7,739 research outputs found
3,4-Dicyanophenyl 2,3,4,6-tetra-O-acetyl-α-d-glucopyranoside
The title compound, C22H22N2O10, was prepared by the glycosidation method through nitrite displacement on substituted nitrophthalonitrile. The molecule contains a benzene ring, two nitrile groups and an acetyl-protected d-glucose fragment which adopts a chair conformation. The absolute configuration was determined by the use of d-glucose as starting material. All substituents of the protected sugar are in equatorial positions, with the exclusive presence of the α-anomer. The crystal packing is stabilized by C—H⋯O and C—H⋯N hydrogen-bonding interactions
Non-linear Structures in Non-critical NSR String
We investigate the Ward identities of the \W_{\infty} symmetry in the
super-Liouville theory coupled to the super-conformal matter of central charge
. The theory is classified into two chiralities.
For the positive chirality, all gravitationally dressed scaling operators are
generated from the gravitational primaries by acting one of the ring
generators in the R-sector on them repeatedly. After fixing the normalizations
of the dressed scaling operators, we find that the Ward identities are
expressed in the form of the {\it usual} \W_q algebra constraints as in the
bosonic case: \W^{(k+1)}_n \tau =0, , where the equations for even and odd come from the currents in the
NS- and the R-sector respectively. The non-linear terms come from the anomalous
contributions at the boundaries of moduli space. The negative chirality is
defined by interchanging the roles of and . Then we get the \W_p
algebra constraints.Comment: 22 pages, Latex file, YITP/U-94-16, UT-Komaba/94-1
Long-term temporal dependence of droplets transiting through a fixed spatial point in gas-liquid twophase turbulent jets
We perform rescaled range analysis upon the signals measured by Dual Particle
Dynamical Analyzer in gas-liquid two-phase turbulent jets. A novel rescaled
range analysis is proposed to investigate these unevenly sampled signals. The
Hurst exponents of velocity and other passive scalars in the bulk of spray are
obtained to be 0.590.02 and the fractal dimension is hence 1.41
0.02, which are in remarkable agreement with and much more precise than
previous results. These scaling exponents are found to be independent of the
configuration and dimensions of the nozzle and the fluid flows. Therefore, such
type of systems form a universality class with invariant scaling properties.Comment: 16 Elsart pages including 8 eps figure
Differential Release and Phagocytosis of Tegument Glycoconjugates in Neurocysticercosis: Implications for Immune Evasion Strategies
Neurocysticercosis (NCC) is an infection of the central nervous system (CNS) by the metacestode of the helminth Taenia solium. The severity of the symptoms is associated with the intensity of the immune response. First, there is a long asymptomatic period where host immunity seems incapable of resolving the infection, followed by a chronic hypersensitivity reaction. Since little is known about the initial response to this infection, a murine model using the cestode Mesocestoides corti (syn. Mesocestoides vogae) was employed to analyze morphological changes in the parasite early in the infection. It was found that M. corti material is released from the tegument making close contact with the nervous tissue. These results were confirmed by infecting murine CNS with ex vivo–labeled parasites. Because more than 95% of NCC patients exhibit humoral responses against carbohydrate-based antigens, and the tegument is known to be rich in glycoconjugates (GCs), the expression of these types of molecules was analyzed in human, porcine, and murine NCC specimens. To determine the GCs present in the tegument, fluorochrome-labeled hydrazides as well as fluorochrome-labeled lectins with specificity to different carbohydrates were used. All the lectins utilized labeled the tegument. GCs bound by isolectinB4 were shed in the first days of infection and not resynthesized by the parasite, whereas GCs bound by wheat germ agglutinin and concavalinA were continuously released throughout the infectious process. GCs bound by these three lectins were taken up by host cells. Peanut lectin-binding GCs, in contrast, remained on the parasite and were not detected in host cells. The parasitic origin of the lectin-binding GCs found in host cells was confirmed using antibodies against T. solium and M. corti. We propose that both the rapid and persistent release of tegumental GCs plays a key role in the well-known immunomodulatory effects of helminths, including immune evasion and life-long inflammatory sequelae seen in many NCC patients
Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET‐DD) study, a collaborative study carried out in 14 countries
Aims
To assess the prevalence and management of depressive disorders in people with Type 2 diabetes in different countries.
Methods
People with diabetes aged 18–65 years and treated in outpatient settings were recruited in 14 countries and underwent a psychiatric interview. Participants completed the Patient Health Questionnaire and the Problem Areas in Diabetes scale. Demographic and medical record data were collected.
Results
A total of 2783 people with Type 2 diabetes (45.3% men, mean duration of diabetes 8.8 years) participated. Overall, 10.6% were diagnosed with current major depressive disorder and 17.0% reported moderate to severe levels of depressive symptomatology (Patient Health Questionnaire scores >9). Multivariable analyses showed that, after controlling for country, current major depressive disorder was significantly associated with gender (women) (PPPPP<0.0001). The proportion of those with either current major depressive disorder or moderate to severe levels of depressive symptomatology who had a diagnosis or any treatment for their depression recorded in their medical records was extremely low and non-existent in many countries (0–29.6%).
Conclusions
Our international study, the largest of this type ever undertaken, shows that people with diabetes frequently have depressive disorders and also significant levels of depressive symptoms. Our findings indicate that the identification and appropriate care for psychological and psychiatric problems is not the norm and suggest a lack of the comprehensive approach to diabetes management that is needed to improve clinical outcomes
Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an <i>in vitro</i> model of CNS tuberculosis
Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized. We demonstrate that Mycobacterium tuberculosis (Mtb) causes breakdown of type IV collagen and decreases tight junction protein (TJP) expression in a co-culture model of the BBB. This increases permeability, surface expression of endothelial adhesion molecules and leukocyte transmigration. TJP breakdown was driven by Mtb-dependent secretion of matrix metalloproteinase (MMP)-9. TJP expression is regulated by Sonic hedgehog (Shh) through transcription factor Gli-1. In our model, the hedgehog pathway was downregulated by Mtb-stimulation, but Shh levels in astrocytes were unchanged. However, Scube2, a glycoprotein regulating astrocyte Shh release was decreased, inhibiting Shh delivery to brain endothelial cells. Activation of the hedgehog pathway by addition of a Smoothened agonist or by addition of exogenous Shh, or neutralizing MMP-9 activity, decreased permeability and increased TJP expression in the Mtb-stimulated BBB co-cultures. In summary, the BBB is disrupted by downregulation of the Shh pathway and breakdown of TJPs, secondary to increased MMP-9 activity which suggests that these pathways are potential novel targets for host directed therapy in CNS TB
Apolipoprotein E, periodontal disease and the risk for atherosclerosis: a review
Foundation of Support to the Scientific and Technological Development of the State of Ceara/Brazil (FUNCAP) PPSUS grant, the Brazilian
Coordination for the Improvement of Higher Education Personnel (CAPES) Procad
(071/2013 # 144494), and by the National Council for Science and Technological
Development (CNPq, grant number 467143/2014-5)
Preliminary Outcomes 1 Year after Laparoscopic Sleeve Gastrectomy Based on Bariatric Analysis and Reporting Outcome System (BAROS)
# The Author(s) 2011. This article is published with open access at Springerlink.com Background The aim of this study was to assess outcomes of laparoscopic sleeve gastrectomy (LSG) as a stand-alone bariatric operation according to the Bariatric Analysis and Reporting Outcome System (BAROS). Methods Out of 112 patients included and operated on initially, 84 patients (F/M, 63:21) were followed up for 14– 56 months (mean 22±6.75). Patients lost to follow-up did not attend scheduled follow-up visits or they have withdrawn their consent. Mean age was 39 years (range 17–67; SD±12.09) with mean initial BMI 44.62 kg/m 2 (range 29.39–82.8; SD±8.17). Statistical significance was established at the p<0.05 level. Results Mean operative time was 61 min (30–140 min) with mean hospital stay of 1.37 days (0–4; SD±0.77). Excellent global BAROS outcome was achieved in 13 % of patients, very good in 30%, good in 34.5%, fair 9.5 % and failure in 13 % patients 12 months after surgery. Females achieved significantly better outcomes than males with the mean 46.5 % of excess weight loss (EWL) versus 35.3 % of EWL at 12 months (p=0.02). The mean percentage of excess weight loss (%EWL) was 43.6 % at 12 months and 46.6 % at 24 months. Major surgical complication rate was 7.1%; minor surgical complication rate 8.3%. There was one conversion (1.2%) due to the massive bleeding. Comorbidities improved or resolved in numerous patients
Oscillations of neutrinos and mesons in quantum field theory
This report deals with the quantum field theory of particle oscillations in
vacuum. We first review the various controversies regarding quantum-mechanical
derivations of the oscillation formula, as well as the different
field-theoretical approaches proposed to settle them. We then clear up the
contradictions between the existing field-theoretical treatments by a thorough
study of the external wave packet model. In particular, we show that the latter
includes stationary models as a subcase. In addition, we explicitly compute
decoherence terms, which destroy interferences, in order to prove that the
coherence length can be increased without bound by more accurate energy
measurements. We show that decoherence originates not only in the width and in
the separation of wave packets, but also in their spreading through space-time.
In this review, we neither assume the relativistic limit nor the stability of
oscillating particles, so that the oscillation formula derived with
field-theoretical methods can be applied not only to neutrinos but also to
neutral K and B mesons. Finally, we discuss oscillations of correlated
particles in the same framework.Comment: v2, 124 pages, 10 figures (7 more); updated review of the literature;
complete derivation of the oscillation probability at short and large
distance; more details on the influence of the spreading of the amplitude on
decoherence; submitted to Physics Report
Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet
\ua9 2024 The AuthorsIn the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, focused, and better funded future for European DILI research. This Roadmap aims to identify key challenges, define a shared vision across all stakeholders for the opportunities to overcome these challenges and propose a high-quality research program to achieve progress on the prediction, prevention, diagnosis and management of this condition and impact on healthcare practice in the field of DILI. This will involve 1. Creation of a database encompassing optimised case report form for prospectively identified DILI cases with well-characterised controls with competing diagnoses, biological samples, and imaging data; 2. Establishing of preclinical models to improve the assessment and prediction of hepatotoxicity in humans to guide future drug safety testing; 3. Emphasis on implementation science and 4. Enhanced collaboration between drug-developers, clinicians and regulatory scientists. This proposed operational framework will advance DILI research and may bring together basic, applied, translational and clinical research in DILI
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