Caseous Stomatitis Caused by Pseudomonas aeruginosa in Boa constrictor amarali

Background: Pseudomonas aeruginosa is a bacterium that belongs to the microbiota of snakes, but it may also be an opportunistic pathogen and contaminate humans through fecal contact, bites, and injuries. In snakes, this microorganism may present high pathogenicity at certain conditions and have been associated with high morbidity and mortality. Reports of infection of Boa constrictor by this pathogen are rare. Thus, this study aimed to describe the P. aeruginosa oral infection in a snake specimen (Boa constrictor amarali), approaching the isolation and identification of the infectious agents involved, the antimicrobial sensitivity and resistance, and the therapeutic protocol adopted.Case: A free-living adult female specimen of Boa constrictor amarali (Amaral's boa), with no described previous history was rescued in an urban area by the Environmental Police. Clinical evaluations showed structures of caseous aspect in the oral cavity, with hyperemia spots in the mucosa. Samples of these lesions were sent for mycological examination, and fungal forms were not found. Samples were collected for isolation and culture. The antimicrobial susceptibility of the isolated microorganisms was determined by the modified Kirby-Bauer disk diffusion method. P. aeruginosa was isolated and showed susceptibility to amikacin, gentamicin, and polymyxin-B; intermediate susceptibility to azithromycin, and ciprofloxacin; and resistance to cephalexin, ceftiofur, chloramphenicol, and enrofloxacin. The treatment consisted of cleaning of the oral cavity, local infiltration of lidocaine for debridement of the caseous area that were later cauterized with iodine. Systemic antibiotic therapy was used, with intramuscular administration of amikacin (5 mg/kg) for the first dose and (2.5 mg/kg) for the other doses with intervals of 72 h, and oral administration of metronidazole (20 mg/kg) with intervals of 48 h, both during 21 days. Daily subcutaneous fluid therapy was performed as support treatment, using Lactated Ringer's solution (25 mg/kg) and Vitamin C (10 mg/kg) with intervals of 24 h, being the cure observed at the end of treatment.Discussion: This paper presents the pathological findings of the Pseudomonas aeruginosa oral infection in a B. constrictor amarali. This bacterium is an opportunistic pathogen that is commonly found  in snakes, thus, humans in contact with these animals may be contaminated with this pathogen. However, oral cavity lesions associated with P. aeruginosa had not yet been related to Boa constrictor amarali, which is a non-venomous species. Few bacteria associated with reptile diseases are primary causative agents. Clinical bacterial infections generally tend to be secondary to viral infections. Predisposing factors for the development of bacterial diseases in these reptiles include immunodepression, malnutrition, poor adaptation to captivity, and the maintenance of these animals at temperatures and humidities outside their thermal comfort range. In the present study, the P. aeruginosa behaved as an opportunistic pathogen, resulting in clinical manifestations with caseous lesions in the oral cavity, probably due to an imbalance of the microbiota caused by stress or immunodepression. The antibiogram allowed the adoption of a correct therapeutic protocol based on the susceptibility of the pathogen, resulting in remission of lesions and clinical signs after 21 days of treatment

Acute Fulminant Cerebral Edema in a Child With Suspected Meningoencephalitis

Acute fulminant cerebral edema (AFCE) is a recently identified encephalitis type associated with significant morbimortality. Described as rare, limited data exists on its early detection and treatment. This paper describes a case of AFCE that progressed to unresponsive intracranial hypertension. A previously healthy four-year-old boy presented with fever, myalgias, and neurological symptoms. Diagnostic assessments showed cerebrospinal fluid abnormalities, and despite medical interventions, his condition deteriorated rapidly and developed severe cerebral edema and herniation within 24 hours. A decompressive craniectomy was attempted to decrease intracranial pressure, without success. This case emphasizes the urgency of early AFCE recognition and effective management strategies given its severe prognosis, aiming to improve understanding and spur further researchinfo:eu-repo/semantics/publishedVersio

ROBOTIC VERSUS LAPAROSCOPIC ROUX-EN-Y-GASTRIC BYPASS: A RETROSPECTIVE STUDY IN A SINGLE CENTER

ABSTRACT BACKGROUND: Bariatric surgery is the best treatment option for patients with obesity. As a result of the advancement of technology, the robotic gastric bypass presents promising results, despite its still high costs. AIMS: The aim of this study was to compare patients submitted to a robotic versus a laparoscopic gastric bypass at a single center by a single surgeon. METHODS: This retrospective study collected data from the medical records of 221 patients (121 laparoscopic procedures versus 100 with daVinci platform). The variables analyzed were sex, age, body mass index, comorbidities, surgical time, length of stay, and complications. RESULTS: The mean surgical time for patients in the robotic group was shorter (102.41±39.44 min versus 113.86±39.03 min, p=0.018). The length of hospital stay in robotic patients was shorter (34.12±20.59 h versus 34.93±11.74 h, p=0.007). There were no serious complications. CONCLUSIONS: The group submitted to the robotic method had a shorter surgical time and a shorter hospital stay. No difference was found regarding strictures, bleeding, or leakage

Nurses knowledge in Transfusion Medicine in a Portuguese university hospital: the impact of an education

info:eu-repo/semantics/publishedVersio

Ulcer healing and mechanism(s) of action involved in the gastroprotective activity of fractions obtained from Syngonanthus arthrotrichus and Syngonanthus bisulcatus

Abstract Background Syngonanthus arthrotrichus and Syngonanthus bisulcatus, currently known for Comanthera aciphylla (Bong.) L.R.Parra & Giul. and Comanthera bisulcata (Koern.) L.R. Parra & Giul, popularly known in Brazil as “sempre-vivas,” are plants from the family Eriocaulaceae. They are found in the states of Minas Gerais and Bahia. The species are known to be rich in flavonoids to which their gastroprotective activity has been attributed. In this research, experimental protocols were performed to elucidate the associated mechanisms of action. Methods The activity was evaluated using induced gastric ulcer models (acetic acid and ethanol-induced gastric lesions in NEM or L-NAME pre-treated mice, and by ischemia/reperfusion). Antioxidant enzymes, serum somatostatin, and gastrin were also evaluated. Results In chronic gastric ulcers, a single daily oral dose of Sa-FRF or Sb-FRF (100 mg/kg body wt.) for 14 consecutive days accelerated ulcer healing to an extent similar to that seen with an equal dose of cimetidine. The pre-treatment of mice with NEM (N-ethylmaleimide) or L-NAME (N-nitro-L-arginine) abolished the protective activity of Sa-FRF, Sa-FDF, Sb-FDF and Sb-FRF or Sa-FRF and Sb-FRF, respectively, which indicates that antioxidant compounds and nitric oxide synthase activity are involved in the gastroprotective. Sa-FRF and Sb-FRF (100 mg/kg p.o) protected the gastric mucosa against ulceration that was induced by ischemia/reperfusion (72 and 76 %, respectively). It also decreased lipid peroxidation and restored total thiols in the gastric wall of mice that had been treated with ethanol. When administered to rats submitted to ethanol-induced gastric lesions, Sa-FRF and Sb-FRF (100 mg/kg, p.o.) increased the somatostatin serum levels, while the gastrin serum levels were proportionally decreased. Conclusions The results indicate significant healing effects and gastroprotective activity for the Sa-FRF and Sb-FRF, which probably involves the participation of SH groups, nitric oxide (NO), the antioxidant system, somatostatin, and gastrin. All are integral parts of the gastrointestinal mucosa’s cytoprotective mechanisms against aggressive factors

A prática de atividade física como promoção de saúde na atenção primária à saúde: um relato de experiência a partir do Pet-Saúde

A prática de atividade física permite ganhos físicos e psicológicos, melhora cognitiva e a diminuição do uso de medicamentos, pois pode ser implementado educação em saúde, a sociabilização, discussão de vivências do dia a dia, ampliação de habilidades de autocuidado e estímulo a um estilo de vida mais saudável. Relatar a experiência vivenciada por acadêmicos de Fisioterapia e Terapia Ocupacional, no grupo de práticas corporais, realizado com adultos na Atenção Primária à Saúde. Trata-se de um estudo qualitativo e descritivo do tipo relato de experiência de discentes de Fisioterapia e Terapia Ocupacional da Universidade Federal do Pará, em um grupo de práticas corporais, por meio de vivências no Programa de Educação pelo Trabalho (PET-Saúde), em uma Unidade Básica de Saúde do distrito d’água em Belém/PA. O grupo era composto por 17 usuários, tendo como média de participação de aproximadamente 12 pessoas, principalmente do sexo feminino. Foram realizados exercícios de alongamento globais, mobilidade de membros superiores e inferiores, resistência e fortalecimento com uso de faixas elásticas e o peso corporal, equilíbrio e propriocepção utilizando obstáculos e exercícios em apoio unipodal com uso do bastão para auxiliar, circuitos funcionais e aeróbico com dinâmicas em grupo, visando estimular a participação. O grupo de práticas corporais pode ser entendido como uma importante estratégia de promoção e prevenção da saúde da população, contribuindo para a troca de experiências e disseminação de informações

Avaliação toxicológica através do bioensaio com Artemia salina Leach de espécimes vegetais pertencentes à caatinga / Toxicological evaluation by Artemia salina Leach bioassay of caatinga plant specimens

Conhecida por sua vasta biodiversidade, a Caatinga inclui variadas espécies vegetais com comprovado potencial terapêutico e perfil toxicológico ainda pouco determinado. Diversas plantas pertencentes a esse bioma apresentam vasta utilização na medicina popular e cultura da sociedade, o objetivo do estudo é determinar a toxicidade aguada de espécies vegetais desse bioma que são adotadas na medicina popular. Exemplares de Bromelia laciniosa (Mart.), Ex schult (Macambira), Caesalpinia férrea Var. Ferrea (Pau ferro), Caesalpinia pyramidalis Tul (Catingueira), Cereus jamacaru DC (Mandacaru) e Nopalea cochenillifera L.Salm-Dyck (Palma), foram coletados, identificados e produzido o extrato bruto seco dos materiais vegetais. A toxicidade foi avaliada a partir da análise de CL50 em ensaio agudo com Artemia Salina L. A espécie Caesalpinia férrea Var. Ferrea foi classificada como toxicidade moderada. Com relação as demais espécies foi observada que as plantas não apresentaram valores de CL50 acima dos parâmetros de toxicidade, sendo assim classificadas como atóxicas. A considerável toxicidade apresentada pela Caesalpina férrea Var. Ferrea demonstra a necessidade da realização de mais estudos que respaldem o resultado encontrado, além da necessidade de realizar outros testes com a finalidade de analisar mais parâmetros e assim possibilitar levar mais informações pra sociedade que faz uso dessa espécie na medicina popular

ANÁLISE DO PERFIL DA SAÚDE CARDIOVASCULAR DE FREQÜENTADORES DO PARQUE DO POVO DE PRESIDENTE PRUDENTE – SP

Os hábitos de vida são responsáveis pelo aumento de indivíduos com hipertensão arterial (HA) e com doenças cardiovasculares (DCV), e a atividade física (AF) é um meio de controle e prevenção de DVC e HA. Este estudo teve como objetivo avaliar o perfil cardiovascular dos frequentadores do Parque do Povo de Presidente Prudente. 87 indivíduos (56,31 ±12,83 anos) responderam a questionários sobre a presença de DCV, HA e recomendação médica para AF e tiveram, em seguida, sua pressão arterial mensurada. Dos 87 indivíduos abordados, 17,24% são cardiopatas e apenas 20% deles realizam exercícios por recomendação médica, 40,23% são hipertensos e desses, 48,57% possuem recomendação para as atividades. Tais resultados mostram uma alta taxa de hipertensos seguida por uma menor de cardiopatas, porém uma taxa muito baixa de recomendação médica para AF, o que alerta que a não supervisão pode ser perigosa por se tratar de uma população de risco

Erratum to: The study of cardiovascular risk in adolescents – ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents

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MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio