26,629 research outputs found
Generation and detection of bound entanglement
We propose a method for the experimental generation of two different families
of bound entangled states of three qubits. Our method is based on the explicit
construction of a quantum network that produces a purification of the desired
state. We also suggest a route for the experimental detection of bound
entanglement, by employing a witness operator plus a test of the positivity of
the partial transposes
Extended-release niacin increases anti-apolipoprotein A-I antibodies that block the antioxidant effect of high-density lipoprotein-cholesterol: the EXPLORE clinical trial.
Extended-release niacin (ERN) is the most effective agent for increasing high-density lipoprotein-cholesterol (HDL-C). Having previously identified anti-HDL antibodies, we investigated whether ERN affected the antioxidant capacity of HDL and whether ERN was associated with the production of antibodies against HDL (aHDL) and apolipoprotein A-I (aApoA-I).
METHODS:
Twenty-one patients older than 18 years, with HDL-C ≤40 mg dl-1 (men) or ≤50 mg dl-1 (women) were randomly assigned to receive daily ERN (n = 10) or placebo (n = 11) for two sequential 12-week periods, with 4 weeks of wash-out before cross-over. Primary outcome was change of paraoxonase-1 (PON1) activity and secondary outcomes were changes in aHDL and aApoA-I antibodies. Clinical Trial Unique Identifier: EudraCT 2006-006889-42.
RESULTS:
The effect of ERN on PON1 activity was nonsignificant (coefficient estimate 20.83 U l-1 , 95% confidence interval [CI] -9.88 to 51.53; P = 0.184). ERN was associated with an increase in HDL-C levels (coefficient estimate 5.21 mg dl-1 , 95% CI 1.16 to 9.25; P = 0.012) and its subclasses HDL2 (coefficient estimate 2.46 mg dl-1 , 95% CI 0.57 to 4.34; P = 0.011) and HDL3 (coefficient estimate 2.73 mg dl-1 , 95% CI 0.47 to 4.98; P = 0.018). ERN was significantly associated with the production of aApoA-I antibodies (coefficient estimate 0.25 μg ml-1 , 95% CI 0.09-0.40; P = 0.001). aApoA-I titres at baseline were correlated with decreased PON activity.
CONCLUSIONS:
The rise in HDL-C achieved with ERN was not matched by improved antioxidant capacity, eventually hampered by the emergence of aApoA-I antibodies. These results may explain why Niacin and other lipid lowering agents fail to reduce cardiovascular risk.info:eu-repo/semantics/publishedVersio
Slow down of a globally neutral relativistic beam shearing the vacuum
The microphysics of relativistic collisionless sheared flows is investigated
in a configuration consisting of a globally neutral, relativistic beam
streaming through a hollow plasma/dielectric channel. We show through
multidimensional PIC simulations that this scenario excites the Mushroom
instability (MI), a transverse shear instability on the electron-scale, when
there is no overlap (no contact) between the beam and the walls of the
hollow plasma channel. The onset of the MI leads to the conversion of the
beam's kinetic energy into magnetic (and electric) field energy, effectively
slowing down a globally neutral body in the absence of contact. The
collisionless shear physics explored in this configuration may operate in
astrophysical environments, particularly in highly relativistic and supersonic
settings where macroscopic shear processes are stable
Direct estimation of functionals of density operators by local operations and classical communication
We present a method of direct estimation of important properties of a shared bipartite quantum state, within the "distant laboratories" paradigm, using only local operations and classical communication. We apply this procedure to spectrum estimation of shared states, and locally implementable structural physical approximations to incompletely positive maps. This procedure can also be applied to the estimation of channel capacity and measures of entanglement
An ALMA study of the Orion Integral Filament : I. Evidence for narrow fibers in a massive cloud
© 2018 ESO. Reproduced with permission from Astronomy & Astrophysics. Content in the UH Research Archive is made available for personal research, educational, and non-commercial purposes only. Unless otherwise stated, all content is protected by copyright, and in the absence of an open license, permissions for further re-use should be sought from the publisher, the author, or other copyright holder.Aim. We have investigated the gas organization within the paradigmatic Integral Shape Filament (ISF) in Orion in order to decipher whether or not all filaments are bundles of fibers. Methods. We combined two new ALMA Cycle 3 mosaics with previous IRAM 30m observations to produce a high-dynamic range N 2H + (1-0) emission map of the ISF tracing its high-density material and velocity structure down to scales of 0.009 pc (or ~2000 AU). Results. From the analysis of the gas kinematics, we identify a total of 55 dense fibers in the central region of the ISF. Independently of their location in the cloud, these fibers are characterized by transonic internal motions, lengths of ~0.15 pc, and masses per unit length close to those expected in hydrostatic equilibrium. The ISF fibers are spatially organized forming a dense bundle with multiple hub-like associations likely shaped by the local gravitational potential. Within this complex network, the ISF fibers show a compact radial emission profile with a median FWHM of 0.035 pc systematically narrower than the previously proposed universal 0.1 pc filament width. Conclusions. Our ALMA observations reveal complex bundles of fibers in the ISF, suggesting strong similarities between the internal substructure of this massive filament and previously studied lower-mass objects. The fibers show identical dynamic properties in both low- and high-mass regions, and their widespread detection in nearby clouds suggests a preferred organizational mechanism of gas in which the physical fiber dimensions (width and length) are self-regulated depending on their intrinsic gas density. Combining these results with previous works in Musca, Taurus, and Perseus, we identify a systematic increase of the surface density of fibers as a function of the total mass per-unit-length in filamentary clouds. Based on this empirical correlation, we propose a unified star-formation scenario where the observed differences between low- and high-mass clouds, and the origin of clusters, emerge naturally from the initial concentration of fibers.Peer reviewedFinal Published versio
Signals for New Spin-1 Resonances in Electroweak Gauge Boson Pair Production at the LHC
The mechanism of electroweak symmetry breaking (EWSB) will be directly
scrutinized soon at the CERN Large Hadron Collider (LHC). We analyze the LHC
potential to look for new vector bosons associated with the EWSB sector. We
present a possible model independent approach to search for these new spin--1
resonances. We show that the analyses of the processes pp --> l^+ l^- Emiss_T,
l^\pm j j Emiss_T, l^\pm l^+ l^- Emiss_T, and l^+ l^- j j (with l=e or \mu and
j=jet) have a large reach at the LHC and can lead to the discovery or exclusion
of many EWSB scenarios such as Higgsless models.Comment: 10 pages, 11 figure
Optical doping and damage formation in AIN by Eu implantation
AlN films grown on sapphire were implanted with 300 keV Eu ions to fluences from 3×1014 to 1.4×1017 atoms/cm2 in two different geometries: “channeled” along the c-axis and “random” with a 10° angle between the ion beam and the surface normal. A detailed study of implantation damage accumulation is presented. Strong ion channeling effects are observed leading to significantly decreased damage levels for the channeled implantation within the entire fluence range. For random implantation, a buried amorphous layer is formed at the highest fluences. Red Eu-related photoluminescence at room temperature is observed in all samples with highest intensities for low damage samples (low fluence and channeled implantation) after annealing. Implantation damage, once formed, is shown to be stable up to very high temperatures.FCT - POCI/FIS/57550/2004FCT - PTDC/FIS/66262/2006FCT - PTDC/CTM/100756/200
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