NEAR INFRARED SPECTROSCOPY TO EVALUATE COMPOSITION OF AGRO-BASED PARTICLEBOARDS

Particleboards can be manufactured from particles of any lignin-cellulosic material that can be combined with an adhesive and consolidated under the action of temperature and pressure. Because the raw materials in the industrial process are continually changing, the particleboard industry requires methods for monitoring the quality of their products. Hence, the aim of this paper was to evaluate the composition of the agro-based particleboards by near infrared spectroscopy. In this study, agro-based particleboards produced with different compositions of Eucalyptus and Pinus wood particles and sugar cane bagasse were evaluated by NIR spectroscopy and partial least square (PLS) regression. The PLS models to estimate the Eucalyptus and Pinus particles and sugar cane bagasse contents presented a strong coefficient of determination (0.90, 0.88 and 0.84, respectively), but also high magnitudes of standard errors of cross-validation were observed (ranging from 8.84 to 11.27%). Development work would be required in order to reduce the standard errors and improve predictive model performance to build robust models that could be applied as quality control tool

Determination of reflectance and transmittance of multi-layer of InGaAs and theoretical methods for obtaining of optical constants

5 páginas, 3 figuras, 2 tablas.-- Trabajo presentado al 1st International Congress on Instrumentation and Applied Sciences celebrado en Cancún (México) del 26 al 29 de Octubre de 2010.The theoretical concepts are necessary to obtain the optical constants of several materials in InGaAs Photodiode and are possible to obtain from experimental dates of reflectance and transmittance and several optical coverings can be designed. In this work we will show how to calculate the reflectance of photodiode for all the wavelengths (each 50 nm, according to the data of refractive index), as well as changing to the angle of incidence and polarization s and p, besides the calculation of the transmittance of a multi-layer ones of InGaAs. A multi-layer is constituted by a series of piled up laminae some on others and in this work we will suppose that they are homogenous, isotropic and plane-parallel, the structure is in the first case we have a transparent layer of NSi, late second layer of InP (Zn), soon a third layer of InGaAs and finally a later of InP (S). These multilayers are destined for optical applications, in our case will be case of study in the case of the photodiodes, the thicknesses of the layers will be of the order of the wavelength of incident radiation, which in the case of radiation IR/NIR is translated in thicknesses of approximately between 1y 100 nm. For the determination of optical constants they are possible to be done of different ways in our case we will concentrate in 1) Measured of reflectance in normal incidence. These measures only provide the value of n in the case of means transparents.2) Measured of reflectance in two angles of incidence. It allows to the use of natural light or polarized.3) Two measures of R p R s in two angles of incidence outside the normal one. 4) Rs and Rp in a single angle of incidence outside the normal one.Peer reviewe

Death receptor 5 expression is inversely correlated with prostate cancer progression.

Prostate carcinoma (PCa) is one of the most common cancers in men. Prostate-specific antigen (PSA) has been widely used to predict the outcome of PCa and screening with PSA has resulted in a decline in mortality. However, PSA is not an optimal prognostic tool as its sensitivity may be too low to reduce morbidity and mortality. Consequently, there is a demand for additional robust biomarkers for prostate cancer. Death receptor 5 (DR5) has been implicated in the prognosis of several cancers and it has been previously shown that it is negatively regulated by Yin Yang 1 (YY1) in prostate cancer cell lines. The present study investigated the clinical significance of DR5 expression in a prostate cancer patient cohort and its correlation with YY1 expression. Immunohistochemical analysis of protein expression distribution was performed using tissue microarray constructs from 54 primary PCa and 39 prostatic intraepithelial neoplasia (PIN) specimens. DR5 expression was dramatically reduced as a function of higher tumor grade. By contrast, YY1 expression was elevated in PCa tumors as compared with that in PIN, and was increased with higher tumor grade. DR5 had an inverse correlation with YY1 expression. Bioinformatic analyses corroborated these data. The present findings suggested that DR5 and YY1 expression levels may serve as progression biomarkers for prostate cancer

Relações entre a coleta de dados, diagnósticos e prescrições de enfermagem a pacientes adultos de uma unidade de terapia intensiva

This descriptive, retrospective study aimed to analyze the relation between nursing data collection, diagnoses and prescriptions for 26 adult patients who were hospitalized at the intense care unit of a large teaching hospital for at least 24 hours. Through the analysis of medical records, 135 diagnoses and 421 nursing prescriptions were established, and 24 different diagnosis categories and 20 different items for prescriptions were identified. The most frequent diagnosis risk was that for infection, present in the medical records of 22 (84.60%) patients, with 175 prescriptions (42%) related to this diagnosis. The data the nurses collected were sufficient to establish the nursing diagnoses, and the majority of prescriptions (87.9%) were related to the diagnoses.La finalidad de este estudio descriptivo y retrospectivo fue analizar la relación entre la recolección de datos, diagnósticos y prescripciones de enfermería para 26 pacientes adultos que estuvieron hospitalizados en una unidad de terapia intensiva en un hospital de enseñanza de gran porte, con permanencia mínima de 24 horas. Mediante el análisis de los archivos se establecieron 135 diagnósticos y 421 prescripciones de enfermería, siendo identificados 24 categorías de diagnóstico y 20 diferentes ítems de prescripción. El diagnóstico de riesgo para la infección fue el más frecuente, que estuvo presente en el registro de 22 (84,60%) pacientes. De las prescripciones, 175 (42%) se refirieron a este diagnóstico. Se observa que los datos registrados por los enfermeros en la recolección de datos fueron suficientes para establecer los diagnósticos de enfermería y que la mayoría de las prescripciones (87,9%) estuvieron relacionadas con los diagnósticos.Trabalho descritivo, retrospectivo, que teve como objetivo analisar a relação entre a coleta de dados, diagnósticos e prescrições de enfermagem estabelecidas por enfermeiros para 26 pacientes adultos que estiveram internados numa unidade de terapia intensiva de um hospital de ensino de grande porte, com permanência mínima de 24 horas. Por meio da análise dos prontuários, foram estabelecidos 135 diagnósticos e 421 prescrições de enfermagem, sendo identificadas 24 diferentes categorias diagnósticas e 20 diferentes itens para prescrição. O diagnóstico de risco para infecção foi o de maior freqüência, presente no prontuário de 22 (84,60%) pacientes. Das prescrições, 175 (42%) relacionaram-se a esse diagnóstico. Observa-se que os dados registrados pelos enfermeiros na coleta de dados foram suficientes para o estabelecimento dos diagnósticos de enfermagem e a maioria das prescrições (87,9%) apresentou relação com os diagnósticos.CNP

Relaciones entre la recolección de datos, diagnósticos y prescripciones de enfermería a pacientes adultos en una unidad de terapia intensiva

Trabalho descritivo, retrospectivo, que teve como objetivo analisar a relação entre a coleta de dados, diagnósticos e prescrições de enfermagem estabelecidas por enfermeiros para 26 pacientes adultos que estiveram internados numa unidade de terapia intensiva de um hospital de ensino de grande porte, com permanência mínima de 24 horas. Por meio da análise dos prontuários, foram estabelecidos 135 diagnósticos e 421 prescrições de enfermagem, sendo identificadas 24 diferentes categorias diagnósticas e 20 diferentes itens para prescrição. O diagnóstico de risco para infecção foi o de maior freqüência, presente no prontuário de 22 (84,60%) pacientes. Das prescrições, 175 (42%) relacionaram-se a esse diagnóstico. Observa-se que os dados registrados pelos enfermeiros na coleta de dados foram suficientes para o estabelecimento dos diagnósticos de enfermagem e a maioria das prescrições (87,9%) apresentou relação com os diagnósticos.La finalidad de este estudio descriptivo y retrospectivo fue analizar la relación entre la recolección de datos, diagnósticos y prescripciones de enfermería para 26 pacientes adultos que estuvieron hospitalizados en una unidad de terapia intensiva en un hospital de enseñanza de gran porte, con permanencia mínima de 24 horas. Mediante el análisis de los archivos se establecieron 135 diagnósticos y 421 prescripciones de enfermería, siendo identificados 24 categorías de diagnóstico y 20 diferentes ítems de prescripción. El diagnóstico de riesgo para la infección fue el más frecuente, que estuvo presente en el registro de 22 (84,60%) pacientes. De las prescripciones, 175 (42%) se refirieron a este diagnóstico. Se observa que los datos registrados por los enfermeros en la recolección de datos fueron suficientes para establecer los diagnósticos de enfermería y que la mayoría de las prescripciones (87,9%) estuvieron relacionadas con los diagnósticos.This descriptive, retrospective study aimed to analyze the relation between nursing data collection, diagnoses and prescriptions for 26 adult patients who were hospitalized at the intense care unit of a large teaching hospital for at least 24 hours. Through the analysis of medical records, 135 diagnoses and 421 nursing prescriptions were established, and 24 different diagnosis categories and 20 different items for prescriptions were identified. The most frequent diagnosis risk was that for infection, present in the medical records of 22 (84.60%) patients, with 175 prescriptions (42%) related to this diagnosis. The data the nurses collected were sufficient to establish the nursing diagnoses, and the majority of prescriptions (87.9%) were related to the diagnoses

Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis

Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis of CCA is challenging and accurate biomarkers are lacking. We aimed to characterize the transcriptomic profile of serum and urine extracellular vesicles (EVs) from patients with CCA, PSC, ulcerative colitis (UC), and healthy individuals. Serum and urine EVs were isolated by serial ultracentrifugations and characterized by nanoparticle tracking analysis, transmission electron microscopy, and immunoblotting. EVs transcriptome was determined by Illumina gene expression array [messenger RNAs (mRNA) and non-coding RNAs (ncRNAs)]. Differential RNA profiles were found in serum and urine EVs from patients with CCA compared to control groups (disease and healthy), showing high diagnostic capacity. The comparison of the mRNA profiles of serum or urine EVs from patients with CCA with the transcriptome of tumor tissues from two cohorts of patients, CCA cells in vitro, and CCA cellsderived EVs, identified 105 and 39 commonly-altered transcripts, respectively. Gene ontology analysis indicated that most commonly-altered mRNAs participate in carcinogenic steps. Overall, patients with CCA present specific RNA profiles in EVs mirroring the tumor, and constituting novel promising liquid biopsy biomarkers

Dwellings, jabuticabas, and affections — trajectories with Sylvia Caiuby Novaes

Sylvia Caiuby Novaes é professora do Departamento de Antropologia da Universidade de São Paulo (USP) e dedica-se há cerca de 50 anos à pesquisa e ao ensino em antropologia. Entre outras realizações, ela é uma das pioneiras da antropologia visual no Brasil, é fundadora do Laboratório de Imagem e Som da Antropologia (LISA) e editora responsável pela revista Gesto, Imagem e Som. Revista de Antropologia (GIS). Nesta entrevista, realizada por mais de 30 orientandos de diferentes gerações, Sylvia fala sobre sua trajetória, projetos, visão de mundo, suas diversas viagens, o fascínio pelas pesquisas de campo e a universidade. Ao contar sobre sua trajetória acadêmica e pessoal, Sylvia traz reflexões sobre sua relação com a fotografia e a produção de imagens.  Sylvia Caiuby Novaes is a Professor in the Department of Anthropology at the University of São Paulo (USP) and has been dedicated to research and teaching in anthropology for nearly 50 years. Among other accomplishments, she is one of the pioneers of visual anthropology in Brazil, is the founder of the Laboratory of Image and Sound of Anthropology (LISA) and the editor in charge of the Gesture, Image and Sound.  Journal of Anthropology (GIS). In this interview, conducted by more than 30 advisees from different generations, Sylvia talks about her trajectory, projects, worldview, her various travels, her fascination with field research and the university. When telling about her academic and personal trajectory, Sylvia reflects on her relationship with photography and the production of images

Early life vitamin D depletion alters the postnatal response to skeletal loading in growing and mature bone

There is increasing evidence of persistent effects of early life vitamin D exposure on later skeletal health; linking low levels in early life to smaller bone size in childhood as well as increased fracture risk later in adulthood, independently of later vitamin D status. A major determinant of bone mass acquisition across all ages is mechanical loading. We tested the hypothesis in an animal model system that early life vitamin D depletion results in abrogation of the response to mechanical loading, with consequent reduction in bone size, mass and strength during both childhood and adulthood. A murine model was created in which pregnant dams were either vitamin D deficient or replete, and their offspring moved to a vitamin D replete diet at weaning. Tibias of the offspring were mechanically loaded and bone structure, extrinsic strength and growth measured both during growth and after skeletal maturity. Offspring of vitamin D deplete mice demonstrated lower bone mass in the non loaded limb and reduced bone mass accrual in response to loading in both the growing skeleton and after skeletal maturity. Early life vitamin D depletion led to reduced bone strength and altered bone biomechanical properties. These findings suggest early life vitamin D status may, in part, determine the propensity to osteoporosis and fracture that blights later life in many individuals

Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2015 and GOLD 2019 staging: a pooled analysis of individual patient data

In 2019, The Global Initiative for Chronic Obstructive Lung Disease (GOLD) modified the grading system for patients with COPD, creating 16 subgroups (1A–4D). As part of the COPD Cohorts Collaborative International Assessment (3CIA) initiative, we aim to compare the mortality prediction of the 2015 and 2019 COPD GOLD staging systems. We studied 17 139 COPD patients from the 3CIA study, selecting those with complete data. Patients were classified by the 2015 and 2019 GOLD ABCD systems, and we compared the predictive ability for 5-year mortality of both classifications. In total, 17 139 patients with COPD were enrolled in 22 cohorts from 11 countries between 2003 and 2017; 8823 of them had complete data and were analysed. Mean±sd age was 63.9±9.8 years and 62.9% were male. GOLD 2019 classified the patients in milder degrees of COPD. For both classifications, group D had higher mortality. 5-year mortality did not differ between groups B and C in GOLD 2015; in GOLD 2019, mortality was greater for group B than C. Patients classified as group A and B had better sensitivity and positive predictive value with the GOLD 2019 classification than GOLD 2015. GOLD 2015 had better sensitivity for group C and D than GOLD 2019. The area under the curve values for 5-year mortality were only 0.67 (95% CI 0.66–0.68) for GOLD 2015 and 0.65 (95% CI 0.63–0.66) for GOLD 2019