The responses of L-gulonolactone oxidase and HKT2;1 genes in Aeluropus littoralis' shoots under high concentration of sodium chloride

ABSTRACT: Salinity is one of the most important abiotic stresses that limit crop growth and production. Salt stress influences plants in two ways: by affecting ion toxicity and increasing osmotic stress. Ion homeostasis, the excretion of Na + and using antioxidant systems are the major strategies of salt tolerance in plants. Na + and K + transporters with enzymes that are involved in detoxification of reactive oxygen species play key roles in salt tolerance in plants. The aim of this study was to investigate the responses of high affinity K + transporter2;1 gene (HKT2;1) which is involved in regulation of ion homeostasis and L-gulonolactone oxidase (GLOase) which is involved in the ascorbic acid biosynthesis pathway, under different concentrations of NaCl over different time points in Aeluropus littoralis shoots. Results from Real Time PCR data showed that expressions of both genes were influenced by external and internal concentrations of Na + and the internal K + content. AlHKT2;1 was significantly upregulated by increasing Na + concentration at all time points. Furthermore, its highest expression level in shoots occurred after 6 days in 300mM NaCl in shoots which was 25folds more than untreated shoots. AlGLOase expression levels increased 54 h after initiation of salt stress. These results indicate that AlHKT2;1 and AlGLOase respond to different salinity conditions and probably are part of the mechanisms involved in tolerance to high salt concentrations in A. littoralis

A Post-Marketing Surveillance Study to Evaluate the Safety Profile of AlvotereⓇ (Docetaxel) in Iranian Patients Diagnosed with Different Types of Cancers Receiving Chemotherapy

Background Docetaxel is a clinically well established antimitotic chemotherapy medication. Labeled docetaxel indications are breast cancer, gastric cancer, head and neck cancer, non–small cell lung cancer, and prostate cancer. Objective This is a Phase IV study to evaluate the safety profile of docetaxel (Alvotere; NanoAlvand, Iran) in Iranian patients diagnosed with different types of cancers receiving chemotherapy regimens with docetaxel. Methods Patients who received Alvotere as a part of their chemotherapy regimen were enrolled in this Phase IV, observational, multicenter, open-label study. Alvotere was administrated as a single agent or in combination with other chemotherapy agents. Safety parameters in each cycle were assessed, and the related data were recorded in booklets. Findings A total of 411 patients with different types of cancers were enrolled from 25 centers in Iran. The most common malignancies among participants were breast cancer (49.88%), followed by gastric cancer (22.63%). Participants’ mean age was 53.33 years, and the mean total dose used in each cycle was 132 mg. According to the results, 341 patients experienced at least 1 adverse event, that the most common was alopecia (41.12%). In total, 92 (22.38%) patients had at least 1 adverse event of grade 3 or 4, and 25 (6.08%) patients showed 54 serious adverse events, which the causality assessment for all was possibly related to Alvotere. There was a significant difference between men and women in the incidence of skin and subcutaneous tissue disorders (55.63% in women vs 41.73% in men; P = 0.009). Also, the incidence of gastrointestinal disorders, nervous system disorders, skin and subcutaneous tissue disorders, hepatic enzymes increase, and fluid retention was significantly higher (P < 0.05) in patients receiving anthracyclines in their chemotherapy regimens. Conclusions The findings of this open-label, observational, multicenter, postmarketing surveillance showed that Alvotere appears to have an acceptable safety profile in Iranian cancer patients receiving chemotherapeutic regimens. (Curr Ther Res Clin Exp. 2022; 82:XXX–XXX) © 2022 Elsevier HS Journals, Inc

Triple-Negative Breast Cancer: Clinical Characteristics, Prognostic Features, and Long-Term Outcome: A Comparative Study

Background: Because of the reported poor prognosis and absence of effective and specific therapeutic approaches, triple-negative breast cancer (TNBC) tumors have remained as an important area of investigations for clinicians and researchers. The aim of this study was to determine the clinical, pathological, histological, prognostic features, and outcome associated with this type of breast cancer in Iran. We also tried to identify main determinants of long-term survival in women suffered from TNBC tumor type. Methods: This is a historical cohort study of 546 consecutive female breast cancer patients with known status of hormonal receptors and diagnosed at the Rasoul-e-Akram University Hospital of Iran between January 2009 and June 2011. Baseline data were collected from patient records and hospital charts. Long-term outcome was determined from clinic records when available or by means of written correspondence with patients&apos; physicians and telephone interviews directly with the patients or with family members. Follow-up data were collected by our research personnel for a mean follow-up duration 5.7 years. Results: A total of 86 of 546 final included participants with breast cancer were identified as having TNBC (15.8%).The patients with TNBC diagnosis were significantly younger than non-TNBC group and family history of breast cancer was more prevalent in former group. Regarding histopathological feature, medullary feature was more prevalent in TNBC group, while other features were similarly revealed in both groups. With respect to tumor grading, TNBC group was graded higher than non-TNBC group that grade III of tumor was reported in 51.1% of the TNBC patients, but in 15.9% of another group. Also, the stage of tumor was significantly higher in the TNBC group. Tumor size &amp;gt; 50 mm was observed in 18.6% of the TNBC and 14.8% of non-TNBC groups. Metastasis to liver as well as concurrent metastasis to brain and pulmonary was more prevalent in TNBC compared with another group. The Kaplan-Meier curves based showed the survival probability at 1-year, 3-year, and 5-year of follow-up in TNBC group was 92.7%, 86.2%, and 44.9%, respectively. This survival rates in non-TNBC group was 98.7%, 87/2%, and 72.5%, respectively. Multivariable logistic regression analysis showed that TNBC diagnosis could strongly predict long-term mortality in breast cancer patients. Besides, tumor size, number of involved lymph nodes and higher tumor grade were other determinants of cancer-related long-term mortality. Conclusion: The present study on Iranian TNBCs population shows that TNBCs account for about 15.8% of all invasive breast cancers, and they usually have a high histological stating and metastasis susceptibility

Clinical Comparison of the Effects of Gabapentin and Megestrol Aacetate on Hot Flashes in Patients with Breast Cancer

Introduction: Hot flash affects approximately 75% of women with breast cancer. Those who experience hot flashes have higher rates of sleep disorders, temper and lower quality of life than women with no hot flashes. The&amp;nbsp; persent&amp;nbsp; study&amp;nbsp; was aimed to compare the effect of megestrol acetate with gabapentin on the severity of hot flashes in patients with breast cancer Materials and Methods: In a randomized controlled clinical-trial study 120 patient with breast cancer who had moderate and&amp;nbsp; severe&amp;nbsp; hot flashes were randomly assiged into two groups; 40 mg megestrol acetate twice daily and 300mg gabapentin oncedaily for a period of 8 weeks. Demographic data and the severity of hot flashes were recorded before treatment and 8 weeks after therapy. The obtained data was analysed using SPSS V15 withstatistical tests chi-square, Student T- Test and Paired T-Tes. Results: After 8 weeks of treatment with megestrol acetat a reduction of 64.3% in hot flash frequency and 37.1% reduction in hot flash severity from base line were observed. In the gabapentin group the decrease was 44.8% and 24.6% compared before treatment respectively.(P=0.005&amp;nbsp; , P=0.04&amp;nbsp; ) After eight weeks of treatment the number of hot flashes was 3.9&amp;plusmn;4.0 and 5.8&amp;plusmn;3.7 in the megestrol acetat and gabapentin groups respectively; the difference was statistically significant(P=0.04).In the megestrol acetat group number of hot flashes was obviously lower than their level in the&amp;nbsp; gabapentin group. After eight weeks of treatment,the serverity of hot flashes was 50.4% and 62.9% in the megestrol and gabapentin&amp;nbsp; groups respectively; the difference was statistically significant (P=0.005&amp;nbsp; ).In the megestrol group severity of hot flash was obviously lower than their levels in the gabapentin group.In the megestrol group frequency and severity of hot flashes were obviously&amp;nbsp; significantly lower than their levels in the gabapentin group. Conclusion: Megestrol acetat is significantly more effective than the Gabapentin in treating hot flash and can be considered as an effective therapy to reduce the disorder

نقش پیش‏‌بینی‌کنندگی محبوبیت والدین و نشاط معنوی از احساس خودارزشمندی در نوجوانان دارای والد با آسیب بینایی در خانواده‌های تحت پوشش سازمان بهزیستی

سابقه و هدف: نشاط معنوی مقوله‏ای است که با وجود اهمیت فراوان آن به‏عنوان موضوعی مجزا کمتر به آن توجه شده است. نشاط لازمۀ زندگی و عامل محرکی برای نیل انسان به سلامت روانی و قُرب الی‏الله است. در عین ‏حال، عامل خانواده به‏ویژه محبوبیت والدین با بهزیستی روانی و کاهش آسیب‏های اجتماعی-روانی ارتباط معناداری دارد. ازاین‌رو، این پژوهش با هدف بررسی نقش پیش‏بینی‏کنندگی محبوبیت والدین و نشاط معنوی با احساس خودارزشمندی نوجوانان انجام شد. روش کار: پژوهش حاضر توصیفی از نوع همبستگی است. جامعۀ آماری همۀ نوجوانان دارای والد نابینای تحت پوشش سازمان بهزیستی در 31 استان ایران در سال 1400 بود که 240 نفر از آنان به‌روش نمونه‏گیری هدفمند و برحسب مراجعات متوالی به مراکز بهزیستی انتخاب شدند و پرسش‏نامه‌های احساس خودارزشمندی روزنبرگ، نشاط معنوی افروز و محبوبیت والدین افروز و اسدی را تکمیل کردند. برای تحلیل داده‏ها از ضریب همبستگی پیرسون و رگرسیون چندگانۀ سلسله‌مراتبی استفاده شد. در این پژوهش همۀ موارد اخلاقی رعایت شده است و مؤلفان مقاله تضاد منافعی گزارش نکرده‌اند. یافته‌ها: نتایج پژوهش نشان داد بین نشاط معنوی با احساس خودارزشمندی (63/0=r و 011/0>P) و همچنین بین محبوبیت والدین (52/0=r و 017/0>P) با احساس خودارزشمندی همبستگی مثبت و معنادار برقرار بود. تحلیل رگرسیون نشان داد به‏ترتیب نشاط معنوی توان تبیین 20% از واریانس احساس خودارزشمندی، نشاط معنوی و محبوبیت والدین با هم توان تبیین 28% از واریانس احساس خودارزشمندی؛ و محبوبیت والدین مستقل از نشاط معنوی توان تبیین 7% از این واریانس را داشتند. دو عامل محبوبیت مادر و پدر نیز توانستند 8% از واریانس احساس خودارزشمندی را پیش‏بینی کنند. در میان متغیّرهای مربوط به محبوبیت مادر و پدر، محبوبیت مادر با ضریب بتای 26/0=β قوی‏ترین پیش‏بینی‌کننده بود. نتیجه‌گیری: ازآنجایی‌که محبوبیت والدین و نشاط معنوی میزان بالایی از تغییرپذیری احساس خودارزشمندی را تبیین می‏کنند، می‏توان توجه به این عوامل را در بهبود احساس خودارزشمندی نوجوانان مهم دانست و در برنامه‏های ارتقای سلامت در جامعه مدنظر قرار داد

Iranian Cancer Network: Introduction, Mission and Its Role in Cancer Management

Objectives: The Iranian Cancer Network was established in May 2003. Our aim was to coordinate re&amp;not;search and treatment programs in all cancer centers in Iran in order to save time and money and enable patients, wherever they live, to receive a uniformly high-standard treatment and care. Methods: After signing a mutual contract with fellow (collaborator) university and holding some shared sessions, the project was planned on the basis of the network missions. Network structure guide&amp;not;lines and the responsibility of the sections and staff in the network were being defined. Cancer teams include physicians, epidemiologists, pathologists, basic scientists, and executive authorities related to cancer management.&quot;nResults: The Iranian Cancer Network has started its work as a preliminary study between two centers. Then some other cancer centers in the country joined it and it is developing gradually. Several common research projects and clinical trials have been started in this network. Genomic DNA bank for patients with hematopoetic malignancies is being constructed. Data bank for all cancers referring to these cen&amp;not;ters is being constructed and its result will be published later.&quot;nConclusion: Cancer networks make a systematic connection between all cancer centers around a coun&amp;not;try (or abroad) to ensure delivery of new information, interventions, and best practices and help others to share their research and laboratory facilities

Comprehensive overview of optimizing PV-DG allocation in power system and solar energy resource potential assessments

Distributed Generation based on Photovoltaic (PV-DG) injected in the power system is considered a highly promising solution due to the advantage of clean energy use. However, the investigation of the optimal PV-DG allocation (site and size) is a significant task for power system requirements and assessment of PV potentials. Recent research works on PV-DG allocation are reviewed from two viewpoints; (1) DG, optimization algorithms and objectives and (2) methodologies of PV potential assessments. Due to the review of recent research works, the research gaps are identified and new methodology will be proposed. The authors strongly believe that this work can be helpful to mitigate power system challenges. Besides, it helps to maximize the PV harness within the power system in particular developing countries. © 2019 The AuthorsArizona Research Institute for Solar Energy, AzRISEAt the beginning, the author is grateful from YTB (Yurtd??? T?rkler ve Akraba Topluluklar Ba?kanl???) to provide the chance for conducting this study in Turkey. He would also like to thank each of Solar Energy Institute (G?ne? Enerjisi Enstit?s?) in Ege University for providing all necessary needs to complete this work, my supervisor for his tangible guiding and motivating during this academic research and my parents for spiritual support