El síndrome psicológico : ¿herramienta analítica o psicologización de la realidad social?

En los últimos años el concepto de síndrome ha ido adquiriendo una enorme importancia, tanto en la psicología como en la psicopatología. En este artículo describiremos no sólo la proliferación de su uso sino también el porqué de su creciente aceptación. Asimismo, pro-cederemos a describir diferentes tipos de síndromes antes de señalar diversos aspectos crí-ticos del uso actual del término, en sintonía con una creciente psicologización de los pro-blemas sociales. Finalmente, mostraremos la forma como se ha instalado en las explicacio-nes de sentido común de los diversos problemas a los que intenta dar respuesta haciendo uso de los procesos de anclaje y objetivación descritos en la teoría de las representaciones sociales de Serge Moscovici.The concept of syndrome has experienced an enormous importance in both psychology and psychopathology in the last years. In this article we will not only describe how its use has increased, but also why it is increasingly accepted. Moreover, different types of syndromes will be described, as well as critical aspects of the current use of the term will be high-lighted. Finally, we will show how the syndromes are been used to give common sense ex-planations of different problems by resorting to the processes of anchoring and objectify-ing described by Sergei Moscovici in his theory of social representations

Assessing the influence of isotopic composition of water on that of clay minerals during chemical treatments.

The isotopic composition of hydrogen in authigenic minerals is a useful tool to reconstruct past paleo-environments. Clay minerals are an important component of authigenic minerals in soils and sediments but they usually occur with other compounds that must be eliminated before the analysis, such as organic matter and carbonates. Thus, various “pre-treatments” are used, generally involving dilute HCl and H2O2 solutions in water. In this work, the influence of the isotopic composition of the water used in these pre-treatment solutions is assessed, using ten different samples of clay minerals. The isotopic composition of hydrogen was measured in each sample after HCl pre-treatment alone, H2O2 pre-treatment alone and both HCl and H2O2 pre-treatments in sequence, using two types of water in the pre-treatment solutions: one 2H-enriched and one 2H-depleted. The results indicate some influence of the isotopic composition of the water on the clay minerals after pre-treatment. In general, the samples showed significant alteration by HCl pre-treatment and negligible alteration by H2O2 pre-treatment. A pure kaolinite reference material did not show any change by chemical pre-treatment while a smectite reference material did show significant effects. Other samples (Ethiopian lacustrine sediment samples and Spanish cave sediments) showed important differences, which also depend on clay mineralogy. Thus, mineralogy seems to be the main cause of the variability in the alteration, especially the quantity of smectite. In addition, this result challenges the utility of clay minerals for isotope studies in acid conditions, such as in acidic soils, to reconstruct past environments and, therefore, climate changes.This study was developed during a stay supported by predoctoral mobility grant from the Spanish MINECO. Financial support for this work was obtained from MINECO Grant CGL2015-65387-C3-3-P. I. Campaña was the beneficiary of a predoctoral FPI Grant from the Spanish MINECO. We thank Jessica Wilson at the University of South Florida School of Geosciences who supported the isotopic analysis. J.G. Wynn was supported by an NSF IR/D program. Special thanks to the local resident of Burgos that help us remove the car from a mud puddle. // Funding for open access charge: Universidad de Málaga / CBU

Revision of TD1 and TD2 stratigraphic sequence of Gran Dolina cave (Sierra de Atapuerca, Spain)

Gran Dolina es una cueva rellena por al menos 25 m de sedimentos pleistocenos dividido en 12 unidades litoestratigráficas y 19 facies sedimentarias. Estas facies sedimentarias se han dividido entre facies alóctonas, definidas como entradas de sedimentos desde el exterior, y facies autóctonas, definidas como sedimentos generadas dentro del karst; sin embargo, esta clasificación de facies ha sido cuestionada en trabajos recientes. En este estudio se ha descrito en detalle las unidades TD1 y TD2 de Gran Dolina y se ha evaluado la idoneidad del uso de facies autóctonas. Para ello, se ha estudiado la sección estratigráfica de la excavación arqueológica, combinando observaciones de campo con análisis de laboratorio (tamizado, difracción láser y DRX) para caracterizar la textura y estructura de los sedimentos. A partir de estos estudios, se han identificado un total de 8 facies sedimentarias, y se han separado la unidad TD1 en dos sub-unidades y 13 niveles, y la unidad TD2 en tres sub-unidades. La asociación de facies indica una sucesión de fases freáticas y vadosas que definiría conjuntamente condiciones epifreáticas en el interior de la cueva, relacionadas con la transición entre la terraza T3 y la terraza T4 del valle del río Arlanzón. Por tanto, se propone el término facies de interior (y facies de entrada en vez de facies alóctonas) para definir los sedimentos de las unidades de TD1 y TD2 de Gran Dolina, ya que el análisis de facies indica transporte de los sedimentos por corrientes subterráneas.This study was supported by the project PGC2018-093925-B-C31 of the Spanish Ministry of Science and Innovation, Spanish State Research Agency and FEDER funds from the UE. Project PID2021-122355NB-C33 financed by MCIN/AEI/10.13039/501100011033/FEDER, UE. Funding for open access charge: Universidad de Málaga/CBUA. I. Campaña is the beneficiary of a postdoctoral grant from Junta de Andalucía. This work has benefited from discussion with Mathieu Duval, Lucía Bermejo, Lucía Ojeda and Sergio Durán. The constructive comments made by one anonymous reviewer and Dr. Ivan Martini contributed to improve the manuscript

Reconstructing depositional environments through cave interior facies: The case of Galería Complex (Sierra de Atapuerca, Spain)

This work showed that cave sediments are useful for geomorphologic studies and for reconstructing depositional environments. While the cave entrance facies have been extensively studied for their relationship with the fossil and archaeological record, the cave interior facies have received much less attention, although they can provide much information on the geomorphological evolution of the karst. This work presents the stratigraphic and sedimentological study of a section >6 m thick and 10 m long of cave interior sediments of Galería Complex (Sierra de Atapuerca, Spain). Galería Complex is a cavity infill of the Sierra de Atapuerca (Spain), composed of three sections filled by at least 30 m of Pleistocene sediments. This sequence is divided into 5 lithostratigraphic units named from bottom to top: GI – GV. GI unit is 19 m thick of interior facies in the base of the Galería Complex, divided into two sub-unit, GIa and GIb, by the Matuyama-Bruhnes paleomagnetic boundary. GI unit shows an issue with the chronology since has uncoherent between TT-OSL and ESR/U-series and paleomagnetism dates. This work has been done by combining field observation with laboratory sedimentary analysis to characterize the texture and structure of the sediments. Based on these studies, 12 layers and 9 sedimentary facies have been identified. The facies associations indicate a clear separation between GIa and GIb sub-units. GIa sub-unit is dominated by epiphreatic conditions and represents continuous relativity sedimentation during the Early Pleistocene; meanwhile, GIb shows important erosion events and facies with reworked materials that indicate vadose conditions during the Middle Pleistocene. This environmental change is related to the geomorphological evolution of the Arlanzón River. In addition, soft-sediment deformation structures have been described, including faults and low-angle folds...Funding for open access charge: Universidad de Málaga / CBU

Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1

Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. Unexpectedly, we find that excitotoxicity provokes an early inactivation of PKD1 through a dephosphorylation-dependent mechanism mediated by protein phosphatase-1 (PP1) and dual specificity phosphatase-1 (DUSP1). This step turns off the IKK/NF-kappa B/SOD2 antioxidant pathway. Neuronal PKD1 inactivation by pharmacological inhibition or lentiviral silencing in vitro, or by genetic inactivation in neurons in vivo, strongly enhances excitotoxic neuronal death. In contrast, expression of an active dephosphorylation-resistant PKD1 mutant potentiates the IKK/NF-kappa B/SOD2 oxidative stress detoxification pathway and confers neuroprotection from in vitro and in vivo excitotoxicity. Our results indicate that PKD1 inactivation underlies excitotoxicity-induced neuronal death and suggest that PKD1 inactivation may be critical for the accumulation of oxidation-induced neuronal damage during aging and in neurodegenerative disorders

Earliest known human burial in Africa

The origin and evolution of hominin mortuary practices are topics of intense interest and debate1,2,3. Human burials dated to the Middle Stone Age (MSA) are exceedingly rare in Africa and unknown in East Africa1,2,3,4,5,6. Here we describe the partial skeleton of a roughly 2.5- to 3.0-year-old child dating to 78.3 ± 4.1 thousand years ago, which was recovered in the MSA layers of Panga ya Saidi (PYS), a cave site in the tropical upland coast of Kenya7,8. Recent excavations have revealed a pit feature containing a child in a flexed position. Geochemical, granulometric and micromorphological analyses of the burial pit content and encasing archaeological layers indicate that the pit was deliberately excavated. Taphonomical evidence, such as the strict articulation or good anatomical association of the skeletal elements and histological evidence of putrefaction, support the in-place decomposition of the fresh body. The presence of little or no displacement of the unstable joints during decomposition points to an interment in a filled space (grave earth), making the PYS finding the oldest known human burial in Africa. The morphological assessment of the partial skeleton is consistent with its assignment to Homo sapiens, although the preservation of some primitive features in the dentition supports increasing evidence for non-gradual assembly of modern traits during the emergence of our species. The PYS burial sheds light on how MSA populations interacted with the dead.Additional co-authors: Pilar Fernández-Colón, Nikos Kourampas, Jorge González García, David Larreina, François-Xavier Le Bourdonnec, Laura Martín-Francés, Diyendo Massilani, Julio Mercader, Jennifer M. Miller, Emmanuel Ndiema, Belén Notario, Africa Pitarch Martí, Mary E. Prendergast, Alain Queffelec, Solange Rigaud, Patrick Roberts, Mohammad Javad Shoaee, Ceri Shipton, Ian Simpson, Nicole Boivin & Michael D. Petragl

Programa piloto de uso del portafolio como herramienta docente en el Grado de Biología

Memoria final del proyecto de Innovación educativa "Programa piloto de uso del portafolio como herramienta docente en el Grado de Biología

Management of acute diverticulitis with pericolic free gas (ADIFAS). an international multicenter observational study

Background: There are no specific recommendations regarding the optimal management of this group of patients. The World Society of Emergency Surgery suggested a nonoperative strategy with antibiotic therapy, but this was a weak recommendation. This study aims to identify the optimal management of patients with acute diverticulitis (AD) presenting with pericolic free air with or without pericolic fluid. Methods: A multicenter, prospective, international study of patients diagnosed with AD and pericolic-free air with or without pericolic free fluid at a computed tomography (CT) scan between May 2020 and June 2021 was included. Patients were excluded if they had intra-abdominal distant free air, an abscess, generalized peritonitis, or less than a 1-year follow-up. The primary outcome was the rate of failure of nonoperative management within the index admission. Secondary outcomes included the rate of failure of nonoperative management within the first year and risk factors for failure. Results: A total of 810 patients were recruited across 69 European and South American centers; 744 patients (92%) were treated nonoperatively, and 66 (8%) underwent immediate surgery. Baseline characteristics were similar between groups. Hinchey II-IV on diagnostic imaging was the only independent risk factor for surgical intervention during index admission (odds ratios: 12.5, 95% CI: 2.4-64, P =0.003). Among patients treated nonoperatively, at index admission, 697 (94%) patients were discharged without any complications, 35 (4.7%) required emergency surgery, and 12 (1.6%) percutaneous drainage. Free pericolic fluid on CT scan was associated with a higher risk of failure of nonoperative management (odds ratios: 4.9, 95% CI: 1.2-19.9, P =0.023), with 88% of success compared to 96% without free fluid ( P <0.001). The rate of treatment failure with nonoperative management during the first year of follow-up was 16.5%. Conclusion: Patients with AD presenting with pericolic free gas can be successfully managed nonoperatively in the vast majority of cases. Patients with both free pericolic gas and free pericolic fluid on a CT scan are at a higher risk of failing nonoperative management and require closer observation

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality