Influence of match status on corner kick in elite soccer

El propósito del estudio es analizar como la variable situacional resultado parcial puede afectar al comportamiento táctico-estratégico en los saques de esquina en fútbol. Se han estudiado 902 saques de esquina realizados en 95 partidos correspondientes a la UEFA Euro 2012, y Fase Final de la FIFA World Cup 2010. Para identificar las interacciones se utilizó el método de crecimiento Chi-square automatic interaction detector (CHAID), que nos ha permitido identificar tres modelos: con el resultado de empate en los últimos minutos de juego, el equipo atacante incorpora al remate entre 2 a 5 jugadores y el equipo rival sitúa 1 ó 2 jugadores bajo palos. Ganando en los últimos minutos del encuentro, el equipo sitúa también entre 2 a 5 jugadores en ataque y el rival no defiende bajo palos. Perdiendo en los últimos minutos del encuentro, el equipo atacante incorpora a 6 o más jugadores al ataqueThe aim of this study was to examine the effects of the situational variable match status on corner kicks performance indicators in 95 matches played during the final stages of the 2012 UEFA European Championships and the 2010 FIFA World Cup. Video recordings of the matches were analyzed and coded post-event using notational analysis. Multiple interactions between the performance indicators and match status were analyzed using the Chi-squared automatic interaction detection (CHAID) decision-tree method. The results show that when a corner kick is taken during the last 30 minutes of the match, teams that are losing place 6 or more attackers in the shooting area, while teams that are drawing place 2-5 attackers in this area. In the same situation, teams that are drawing place 1-2 defenders at the goalposts while winning teams place non

Análisis de la eficacia de los saques de esquina en la copa del mundo de fútbol 2010 : un intento de identificación de variables explicativas

Las acciones a balón parado (ABP) en fútbol son todas aquellas situaciones de juego que se inician con un saque desde parado después de una interrupción reglamentaria del mismo. En este trabajo se ha pretendido analizar la eficacia de una de estas acciones, el saque de esquina; identificar las variables más relevantes para conducir al éxito (el remate) a estas acciones y proponer un modelo de saque de esquina exitoso. Después del registro de 554 saques de esquina ejecutados en el Mundial de Sudáfrica 2010 y de realizar análisis a nivel univariado, bivariado y multivariado, los resultados indican una baja eficacia en el remate en este tipo de acciones, la identificación de una serie de variables que presentan una relación estadísticamente significativa y la propuesta de un modelo explicativo, que aunque presenta una capacidad explicativa limitada, ayuda a interpretar de forma práctica la ejecución de estas acciones.In soccer, dead-ball moves are those in which the ball is returned to play from a stationary position following an interruption of play. The aim of this study was to analyse the effectiveness of one such dead-ball move, namely corner kicks, and to identify the key variables that determine the success of a shot or header following a corner, thereby enabling a model of successful corner kicks to be proposed. We recorded 554 corner kicks performed during the 2010 World Cup in South Africa and carried out a univariate, bivariate and multivariate analysis of the data. The results indicated that corners were of limited effectiveness in terms of the success of subsequent shots or headers. The analysis also revealed a series of variables that were significantly related to one another, and this enabled us to propose an explanatory model. Although this model had limited explanatory power, it nonetheless helps to understand the execution of corner kicks in practical terms.As acções de bola parada (ABP) no futebol são todas as situações de jogo que se iniciam depois de uma interrupção regulamentar do mesmo. Neste trabalho pretendeu-se analisar a eficácia de uma destas acções, o canto; identificar as variáveis mais relevantes para levar ao êxito (o remate) estas acções e propor um modelo de canto bem sucedido. Após o registo de 554 cantos executados no Mundial de 2010 na África do Sul e da realização de uma análise a nível univariado, bivariado e multivariado, os resultados indicam uma baixa eficácia no remate neste tipo de acções, a identificação de uma série de variáveis que apresentam uma relação estatisticamente significativa e a proposta de um modelo explicativo que, embora apresente capacidade explicativa limitada, ajuda a interpretar de forma prática a execução destas acções

Mono and Di-Fucosylated Glycans of the Parasitic Worm S. Mansoniare Recognized Differently by the Innate Immune Receptor DC-SIGN

The parasitic worm,Schistosoma mansoni, expresses unusual fucosylated glycans in a stage-dependent manner that can be recognized by the human innate immune receptor DC-SIGN, thereby shaping host immune responses. We have developed a synthetic approach for mono- and bis-fucosylated LacdiNAc (LDN-F and LDN-DF, respectively), which are epitopes expressed on glycolipids and glycoproteins ofS. mansoni. It is based on the use of monosaccharide building blocks having carefully selected amino-protecting groups, facilitating high yielding and stereoselective glycosylations. The molecular interaction between the synthetic glycans and DC-SIGN was studied by NMR and molecular modeling, which demonstrated that the alpha 1,3-fucoside of LDN-F can coordinate with the Ca2+-ion of the canonical binding site of DC-SIGN allowing for additional interactions with the underlying LDN backbone. The 1,2-fucoside of LDN-DF can be complexed in a similar manner, however, in this binding mode GlcNAc and GalNAc of the LDN backbone are placed away from the protein surface resulting in a substantially lower binding affinity. Glycan microarray binding studies showed that the avidity and selectivity of binding is greatly enhanced when the glycans are presented multivalently, and in this format Le(x)and LDN-F gave strong responsiveness, whereas no binding was detected for LDN-DF. The data indicates thatS. mansonihas developed a strategy to avoid detection by DC-SIGN in a stage-dependent manner by the addition of a fucoside to a number of its ligands.This research was supported by the Netherlands Organization for Scientific Research (NWO; TOP-PUNT grant 718.015.003 to G.-J.B.), the Human Frontier Science Program Organization (HFSP; grant LT000747/2018-C to L.U.), the European Research Council (ERC-2017-AdG, project number 788143-RECGLYC-ANMR to J.J.-B.), the Agencia Estatal Investigacion of Spain (AEI; grant RTI2018-094751-B-C21 to J.J.-B.) and the Severo Ochoa Excellence Accreditation (SEV-2016-0644 to J.J.-B.)

1,3,5-Triazines with aromatic amino acids: Exploring their potential as lectin mimetics

VII Escuela de verano de la SEQT, Sociedad Española de Química Terapeútica, Barcelona, 19-21 Julio, 202

The corner kick as a performance profile in football. An empirical review

El presente trabajo consiste en una profunda revisión sobre los estudios cuantitativos y cualitativos relacionados con la eficacia de los saques de esquina en fútbol. Se han consultado cinco de las bases de datos con mayor reconocimiento internacional, Google Académico, PubMed, SPORTDiscus, Scopus y Web of Science. El criterio para la selección de los descriptores y del período de búsqueda tuvo como objetivo acceder a los principales trabajos empíricos que incluían los saques de esquina El objetivo principal es alcanzar un conocimiento más profundo (y con el soporte empírico adecuado) de los saques de esquina en fútbol. Se han clasificado los resultados en tres apartados: 1) A nivel descriptivo, conocer la regularidad, influencia e incidencia de estas acciones en el fútbol actual; 2) conocer las variables estadísticamente significativas asociadas al éxito en este tipo de acciones; 3) Por último, conocer y analizar los estudios que recogen diferentes modelos explicativos (análisis multivariante). Finalmente, se presentan orientaciones prácticas derivadas de los resultados de las investigaciones revisadas que pueden contribuir a la optimización de éste tipo de acciones en el fútbol profesionalThe present manuscript consists in a deep revision on the quantitative and qualitative studies related to the effectiveness of the corners in football. We have consulted five of the most internationally recognized databases, Google Scholar, PubMed, SPORTDiscus, Scopus and Web of Science. The criterion for the selection of the descriptors and the search period was aimed at accessing the main empirical works that included corner kicks. The main objective is to reach a deeper knowledge (and with the adequate empirical support) of the corner kicks in soccer. The results have been classified into three sections: 1) On a descriptive level, to know the regularity, influence and incidence of these actions in current football; 2) know the statistically significant variables associated with success in this type of actions; 3) Finally, to know and analyze the studies that collect different explanatory models (multivariate analysis). Finally, practical guidelines derived from the results of the reviewed research that can contribute to the optimization of this type of actions in professional football are presentedWe gratefully acknowledge the support of both Spanish government projects: Avances metodológicos y tecnológicos en el estudio observacional del comportamiento deportivo (Secretaría de Estado de Investigación, Desarrollo e Innovación del Ministerio de Economía y Competitividad) during the period 2015-2017 [Grant PSI2015-71947-REDT; MINECO/FEDER, UE], and La actividad física y el deporte como potenciadores del estilo de vida saludable: Evaluación del comportamiento deportivo desde metodologías no intrusivas (Secretaría de Estado de Investigación, Desarrollo e Innovación del Ministerio de Economía y Competitividad) during the period 2016-2018 [Grant DEP2015-66069-P; MINECO/FEDER, UE]. We gratefully acknowledge the support of the Generalitat de Catalunya Research Group (GRUP DE RECERCA E INNOVACIÓ EN DISSENYS [GRID]). Tecnología i aplicació multimedia i digital als dissenys observacionals], [Grant 2014 SGR 971S

Molecular Recognition of Glycan-Bearing Glycomacromolecules Presented at Membrane Surfaces by Lectins: An NMR View

Lectin–glycan interactions are at the heart of a multitude of biological events. Glycans are usually presented in a multivalent manner on the cell surface as part of the so-called glycocalyx, where they interact with other entities. This multivalent presentation allows us to overcome the typical low affinities found for individual glycan–lectin interactions. Indeed, the presentation of glycans may drastically impact their binding by lectins, highly affecting the corresponding binding affinity and even selectivity. In this context, we herein present the study of the interaction of a variety of homo- and heteromultivalent lactose-functionalized glycomacromolecules and their lipid conjugates with two human galectins. We have employed as ligands the glycomacromolecules, as well as liposomes decorated with those structures, to evaluate their interactions in a cell-mimicking environment. Key details of the interaction have been unravelled by NMR experiments, both from the ligand and receptor perspectives, complemented by cryo-electron microscopy methods and molecular dynamics simulations.M.H. and L.H. thank the DFG for support through the ViroCarb research consortium (HA5950/5-2) and the CeMSA@HHU (Center for Molecular and Structural Analytics @ Heinrich-Heine University) for recording the mass spectrometric and the NMR-spectroscopic data for the structural conformation of the glycomacromolecules and their lipid conjugates. The CIC bioGUNE EM platform is also thanked for infrastructural support during cryo-EM data collection. The group in Spain thank the European Research Council (RECGLYCANMR, Advanced grant no. 788143), MCIN/AEI/10.13039/501100011033 for grants PDI2021-1237810B-C21, PID2021-126130OB-I00, CEX2021-001136-S, and CIBERES, an initiative of Instituto de Salud Carlos III (ISCIII), Madrid, Spain, for generous funding

Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins

info:eu-repo/grantAgreement/WT/Physiological Sciences/095700 ERC‐2017‐AdG, 788143‐RECGLYCANMR grant 200077 grant RTI2018‐094751‐B‐C21 GC2018‐098996‐B‐I00 RTI2018‐099592‐B‐C22 RTI2018‐101269‐B‐I00 SEV‐2016‐0644 IF/00780/2015 PTDC/BIA‐MIB/31028/2017 UCIBIO UIDB/04378/2020 Infrastructure project 22161 PD/BD/142847/2018The glycan structures of the receptor binding domain of the SARS-CoV2 spike glycoprotein expressed in human HEK293F cells have been studied by using NMR. The different possible interacting epitopes have been deeply analysed and characterized, providing evidence of the presence of glycan structures not found in previous MS-based analyses. The interaction of the RBD 13C-labelled glycans with different human lectins, which are expressed in different organs and tissues that may be affected during the infection process, has also been evaluated by NMR. In particular, 15N-labelled galectins (galectins-3, -7 and -8 N-terminal), Siglecs (Siglec-8, Siglec-10), and C-type lectins (DC-SIGN, MGL) have been employed. Complementary experiments from the glycoprotein perspective or from the lectin's point of view have permitted to disentangle the specific interacting epitopes in each case. Based on these findings, 3D models of the interacting complexes have been proposed.publishersversionpublishe

EUROCarbDB: An open-access platform for glycoinformatics

The EUROCarbDB project is a design study for a technical framework, which provides sophisticated, freely accessible, open-source informatics tools and databases to support glycobiology and glycomic research. EUROCarbDB is a relational database containing glycan structures, their biological context and, when available, primary and interpreted analytical data from high-performance liquid chromatography, mass spectrometry and nuclear magnetic resonance experiments. Database content can be accessed via a web-based user interface. The database is complemented by a suite of glycoinformatics tools, specifically designed to assist the elucidation and submission of glycan structure and experimental data when used in conjunction with contemporary carbohydrate research workflows. All software tools and source code are licensed under the terms of the Lesser General Public License, and publicly contributed structures and data are freely accessible. The public test version of the web interface to the EUROCarbDB can be found at http://www.ebi.ac.uk/eurocar