Mechanical behaviour of heavily compacted bentonite under high suction changes

The paper reports the results of an experimental study carried out on a bentonite compacted to a dry density of up to 1·7 Mg=m3, a high value for this type of soil. The soil fabric has been studied using a variety of techniques, revealing a clear bimodal pore distribution that corresponds to two distinct structural levels: a microstructural one and a macrostructural one. The main testing programme has been performed using oedometers especially designed to apply a very large range of suctions. By applying the axis-translation technique (using nitrogen as the gas fluid), it has been possible to reach suctions up to 15 MPa. The higher suction range has been achieved by applying a controlled atmosphere where the relative humidity has been fixed by a solution of sulphuric acid or salts. In this way suctions up to 550 MPa could be reached. The maximum vertical stress that could be applied in the apparatus was 10 MPa. Two types of test have been carried out: (a) tests in which a combination of loading paths at constant suction and drying/wetting paths at constant load were applied; (b) swelling tests under constant-volume conditions in order to determine the swelling pressure and the stress path followed during wetting. The results of the experimental programme are examined, taking into account the role of the soil fabric in controlling observed mechanical behaviour. In addition, the results of the laboratory tests are reproduced and interpreted using a generalised plasticity model that considers explicitly the interaction between macrostructure and microstructure. In this way, it is possible to achieve a more complete understanding of the mechanisms that underlie observed behaviour, and in particular the interplay between the two structural level

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Mechanical behaviour of heavily compacted bentonite under high suction changes

The paper reports the results of an experimental study carried out on a bentonite compacted to a dry density of up to 1·7 Mg=m3, a high value for this type of soil. The soil fabric has been studied using a variety of techniques, revealing a clear bimodal pore distribution that corresponds to two distinct structural levels: a microstructural one and a macrostructural one. The main testing programme has been performed using oedometers especially designed to apply a very large range of suctions. By applying the axis-translation technique (using nitrogen as the gas fluid), it has been possible to reach suctions up to 15 MPa. The higher suction range has been achieved by applying a controlled atmosphere where the relative humidity has been fixed by a solution of sulphuric acid or salts. In this way suctions up to 550 MPa could be reached. The maximum vertical stress that could be applied in the apparatus was 10 MPa. Two types of test have been carried out: (a) tests in which a combination of loading paths at constant suction and drying/wetting paths at constant load were applied; (b) swelling tests under constant-volume conditions in order to determine the swelling pressure and the stress path followed during wetting. The results of the experimental programme are examined, taking into account the role of the soil fabric in controlling observed mechanical behaviour. In addition, the results of the laboratory tests are reproduced and interpreted using a generalised plasticity model that considers explicitly the interaction between macrostructure and microstructure. In this way, it is possible to achieve a more complete understanding of the mechanisms that underlie observed behaviour, and in particular the interplay between the two structural levels.Peer Reviewe

A Multiplex Immunosensor for Detecting Perchlorate-Reducing Bacteria for Environmental Monitoring and Planetary Exploration

© 2020 Gallardo-Carreño, Moreno-Paz, Aguirre, Blanco, Alonso-Pintado, Raymond-Bouchard, Maggiori, Rivas, Engelbrektson, Whyte and Parro.Perchlorate anions are produced by chemical industries and are important contaminants in certain natural ecosystems. Perchlorate also occurs in some natural and uncontaminated environments such as the Atacama Desert, the high Arctic or the Antarctic Dry Valleys, and is especially abundant on the surface of Mars. As some bacterial strains are capable of using perchlorate as an electron acceptor under anaerobic conditions, their detection is relevant for environmental monitoring on Earth as well as for the search for life on Mars. We have developed an antibody microarray with 20 polyclonal antibodies to detect perchlorate-reducing bacteria (PRB) strains and two crucial and highly conserved enzymes involved in perchlorate respiration: perchlorate reductase and chlorite dismutase. We determined the cross-reactivity, the working concentration, and the limit of detection of each antibody individually and in a multiplex format by Fluorescent Sandwich Microarray Immunoassay. Although most of them exhibited relatively high sensitivity and specificity, we applied a deconvolution method based on graph theory to discriminate between specific signals and cross-reactions from related microorganisms. We validated the system by analyzing multiple bacterial isolates, crude extracts from contaminated reactors and salt-rich natural samples from the high Arctic. The PRB detecting chip (PRBCHIP) allowed us to detect and classify environmental isolates as well as to detect similar strains by using crude extracts obtained from 0.5 g even from soils with low organic-matter levels (<103 cells/g of soil). Our results demonstrated that PRBCHIP is a valuable tool for sensitive and reliable detection of perchlorate-reducing bacteria for research purposes, environmental monitoring and planetary exploration.This work was funded by the Ministry of Economy and Competitiveness, (MINECO)/Fondo Europeo de Desarrollo Regional (FEDER) grant numbers AYA2011-24803, ESP2015-69540-R, and RTI2018-094368-B-I00, and MDM-2017-0737 Unidad de Excelencia “Maria de Maeztu”, Centro de Astrobiología (INTA-CSIC). JA was supported by the Spanish MINECO project MiMevo FIS2017 89773-P and SEV 2017-0712. IG-C was a FPI program fellowship (MINECO)

A proto-pseudobulge in ESO 320-G030 fed by a massive molecular inflow driven by a nuclear bar

Galaxies with nuclear bars are believed to efficiently drive gas inward, generating a nuclear starburst and possibly an active galactic nucleus. We confirm this scenario for the isolated, double-barred, luminous infrared galaxy ESO 320-G030 based on an analysis of Herschel and ALMA spectroscopic observations. Herschel/PACS and SPIRE observations of ESO 320-G030 show absorption or emission in 18 lines of H2O, which we combine with the ALMA H2O 423 − 330 448 GHz line (Eupper ∼ 400 K) and continuum images to study the physical properties of the nuclear region. Radiative transfer models indicate that three nuclear components are required to account for the multi-transition H2O and continuum data. An envelope, with radius R ∼ 130 − 150 pc, dust temperature Tdust ≈ 50 K, and NH2 ∼ 2 × 1023 cm−2, surrounds a nuclear disk with R ∼ 40 pc that is optically thick in the far-infrared (τ100 μm ∼ 1.5 − 3, NH2 ∼ 2 × 1024 cm−2). In addition, an extremely compact (R ∼ 12 pc), warm (≈100 K), and buried (τ100 μm >  5, NH2 ≳ 5 × 1024 cm−2) core component is required to account for the very high-lying H2O absorption lines. The three nuclear components account for 70% of the galaxy luminosity (SFR ∼ 16 − 18 M⊙ yr−1). The nucleus is fed by a molecular inflow observed in CO 2-1 with ALMA, which is associated with the nuclear bar. With decreasing radius (r = 450 − 225 pc), the mass inflow rate increases up to Ṁinf ∼ 20 Ṁ yr−1, which is similar to the nuclear star formation rate (SFR), indicating that the starburst is sustained by the inflow. At lower r, ∼100 − 150 pc, the inflow is best probed by the far-infrared OH ground-state doublets, with an estimated Ṁinf ∼ 30 Ṁ yr−1. The inferred short timescale of ∼20 Myr for nuclear gas replenishment indicates quick secular evolution, and indicates that we are witnessing an intermediate stage (< 100 Myr) proto-pseudobulge fed by a massive inflow that is driven by a strong nuclear bar. We also apply the H2O model to the Herschel far-infrared spectroscopic observations of H$_2^{18}$ O, OH, 18OH, OH+, H2O+, H3O+, NH, NH2, NH3, CH, CH+, 13CH+, HF, SH, and C3, and we estimate their abundances

Immunocompromised patients with acute respiratory distress syndrome : Secondary analysis of the LUNG SAFE database

The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013

Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database

Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p &lt; 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p &lt; 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013

Estableciendo "puentes" entre la Universidad y el tejido social madrileño : cómo los estudiantes de la Asignatura Ciudad y Urbanismo pueden colaborar en la búsqueda de soluciones urbanísticas a históricas reclamaciones vecinales en el entorno de Puente de Vallecas

Publicación de los trabajos elaborados por los estudiantes del curso 2022/23 de la asignatura Ciudad y Urbanismo (35001304) de la Escuela Técnica Superior de Arquitectura de la Universidad Politécnica de Madrid en el marco de un proyecto de Aprendizaje-Servicio y reflexiones sobre el proceso tanto de los agentes sociales que formaron parte del mismo, como de los profesores que ha participado en la docencia