saturation of aggregates on the shrinkage induced cracking risk of concrete at early age. Cem Concr Compos. 2014;50:1–9.Black R. The determination of specific gravity using Siphon-Can method. Cem Concr Aggreg. 1986;8:46–50.Saxer E. A direct method of determining absorption and specific gravity of aggregates. 1956;2.Hughes B, Famili H., Part 1—Absorption of concrete aggregates, Part 2—saturated air techniques for determining the absorption of aggregates. In: Absorptions of concrete aggregates. Birmingham University; 1971.Tam VWY, Gao XF, Tam CM, Chan CH. New approach in measuring water absorption of recycled aggregates. Constr Build Mater. 2008;22:364–9.Balcedowiak W. Phase analysis of high-calcium line by TG. J Therm Anal Calorim. 2000;60:70–7.Mendoza O, Tobón JI. An alternative thermal method for identification of pozzolanic activity in Ca(OH)2/pozzolan pastes. J Therm Anal Calorim. 2013;114:589–96.Kosmatka SH, Kerkhoff B, Panarese W, MacLeod NF, McGrath RJ, Design and control of concrete mixtures. 7rd ed. Cement association of Canada. 2002. pp. 88.Cárdenas JI, Restrepo C. Patrimonio geológico y patrimonio minero de la cuenca carbonífera del suroeste antioqueño, Colombia. Boletín de ciencias de la tierra. 2006;18:91–102 ISSN 0120-3630 .Klein NS, Aguado A, Tollares-Carbonari BM, Real LV. Prediction of the water absorption by aggregates over time: modelling through the use of value function and experimental validation. Constr Build Mater. 2014;69:213–20

Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy

Background: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and K219E/Q, and sometimes T215F. Secondary mutations, including thumb subdomain polymorphisms (e.g. R284K) have been identified in association with TAMs. We have identified mutational clusters associated with virological failure during salvage therapy with tenofovir/emtricitabine-based regimens. In this context, we have studied the role of R284K as a secondary mutation associated with mutations of the TAM1 complex. Results: The cross-sectional study carried out with >200 HIV-1 genotypes showed that virological failure to tenofovir/emtricitabine was strongly associated with the presence of M184V (P < 10-10) and TAMs (P < 10-3), while K65R was relatively uncommon in previously-treated patients failing antiretroviral therapy. Clusters of mutations were identified, and among them, the TAM1 complex showed the highest correlation coefficients. Covariation of TAM1 mutations and V118I, V179I, M184V and R284K was observed. Virological studies showed that the combination of R284K with TAM1 mutations confers a fitness advantage in the presence of zidovudine or tenofovir. Studies with recombinant HIV-1 RTs showed that when associated with TAM1 mutations, R284K had a minimal impact on zidovudine or tenofovir inhibition, and in their ability to excise the inhibitors from blocked DNA primers. However, the mutant RT M41L/L210W/T215Y/R284K showed an increased catalytic rate for nucleotide incorporation and a higher RNase H activity in comparison with WT and mutant M41L/L210W/T215Y RTs. These effects were consistent with its enhanced chain-terminated primer rescue on DNA/DNA template-primers, but not on RNA/DNA complexes, and can explain the higher fitness of HIV-1 having TAM1/R284K mutations. Conclusions: Our study shows the association of R284K and TAM1 mutations in individuals failing therapy with tenofovir/emtricitabine, and unveils a novel mechanism by which secondary mutations are selected in the context of drug-resistance mutations

Small-spatial scale variations of nebular properties and the abundance discrepancy in three Galactic HII regions

We present results of long-slit spectroscopy in several slit positions that cover different morphological structures of the central parts of three bright Galactic HII regions: M8, M17 and NGC7635. We study the spatial distributions of a large number of nebular parameters such as the extinction coefficient, line fluxes, physical conditions and ionic abundances at the maximum spatial resolution attainable with our instrumentation. Particularly, our goal is to study the behaviour of the abundance discrepancy factor of O^{2+}, ADF(O^{2+}), defined as the logarithmic difference of the O^{2+} abundances derived from collisionally excited and recombination lines. We find that the ADF(O^{2+}) remains fairly constant along the slit positions of M8 and M17. In the case of NGC7635, we only detect the OII recombination lines in the integrated spectrum along the whole slit, where the ADF(O^{2+}) reaches a remarkably high value of about 0.59 dex. We compare our results with previous ones obtained for the Orion Nebula. We find several evidences that suggest the presence of a candidate to Herbig-Haro object in M8.Comment: 18 pages, 9 figures. Table A1 available only in the online version. Accepted for publication in MNRAS

The Sensitivity of HAWC to High-Mass Dark Matter Annihilations

The High Altitude Water Cherenkov (HAWC) observatory is a wide field-of-view detector sensitive to gamma rays of 100 GeV to a few hundred TeV. Located in central Mexico at 19 degrees North latitude and 4100 m above sea level, HAWC will observe gamma rays and cosmic rays with an array of water Cherenkov detectors. The full HAWC array is scheduled to be operational in Spring 2015. In this paper, we study the HAWC sensitivity to the gamma-ray signatures of high-mass (multi- TeV) dark matter annihilation. The HAWC observatory will be sensitive to diverse searches for dark matter annihilation, including annihilation from extended dark matter sources, the diffuse gamma-ray emission from dark matter annihilation, and gamma-ray emission from non-luminous dark matter subhalos. Here we consider the HAWC sensitivity to a subset of these sources, including dwarf galaxies, the M31 galaxy, the Virgo cluster, and the Galactic center. We simulate the HAWC response to gamma rays from these sources in several well-motivated dark matter annihilation channels. If no gamma-ray excess is observed, we show the limits HAWC can place on the dark matter cross-section from these sources. In particular, in the case of dark matter annihilation into gauge bosons, HAWC will be able to detect a narrow range of dark matter masses to cross-sections below thermal. HAWC should also be sensitive to non-thermal cross-sections for masses up to nearly 1000 TeV. The constraints placed by HAWC on the dark matter cross-section from known sources should be competitive with current limits in the mass range where HAWC has similar sensitivity. HAWC can additionally explore higher dark matter masses than are currently constrained.Comment: 15 pages, 4 figures, version to be published in PR

VAMOS: a Pathfinder for the HAWC Gamma-Ray Observatory

VAMOS was a prototype detector built in 2011 at an altitude of 4100m a.s.l. in the state of Puebla, Mexico. The aim of VAMOS was to finalize the design, construction techniques and data acquisition system of the HAWC observatory. HAWC is an air-shower array currently under construction at the same site of VAMOS with the purpose to study the TeV sky. The VAMOS setup included six water Cherenkov detectors and two different data acquisition systems. It was in operation between October 2011 and May 2012 with an average live time of 30%. Besides the scientific verification purposes, the eight months of data were used to obtain the results presented in this paper: the detector response to the Forbush decrease of March 2012, and the analysis of possible emission, at energies above 30 GeV, for long gamma-ray bursts GRB111016B and GRB120328B.Comment: Accepted for pubblication in Astroparticle Physics Journal (20 pages, 10 figures). Corresponding authors: A.Marinelli and D.Zaboro