1,153 research outputs found
Using Neural Networks for Relation Extraction from Biomedical Literature
Using different sources of information to support automated extracting of
relations between biomedical concepts contributes to the development of our
understanding of biological systems. The primary comprehensive source of these
relations is biomedical literature. Several relation extraction approaches have
been proposed to identify relations between concepts in biomedical literature,
namely, using neural networks algorithms. The use of multichannel architectures
composed of multiple data representations, as in deep neural networks, is
leading to state-of-the-art results. The right combination of data
representations can eventually lead us to even higher evaluation scores in
relation extraction tasks. Thus, biomedical ontologies play a fundamental role
by providing semantic and ancestry information about an entity. The
incorporation of biomedical ontologies has already been proved to enhance
previous state-of-the-art results.Comment: Artificial Neural Networks book (Springer) - Chapter 1
Cell walls of the dimorphic fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and sloughing of extensive and intact layers
This work was supported by the Fundação Carlos Chagas de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), grants E-26/202.974/2015 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), grants 229755/2013-5, Brazil. LMLB is a senior research fellow of CNPq and Faperj. NG acknowledged support from the Wellcome Trust (Trust (097377, 101873, 200208) and MRC Centre for Medical Mycology (MR/N006364/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
Níveis de hidroxiprolina em adultos ativos submetidos a exercício de alongamento
Estudos anteriores demonstram relação entre a lesão do aparelho locomotor e o aumento na excreção urinária da hidroxiprolina (HP). O objetivo foi avaliar os efeitos do alongamento sobre os níveis de HP em militares do sexo masculino. No estudo foram avaliados 64 indivíduos (idade: 18,7 ± 5 anos; massa corporal: 63,8 ± 7,3 kg) distribuídos em grupo alongamento (GA: n=32) e grupo controle (GC: n=32). O alongamento foi realizado no GA por meio do método de estiramento misto, em três séries de quatro insistências submáximas com permanência de quatro segundos no ponto máximo atingido. O intervalo foi de cinco segundos entre as séries, realizando-se: flexão e extensão de ombros (FO e EO) e flexão e extensão de quadril (FQ e EQ). O GC não realizou exercícios físicos. A coleta de urina foi realizada em ambos os grupos nos momentos (basal), 24 e 48 horas após a intervenção. As amostras foram analisadas mediante o método Colorimétrico. Utilizou-se o teste de normalidade Shapiro-Wilk e a Anova One-way, considerando um nível de significância de
Efeitos hemorreológicos e cardiovasculares da eritropoietina num modelo de rato em exercício físico sob a acção de drogas
Recombinant human erythropoietin
(rhEPO) has been therapeutically
used for correction of anaemia. However,
due to the increase in circulating
red blood cells (RBCs) it promotes,
thus increasing oxygen delivery to
muscles and improving performance
in sport, it has been also illegally used
as sports doping. Besides the well
known increase of hematocrit and
blood viscosity; which might cause
serious complications for the athletes,
other disturbances could occur, whose
mechanisms remain to be fully elucidated.
This study aimed to evaluate
the hemorheological and cardiovascular
effects of administration of
rhEPO to rats under chronic aerobic
exercise. A ten week-protocol was
performed in four male Wistar rat
groups: control — sedentary; rhEPO
— 50 IV/kg, 3 times/wk; exercised
(EX) — swimming for 1 hr, 3 times/
wk; EX+rhEPO. rhEPO in trained
rats promoted erythrocyte count increase,
hypertension, heart hypertro-phy, sympathetic and serotonergic
overactivation, as well as a trend to
increased oxidative stress. In conclusion,
rhEPO doping in rats under
chronic exercise promotes not only
the expected increased hematocrit,
but also other serious deleterious cardiovascular
and thromboembolic
modifications, including live risk,
which might be known and assumed
by all sports authorities, including
athletes and their physicians.info:eu-repo/semantics/publishedVersio
Influence of the Carbon Source on Gordonia alkanivorans Strain 1B Resistance to 2-Hydroxybiphenyl Toxicity
Prevalence of temporomandibular joint disorders and neck pain in musicians: a sytematic review
Influence of the substitutional solute on the mechanical properties of Ti-Nb binary alloys for biomedical use
International Veterinary Epilepsy Task Force consensus proposal: Medical treatment of canine epilepsy in Europe
In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years. Nevertheless, the same questions remain, which include, 1) when to start treatment, 2) which drug is best used initially, 3) which adjunctive AED can be advised if treatment with the initial drug is unsatisfactory, and 4) when treatment changes should be considered. In this consensus proposal, an overview is given on the aim of AED treatment, when to start long-term treatment in canine epilepsy and which veterinary AEDs are currently in use for dogs. The consensus proposal for drug treatment protocols, 1) is based on current published evidence-based literature, 2) considers the current legal framework of the cascade regulation for the prescription of veterinary drugs in Europe, and 3) reflects the authors’ experience. With this paper it is aimed to provide a consensus for the management of canine idiopathic epilepsy. Furthermore, for the management of structural epilepsy AEDs are inevitable in addition to treating the underlying cause, if possible
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis
SBMLsqueezer: A CellDesigner plug-in to generate kinetic rate equations for biochemical networks
<p>Abstract</p> <p>Background</p> <p>The development of complex biochemical models has been facilitated through the standardization of machine-readable representations like SBML (Systems Biology Markup Language). This effort is accompanied by the ongoing development of the human-readable diagrammatic representation SBGN (Systems Biology Graphical Notation). The graphical SBML editor CellDesigner allows direct translation of SBGN into SBML, and vice versa. For the assignment of kinetic rate laws, however, this process is not straightforward, as it often requires manual assembly and specific knowledge of kinetic equations.</p> <p>Results</p> <p>SBMLsqueezer facilitates exactly this modeling step via automated equation generation, overcoming the highly error-prone and cumbersome process of manually assigning kinetic equations. For each reaction the kinetic equation is derived from the stoichiometry, the participating species (e.g., proteins, mRNA or simple molecules) as well as the regulatory relations (activation, inhibition or other modulations) of the SBGN diagram. Such information allows distinctions between, for example, translation, phosphorylation or state transitions. The types of kinetics considered are numerous, for instance generalized mass-action, Hill, convenience and several Michaelis-Menten-based kinetics, each including activation and inhibition. These kinetics allow SBMLsqueezer to cover metabolic, gene regulatory, signal transduction and mixed networks. Whenever multiple kinetics are applicable to one reaction, parameter settings allow for user-defined specifications. After invoking SBMLsqueezer, the kinetic formulas are generated and assigned to the model, which can then be simulated in CellDesigner or with external ODE solvers. Furthermore, the equations can be exported to SBML, LaTeX or plain text format.</p> <p>Conclusion</p> <p>SBMLsqueezer considers the annotation of all participating reactants, products and regulators when generating rate laws for reactions. Thus, for each reaction, only applicable kinetic formulas are considered. This modeling scheme creates kinetics in accordance with the diagrammatic representation. In contrast most previously published tools have relied on the stoichiometry and generic modulators of a reaction, thus ignoring and potentially conflicting with the information expressed through the process diagram. Additional material and the source code can be found at the project homepage (URL found in the Availability and requirements section).</p
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