190 research outputs found

    Optimising Health Emergency Resource Management from Multi-Model Databases

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    The health care sector is one of the most sensitive sectors in our society, and it is believed that the application of specific and detailed database creation and design techniques can improve the quality of patient care. In this sense, better management of emergency resources should be achieved. The development of a methodology to manage and integrate a set of data from multiple sources into a centralised database, which ensures a high quality emergency health service, is a challenge. The high level of interrelation between all of the variables related to patient care will allow one to analyse and make the right strategic decisions about the type of care that will be needed in the future, efficiently managing the resources involved in such care. An optimised database was designed that integrated and related all aspects that directly and indirectly affected the emergency care provided in the province of Jaén (city of Jaén, Andalusia, Spain) over the last eight years. Health, social, economic, environmental, and geographical information related to each of these emergency services was stored and related. Linear and nonlinear regression algorithms were used: support vector machine (SVM) with linear kernel and generated linear model (GLM), and the nonlinear SVM with Gaussian kernel. Predictive models of emergency demand were generated with a success rate of over 90%

    Método objetivo para analizar dos modelos de la línea de tres puntos en Minibasket

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    The aim of this manuscript was to show the methodology used to design a category system that allows analyzing the game in mini-basketball, to compare two shapes of the three-point line. Six experts and 123 girls from 12 teams participated. The methodology used to design the category system was qualitative and followed four stages: a) to identify a criteria list, b) to delimit and to define each criteria and its categories, c) to improve the category system y d) to analyse its validity and reliability. The category system was exhaustive and mutually exclusive, it had content validity and it made possible the reliability of the observation.El objetivo de este trabajo fue presentar el procedimiento seguido para la elaboración de un sistema de categorías que permitiera analizar las acciones de juego con dos modelos diferentes de la línea de tres puntos en minibasket. Participaron seis expertos y 123 niñas de 12 equipos. La metodología seguida para diseñar el sistema de categorías fue cualitativa y siguió cuatro etapas: a) identificación de una lista de criterios, b) delimitación y definición operacional de cada criterio y de sus categorías, c) perfeccionamiento del sistema de categorías y d) análisis de su validez y fiabilidad. El sistema de categorías final fue exhaustivo y mutuamente excluyente, tuvo validez de contenido y posibilitó la fiabilidad de la observación

    Diseño y construcción de una cámara de niebla salina para ensayos de corrosión

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    La cámara de niebla salina es un equipo de laboratorio planteado para realizar ensayos de corrosión de forma acelerada, el cual proporciona una atmósfera corrosiva formada por una niebla salina, controlando las variables que intervienen en este proceso. El diseño se basó en equipos del mismo tipo disponibles en el mercado, empleando los parámetros establecidos en la norma ASTM B117 (1997) “Salt Spray (fog) Test”

    Two QTLs govern the resistance to Sclerotinia minor in an interspecific peanut RIL population

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    Sclerotinia blight is a soilborne disease caused by Sclerotinia minor Jagger and can produce severe decrease in yield. Cultural management strategies and chemical treatment are not completely effective; therefore, growing peanut-resistant varieties is likely to be the most effective control method for this disease. Sclerotinia blight resistance has been identified in wild Arachis species and further transferred to peanut elite cultivars. To identify the genome regions conferring Sclerotinia blight resistance within a tetraploid genetic background, this study evaluated a population of recombinant inbred lines (RIL) with introgressed genes from three wild diploid species: A. cardenasii, A. correntina, and A. batizocoi. Two consistent quantitative trait loci (QTLs), qSbIA04 and qSbIB04 located on chromosomes A04 and B04, respectively, were identified. The QTL qSbIA04 was mapped at 56.39 cM explaining 29% of the phenotypic variance and qSbIB04 was mapped at 13.38 cM explaining 22% of the overall phenotypic variance

    Evaluación de los recursos solares en el sur de la Península utilizando el modelo MM5

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    Ponencia presentada en: XXIX Jornadas Científicas de la AME y el VII Encuentro Hispano Luso de Meteorología celebrado en Pamplona, del 24 al 26 de abril de 2006

    Evaluación de diferentes pruebas para el diagnóstico de H. Pylori.

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    Todos los métodos disponibles para el diagnóstico de H. pylori tienen diferencias en su sensibilidad y especificidad. El propósito de este estudio es determinar el índice de desempeño, sensibilidad, especificidad y valores predictivos de cuatro métodos invasivos, teniendo como técnica de referencia la definición de caso: cultivo positivo o la concordancia de por lo menos dos procesos de diagnósticos positivos

    Noisy-threshold control of cell death

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    <p>Abstract</p> <p>Background</p> <p>Cellular responses to death-promoting stimuli typically proceed through a differentiated multistage process, involving a lag phase, extensive death, and potential adaptation. Deregulation of this chain of events is at the root of many diseases. Improper adaptation is particularly important because it allows cell sub-populations to survive even in the continuous presence of death conditions, which results, among others, in the eventual failure of many targeted anticancer therapies.</p> <p>Results</p> <p>Here, I show that these typical responses arise naturally from the interplay of intracellular variability with a threshold-based control mechanism that detects cellular changes in addition to just the cellular state itself. Implementation of this mechanism in a quantitative model for T-cell apoptosis, a prototypical example of programmed cell death, captures with exceptional accuracy experimental observations for different expression levels of the oncogene Bcl-x<sub>L </sub>and directly links adaptation with noise in an ATP threshold below which cells die.</p> <p>Conclusions</p> <p>These results indicate that oncogenes like Bcl-x<sub>L</sub>, besides regulating absolute death values, can have a novel role as active controllers of cell-cell variability and the extent of adaptation.</p
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