Medium dependence of multiplicity distributions in MLLA

We study the modification of the multiplicity distributions in MLLA due to the presence of a QCD medium. The medium is introduced though a multiplicative constant ($f_{med}$) in the soft infrared parts of the kernels of QCD evolution equations. Using the asymptotic ansatz for quark and gluons mean multiplicities $=e^{\gamma y}$ and $=r^{-1}e^{\gamma y}$ respectively, we study two cases: fixed $\gamma$ as previously considered in the literature, and fixed $\alpha_s$. We find opposite behaviors of the dispersion of the multiplicity distributions with increasing $f_{med}$ in both cases. For fixed $\gamma$ the dispersion decreases, while for fixed $\alpha_s$ it increases.Comment: LaTeX, 9 pages, 4 eps figures; proceedings of the 3rd International Conference on Hard and Electromagnetic Probes in High-Energy Nuclear Collisions - Hard Probes 2008 (Illa de A Toxa, Spain, June 8th-14th 2008

Obtención de un polímero de tipo Elastina modificado con secuencias Bioactivas y Biodegradables, para su aplicación en ingeniería

La matriz extracelular es uno de los principales elementos reguladores de la actividad celular. Los diferentes módulos de las macromoléculas que la componen son capaces de desencadenar señales que activan diferentes rutas intracelulares que organizan las funciones vitales de las células. La ingeniería de tejidos se dedica a desarrollar sistemas capaces de imitar, temporalmente, el comportamiento de la matriz extracelular con objeto de promover la regeneración o el reemplazo de tejidos y órganos dañados, actuando como un soporte atractivo para las células que deben adherirse y crecer sobre ella, hasta reemplazarla por tejido sano. En este trabajo se describe el proceso de diseño y producción de un polímero de tipo elastina que se ha funcionalizado con secuencias bioactivas que añaden actividades específicas al andamio o soporte celular que constituye la elastina. Así,algunos dominios elastoméricos se modificaron con el aminoácido lisina para poder entrecruzar las moléculas de polímero y conseguir matrices. También se incluyó la secuencia REDV, presente el dominio CS5 de la fibronectina humana, como motivo de adhesión celular. Por último, el polímero se funcionalizó con secuencias diana de enzimas proteolíticas para mejorar su bioprocesabilidad.Extracellular matrix (ECM) is a major component for the regulation of cell activity. The different modules of the proteins which constitute the extracellular matrix macromolecules represent for the cells which enter in contact with them, new signals capable of activating several intracellular signaling pathways, resulting in the modulation of numerous cell functions. Tissue engineering tries to develop new materials based on these components as scaffolds for cells to promote their adhesion and growth. In this work, genetic engineering techniques were used to design and biosynthesize an extracellular matrix analogue based in the elastin component. The structural base of our scaffold is an elastin –derived sequence which confers an adequate mechanical behavior. In addition, several domains were included, for adding new bioactivities to this elastin-like polymer (ELP). Some of these elastic domains were modified to contain lysine for cross linking purposes. The polymer also contained periodically spaced fibronectin CS5 domain enclosing the well known cell attachment sequence REDV. Finally, the polymer had target sequences for proteolitic action.Peer ReviewedAward-winnin

Segmenting Critical Factors for Enhancing the use of IT in Humanitarian Supply Chain Management

AbstractThis study intends to explore and segment the critical factors (CFs) to enhance the use of Information Technology (IT) in Humanitarian Supply Chain (HSC), particularly in the Indian context. In this study, ten influencing factors has been identified through an extensive literature review and expert opinion. A structural model and cause–effect relationship diagram was developed using decision-making trial and evaluation laboratory (DEMATEL) method for the identification of CFs. The present study adopt a comprehensive and rigorous procedure to identify six CFs namely, top management support, Government support, feedback mechanism to facilitate learning from prior experiences, transparent and accountable supply chain, strategic planning, and mutual learning with other commercial organizations (COs). The developed framework provides a simple, effective and efficient way to enhance the utilization of IT in HSC and in large to improve the competencies and performance of HSC

Application of direct bioautography and SPME-GC-MS for the study of antibacterial chamomile ingredients

The isolation and characterization of antibacterial chamomile components were performed by the use of direct bioautography and solid phase microextraction (SPME)-GC-MS. Four ingredients, active against Vibrio fischeri, were identified as the polyacetylene geometric isomers cis- and trans-spiroethers, the coumarin related herniarin, and the sesquiterpene alcohol (-)-alpha-bisabolol

Reliability of low-cost near-infrared spectroscopy in the determination of muscular oxygen saturation and hemoglobin concentration during rest, isometric and dynamic strength activity

Indexación ScopusBackground: The objective of this study was to establish the reliability of the Humon Hex near-infrared reflectance spectroscopy (NIRS) in determining muscle oxygen saturation (SmO2) and hemoglobin concentration (Hgb) at rest and during isometric and dynamic strength exercises using a functional electromechanical dynamometer (FEMD). Methods: The SmO2 and Hgb values of sixteen healthy adults (mean ± standard deviation (SD): Age = 36.1 ± 6.4 years) were recorded at rest and during isometry (8 s), dynamic strength I (initial load of 40% of the average isometric load, with 2 kg increments until muscle failure) and dynamic strength II (same as I, but with an initial load of 40% of the maximum isometric load) activity. To evaluate the reliability in the determination of SmO2 and Hgb of this device, intraclass correlation coefficient (ICC), standard error of measurement (SEM) and coefficient of variation (CV) were obtained. Results: The main results obtained are SmO2 at rest (CV = 5.76%, SEM = 3.81, ICC = 0.90), isometric strength (CV = 3.03%, SEM = 2.08, ICC = 0.92), dynamic strength I (CV = 10.6, SEM = 7.17, ICC = 0.22) and dynamic strength II (CV = 9.69, SEM = 6.75, ICC = 0.32); Hgb at rest (CV = 1.97%, SEM = 0.24, ICC = 0.65), isometric strength (CV = 0.98%, SEM = 0.12, ICC = 0.96), dynamic strength I (CV = 3.25, SEM = 0.40, ICC = 0.54) and dynamic strength II (CV = 2.74, SEM = 0.34, ICC = 0.65). Conclusions: The study shows that Humon Hex is a reliable device to obtain SmO2 and Hgb data in healthy adult subjects at rest and during isometric strength, providing precision for measurements made with this device. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.https://www.mdpi.com/1660-4601/17/23/882

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Establishment and cryptic transmission of Zika virus in Brazil and the Americas

Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast Brazil1. Brazil has had the highest number of reported ZIKV cases worldwide (more than 200,000 by 24 December 20162) and the most cases associated with microcephaly and other birth defects (2,366 confirmed by 31 December 20162). Since the initial detection of ZIKV in Brazil, more than 45 countries in the Americas have reported local ZIKV transmission, with 24 of these reporting severe ZIKV-associated disease3. However, the origin and epidemic history of ZIKV in Brazil and the Americas remain poorly understood, despite the value of this information for interpreting observed trends in reported microcephaly. Here we address this issue by generating 54 complete or partial ZIKV genomes, mostly from Brazil, and reporting data generated by a mobile genomics laboratory that travelled across northeast Brazil in 2016. One sequence represents the earliest confirmed ZIKV infection in Brazil. Analyses of viral genomes with ecological and epidemiological data yield an estimate that ZIKV was present in northeast Brazil by February 2014 and is likely to have disseminated from there, nationally and internationally, before the first detection of ZIKV in the Americas. Estimated dates for the international spread of ZIKV from Brazil indicate the duration of pre-detection cryptic transmission in recipient regions. The role of northeast Brazil in the establishment of ZIKV in the Americas is further supported by geographic analysis of ZIKV transmission potential and by estimates of the basic reproduction number of the virus

Obtención de un polímero de tipo Elastina modificado con secuencias Bioactivas y Biodegradables, para su aplicación en ingeniería

La matriz extracelular es uno de los principales elementos reguladores de la actividad celular. Los diferentes módulos de las macromoléculas que la componen son capaces de desencadenar señales que activan diferentes rutas intracelulares que organizan las funciones vitales de las células. La ingeniería de tejidos se dedica a desarrollar sistemas capaces de imitar, temporalmente, el comportamiento de la matriz extracelular con objeto de promover la regeneración o el reemplazo de tejidos y órganos dañados, actuando como un soporte atractivo para las células que deben adherirse y crecer sobre ella, hasta reemplazarla por tejido sano. En este trabajo se describe el proceso de diseño y producción de un polímero de tipo elastina que se ha funcionalizado con secuencias bioactivas que añaden actividades específicas al andamio o soporte celular que constituye la elastina. Así,algunos dominios elastoméricos se modificaron con el aminoácido lisina para poder entrecruzar las moléculas de polímero y conseguir matrices. También se incluyó la secuencia REDV, presente el dominio CS5 de la fibronectina humana, como motivo de adhesión celular. Por último, el polímero se funcionalizó con secuencias diana de enzimas proteolíticas para mejorar su bioprocesabilidad.Extracellular matrix (ECM) is a major component for the regulation of cell activity. The different modules of the proteins which constitute the extracellular matrix macromolecules represent for the cells which enter in contact with them, new signals capable of activating several intracellular signaling pathways, resulting in the modulation of numerous cell functions. Tissue engineering tries to develop new materials based on these components as scaffolds for cells to promote their adhesion and growth. In this work, genetic engineering techniques were used to design and biosynthesize an extracellular matrix analogue based in the elastin component. The structural base of our scaffold is an elastin –derived sequence which confers an adequate mechanical behavior. In addition, several domains were included, for adding new bioactivities to this elastin-like polymer (ELP). Some of these elastic domains were modified to contain lysine for cross linking purposes. The polymer also contained periodically spaced fibronectin CS5 domain enclosing the well known cell attachment sequence REDV. Finally, the polymer had target sequences for proteolitic action.Peer ReviewedAward-winnin