Predicting the Impact of Climate Change on U.S. Power Grids and Its Wider Implications on National Security

Abstract We discuss our technosocial analytics research and development on predicting and assessing the impact of climate change on U.S. power-grids and the wider implications for national security. The ongoing efforts extend cutting-edge modeling theories derived from climate, energy, social sciences, and national security domains to form a unified system coupled with an interactive visual interface for technosocial analysis. The goal of the system is to create viable future scenarios that address both technical and social factors involved in the model domains. These scenarios enable policymakers to formulate a coherent, unified strategy towards building a safe and secure society. The paper gives an executive summary of our preliminary efforts in the past year and provides a glimpse of our work planned for the second year of a multi-year project

Brain dysfunction in tubular and tubulointerstitial kidney diseases

Kidney function has two important elements: glomerular filtration and tubular function (secretion and reabsorption). A persistent decrease in glomerular filtration rate (GFR), with or without proteinuria, is diagnostic of chronic kidney disease (CKD). While glomerular injury or disease is a major cause of CKD and usually associated with proteinuria, predominant tubular injury, with or without tubulointerstitial disease, is typically non-proteinuric. CKD has been linked with cognitive impairment, but it is unclear how much this depends on a decreased GFR, altered tubular function or the presence of proteinuria. Since CKD is often accompanied by tubular and interstitial dysfunction, we explore here for the first time the potential role of the tubular and tubulointerstitial compartments in cognitive dysfunction. To help address this issue we selected a group of primary tubular diseases with preserved GFR in which to review the evidence for any association with brain dysfunction. Cognition, mood, neurosensory and motor disturbances are not well characterized in tubular diseases, possibly because they are subclinical and less prominent than other clinical manifestations. The available literature suggests that brain dysfunction in tubular and tubulointerstitial diseases is usually mild and is more often seen in disorders of water handling. Brain dysfunction may occur when severe electrolyte and water disorders in young children persist over a long period of time before the diagnosis is made. We have chosen Bartter and Gitelman syndromes and nephrogenic diabetes insipidus as examples to highlight this topic. We discuss current published findings, some unanswered questions and propose topics for future research

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema

Avaliação de dissertação de Mestrado em projetos de saúde pública.

Los resultados obtenidos sobre los determinantes del anteproyecto de tesis muestran un perfil en concordancia con lo esperado. Al desglosar la evaluación realizada por los jurados, se aprecia una mayor dispersión en los resultados, encontrándose valores de R y M (las calificaciones menores de 15 son no aprobatorias, por lo cual se deberían reforzar estos puntos para el momento de realizar la tesis de maestría). En lo relativo al planteamiento del problema, la discrepancia en las calificaciones dadas por el jurado es mayor, por ende, éstas se deberían normar más detalladamente, para evitar o disminuir tales [email protected]@ula.ve / [email protected][email protected] / [email protected]@[email protected] results obtained on the determinants of the preliminary draft of thesis show a profile in line with expectations. Drill down on the assessment made by the jurors, appreciates a greater dispersion in results, finding values of R y M (under the age of 15 grades are not accordance, by which these points should be strengthened for the time of the master’s thesis). As regards the statement of the problem, the discrepancy in the ratings given by the jury is greater, therefore, they should regulate in more detail, to avoid or reduce such differences.Os resultados obtidos sobre os determinantes do anteprojeto de tese mostram um perfil em consonância com as expectativas. Broca para baixo sobre a avaliação feita pelos jurados, aprecia uma maior dispersão nos resultados, encontrar os valores de R y M (com idade inferior a 15 graus não são acordo, pelo que estes pontos devem ser reforçados para o momento da tese de Mestrado). No que diz respeito a declaração do problema, a discrepância nas avaliações dada pelo júri é maior, portanto, eles devem regular com mais detalhes, para evitar ou reduzir essas diferenças

The SGLT2 inhibitor dapagliflozin improves kidney function in glycogen storage disease XI

: Glycogen storage disease XI, also known as Fanconi-Bickel syndrome (FBS), is a rare autosomal recessive disorder caused by mutations in the SLC2A2 gene that encodes the glucose-facilitated transporter type 2 (GLUT2). Patients develop a life-threatening renal proximal tubule dysfunction for which no treatment is available apart from electrolyte replacement. To investigate the renal pathogenesis of FBS, SLC2A2 expression was ablated in mouse kidney and HK-2 proximal tubule cells. GLUT2Pax8Cre+ mice developed time-dependent glycogen accumulation in proximal tubule cells and recapitulated the renal Fanconi phenotype seen in patients. In vitro suppression of GLUT2 impaired lysosomal autophagy as shown by transcriptomic and biochemical analysis. However, this effect was reversed by exposure to a low glucose concentration, suggesting that GLUT2 facilitates the homeostasis of key cellular pathways in proximal tubule cells by preventing glucose toxicity. To investigate whether targeting proximal tubule glucose influx can limit glycogen accumulation and correct symptoms in vivo, we treated mice with the selective SGLT2 inhibitor dapagliflozin. Dapagliflozin reduced glycogen accumulation and improved metabolic acidosis and phosphaturia in the animals by normalizing the expression of Napi2a and NHE3 transporters. In addition, in a patient with FBS, dapagliflozin was safe, improved serum potassium and phosphate concentrations, and reduced glycogen content in urinary shed cells. Overall, this study provides proof of concept for dapagliflozin as a potentially suitable therapy for FBS

Bariatric Surgery Can Correct Iron Depletion in Morbidly Obese Women: A Link with Chronic Inflammation

International audienceObesity is associated with a chronic and low-grade inflammation which may cause hypoferremia as seen in patients with chronic inflammatory diseases. The aim of the present study was to investigate the relationship between iron status and markers of inflammation in morbidly obese women and the effect of bariatric surgery