Cascaded multiplexed optical link on a telecommunication network for frequency dissemination

We demonstrate a cascaded optical link for ultrastable frequency dissemination comprised of two compensated links of 150 km and a repeater station. Each link includes 114 km of Internet fiber simultaneously carrying data traffic through a dense wavelength division multiplexing technology, and passes through two routing centers of the telecommunication network. The optical reference signal is inserted in and extracted from the communication network using bidirectional optical add-drop multiplexers. The repeater station operates autonomously ensuring noise compensation on the two links and the ultra-stable signal optical regeneration. The compensated link shows a fractional frequency instability of 3 \times 10-15 at one second measurement time and 5 \times 10-20 at 20 hours. This work paves the way to a wide dissemination of ultra-stable optical clock signals between distant laboratories via the Internet network

Student Affairs Professionals’ Perceptions of Campus Incivility

Student Affairs Professionals’ Perceptions of Campus Incivility Amy J. Zieziula, Armstrong State UniversityDaniel W. Calhoun, Georgia Southern University Abstract The purpose of this study was to gather data regarding student affairs professionals’ perceptions of student incivility and which acts of incivility are most often observed. Results from 409 participants suggested that student affairs professionals perceive that “very uncivil” acts are observed less often whereas acts that are perceived to be neither civil nor uncivil are witnessed more frequently. In addition, findings indicated that student affairs professionals are seeing an increase in uncivil acts related to social media and technology, and the manner in which students are using social media to vent frustrations with campus staff and their peers. Finally, recommendations for practice and further research are provided

High-resolution microwave frequency dissemination on an 86-km urban optical link

We report the first demonstration of a long-distance ultra stable frequency dissemination in the microwave range. A 9.15 GHz signal is transferred through a 86-km urban optical link with a fractional frequency stability of 1.3x10-15 at 1 s integration time and below 10-18 at one day. The optical link phase noise compensation is performed with a round-trip method. To achieve such a result we implement light polarisation scrambling and dispersion compensation. This link outperforms all the previous radiofrequency links and compares well with recently demonstrated full optical links.Comment: 11 pages, 5 figure

Student Affairs Professionals’ Perceptions of Campus Incivility

The purpose of this study was to gather data regarding student affairs professionals’ perceptions of student incivility and which acts of incivility are most often observed. Results from 409 participants suggested that student affairs professionals perceive that “very uncivil” acts are observed less often whereas acts that are perceived to be neither civil nor uncivil are witnessed more frequently. In addition, findings indicated that student affairs professionals are seeing an increase in uncivil acts related to social media and technology, and the manner in which students are using social media to vent frustrations with campus staff and their peers. Finally, recommendations for practice and further research are provided

Supplier Collaborative and Ethical Consideration in the Vendor Selection Process

Abstract This examination of location strategy implementation by Pittsburgh-based service firms, particularly eco-friendly initiatives, was pursued via a case-study approach. The factors selected for comparison were site size and cost; air, rail, highway, and waterway systems; zoning restrictions; proximity to markets/suppliers/competitors; and environmental impact issues. The study included five service-based firms, most of which made decisions concerning new locations within the last few years, and highlighted those factors most significant in the location strategies of local service firms. Findings evidence proximity to market/suppliers/competitors was the most heavily weighted factor in site selection among Pittsburgh-based service firms. The least considered factor in site selection was economic impact. Further, while each firm practiced various eco-friendly initiatives, those initiatives were largely intended to reduce firm costs rather than minimize environmental impact. The present study suggests that using technology in conjunction with a solid supply chain and locational strategy contributes to a successful business operation. As e-commerce is only one segment of supply chain and location management, it is worthwhile to note that a complete supply chain strategy (as previously presented in the text) is necessary to improve business performance. The results of this study show that missing parts of a supply chain strategy will lead to an ineffective supply chain strategy. Ineffective implementation of any business strategy will contribute to failure to succeed

The Splicing Efficiency of Activating HRAS Mutations Can Determine Costello Syndrome Phenotype and Frequency in Cancer

Costello syndrome (CS) may be caused by activating mutations in codon 12/13 of the HRAS proto-oncogene. HRAS p.Gly12Val mutations have the highest transforming activity, are very frequent in cancers, but very rare in CS, where they are reported to cause a severe, early lethal, phenotype. We identified an unusual, new germline p.Gly12Val mutation, c.35_36GC>TG, in a 12-year-old boy with attenuated CS. Analysis of his HRAS cDNA showed high levels of exon 2 skipping. Using wild type and mutant HRAS minigenes, we confirmed that c.35_36GC>TG results in exon 2 skipping by simultaneously disrupting the function of a critical Exonic Splicing Enhancer (ESE) and creation of an Exonic Splicing Silencer (ESS). We show that this vulnerability of HRAS exon 2 is caused by a weak 3' splice site, which makes exon 2 inclusion dependent on binding of splicing stimulatory proteins, like SRSF2, to the critical ESE. Because the majority of cancer- and CS- causing mutations are located here, they affect splicing differently. Therefore, our results also demonstrate that the phenotype in CS and somatic cancers is not only determined by the different transforming potentials of mutant HRAS proteins, but also by the efficiency of exon 2 inclusion resulting from the different HRAS mutations. Finally, we show that a splice switching oligonucleotide (SSO) that blocks access to the critical ESE causes exon 2 skipping and halts proliferation of cancer cells. This unravels a potential for development of new anti-cancer therapies based on SSO-mediated HRAS exon 2 skipping

How We Close the Gaps: Our Interprofessional Team Approach to Meeting Quality Measures

Define the role/function of an interprofessional team in the management of complex outpatients. Identify the types of patients that would benefit most from a team-based approach. Implement elements of our team-based patient care model into individual practices

Movement behavior in a dominant ungulate underlies successful adjustment to a rapidly changing landscape following megafire.

BACKGROUND: Movement plays a key role in allowing animal species to adapt to sudden environmental shifts. Anthropogenic climate and land use change have accelerated the frequency of some of these extreme disturbances, including megafire. These megafires dramatically alter ecosystems and challenge the capacity of several species to adjust to a rapidly changing landscape. Ungulates and their movement behaviors play a central role in the ecosystem functions of fire-prone ecosystems around the world. Previous work has shown behavioral plasticity is an important mechanism underlying whether large ungulates are able to adjust to recent changes in their environments effectively. Ungulates may respond to the immediate effects of megafire by adjusting their movement and behavior, but how these responses persist or change over time following disturbance is poorly understood. METHODS: We examined how an ecologically dominant ungulate with strong site fidelity, Columbian black-tailed deer (Odocoileus hemionus columbianus), adjusted its movement and behavior in response to an altered landscape following a megafire. To do so, we collected GPS data from 21 individual female deer over the course of a year to compare changes in home range size over time and used resource selection functions (RSFs) and hidden Markov movement models (HMMs) to assess changes in behavior and habitat selection. RESULTS: We found compelling evidence of adaptive capacity across individual deer in response to megafire. Deer avoided exposed and severely burned areas that lack forage and could be riskier for predation immediately following megafire, but they later altered these behaviors to select areas that burned at higher severities, potentially to take advantage of enhanced forage. CONCLUSIONS: These results suggest that despite their high site fidelity, deer can navigate altered landscapes to track rapid shifts in encounter risk with predators and resource availability. This successful adjustment of movement and behavior following extreme disturbance could help facilitate resilience at broader ecological scales

Explaining cognitive function in multiple sclerosis through networks of grey and white matter features: a joint independent component analysis

Cognitive impairment (CI) in multiple sclerosis (MS) is only partially explained by whole-brain volume measures, but independent component analysis (ICA) can extract regional patterns of damage in grey matter (GM) or white matter (WM) that have proven more closely associated with CI. Pathology in GM and WM occurs in parallel, and so patterns can span both. This study assessed whether joint-ICA of GM and WM features better explained cognitive function compared to single-tissue ICA. 89 people with MS underwent cognitive testing and magnetic resonance imaging. Structural T1 and diffusion-weighted images were used to measure GM volumes and WM connectomes (based on fractional anisotropy weighted by the number of streamlines). ICA was performed for each tissue type separately and as joint-ICA. For each tissue type and joint-ICA, 20 components were extracted. In stepwise linear regression models, joint-ICA components were significantly associated with all cognitive domains. Joint-ICA showed the highest variance explained for executive function (Adjusted R2 = 0.35) and visual memory (Adjusted R2 = 0.30), while WM-ICA explained the highest variance for working memory (Adjusted R2 = 0.23). No significant differences were found between joint-ICA and single-tissue ICA in information processing speed or verbal memory. This is the first MS study to explore GM and WM features in a joint-ICA approach and shows that joint-ICA outperforms single-tissue analysis in some, but not all cognitive domains. This highlights that cognitive domains are differentially affected by tissue-specific features in MS and that processes spanning GM and WM should be considered when explaining cognition