Efecto de la suplementación con semilla de algodón y maíz molido sobre el consumo y el desempeño productivo de ovinos de pelo colombiano

Objetivo. Efecto de la suplementación con semilla de algodón y maíz molido sobre el consumo y el desempeño productivos de ovinos de pelo Colombiano. Materiales y métodos. Se utilizaron 24 ovinos con peso de 16 ± 2 kg durante 127 días. Los tratamientos fueron T0: pastoreo, T1: pastoreo + 25% semilla de algodón (SA) + 75% maíz molido (MM), T2: pastoreo + 50% (SA) + 50% (MM) y T3: pastoreo + 75% (SA) + 25% (MM). Para estimar la digestibilidad se utilizó la fibra en detergente ácido indigerible (FDAi) recuperada en las muestras de heces, forrajes y suplementos, las cuales fueron incubadas in situ durante 144 horas y oxido de cromo (Cr2O3) como marcador externo para cuantificar la producción de heces. Se utilizó un diseño completo aleatorizado con cuatro tratamientos y seis repeticiones, se realizó análisis de varianza para determinar diferencias significativas al nivel de (p<0.05) Resultados. Se encontró diferencias (p≤0.05) para la digestibilidad y el consumo de materia seca. Los valores medios de digestibilidad fueron 47.6, 56.2, 58.6 y 59.0% y de consumo de 0.514, 0.788, 1.02 y 1.40 kg d-1 para T0, T1, T2 y T3, respectivamente. Para la ganancia de peso y la condición corporal se encontraron diferencias significativas (p≤0,05) presentando promedios de 0.053, 0.126, 0.128 y 0.130 kg d-1 y una condición corporal de 2, 3, 3, 3 para T0, T1, T2 y T3, respectivamente. Conclusiones. La suplementación con semilla de algodón y maíz estimuló el consumo y mejoró el desempeño productivo de los animales.

Efecto de la suplementación con semilla de algodón y maíz molido sobre el consumo y el desempeño productivo de ovinos de pelo colombiano

Objective. Effect of supplementation with cotton seed and ground corn on the intake and productive performance of Colombian hair sheep. Materials and methods. 24 sheep with an average weight of 16 ± 2 kg were distributed in four treatments T0: grazing, T1: grazing + 25% cotton seed (CS) + 75% ground corn (GC), T2: grazing + 50% CS + 50% GC and T3: grazing + 75% CS + 25% GC. The indigestible acid detergent fiber (FDAi) was used as internal marker and chromium oxide (Cr2O3) as an external marker. Samples of feces, forages and supplements were incubated in situ (rumen) for 144 hours. To calculate fecal production, 1 g of (Cr2O3) was given to each ovine in a gelatin capsule for 15 days. A complete randomized design with four treatments and six replicates was used. The animals were weighed every 14 days to determine the daily weight gains. Food conversion and feed efficiency were determined. An ANOVA was performed in a completely randomized design. Results. There were differences (p≤0.05) for digestibility and dry matter intake (DMi) and, presenting values of 47.6, 56.2, 58.6, and 59.0% and DMi were 0.514, 0.788, 1.02, and 1.40 kg/animal/d for T0, T1, T2 and T3, respectively. For DWG differences (p≤0.05) were found, being 0.053, 0.126, 0.128 and 0.130 kg d-1 for T0, T1, T2, and T3, respectively. Conclusions. Supplementation with cotton seed and ground corn stimulated DMS and improved the productive performance of the animals.Objetivo. Efecto de la suplementación con semilla de algodón y maíz molido sobre el consumo y el desempeño productivos de ovinos de pelo Colombiano. Materiales y métodos. Se utilizaron 24 ovinos con peso de 16 ± 2 kg durante 127 días. Los tratamientos fueron T0: pastoreo, T1: pastoreo + 25% semilla de algodón (SA) + 75% maíz molido (MM), T2: pastoreo + 50% (SA) + 50% (MM) y T3: pastoreo + 75% (SA) + 25% (MM). Para estimar la digestibilidad se utilizó la fibra en detergente ácido indigerible (FDAi) recuperada en las muestras de heces, forrajes y suplementos, las cuales fueron incubadas in situ durante 144 horas y oxido de cromo (Cr2O3) como marcador externo para cuantificar la producción de heces. Se utilizó un diseño completo aleatorizado con cuatro tratamientos y seis repeticiones, se realizó análisis de varianza para determinar diferencias significativas al nivel de (p&lt;0.05) Resultados. Se encontró diferencias (p≤0.05) para la digestibilidad y el consumo de materia seca. Los valores medios de digestibilidad fueron 47.6, 56.2, 58.6 y 59.0% y de consumo de 0.514, 0.788, 1.02 y 1.40 kg d-1 para T0, T1, T2 y T3, respectivamente. Para la ganancia de peso y la condición corporal se encontraron diferencias significativas (p≤0,05) presentando promedios de 0.053, 0.126, 0.128 y 0.130 kg d-1 y una condición corporal de 2, 3, 3, 3 para T0, T1, T2 y T3, respectivamente. Conclusiones. La suplementación con semilla de algodón y maíz estimuló el consumo y mejoró el desempeño productivo de los animales.

Diazoxide choline extended‐release tablet in people with Prader‐Willi syndrome: results from long‐term open‐label study

Objective: This study assessed the effect of 1-year administration of diazoxide choline extended-release tablet (DCCR) on hyperphagia and other complications of Prader-Willi syndrome (PWS). Methods: The authors studied 125 participants with PWS, age ≥ 4 years, who were enrolled in the DESTINY PWS Phase 3 study and who received DCCR for up to 52 weeks in DESTINY PWS and/or its open-label extension. The primary efficacy endpoint was Hyperphagia Questionnaire for Clinical Trials (HQ-CT) score. Other endpoints included behavioral assessments, body composition, hormonal measures, and safety. Results: DCCR administration resulted in significant improvements in HQ-CT (mean [SE] −9.9 [0.77], p &lt; 0.0001) and greater improvements in those with more severe baseline hyperphagia (HQ-CT &gt; 22). Improvements were seen in aggression, anxiety, and compulsivity (all p &lt; 0.0001). There were reductions in leptin, insulin, and insulin resistance, as well as a significant increase in adiponectin (all p &lt; 0.004). Lean body mass was increased (p &lt; 0.0001). Disease severity was reduced as assessed by clinician and caregiver (both p &lt; 0.0001). Common treatment-emergent adverse events included hypertrichosis, peripheral edema, and hyperglycemia. Adverse events infrequently resulted in discontinuation (7.2%). Conclusions: DCCR administration to people with PWS was well tolerated and associated with broad-ranging improvements in the syndrome. Sustained administration of DCCR has the potential to reduce disease severity and the burden of care for families

Prader-Willi syndrome: A primer for clinicians

The advent of sensitive genetic testing modalities for the diagnosis of Prader-Willi syndrome has helped to define not only the phenotypic features of the syndrome associated with the various genotypes but also to anticipate clinical and psychological problems that occur at each stage during the life span. With advances in hormone replacement therapy, particularly growth hormone children born in circumstances where therapy is available are expected to have an improved quality of life as compared to those born prior to growth hormone

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Effect of supplementation with cottonseed and corn on the productive performance and quality of sheep meat

La alimentación de los ovinos para producción de carne en la región Caribe colombiana, se fundamenta en el uso de gramíneas, en virtud de sus bajos costos; sin embargo, los rendimientos y la calidad nutricional, se ven afectados por la estacionalidad de las lluvias, por lo que se presentan bajas ganancias de peso. El objetivo de este trabajo fue evaluar el efecto de la suplementación con semilla de algodón y de maíz sobre el desempeño productivo y calidad de la carne de ovinos criollos de pelo. El estudio, se realizó en la Facultad de Medicina Veterinaria y Zootecnia de la Universidad de Córdoba, Ciénaga de Oro-Colombia. Se utilizaron 24 ovinos, distribuidos aleatoriamente en cuatro tratamientos consistentes en: T0: pastoreo; T1: pastoreo + 25% SA + 75% M; T2: pastoreo + 50 SA + 50% M y T3: pastoreo + 75% SA + 25% M. Los animales, se pesaron al inicio de la fase experimental y cada 15 días. Se estudiaron las siguientes variables: peso de la canal caliente y fría, rendimiento canal fría, longitud de la canal, perímetro de pierna, perímetro torácico, grasa de cobertura, índice de compacidad, humedad, pH, capacidad de retención de agua y color. La ganancia de peso difirió (p≤0,05) entre tratamiento, presentando valores medios de 0,053; 0,126; 0,128; 0,130kg, para T0, T1, T2 y T3, respectivamente. De igual forma, se detectaron diferencias (p≤0,05) para los pesos y rendimientos en canal. Los animales suplementados con 75% de semilla de algodón y 25% de maíz generaron las mayores ganancias de peso, viéndose reflejado en un mayor peso al sacrificio y rendimientos.The feeding of sheep for meat production in the Colombian Caribbean Region is based on the use of grasses by virtue of their low costs. However, the yields and nutritional quality are affected by the seasonality of the rains, so there are low weight gains. The objective of this work was to evaluate the effect of the supplementation with cotton seed and corn grain on the productive performance and quality of the meat of sheep creole of Colombian hair. The study was carried out in the the Faculty of Veterinary Medicine and Zootechnics of the University of Córdoba, Ciénaga de Oro-Colombia. Twenty four male creole lambs with initial weight of 16 ± 2kg were used, which were randomly distributed in four experimental treatments consisting of: T0: Grazing, T1: Grazing + 25% cottonseed (CS) + 75% corn (C), T2: Grazing + 50CS+50%C and T3: Grazing + 75% CS+25%C. Animals were weighed at the start of the experimental phase and every 15 days. The following variables were studied: weight of the hot and cold carcass, performance of the cold carcass, carcass length, leg perimeter, thoracic perimeter, covering fat, compactness index, humidity, pH, water retention capacity and color. The weight gain differed (p≤0.05) between treatment, presenting mean values of 0.053; 0.126; 0.128; 0.130kg for T0, T1, T2 and T3, respectively. Similarly, differences (p≤0.05) were detected for carcass weights and yields. The supplementation with cottonseed and corn improved the productive performance of the animals, being reflected in greater gains of weights and yields.Incluye referencias bibliográfica

Effect of supplementation on weight gain and Carcass dressing of sudan lambs

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