Predicting airborne coronavirus inactivation by far-UVC in populated rooms using a high-fidelity coupled radiation-CFD model

There are increased risks of contracting COVID-19 in hospitals and long-term care facilities, particularly for vulnerable groups. In these environments aerosolised coronavirus released through breathing increases the chance of spreading the disease. To reduce aerosol transmissions, the use of low dose far-UVC lighting to disinfect in-room air has been proposed. Unlike typical UVC, which has been used to kill microorganisms for decades but is carcinogenic and cataractogenic, recent evidence has shown that far-UVC is safe to use around humans. A high-fidelity, fully-coupled radiation transport and fluid dynamics model has been developed to quantify disinfection rates within a typical ventilated room. The model shows that disinfection rates are increased by a further 50-85% when using far-UVC within currently recommended exposure levels compared to the room’s ventilation alone. With these magnitudes of reduction, far-UVC lighting could be employed to mitigate SARS-CoV-2 transmission before the onset of future waves, or the start of winter when risks of infection are higher. This is particularly significant in poorly-ventilated spaces where other means of reduction are not practical, in addition social distancing can be reduced without increasing the ris

Asynchronous accretion can mimic diverse white dwarf pollutants II: water content

Volatiles, notably water, are key to the habitability of rocky planets. The presence of water in planetary material can be inferred from the atmospheric oxygen abundances of polluted white dwarfs, but this interpretation is often complex. We study the accretion process, and find that ices may sublimate and accrete before more refractory minerals reach the star. As a result, a white dwarf's relative photospheric abundances may vary with time during a single accretion event, and do not necessarily reflect the bulk composition of a pollutant. We offer two testable predictions for this hypothesis: 1. cooler stars will more often be inferred to have accreted wet pollutants, and 2. there will be rare occurrences of accretion events with inferred volatile levels far exceeding those of pristine comets. To observationally test these predictions, we statistically constrain the water content of white dwarf pollutants. We find that in the current sample, only three stars show statistically significant evidence of water at the 2$\sigma$ level, due to large typical uncertainties in atmospheric abundances and accretion states. In the future, an expanded sample of polluted white dwarfs with hydrogen-dominated atmospheres will allow for the corroboration of our theoretical predictions. Our work also shows the importance of interpreting pollutant compositions statistically, and emphasizes the requirement to reduce uncertainties on measured abundances to allow for statistically significant constraints on their water content.Comment: Accepted for publication in MNRAS. Part two of a series of two papers. Comments and questions welcom

Body mass index relates weight to height differently in women and older adults

This study was partly supported by the University of Manchester’s Health eResearch Centre (HeRC) funded by the Medical Research Council (MRC) Grant MR/K006665/1 and partly funded by the ESRC Obesity eLab Grant (RES-149-25-1076).Background Body mass index (BMI) tends to be higher among shorter adults, especially women. The dependence of BMI–height correlation on age and calendar time may inform us about temporal determinants of BMI. Methods Series of cross-sectional surveys: Health Survey for England, 1992–2011. We study the Benn Index, which is the coefficient in a regression of log(weight) on log(height). This is adjusted for age, gender and calendar time, allowing for non-linear terms and interactions. Results By height quartile, mean BMI decreased with increasing height, more so in women than in men (P < 0.001). The decrease in mean BMI in the tallest compared with the shortest height quartile was 0.77 in men (95% CI 0.69, 0.86) and 1.98 in women (95% CI 1.89, 2.08). Regression analysis of log(weight) on log(height) revealed that the inverse association between BMI and height was more pronounced in older adults and stronger in women than in men, with little change over calendar time. Conclusions Unlike early childhood, where taller children tend to have higher BMI, adults, especially women and older people, show an inverse BMI–height association. BMI is a heterogeneous measure of weight-for-height; height may be an important and complex determinant of BMI trajectory over the life course.Publisher PDFPeer reviewe

Symptomatic hemorrhage after alteplase therapy not due to silent ischemia

BACKGROUND: Stroke thrombolysis-related intracerebral hemorrhage may occur remotely from the anatomical site of ischemia. One postulated mechanism for this is simultaneous multiple embolization with hemorrhage into a "silent" area of ischemia. RESULTS: A patient suffered a disabling stroke affecting the right cerebral hemisphere. He was treated with intravenous alteplase and underwent extensive early imaging with multimodal MRI. Several hours after treatment he developed a brainstem hemorrhage despite having no evidence of ischemia on DWI MRI in the brainstem. CONCLUSION: Not all occurrences of remote ICH after stroke thrombolysis are secondary to multiple emboli with silent ischemia

Improved estimates of 222 nm far-UVC susceptibility for aerosolized human coronavirus via a validated high-fidelity coupled radiation-CFD code

Transmission of SARS-CoV-2 by aerosols has played a significant role in the rapid spread of COVID-19 across the globe. Indoor environments with inadequate ventilation pose a serious infection risk. Whilst vaccines suppress transmission, they are not 100% effective and the risk from variants and new viruses always remains. Consequently, many efforts have focused on ways to disinfect air. One such method involves use of minimally hazardous 222 nm far-UVC light. Whilst a small number of controlled experimental studies have been conducted, determining the efficacy of this approach is difficult because chamber or room geometry, and the air flow within them, influences both far-UVC illumination and aerosol dwell times. Fortunately, computational multiphysics modelling allows the inadequacy of dose-averaged assessment of viral inactivation to be overcome in these complex situations. This article presents the first validation of the WYVERN radiation-CFD code for far-UVC air-disinfection against survival fraction measurements, and the first measurement-informed modelling approach to estimating far-UVC susceptibility of viruses in air. As well as demonstrating the reliability of the code, at circa 70% higher, our findings indicate that aerosolized human coronaviruses are significantly more susceptible to far-UVC than previously thought

Adaptive Haar wavelets for the angular discretisation of spectral wave models

A new framework for applying anisotropic angular adaptivity in spectral wave modelling is presented. The angular dimension of the action balance equation is discretised with the use of Haar wavelets, hierarchical piecewise-constant basis functions with compact support, and an adaptive methodology for anisotropically adjusting the resolution of the angular mesh is proposed. This work allows a reduction of computational effort in spectral wave modelling, through a reduction in the degrees of freedom required for a given accuracy, with an automated procedure and minimal cost

Inactivation rates for airborne human coronavirus by low doses of 222nm far-UVC radiation

Recent research using UV radiation with wavelengths in the 200–235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier experimental studies estimated the susceptibility of airborne human coronavirus OC43 exposed to 222-nm radiation based on fitting an exponential dose–response curve to the data. The current study extends the results to a wider range of doses of 222 nm far-UVC radiation and uses a computational model coupling radiation transport and computational fluid dynamics to improve dosimetry estimates. The new results suggest that the inactivation of human coronavirus OC43 within our exposure system is better described using a bi-exponential dose–response relation, and the estimated susceptibility constant at low doses—the relevant parameter for realistic low dose rate exposures—was 12.4 ± 0.4 cm2/mJ, which described the behavior of 99.7% ± 0.05% of the virus population. This new estimate is more than double the earlier susceptibility constant estimates that were based on a single-exponential dose response. These new results offer further evidence as to the efficacy of far-UVC to inactivate airborne pathogens.EPSRC: EP/M022684/2 and Natural Sciences and Engineering Research Council of Canada (NSERC): IRCPJ 549979-19