Parametrization of gamma-ray production cross-sections for pp interactions in a broad proton energy range from the kinematic threshold to PeV energies

Using publicly available Monte Carlo codes as well as compilation of published data on p--p interactions for proton kinetic energy below 2 GeV, we parametrize the energy spectra and production rates of $\gamma$-rays by simple but quite accurate ($\leq 20 \%$) analytical expressions in a broad range from the kinematic threshold to PeV energies.Comment: 19 pages, 15 figures, v2 version fixes the cross reference

Evidence-based management of multiple sclerosis spasticity with nabiximols oromucosal spray in clinical practice: a 10-year recap.

Effective symptomatic management of multiple sclerosis (MS) spasticity remains an unmet need for many patients. The second-line option nabiximols is the most widely investigated of the noninvasive antispasticity medications in this patient population. Clinical evidence accumulated with nabiximols since it was first approved in Europe in 2010 suggests that about 40% of initial responders (i.e., those with ≥20% improvement in their baseline 0-10 Numerical Rating Scale score) may expect to achieve clinically meaningful (≥30% Numerical Rating Scale response) and durable symptomatic improvement in MS spasticity. During 10 years' routine use of nabiximols, no new safety signals have emerged. Nabiximols-associated improvement in MS spasticity-related symptoms such as pain and sleep disruption suggests a need to track possible therapeutic effects beyond muscle tone control

The birth place of gamma-ray bursts: abundance gradients and constraints on progenitors

The physics of gamma-ray bursts (GRBs) and their offsets from the centers of their host galaxies are used to investigate the evolutionary state of their progenitors, motivated by the popular idea that GRBs are linked with the cataclysmic collapse of massive stars. We suggest that GRB progenitors in the inner and outer regions of hosts may be intrinsically different: outer bursts appear to have systematically greater isotropic equivalent energies (or narrower jets). This may provide an interesting clue to the nature of GRBs, and could reflect a relation between metallicity and the evolution of GRB progenitors. If true, then this offset-isotropic luminosity correlation is a strong argument for a collapsar origin of long-duration GRBs.Comment: 10 pages, 1 figure, accepted for publication in ApJ Letter

Nanoplasmonic Paper-Based Platform for General Screening of Biomacromolecules

Hygiene assessment in industrial and clinical environments is crucial in the prevention of health risks. Current technologies for routine cleanliness evaluation rely on the detection of specific biomolecules, thus requiring more than one test for broad-range screening. Herein, the modulation of the catalytic activity of gold nanoparticles (AuNPs) by biomacromolecules was employed to develop a nanoplasmonic platform for general hygiene screening. AuNPs were immobilized on cellulose paper by simple adsorption. When ferricyanide was dispensed onto the paper, the AuNPs catalysed the ferricyanide's dissociation, releasing free cyanide ions that dissolved them. The AuNP dissolution produced an intense colour shift detectable with the naked eye. When biomacromolecules (e.g., proteins and polysaccharides) were present, they spontaneously attached to AuNPs, forming a biomolecular corona (biocorona), reducing their catalytic activity until complete suppression when the NPs were fully covered by molecules. The concentration-dependent decrease in the catalytic activity was here used to quantify biomacromolecules and complex samples such as milk, eggs, soy sauce and yeast extract (in 20 min), with detection limits comparable to those of standard methods, i.e., 0.25 µg mL −1 for albumin. This nano-enabled technology may be applied as a broad-range (unspecific) alert system for inexpensive cleanliness evaluation, with potential applications in sensitive sectors including productive industries and hospitals

Soil health—a new challenge for microbiologists and chemists

Soil health refers to the biological, chemical, and physical features of soil that are essential to long-term, sustainable agricultural productivity with minimal environmental impact. Thus, soil health provides an overall picture of soil functionality. Although it cannot be measured directly, soil health can be inferred by measuring specific soil properties (e.g. organic matter content) and by observing soil status (e.g. fertility). There is also increased interest in studying soil microorganisms in their particular environments, as microbial diversity is intimately related to soil structure and function. One of the key objectives in determining soil health is to acquire indicators that can be used to evaluate the soil’s current status and hence to develop sustainable agricultural systems. In this regard, significant progress has been made over the last few years in the development of specific biomarkers and macromolecular probes, enabling rapid and reliable measurements of soil microbial communities. In addition, modern molecular biological techniques, such as fluorescence in situ hybridization (FISH), reverse transcriptase polymerase chain reaction (RT-PCR), denaturing gradient gel electrophoresis (DGGE), and terminal restriction fragment length polymorphism (T-RFLP), have facilitated the analysis of microbial biodiversity and activity, whereas the application of modern analytical techniques, such as nuclear magnetic resonance (NMR) and pyrolysisgas chromatography-mass spectrometry (Py-GC-MS), have provided data on soil chemistry. The combination of these two approaches offers promise in determining soil health status. [Int Microbiol 2005; 8(1):13-21

Soil health -- a new challenge for microbiologists and chemists.

The original publication is available on LINK at http://revistes.iec.cat/index.php/IM/article/view/4c457c718d531.002 This work, including photographs and other illustrations, unless the contrary is indicated, is subject to an Attributions–Non-Commercial–ShareAlike 3.0 Creative Commons License, the full text of which can be consulted at http://creativecommons.org/licenses/by-nc-sa/3.0/. You are free to share, copy, distribute and transmit the work provided that the author is credited and reuse of the material is restricted to non-commercial purposes only and that if you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this on

3-D Modelling of Megaloolithid Clutches: Insights about Nest Construction and Dinosaur Behaviour

BACKGROUND: Megaloolithid eggs have long been associated with sauropod dinosaurs. Despite their extensive and worldwide fossil record, interpretations of egg size and shape, clutch morphology, and incubation strategy vary. The Pinyes locality in the Upper Cretaceous Tremp Formation in the southern Pyrenees, Catalonia provides new information for addressing these issues. Nine horizons containing Megaloolithus siruguei clutches are exposed near the village of Coll de Nargó. Tectonic deformation in the study area strongly influenced egg size and shape, which could potentially lead to misinterpretation of reproductive biology if 2D and 3D maps are not corrected for bed dip that results from tectonism. METHODOLOGY/FINDINGS: Detailed taphonomic study and three-dimensional modelling of fossil eggs show that intact M. siruguei clutches contained 20-28 eggs, which is substantially larger than commonly reported from Europe and India. Linear and grouped eggs occur in three superimposed levels and form an asymmetric, elongate, bowl-shaped profile in lateral view. Computed tomography data support previous interpretations that the eggs hatched within the substrate. Megaloolithid clutch sizes reported from other European and Indian localities are typically less than 15 eggs; however, these clutches often include linear or grouped eggs that resemble those of the larger Pinyes clutches and may reflect preservation of incomplete clutches. CONCLUSIONS/SIGNIFICANCE: We propose that 25 eggs represent a typical megaloolithid clutch size and smaller egg clusters that display linear or grouped egg arrangements reported at Pinyes and other localities may represent eroded remnants of larger clutches. The similarity of megaloolithid clutch morphology from localities worldwide strongly suggests common reproductive behaviour. The distinct clutch geometry at Pinyes and other localities likely resulted from the asymmetrical, inclined, and laterally compressed titanosaur pes unguals of the female, using the hind foot for scratch-digging during nest excavation

Studying Growth and Vigor as Quantitative Traits in Grapevine Populations

Vigor is considered as a propensity to assimilate, store, and/or use nonstructural carbohydrates for producing large canopies, and it is associated with high metabolism and fast growth. Growth involves cell expansion and cell division. Cell division depends on hormonal and metabolic processes. Cell expansion occurs because cell walls are extensible, meaning they deform under the action of tensile forces, generally caused by turgor. There is increasing interest in understanding the genetic basis of vigor and biomass production. It is well established that growth and vigor are quantitative traits and their genetic architecture consists of a big number of genes with small individual effects. The search for groups of genes with small individual effects, which control a specific quantitative trait, is performed by QTL analysis and genetic mapping. Today, several linkage maps are available, like “Syrah” × “grenache,” “Riesling” × “Cabernet Sauvignon,” and “Ramsey” × Vitis riparia. This last progeny segregates for vigor and constituted an interesting tool for our genetic studies on growth

Gas Dynamics in the LINER Galaxy NGC 5005: Episodic Fueling of a Nuclear Disk

We report high-resolution CO(1-0) observations in the central 6 kpc of the LINER galaxy NGC 5005 with the Owens Valley Radio Observatory millimeter array. Molecular gas is distributed in three components - a ring at a radius of about 3 kpc, a strong central condensation, and a stream to the northwest of the nucleus but inside the 3 kpc ring. The central condensation is a disk of about 1 kpc radius with a molecular gas mass of 2 x 10^9 M_sun. The stream between the 3 kpc ring and the nuclear disk lies on a straight dust lane seen in the optical. If this material moves in the plane of the galaxy, it has a velocity offset by up to ~ 150 km/s from galactic rotation. We suggest that an optically inconspicuous stellar bar lying within the 3 kpc ring can explain the observed gas dynamics. This bar is expected to connect the nuclear disk and the ring along the position angle of the northwest stream. A position-velocity cut in this direction reveals features which match the characteristic motions of gas in a barred potential. Our model indicates that gas in the northwest stream is on an x_1 orbit at the bar's leading edge; it is falling into the nucleus with a large noncircular velocity, and will eventually contribute about 2 x 10^8 M_sun to the nuclear disk. If most of this material merges with the disk on its first passage of pericenter, the gas accretion rate during the collision will be 50 M_sun/yr. We associate the nuclear disk with an inner 2:1 Lindblad resonance, and the 3 kpc ring with an inner 4:1 Lindblad resonance. The high rate of bar-driven inflow and the irregular appearance of the northwest stream suggest that a major fueling event is in progress in NGC 5005. Such episodic (rather than continuous) gas supply can regulate the triggering of starburst and accretion activity in galactic nuclei. (abridged)Comment: 26 pages, 12 figures, AASTeX, ApJ in press (Feb. 10, 2000). For full-resolution figures, see http://www.ovro.caltech.edu/mm/science/science.htm

Modeling vegetative vigour in grapevine: unraveling underlying mechanisms

Mechanistic modeling constitutes a powerful tool to unravel complex biological phenomena. This study describes the construction of a mechanistic, dynamic model for grapevine plant growth and canopy biomass (vigor). To parametrize and validate the model, the progeny from a cross of Ramsey (Vitis champinii) × Riparia Gloire (V. riparia) was evaluated. Plants with different vigor were grown in a greenhouse during the summer of 2014 and 2015. One set of plants was grafted with Cabernet Sauvignon. Shoot growth rate (b), leaf area (LA), dry biomass, whole plant and root specific hydraulic conductance (kH and Lpr), stomatal conductance (gs), and water potential (Ψ) were measured. Partitioning indices and specific leaf area (SLA) were calculated. The model includes an empirical fit of a purported seasonal pattern of bioactive GAs based on published seasonal evolutionary levels and reference values. The model provided a good fit of the experimental data, with R = 0.85. Simulation of single trait variations defined the individual effect of each variable on vigor determination. The model predicts, with acceptable accuracy, the vigor of a young plant through the measurement of Lpr and SLA. The model also permits further understanding of the functional traits that govern vigor, and, ultimately, could be considered useful for growers, breeders and those studying climate change.EEA MendozaFil: Hugalde, Ines Pilar. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; Argentina. University of California at Davis. Department of Viticulture and Enology; Estados UnidosFil: Agüero, Cecilia B. University of California at Davis. Department of Viticulture and Enology; Estados UnidosFil: Barrios-Masias, Felipe H. University of California at Davis. Department of Viticulture and Enology; Estados Unidos. University of Nevada. Department of Agriculture, Veterinary and Rangeland Sciences; Estados UnidosFil: Romero, Nina. University of California at Davis. Department of Viticulture and Enology; Estados UnidosFil: Nguyen, Andy Viet. University of California at Davis. Department of Viticulture and Enology; Estados UnidosFil: Riaz, Summaira. University of California at Davis. Department of Viticulture and Enology; Estados UnidosFil: Piccoli, Patricia Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: McElrone, Andrew J. University of California at Davis. Department of Viticulture and Enology; Estados Unidos. US Department of Agriculture. ARS; Estados UnidosFil: Walker, M. Andrew. University of California at Davis. Department of Viticulture and Enology; Estados UnidosFil: Vila, Hernan Felix. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mendoza; Argentin